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Articles 3691 - 3720 of 7020

Full-Text Articles in Pharmacology, Toxicology and Environmental Health

Cost-Effectiveness Analysis Of Aripiprazole Compared With Risperidone In Treatment Of Acute Schizophrenia Patients In Thailand, Wiwat Thavornwattanayong Jan 2018

Cost-Effectiveness Analysis Of Aripiprazole Compared With Risperidone In Treatment Of Acute Schizophrenia Patients In Thailand, Wiwat Thavornwattanayong

The Thai Journal of Pharmaceutical Sciences

OBJECTIVES: Schizophrenia is the third leading cause of loss of life years in Thailand. Currently, aripiprazole is the latest drug for the treatment of acute schizophrenia in Thailand but its cost-effectiveness has not been studied. The purpose of this s.

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The Forensic Characterization Of Bacterial And Fungal Organisms In Traditional Chinese Medicine, Julia Grzymkowski, Christopher J. Ehrhardt, Justin L. Poklis, Michelle R. Peace Jan 2018

The Forensic Characterization Of Bacterial And Fungal Organisms In Traditional Chinese Medicine, Julia Grzymkowski, Christopher J. Ehrhardt, Justin L. Poklis, Michelle R. Peace

UROP Posters

There has been an increase in use of Traditional Chinese Medicine (TCM) in the United States because they are less expensive and believed to be more effective with less adverse effects in comparison to traditional pharmaceutics. Therefore, sales have increased in the US, despite articles and case studies demonstrating the dangers, such as injury and death, related to TCM, stemming from improper labelling, toxic contaminants, and, in some cases, the presence of pathogenic bacteria. The aim of this study was to perform a survival experiment to demonstrate the importance of proper herbal brewing technique and to conduct a molecular and …

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The Effects Of The Red Tide Producing Dinoflagellate, Karenia Brevis, And Associated Brevetoxins On Viability And Sublethal Stress Responses In Scleractinian Coral: A Potential Regional Stressor To Coral Reefs, David A. Reynolds Jan 2018

The Effects Of The Red Tide Producing Dinoflagellate, Karenia Brevis, And Associated Brevetoxins On Viability And Sublethal Stress Responses In Scleractinian Coral: A Potential Regional Stressor To Coral Reefs, David A. Reynolds

UNF Graduate Theses and Dissertations

Coral cover is in decline on a global scale, with increased mortality events being attributed to a number of global and regional stressors. While the impacts of global stressors (e.g. sea surface temperature rise, ocean acidification) are well documented, there is growing interest in identifying and understanding the impacts of regional stressors. The reason for this change in focus is that regional stressors can often work in combination, sometimes synergistically, with global stressors and that stressors on a regional scale tend to be more easily mitigated by management practices. One regional stressor that impacts a myriad of marine organisms in …

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A Cluster-Randomized Trial To Evaluate The Impact Of An Inclusive, Community-Led Total Sanitation Intervention On Sanitation Access For People With Disabilities In Malawi., Adam Biran, Lisa Danquah, Joseph Chunga, Wolf Peter Schmidt, Rochelle Holm, Ambumulire Itimu-Phiri, Wales Singini, Hazel Jones, Hannah Kuper, Sian White Jan 2018

A Cluster-Randomized Trial To Evaluate The Impact Of An Inclusive, Community-Led Total Sanitation Intervention On Sanitation Access For People With Disabilities In Malawi., Adam Biran, Lisa Danquah, Joseph Chunga, Wolf Peter Schmidt, Rochelle Holm, Ambumulire Itimu-Phiri, Wales Singini, Hazel Jones, Hannah Kuper, Sian White

Faculty and Staff Scholarship

Community-led total sanitation (CLTS) is a common method for promoting sanitation in low-income settings. This cluster-randomized trial evaluated an intervention to improve inclusion of people with disability in CLTS through training facilitators. A qualitative study examined intervention acceptability. The trial included 171 people with disabilities (78 control and 93 intervention) living in 15 intervention and 15 control communities. In the intervention arm, respondents were more likely to participate in a community meeting about sanitation (+18.7%, 95% confidence interval [CI]: 3.2, 34.2) and to have been visited to discuss sanitation (+19.7, 95% CI: 0.6, 37.8). More intervention households improved latrine access …

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A Novel Assay For Evaluation Of The Total Antioxidant Capacity (Tac) Using A Nontoxic Probe, Sirirat Panich Jan 2018

A Novel Assay For Evaluation Of The Total Antioxidant Capacity (Tac) Using A Nontoxic Probe, Sirirat Panich

The Thai Journal of Pharmaceutical Sciences

A novel and simple method for measuring total antioxidant capacity (TAC) was established. Herein, the new assay is based on generating the deep blue Imipramine (IMI) free radical by oxidising IMI with ammonium tetra vanadate (NH4VO3) in acid medium. Once.

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In Silico Evaluation Of Molecular Interactions Between Known ?-Glucosidase Inhibitors And Homologous ?-Glucosidase Enzymes From Saccharomyces Cerevisiae, Rattus Norvegicus, And Ganc-Human, Teni Ernawati Jan 2018

In Silico Evaluation Of Molecular Interactions Between Known ?-Glucosidase Inhibitors And Homologous ?-Glucosidase Enzymes From Saccharomyces Cerevisiae, Rattus Norvegicus, And Ganc-Human, Teni Ernawati

The Thai Journal of Pharmaceutical Sciences

The aim of this study was to observe molecular interactions between alpha glucosidase inhibitor waith alpha glucosidase enzyme derived from Saccharomyces cereviseae, Rattus norvegicus and GANC-human. Therefore, they were used against four of the well-kno.

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Intended High-Performance Liquid Chromatography Procedure For The Quantification Of Norfloxacin And Its Potential Impurities In Active Pharmaceutical Ingredient And Tablet Dosage Forms, Bikshal Babu Kasimala, Venkateswara Rao Anna, Useni Reddy Mallu, L. Maheshwara Reddy Jan 2018

Intended High-Performance Liquid Chromatography Procedure For The Quantification Of Norfloxacin And Its Potential Impurities In Active Pharmaceutical Ingredient And Tablet Dosage Forms, Bikshal Babu Kasimala, Venkateswara Rao Anna, Useni Reddy Mallu, L. Maheshwara Reddy

The Thai Journal of Pharmaceutical Sciences

Norfloxacin [NFXC] is an active pharmaceutical ingredient belongs to 4-quinolone antibacterial agent used for the prophylaxis of gram +ve and gram-ve bacterial infections. A reliable stability-indicating RP-HPLC method was developed for the separation an.

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Development And Validation Of Novel Stability-Indicating High-Performance Liquid Chromatography Method For The Determination Of Miglitol In Pharmaceuticals, Kanakapura Basavaiah, Nagaraju Rajendraprasad Jan 2018

Development And Validation Of Novel Stability-Indicating High-Performance Liquid Chromatography Method For The Determination Of Miglitol In Pharmaceuticals, Kanakapura Basavaiah, Nagaraju Rajendraprasad

The Thai Journal of Pharmaceutical Sciences

A reversed phase high performance liquid chromatographic (RP-HPLC) method for the determination of miglitol (MGL) in pharmaceuticals is presented. The assay was performed on a Phenomenex Luna C18 (150 × 4.6 mm; 5µm particle size) column using phosphate...

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Quantitative Structure–Activity Relationship Modeling Of S-Triazines And 2-Arylpyrimidines As Selective Pde4b Inhibitors, Anand Gaurav, Gabriel Akyirem Akowuah, Choo Shiuan Por Jan 2018

Quantitative Structure–Activity Relationship Modeling Of S-Triazines And 2-Arylpyrimidines As Selective Pde4b Inhibitors, Anand Gaurav, Gabriel Akyirem Akowuah, Choo Shiuan Por

The Thai Journal of Pharmaceutical Sciences

A QSAR analysis was conducted on a series of 2-arylpyrimidine and s-triazine derivatives as selective PDE4B inhibitors. Primary objective of the study is to develop predictive QSAR models for s-triazines and 2-arylpyrimidines as selective PDE4B and to id.

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Ethical Cases On Pharmacy Profession Practice In Thailand During A.D. 1995 To 2015, Wanna Sriviriyanupap, Usawadee Sutapuk Jan 2018

Ethical Cases On Pharmacy Profession Practice In Thailand During A.D. 1995 To 2015, Wanna Sriviriyanupap, Usawadee Sutapuk

The Thai Journal of Pharmaceutical Sciences

Background: Code of ethics for the pharmacy profession was established to enforce all pharmacists to abide by a rule for a good pharmacy professional practice. Objective: to study the ethical problems, related to the pharmacy profession practice, and to .

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Population Pharmacokinetics Analysis Of Vancomycin In Critically Ill Patients, Wanchai Treyaprasert Jan 2018

Population Pharmacokinetics Analysis Of Vancomycin In Critically Ill Patients, Wanchai Treyaprasert

The Thai Journal of Pharmaceutical Sciences

Objectives: The aim of this study was to determine population pharmacokinetic parameters of vancomycin in adult critically ill patients and to investigate the covariates affecting population pharmacokinetic parameters. Methods: Plasma concentration data..

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Effect Of Temperature And Time On Free Amino Acid Profile In Thai Chicken Bone Soup Stock Preparation, Nattida Chotechuang, Matichon Lokkhumlue, Pawinee Deetae Jan 2018

Effect Of Temperature And Time On Free Amino Acid Profile In Thai Chicken Bone Soup Stock Preparation, Nattida Chotechuang, Matichon Lokkhumlue, Pawinee Deetae

The Thai Journal of Pharmaceutical Sciences

Soup stock is the basic material for cooking various types of food, including Thai food. General practice to prepare Thai soup stock is to gentle boil chicken bone soup stock between 85-95°C for 1-3 hours to get good quality soup stock. Free amino aci..

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Apigenin And Baicalin, Each Alone Or In Low Dose Combination, Attenuated Chloroquine Induced Male Infertility In Adult Rats, Amira Akilah, Mohamed Balaha, Mohamed-Nabeih Abd-El Rahman, Sabiha Hedya Jan 2018

Apigenin And Baicalin, Each Alone Or In Low Dose Combination, Attenuated Chloroquine Induced Male Infertility In Adult Rats, Amira Akilah, Mohamed Balaha, Mohamed-Nabeih Abd-El Rahman, Sabiha Hedya

The Thai Journal of Pharmaceutical Sciences

Male infertility is a worldwide health problem, which accounts for about 50% of all cases of infertility and considered as the commonest single defined cause of infertility. Recently, apigenin and baicalin exhibited a powerful antioxidant and antiapoptot.

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The Protective Effect Of Lycopene-Rich Products On Skin Photodamage: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Witoo Dilokthornsakul, Teerapon Dhippayom, Piyameth Dilokthornsakul Jan 2018

The Protective Effect Of Lycopene-Rich Products On Skin Photodamage: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Witoo Dilokthornsakul, Teerapon Dhippayom, Piyameth Dilokthornsakul

The Thai Journal of Pharmaceutical Sciences

Background: Ultraviolet (UV) radiation has known as a major cause of photodamage, photoaging and skin cancer as it involves in reactive oxygen species generation. Several natural antioxidants including lycopene has been suggested for photoprotection. How.

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Suitability Of Alternative Atp Potency Assay For Lot Release Of Tokyo Bcg- 172-1 Vaccines In Thailand, Supaporn Phumiamorn Jan 2018

Suitability Of Alternative Atp Potency Assay For Lot Release Of Tokyo Bcg- 172-1 Vaccines In Thailand, Supaporn Phumiamorn

The Thai Journal of Pharmaceutical Sciences

The potency assay of the BCG vaccine is routinely performed by a conventional viable count on a solid medium. This assay method is not only time-consuming, but can give variable results because of the tendency to clump of mycobacterium. The intracellular.

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A Simple High-Performance Liquid Chromatographic Method For Quantitative Analysis Of Brazilin In Caesalpinia Sappan L. Extracts, Sakan Warinhomhaun, Boonchoo Sritularak, Dusadee Charnvanich Jan 2018

A Simple High-Performance Liquid Chromatographic Method For Quantitative Analysis Of Brazilin In Caesalpinia Sappan L. Extracts, Sakan Warinhomhaun, Boonchoo Sritularak, Dusadee Charnvanich

The Thai Journal of Pharmaceutical Sciences

The specific aim of the study was to develop and validate a simple reversed-phase high-performance liquid chromatographic (HPLC) method for assay of brazilin in Caesalpinia sappan L. (sappanwood) extracts. Validation of the HPLC method was conducted unde.

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Access To Medicines For Breast, Colorectal, And Lung Cancer In Thailand, Pornsroung Saerekul, Tharin Limsakun, Puree Anantachoti, Rungpetch Sakulbumrungsil Jan 2018

Access To Medicines For Breast, Colorectal, And Lung Cancer In Thailand, Pornsroung Saerekul, Tharin Limsakun, Puree Anantachoti, Rungpetch Sakulbumrungsil

The Thai Journal of Pharmaceutical Sciences

Cancer drugs have become prohibitive, and consequently their accessibility has increasingly been of great concern in many countries. Particularly, the information about cancer drug access in Thailand has been sporadic. Therefore, the goal of the study wa.

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Anti-Inflammatory Effect Of Centella Asiatica Extract On Prevented Aortic Intima-Media Thickening In Diabetic Rats, Amalia Anita Hawas, Dwi Aris Agung Nugrahaningsih, Eti Nurwening Sholikhah, Sadli Syarifuddin, Rahmi Ayu Wijayaningsih, Ngatidjan Jan 2018

Anti-Inflammatory Effect Of Centella Asiatica Extract On Prevented Aortic Intima-Media Thickening In Diabetic Rats, Amalia Anita Hawas, Dwi Aris Agung Nugrahaningsih, Eti Nurwening Sholikhah, Sadli Syarifuddin, Rahmi Ayu Wijayaningsih, Ngatidjan

The Thai Journal of Pharmaceutical Sciences

Objectives: To explore the effect of C. asiatica extract on intima-media thickness, eNOS expression, and macrophage M1/M2 ratio in diabetic rats aorta. Materials and Methods: Wistar rats consisted of normal group and diabetic group which divided into neg.

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Effect Of Ipomoea Hederacea Jacq. Methanolic Extract On Blood Pressure And Relaxation Of Rat Thoracic Aorta: Evidence Indicated The Release Of No And H2s, Chaweewan Jansakul Jan 2018

Effect Of Ipomoea Hederacea Jacq. Methanolic Extract On Blood Pressure And Relaxation Of Rat Thoracic Aorta: Evidence Indicated The Release Of No And H2s, Chaweewan Jansakul

The Thai Journal of Pharmaceutical Sciences

Seeds of Ipomoeahederacea Jacq. (IH) are used in traditional medicine to manage ailments pertaining to the vasculature, circulatory system and related disorders. However no study exists to validate their usage for said ailments. The present study was con.

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Solubilization Of Fluocinolone Acetonide By Cosolvents And Surfactants For Buccal Solution Preparation, Pornpen Werawatganone, Walaisiri Muangsiri, Tipanan Chaivanon, Pavinee Kungwanpongpun, Paricha Rattanawong Jan 2018

Solubilization Of Fluocinolone Acetonide By Cosolvents And Surfactants For Buccal Solution Preparation, Pornpen Werawatganone, Walaisiri Muangsiri, Tipanan Chaivanon, Pavinee Kungwanpongpun, Paricha Rattanawong

The Thai Journal of Pharmaceutical Sciences

Fluocinolone acetonide (FA) buccal solution was prepared for treatment of oral lichen planus using cosolvents and surfactant to enhance FA solubility. Based on solubility power (s), cosolvents enhanced FA solubility in the order; polyethylene glycol 400 .

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Antioxidant Potential Of Wild Lagenaria Siceraria (Molina) Standl, Suraj B. Patel, Usmangani A. Attar, S G. Ghane Jan 2018

Antioxidant Potential Of Wild Lagenaria Siceraria (Molina) Standl, Suraj B. Patel, Usmangani A. Attar, S G. Ghane

The Thai Journal of Pharmaceutical Sciences

Objective: The aim of the present study was to evaluate the phytochemicals and antioxidant activity of leaf and fruit of wild Bottle gourd. Methods: Successive extraction of dried material was done by soxhlet apparatus and phytochemicals such as total p..

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Study Of Antioxidant, Antimicrobial, Tyrosinase Inhibitory, Alcohol Dehydrogenase, And Acetaldehyde Dehydrogenase Activity Of Roasted Dendropanax Morbifera Lev. Leaves With Different Ethanol Concentrations, Masaya Nakamura, Ra Jong-Hwan, Kim Ju-Sung Jan 2018

Study Of Antioxidant, Antimicrobial, Tyrosinase Inhibitory, Alcohol Dehydrogenase, And Acetaldehyde Dehydrogenase Activity Of Roasted Dendropanax Morbifera Lev. Leaves With Different Ethanol Concentrations, Masaya Nakamura, Ra Jong-Hwan, Kim Ju-Sung

The Thai Journal of Pharmaceutical Sciences

Introduction: The history of Dendropanax morbifera LEV., which is indigenous plant in Korea, is quit old and simultaneously, known for locals as remedy of various diseases such as migraine and inflammation. The aim of this study is evaluating the antioxi.

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Quick-Fat Diet Inhibits The Development Of Diabetes In Spontaneously Diabetic Torii (Sdt) Rats, Takeshi Ohta, Takahisa Yamada, Taiichiro Kamiya, Takayuki Gotoh, Masataka Tsubaki, Masami Shinohara Jan 2018

Quick-Fat Diet Inhibits The Development Of Diabetes In Spontaneously Diabetic Torii (Sdt) Rats, Takeshi Ohta, Takahisa Yamada, Taiichiro Kamiya, Takayuki Gotoh, Masataka Tsubaki, Masami Shinohara

The Thai Journal of Pharmaceutical Sciences

The diabetic animal model is very useful for developing functional foods and medicinal drugs. Spontaneously Diabetic Torii (SDT) rat, a non-obese type 2 diabetic model, is one of the hopeful models to play an important role for research and development o.

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Hepatoprotective Activity Of Curcuma Xanthorrhiza Roxb. Paracetamol-Induced Liver Damage In Rats And Correlation With Their Chemical Compounds, Suwijiyo Pramono, Fitriana Hayyu Arifah, Fitrawan Hernuza Pribadi, Agung Endro Nugroho Jan 2018

Hepatoprotective Activity Of Curcuma Xanthorrhiza Roxb. Paracetamol-Induced Liver Damage In Rats And Correlation With Their Chemical Compounds, Suwijiyo Pramono, Fitriana Hayyu Arifah, Fitrawan Hernuza Pribadi, Agung Endro Nugroho

The Thai Journal of Pharmaceutical Sciences

Paracetamol is a widely used drug, but at high dose, it can produce undesirable side effects such as hepatotoxicity. Curcuma xanthorrhiza Roxb. is the one of Indonesian medicinal plants that traditionally used to treat liver disorders. The present study .

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Effects Of Unweathered Or Soil Weathered Copper-Based Nanoparticles And Compounds On Soil Grown Bell Pepper (Capsicum Annuum) And Spinach (Spinacia Oleracea) Plants, Swati Rawat Jan 2018

Effects Of Unweathered Or Soil Weathered Copper-Based Nanoparticles And Compounds On Soil Grown Bell Pepper (Capsicum Annuum) And Spinach (Spinacia Oleracea) Plants, Swati Rawat

Open Access Theses & Dissertations

Engineered nanoparticles (ENPs) find large scale industrial application because of their promising chemical, physical, electrical, magnetic, optical, and electronic properties. Copper-based ENP are used as gas sensors, in catalysts, electronics, semi-conductors, and in agriculture. They have been useful as agricultural amendments in the form of pesticides, herbicides, and fertilizers because of their antifungal and antibacterial properties. They also find application in electronics and sensors used in precision agriculture. Due to their massive production and use, ENPs are likely to be ubiquitous in the environment around us in the near future. Application of biosolids for fertilization and water from wastewater treatment …

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Insulin Modulates The Strong Reinforcing Effects Of Nicotine And Changes In Insulin Biomarkers In A Rodent Model Of Diabetes, Bryan Cruz Jan 2018

Insulin Modulates The Strong Reinforcing Effects Of Nicotine And Changes In Insulin Biomarkers In A Rodent Model Of Diabetes, Bryan Cruz

Open Access Theses & Dissertations

This study examined whether the strong reinforcing effects of nicotine and changes in insulin biomarkers observed in diabetic rats are modulated via insulin. A model of diabetes was employed involving administration of streptozotocin (STZ), which produces hypoinsulinemia in rats. The present study included vehicle- or STZ-treated rats that received sham surgery or an insulin pellet. Two-weeks later, the rats were given extended access to intravenous self-administration (IVSA) of saline or nicotine. Concomitant changes in food intake, water responses, and body weight were assessed during 12 days of IVSA. After the last session, plasma levels of insulin, leptin, amylin, and glucagon-like …

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Potential Candidates For Treating Deficits Associated With Developmental Ethanol Exposure In A Rodent Model: Solidago Nemoralis & Dimethoxybenzylidene-Anabasine, Logan James Fields Jan 2018

Potential Candidates For Treating Deficits Associated With Developmental Ethanol Exposure In A Rodent Model: Solidago Nemoralis & Dimethoxybenzylidene-Anabasine, Logan James Fields

Theses and Dissertations--Psychology

Prenatal alcohol exposure (Fetal Alcohol Syndrome [FAS] and Fetal Alcohol Spectrum Disorders [FASD’s]) represents the leading preventable cause of intellectual disabilities in the western world, with FASDs estimated to affect approximately 2-5% of live births in the United States at an approximate annual cost of $3.6 billion (CDC, 2015; May et al., 2009). Ethanol (ETOH) exposure during development can lead to a variety of long-term behavioral impairments including problems with executive functioning, motor coordination, spatial learning, attention, and hyperactivity (Jones, 2011; Mattson & Riley, 1998). Much research has been conducted to develop pharmacological and/or environmental interventions to reduce these deficits, …

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Effect Of Environmental Factors On The Aggregation Behavior Of Silver Nanoparticles In The Aquatic Environment, Kamelia Afshinnia Jan 2018

Effect Of Environmental Factors On The Aggregation Behavior Of Silver Nanoparticles In The Aquatic Environment, Kamelia Afshinnia

Theses and Dissertations

Understanding the environmental factors that affect the fate and effects of engineered nanoparticles (ENPs) in the environment is crucial for NP risk assessment. Silver nanoparticles (Ag NPs) readily transform in the environment, which alters their properties and subsequently their transport, fate, and toxicity. The overall aim of this dissertation was to evaluate the effects of Ag NPs physicochemical properties (e.g., size, surface charge, surface coating) and water chemistry (e.g., buffer concentration, organic ligands, natural organic matter) in controlling Ag NPs colloidal stability. This aim was achieved by systematically 1) review and rationalize many studies that investigated the aggregation kinetics of …

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Decoding The Signaling Of The D2r-2ar Heteromer: Relevance To Schizophrenia, Miao Huang Jan 2018

Decoding The Signaling Of The D2r-2ar Heteromer: Relevance To Schizophrenia, Miao Huang

Theses and Dissertations

Schizophrenia is a severe mental disorder affecting ~1% of world population. Two G protein coupled receptors (GPCRs): Gi-coupled dopamine D2 receptor (D2R), and Gq-coupled serotonin 2A receptor (2AR), are targeted by the typical and atypical antipsychotic drugs to treat schizophrenia. These two receptors have been shown to co-localize in brain regions relevant to schizophrenia, including the ventral tegmental area (VTA), striatum, and prefrontal cortex (PFC). Studies in our lab characterized the integrated signaling of the D2R-2AR heteromer and found that both the Gi activity of D2R and the Gq activity of 2AR were potentiated …

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Targeting Monoacylglycerol Lipase For The Reversal And Prevention Of Paclitaxel-Induced Allodynia In Mice, Zachary Curry Jan 2018

Targeting Monoacylglycerol Lipase For The Reversal And Prevention Of Paclitaxel-Induced Allodynia In Mice, Zachary Curry

Theses and Dissertations

Chemotherapy-induced peripheral neuropathy (CIPN) is a side-effect of chemotherapy causing pain in the hands and feet. In particular, paclitaxel causes CIPN lasting for years without effective treatment. There is a strong need for analgesics to both treat and prevent CIPN. One system containing multiple targets to treat CIPN is the endogenous cannabinoid system. This system consists of cannabinoid type 1 (CB1) and type 2 (CB2) receptors primarily expressed on presynaptic neurons and cells of the immune system, respectively. Inhibition of monoacylglycerol lipase (MAGL), which hydrolyzes the endogenous cannabinoid 2- arachidonoylglycerol (2-AG), with JZL184 or MJN110 produces …

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