Open Access. Powered by Scholars. Published by Universities.®

Pharmacology, Toxicology and Environmental Health Commons™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 3241 - 3270 of 7020

Full-Text Articles in Pharmacology, Toxicology and Environmental Health

Untargeted Safety Pharmacology Screen Of Blood-Activating And Stasis-Removing Patent Chinese Herbal Medicines Identified Nonherbal Ingredients As A Cause Of Organ Damage In Experimental Models, Xinyan Liu, Rui Shao, Xinyue Yang, Guangxu Xiao, Shuang He, Benjamin Feng, Yan Zhu Sep 2019

Untargeted Safety Pharmacology Screen Of Blood-Activating And Stasis-Removing Patent Chinese Herbal Medicines Identified Nonherbal Ingredients As A Cause Of Organ Damage In Experimental Models, Xinyan Liu, Rui Shao, Xinyue Yang, Guangxu Xiao, Shuang He, Benjamin Feng, Yan Zhu

Peer Reviewed Articles

Blood activation and stasis removal from circulation is a central principle for treatment of syndromes related to cerebral and cardiovascular diseases in Chinese herbal medicine. However, blood-activating and stasis-removing patent Chinese herbal medicine (BASR-pCHM) widely used with or without prescription in China and elsewhere are highly variable in composition and manufacture standard, making their safety assessment a challenging task. We proposed that an integrated evaluation of multiple toxicity parameters of BASR-pCHM would provide critical reference and guidelines for their safe clinical application. Examination of standardized extracts from 58 compound BASR-pCHM in vivo in VEGFR2-luc mice and in vitro in cardiac, …

Go to article

Zero Waste, Spring/Summer 2017, Issue 36 Sep 2019

Zero Waste, Spring/Summer 2017, Issue 36

Sustain Magazine

No abstract provided.

Go to article

Consent Decrees, Fall/Winter 2017, Issue 35 Sep 2019

Consent Decrees, Fall/Winter 2017, Issue 35

Sustain Magazine

No abstract provided.

Go to article

Human Ecology, Spring/Summer 2016, Issue 34 Sep 2019

Human Ecology, Spring/Summer 2016, Issue 34

Sustain Magazine

No abstract provided.

Go to article

Citizen Science, Fall/Winter 2016, Issue 33 Sep 2019

Citizen Science, Fall/Winter 2016, Issue 33

Sustain Magazine

No abstract provided.

Go to article

Urban Streams, Spring/Summer 2015, Issue 32 Sep 2019

Urban Streams, Spring/Summer 2015, Issue 32

Sustain Magazine

No abstract provided.

Go to article

Unconventional Energy, Fall/Winter 2015, Issue 31 Sep 2019

Unconventional Energy, Fall/Winter 2015, Issue 31

Sustain Magazine

No abstract provided.

Go to article

Carbon Neutral, Spring/Summer 2018, Issue 38 Sep 2019

Carbon Neutral, Spring/Summer 2018, Issue 38

Sustain Magazine

No abstract provided.

Go to article

Political Will, Fall/Winter 2018, Issue 37 Sep 2019

Political Will, Fall/Winter 2018, Issue 37

Sustain Magazine

No abstract provided.

Go to article

Adminstration Of Micronized Caffeine Using A Novel Oral Delivery Film Results In Rapid Absorption And Electroencephalogram Suppression, Rochelle M. Hines, Matthew Khumnark, Ben Macphail, Dustine J. Hines Sep 2019

Adminstration Of Micronized Caffeine Using A Novel Oral Delivery Film Results In Rapid Absorption And Electroencephalogram Suppression, Rochelle M. Hines, Matthew Khumnark, Ben Macphail, Dustine J. Hines

Psychology Faculty Research

Route of administration is well-known to impact factors ranging from absorption and distribution, up through the subjective effects of active ingredients. Different routes of administration confer specific advantages, such as more rapid absorption resulting from intravenous injection, or increased convenience with oral administration, but a combination of both rapid and convenient delivery is highly desirable. QuickStrip™ was designed as a rapidly dissolving thin film matrix that contains active ingredients, which may be promising for rapid and convenient delivery via the oral mucosa. To assess the delivery of QuickStrip™, we administered the well-characterized active ingredient caffeine to mice and compared QuickStrip™ …

Go to article

Cold Atmospheric Plasma Induces Accumulation Of Lysosomes And Caspase-Independent Cell Death In U373mg Glioblastoma Multiforme Cells, Gillian Conway, Zhonglei He, Ana L. Hutanu, George P. Cribaro, Eline Manaloto, Alan Casey, Damien Traynor, Vladimir Milosavljevic, Orla Howe, Carlos Barcia, James T. Murray, Patrick J. Cullen, James Curtin Sep 2019

Cold Atmospheric Plasma Induces Accumulation Of Lysosomes And Caspase-Independent Cell Death In U373mg Glioblastoma Multiforme Cells, Gillian Conway, Zhonglei He, Ana L. Hutanu, George P. Cribaro, Eline Manaloto, Alan Casey, Damien Traynor, Vladimir Milosavljevic, Orla Howe, Carlos Barcia, James T. Murray, Patrick J. Cullen, James Curtin

Articles

Room temperature Cold Atmospheric Plasma (CAP) has shown promising efficacy for the treatment of cancer but the exact mechanisms of action remain unclear. Both apoptosis and necrosis have been implicated as the mode of cell death in various cancer cells. We have previously demonstrated a caspase-independent mechanism of cell death in p53-mutated glioblastoma multiforme (GBM) cells exposed to plasma. The purpose of this study was to elucidate the molecular mechanisms involved in caspase-independent cell death induced by plasma treatment. We demonstrate that plasma induces rapid cell death in GBM cells, independent of caspases. Accumulation of vesicles was observed in plasma …

Go to article

Pm25 Metal Constituent Exposure And Stillbirth Risk In Harris County, Texas, Amal Rammah, Kristina W Whitworth, Inkyu Han, Wenyaw Chan, Elaine Symanski Sep 2019

Pm25 Metal Constituent Exposure And Stillbirth Risk In Harris County, Texas, Amal Rammah, Kristina W Whitworth, Inkyu Han, Wenyaw Chan, Elaine Symanski

Faculty, Staff and Student Publications

There is limited evidence on the role of exposure to chemical constituents of fine particulate matter (PM

Go to article

Food Safety Policies And Practices In Public Spaces: The Urban Water, Sanitation, And Hygiene Environment For Fresh Fish Sold From Individual Vendors In Mzuzu, Malawi., Jazimoni Lazaro, Fanuel Kapute, Rochelle H. Holm Sep 2019

Food Safety Policies And Practices In Public Spaces: The Urban Water, Sanitation, And Hygiene Environment For Fresh Fish Sold From Individual Vendors In Mzuzu, Malawi., Jazimoni Lazaro, Fanuel Kapute, Rochelle H. Holm

Faculty and Staff Scholarship

In sub-Saharan Africa, informal markets account for more than 80% of the total food selling. Fish is a major protein source for households in Malawi and is commonly purchased from individual vendors. The aim of this study was to review national acts and policies and local regulations focused on fresh fish sold at open-air markets or by mobile vendors and to further examine the water, sanitation, and hygiene environment that may impact food safety in Mzuzu City, Malawi. The study used interviews, an observational checklist, and sampling of water and fish skin. In general, there was limited oversight of food …

Go to article

Developing A Dissociative Nanocontainer For Peptide Drug Delivery, Michael Patrick Kelly Sep 2019

Developing A Dissociative Nanocontainer For Peptide Drug Delivery, Michael Patrick Kelly

Dissertations, Theses, and Capstone Projects

The potency and specificity of bioactive peptides have propelled these agents to the forefront of pharmacological research. However, delivery of peptides to their molecular target in cells is a major obstacle to their widespread application. A Trojan Horse strategy of packaging a bioactive peptide within a modified protein cage to protect it during transport, and releasing it at the target site, is a promising delivery method. Recent work has demonstrated that the viral capsid of the P22 bacteriophage can be loaded with an arbitrary, genetically-encoded peptide, and externally decorated with a cell-penetrating peptide, such as HIV-Tat, to translocate across in …

Go to article

Socio-Ecological Wellness Wheel: Applied To Community Gardens To Measure Green Gentrification, Micajah Daniels, Courtney Coughenour Aug 2019

Socio-Ecological Wellness Wheel: Applied To Community Gardens To Measure Green Gentrification, Micajah Daniels, Courtney Coughenour

McNair Poster Presentations

This project is intended to use Black Feminist Health Studies as an interdisciplinary approach to analyze the holisitc impacts of community gardens on nutrition behaviors. The implementation of green spaces such as community gardens have been correlated to both benefits and unintended consequences which this study demonstrates through the Socio-Ecological Wellness Wheel. An empirical and systematic way of measuring garden quality through an audit tool using Black Feminist Health Studies could help measure the nutrition environment of the community gardens and how they may influence fruit and vegetable consumption of food insecure populations. The need for this study is highlighted …

Go to article

Mechanisms Of Simvastatin Myotoxicity: The Role Of Autophagy Flux Inhibition., Arya Emami, Shahla Shojaei, Simone C. Da Silva Rosa, Mahmoud Aghaei, Ehsan Samiei, Amir Reza Vosoughi, Forouh Kalantari, Philip Kawalec, James Thliveris, Pawan Sharma, Amir A. Zeki, Mohsen Akbari, Joseph W. Gordon, Saeid Ghavami Aug 2019

Mechanisms Of Simvastatin Myotoxicity: The Role Of Autophagy Flux Inhibition., Arya Emami, Shahla Shojaei, Simone C. Da Silva Rosa, Mahmoud Aghaei, Ehsan Samiei, Amir Reza Vosoughi, Forouh Kalantari, Philip Kawalec, James Thliveris, Pawan Sharma, Amir A. Zeki, Mohsen Akbari, Joseph W. Gordon, Saeid Ghavami

Center for Translational Medicine Faculty Papers

Statins are some of the most widely used drugs worldwide, but one of their major side effects is myotoxicity. Using mouse myoblast (C2C12) and human alveolar rhabdomyosarcoma cell lines (RH30) in both 2-dimensional (2D) and 3-dimensional (3D) cell culture, we investigated the mechanisms of simvastatin's myotoxicity. We found that simvastatin significantly reduced cell viability in C2C12 cells compared to RH30 cells. However, simvastatin induced greater apoptosis in RH30 compared to C2C12 cells. Simvastatin-induced cell death is dependent on geranylgeranyl pyrophosphate (GGPP) in C2C12 cells, while in RH30 cells it is dependent on both farnesyl pyrophosphate (FPP) and GGPP. Simvastatin inhibited …

Go to article

Our Envirome, Spring/Summer 2019, Issue 40 Aug 2019

Our Envirome, Spring/Summer 2019, Issue 40

Sustain Magazine

No abstract provided.

Go to article

Plastic Pollution, Fall/Winter 2019, Issue 39.3 Aug 2019

Plastic Pollution, Fall/Winter 2019, Issue 39.3

Sustain Magazine

No abstract provided.

Go to article

Plastic Pollution, Fall/Winter 2019, Issue 39.2 Aug 2019

Plastic Pollution, Fall/Winter 2019, Issue 39.2

Sustain Magazine

No abstract provided.

Go to article

Plastic Pollution, Fall/Winter 2019, Issue 39 Aug 2019

Plastic Pollution, Fall/Winter 2019, Issue 39

Sustain Magazine

No abstract provided.

Go to article

Defining The Developmental Toxicity Of The Herbicide Dicamba Using The Zebrafish Model System, Lucas W. Turner Aug 2019

Defining The Developmental Toxicity Of The Herbicide Dicamba Using The Zebrafish Model System, Lucas W. Turner

The Journal of Purdue Undergraduate Research

No abstract provided.

Go to article

Characteristics Of Nanoparticles Emitted From Kanthal A1 And Nichrome Heaters Used In Electronic Cigarettes, Kaushal Arvind Prasad Aug 2019

Characteristics Of Nanoparticles Emitted From Kanthal A1 And Nichrome Heaters Used In Electronic Cigarettes, Kaushal Arvind Prasad

The Journal of Purdue Undergraduate Research

No abstract provided.

Go to article

Whole-Brain Approaches For Investigating Iron Accumulation By Mri Show No Excess From Occupational Exposure To Welding Fumes, Jennifer Davis Aug 2019

Whole-Brain Approaches For Investigating Iron Accumulation By Mri Show No Excess From Occupational Exposure To Welding Fumes, Jennifer Davis

The Journal of Purdue Undergraduate Research

No abstract provided.

Go to article

Toxicity Interaction Of The Two Most Common Agricultural Herbicides In The United States: Glyphosate And Atrazine, Lauren E. Brulinski Aug 2019

Toxicity Interaction Of The Two Most Common Agricultural Herbicides In The United States: Glyphosate And Atrazine, Lauren E. Brulinski

The Journal of Purdue Undergraduate Research

No abstract provided.

Go to article

Analysis Of Manganese Accumulation In The Pituitary Gland And Hippocampus Of Smelters Using High Resolution 3-D T1-Weighted Mri, Alison Jeffries, Zeinab Aly, Molly Cromer Aug 2019

Analysis Of Manganese Accumulation In The Pituitary Gland And Hippocampus Of Smelters Using High Resolution 3-D T1-Weighted Mri, Alison Jeffries, Zeinab Aly, Molly Cromer

The Journal of Purdue Undergraduate Research

No abstract provided.

Go to article

Astragaloside Iii Enhances Anti-Tumor Response Of Nk Cells By Elevating Nkg2d And Ifn-Γ, Xingmeng Chen, Xi Chen, Junxiao Gao, Han Yang, Yue Duan, Benjamin Feng, Xin He, Xiaoqun Gong, Hanjie Wang, Xiaoli Wu, Jin Chang Aug 2019

Astragaloside Iii Enhances Anti-Tumor Response Of Nk Cells By Elevating Nkg2d And Ifn-Γ, Xingmeng Chen, Xi Chen, Junxiao Gao, Han Yang, Yue Duan, Benjamin Feng, Xin He, Xiaoqun Gong, Hanjie Wang, Xiaoli Wu, Jin Chang

Peer Reviewed Articles

Natural killer (NK) cells play an irreplaceable role in the development of colon cancer, in which antitumor function of NK cells was impaired. Astragaloside III is a natural compound from Astragalus that has been shown to have immunomodulatory effects in various systems. However, few studies have evaluated the antitumor effects of Astragaloside III through stimulating systemic immunity and regulating NK cells. In this study, flow cytometry, immunohistochemical analysis, and immunofunctional assays were performed to elucidate the functions of Astragaloside III in restoring antitumor function of NK cells. We demonstrated that Astragaloside III significantly elevated the expression of natural killer group …

Go to article

Dual Inhibition Of The Pi3k/Akt And Mek5/Erk5 Pathways For The Treatment Of Breast Cancer, Thomas Douglas Wright Aug 2019

Dual Inhibition Of The Pi3k/Akt And Mek5/Erk5 Pathways For The Treatment Of Breast Cancer, Thomas Douglas Wright

Electronic Theses and Dissertations

Breast cancer is a heterogeneous disease state with several challenging frontiers. In particular, aberrations in the Phosphoinositide-3-kinase (PI3K) and Mitogen Activated Protein Kinase (MAPK) pathways have been linked to increased breast cancer proliferation and survival. It has been proposed that these survival characteristics are enhanced through compensatory signaling and crosstalk mechanisms. New evidence suggests that MEK5/ERK5, a member of the MAPK family, is a crucial component in the proliferation and survival of several aggressive cancers. We hypothesize that inhibiting both PI3K/Akt and MEK5/ERK5 pathways will decrease cell viability while maintaining limited collateral toxicity. In this study, we examined the effects …

Go to article

Evaluation Of Biodegradability Characteristics Of Cellulose-Based Film As Per Is/Iso 14855-1, Narayan C. Saha Dr, Gaurav Madhu Dr, Diksha B. Kadu Ms Aug 2019

Evaluation Of Biodegradability Characteristics Of Cellulose-Based Film As Per Is/Iso 14855-1, Narayan C. Saha Dr, Gaurav Madhu Dr, Diksha B. Kadu Ms

Journal of Applied Packaging Research

Biodegradable polymers (especially those derived from plant sources) begin their lifecycle as renewable resources, usually in the form of starch or cellulose. In this paper, the evaluation of biodegradability of cellulose-based polymer film under controlled composting conditions as per the guidelines of IS/ISO 14855 (Part-1) standard has been described. Microcrystalline cellulose (MCC) powder was taken as positive-control polymer. The apparatus used to analyse the degree and rate of biodegradation was developed indigenously. The validation of the biodegradability testing apparatus was also performed as per the prescribed test method given in IS/ISO 14855-1.

Go to article

Spatiotemporal Patterns Of Small For Gestational Age And Low Birth Weight Births And Associations With Land Use And Socioeconomic Status, Charlene Nielsen, Carl Amrhein, Prakesh S Shah, Khalid Aziz, Alvaro R Osornio-Vargas Aug 2019

Spatiotemporal Patterns Of Small For Gestational Age And Low Birth Weight Births And Associations With Land Use And Socioeconomic Status, Charlene Nielsen, Carl Amrhein, Prakesh S Shah, Khalid Aziz, Alvaro R Osornio-Vargas

Office of the Provost

In addition to small for gestational age (SGA) and low birth weight at term (LBWT), critically ill cases of SGA/LBWT are significant events from outcomes and economic perspectives that require further understanding of risk factors. We aimed to assess the spatiotemporal distribution of locations where there were consistently higher numbers of critically ill SGA/LBWT (hot spots) in comparison with all SGA/LBWT and all births. We focused on Edmonton (2008-2010) and Calgary (2006-2010), Alberta, and used a geographical information system to apply emerging hot spot analysis, as a new approach for understanding SGA, LBWT, and the critically ill counterparts (ciSGA or …

Go to article

The Role Of Secretory Phospholipase A2 Group Iia In Obesity And Metabolism, Michael S. Kuefner Aug 2019

The Role Of Secretory Phospholipase A2 Group Iia In Obesity And Metabolism, Michael S. Kuefner

Theses and Dissertations (ETD)

Secretory phospholipase A2 group IIA (PLA2G2A) is a member of a family of secretory phospholipases previously implicated in inflammation, atherogenesis, and antibacterial actions. These enzymes hydrolyze glycerophospholipids at the sn-2 position releasing lysophospholipids and fatty acids. Though studies have shown PLA2G2A is pro-inflammatory and promotes atherosclerosis, no research has analyzed the role of this enzyme in obesity and metabolism. Studies in the past 5-10 years utilizing various knock- out or over-expression mouse models have analyzed the role of different secretory phospholipase A2s (sPLA2) in metabolic diseases. From these studies, it is known that at least seven of the 11 sPLA2 …

Go to article

First Prev Next Last