Open Access. Powered by Scholars. Published by Universities.®

Pharmacology, Toxicology and Environmental Health Commons™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 1321 - 1350 of 7020

Full-Text Articles in Pharmacology, Toxicology and Environmental Health

A Polypharmacological Approach To Relapse Prevention In An Animal Model Of Heroin Addiction, Scott T. Ewing Sep 2022

A Polypharmacological Approach To Relapse Prevention In An Animal Model Of Heroin Addiction, Scott T. Ewing

Dissertations, Theses, and Capstone Projects

Chemical compounds that target dopamine (DA) D1 or D3 receptors have shown promise as potential interventions in animal models of cue-induced relapse. However, undesirable side effects or pharmacodynamic profiles have limited the advancement of new compounds in preclinical studies when administered as independent treatments. In this series of experiments, we explored the effects of co-administration of a D1-recepter partial agonist (SKF 77434) and a D3-receptor antagonist (NGB 2904) in heroin-seeking rats within a ‘conflict’ model of abstinence and cue-induced relapse. Rats were first trained to press a lever to self-administer heroin and drug delivery was paired contingently with cues (e.g., …

Go to article

Expulsive Greening: A Cross-Sectional Analysis Of Green Gentrification In The Resilience Paradigm, Brooklyn 2010–2020, Rose Jimenez Sep 2022

Expulsive Greening: A Cross-Sectional Analysis Of Green Gentrification In The Resilience Paradigm, Brooklyn 2010–2020, Rose Jimenez

Dissertations, Theses, and Capstone Projects

Background: This project analyzes the spatial coincidence between gentrification typologies and urban greening in Brooklyn, New York from 2010 to 2020. Assets formed under the NYC Green Infrastructure Program were chosen as a proxy for urban greening to represent the spatial practice specifically within the 21st-century climate change resilience paradigm of development. Methods: First, five indexes measuring variations of economic and demographic conditions related to gentrification were applied to Brooklyn for comparative analysis: NOAA’s Social Vulnerability Indicators of Gentrification Pressure, The NYC Heat Vulnerability Index, The Small Area Index of Gentrification, Typologies of Gentrification and Displacement, and The Housing Risk …

Go to article

Novel Therapeutic Strategies For Alzheimer’S Disease: Prostaglandin D2 Signaling And Its Human Polymorphisms As Well As A Polypharmacological Approach, Charles H. Wallace Sep 2022

Novel Therapeutic Strategies For Alzheimer’S Disease: Prostaglandin D2 Signaling And Its Human Polymorphisms As Well As A Polypharmacological Approach, Charles H. Wallace

Dissertations, Theses, and Capstone Projects

Alzheimer’s disease (AD) is an age related neurodegenerative disease with pathology that includes amyloid plaques, neurofibrillary tangles and non-resolving neuroinflammation. Non-resolving neuroinflammation lasts the entire course of the disease and has deleterious effects and is often thought to accelerate AD pathology. Non-Steroidal Anti-inflammatory Drugs (NSAIDs) have commonly been used as therapeutics to treat pain, inflammation and vascular. NSAIDs work by altering the cyclooxygenase (COX) mediated biosynthesis of prostaglandins which are lipid mediators that have many physiological functions, for example nociception, inflammation and vasodilation. Epidemiological studies support the notion that NSAIDs could be used to treat AD. Yet, clinical trials using …

Go to article

Analysis Of Sanitizer Rotation On The Susceptibility, Biofilm Forming Ability And Caco-2 Cell Adhesion And Invasion Of Listeria, Md Asfakur Rahman, Nirakar Sahoo, Veerachandra K. Yemmireddy Aug 2022

Analysis Of Sanitizer Rotation On The Susceptibility, Biofilm Forming Ability And Caco-2 Cell Adhesion And Invasion Of Listeria, Md Asfakur Rahman, Nirakar Sahoo, Veerachandra K. Yemmireddy

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

The purpose of this study was to determine the effect of sanitizer use conditions on the susceptibility, biofilm forming ability and pathogenicity of Listeria monocytogenes. Two different strains of L. monocytogenes and a non-pathogenic L. innocua were exposed to sodium hypochlorite, benzalkonium chloride and peroxyacetic acid at different concentrations (4 to 512 ppm) and treatment times (30 s to 5 min), respectively. Under the tested conditions, no significant difference (p > 0.05) in reduction was observed among the three tested sanitizers. A reduction of 1 to 8 log CFU/mL was observed depending upon the sanitizer concentration and treatment times. The survived …

Go to article

Practical Approaches To Improve Vancomycin-Related Patient Outcomes In Pediatrics- An Alternative Strategy When Auc/Mic Is Not Feasible, Kashif Hussain, Muhammad Sohail Salat, Shahzad Rauf, Manoj Rathi, Midhat Khan, Fizzah Naz, Wasif Ahmed Khan, Rahila Ikram, Gul Ambreen Aug 2022

Practical Approaches To Improve Vancomycin-Related Patient Outcomes In Pediatrics- An Alternative Strategy When Auc/Mic Is Not Feasible, Kashif Hussain, Muhammad Sohail Salat, Shahzad Rauf, Manoj Rathi, Midhat Khan, Fizzah Naz, Wasif Ahmed Khan, Rahila Ikram, Gul Ambreen

Department of Biological & Biomedical Sciences

Background: Anecdotal experience and studies have shown that most pediatric patients fail to reach target therapeutic vancomycin trough levels (VTLs) and required higher total daily doses (TDD). This retrospective study aims to evaluate the frequency of hospitalized children who achieved target VTLs with a vancomycin (VNCO) dosing regimen of 40-60 mg/kg/d q6h and to assess the VNCO-TDD required to attain the target and their effects on clinical outcomes in pediatric patients.
Methods: After ethical approval, patients of 3 month-12 years were evaluated in this chart review study who received ≥ 3 intravenous-VNCO doses and appropriately drawn blood samples of VTLs …

Go to article

Evaluating The Potential Effect Of Nitrogen And Toxicological Responses Of Juvenile Lampsilis Reeveiana (Mollusca: Unionidae) In The Buffalo National River, Anna Marie Pieri Aug 2022

Evaluating The Potential Effect Of Nitrogen And Toxicological Responses Of Juvenile Lampsilis Reeveiana (Mollusca: Unionidae) In The Buffalo National River, Anna Marie Pieri

Student Theses and Dissertations

The Buffalo National River (BUFF) was established as the first national river in 1972 and later designated as an Extraordinary Resource Water and Natural and Scenic Waterway. This thesis seeks to address the potential threat of elevated nutrients and its association with freshwater mussel declines in the BUFF through laboratory and in situ exposures. Water and sediment chemistry data were collected, and relevant thresholds were used to extrapolate lab-to-field toxicity during low-flow events. Acute toxicity was not observed; however, low-concentration chronic toxicity may be influencing mussel assemblages with rising temperatures. Water quality degradation is likely the result of combined sources …

Go to article

Neuropilin-2 In Advanced Prostate Cancer And Its Targeting With Novel Small Molecule Inhibitors, Ridwan Islam Aug 2022

Neuropilin-2 In Advanced Prostate Cancer And Its Targeting With Novel Small Molecule Inhibitors, Ridwan Islam

Theses & Dissertations

Despite the development of new therapies, clinical management of advanced metastatic castrationresistant prostate cancer (mCRPC) still remains challenging owing to the emergence of therapy resistance. Resistance to the therapies is driven by both AR and non-AR pathways. Non-AR pathway is characterized by a lineage switch that leads to the development of neuroendocrine-like (NE-like) prostate cancer (PCa), which has a fulminant clinical course due to the lack of effective treatment strategy. Therefore, novel molecular targets need to be identified to develop effective therapeutic regimen to improve the outcomes in advanced PCa patients including NE-like PCa. Recent investigation on advanced PCa patients …

Go to article

Identifying A Glucocorticoid-Activated Gpcr That Rapidly And Non-Genomically Increases Camp Levels In Mammalian Cells, Francisco Nunez Aug 2022

Identifying A Glucocorticoid-Activated Gpcr That Rapidly And Non-Genomically Increases Camp Levels In Mammalian Cells, Francisco Nunez

Pharmaceutical Sciences (PhD) Dissertations

Glucocorticoids (GCs) are steroid hormones that regulate diverse physiological processes. Synthetic versions of GCs are commonly used to treat inflammatory diseases such as asthma by modulating gene expression to suppressing several inflammatory activities. However, it is estimated that 5-10% of asthmatics are unresponsive to GCs, which may be explained by receptor desensitization and/or the presence of a neutrophilic endotype. One understudied phenomenon of GCs is their ability to induce rapid, non-genomic actions. For example, GCs can acutely modulate calcium concentrations levels, induce smooth muscle relaxation and modulate nitric oxide synthase activity, within minutes and sometimes seconds, which is too rapid …

Go to article

Application Of Cannabidol To Ocular Pharmacokinetics And Pharmacodynamics., Alyssa Laun Aug 2022

Application Of Cannabidol To Ocular Pharmacokinetics And Pharmacodynamics., Alyssa Laun

Electronic Theses and Dissertations

Cannabidiol (CBD) is the most abundant non-psychotropic cannabinoid constituent of Cannabis sativa. CBD is potentially therapeutic for the eye through antioxidant, anti-inflammatory, and neuroprotective effects. However, the effect of CBD on intraocular pressure (IOP)- the major risk factor for glaucoma- is controversial and large variability exists in the literature. IOP is regulated through aqueous humor (AH) dynamics in trabecular meshwork (TM) tissues. Measurement of CBD in AH and correlation with effects on IOP would clarify what concentrations mediate changes to IOP. Therefore, the overall goal of this dissertation is to measure CBD in ocular tissues and correlate concentrations with …

Go to article

Identification And Quantitation Of Unspecified Impurities Discovered In Novel Oral Irinotecan By Lc-Ms/Ms And Uhplc, Laura B. Miller Aug 2022

Identification And Quantitation Of Unspecified Impurities Discovered In Novel Oral Irinotecan By Lc-Ms/Ms And Uhplc, Laura B. Miller

Forensic Science Master's Projects

Irinotecan is a cancer medication approved for medical use in the United States in 1996. It is currently administered via intravenous injection. However, intravenous dosing has disadvantages such as requirement of administration by a trained professional in a medical facility, possible severe adverse effects, pain at the injection site, and possible hemolysis if injected too rapidly. Previously oral administration was not feasible because the p-glycoprotein (p-GP) on the cell membrane of stomach cells acts as a defense mechanism against harmful substances by pumping the irinotecan back into the intestinal lumen for excretion. With the discovery of the p-GP inhibitor encequidar …

Go to article

Validation Of The 40 Hz Auditory Steady State Response As A Pharmacodynamic Biomarker Of Evoked Neural Synchrony, Muhammad Ummear Raza Aug 2022

Validation Of The 40 Hz Auditory Steady State Response As A Pharmacodynamic Biomarker Of Evoked Neural Synchrony, Muhammad Ummear Raza

Electronic Theses and Dissertations

Schizophrenia is a troubling and severe mental illness that is only incompletely treated by currently available drugs. New drug development is hindered by a scarcity of functionally relevant pharmacodynamic biomarkers that are translatable across preclinical and human subjects. Although psychosis is a major feature of schizophrenia, cognitive and negative symptoms determine the long-term functional outcomes for patients. Stimulus-evoked neural synchrony at gamma (~ 40 Hz) frequency plays an important role in the processing and integration of sensory information. Not surprisingly, schizophrenia patients show deficits in gamma oscillations. NMDA receptor (NMDAR) activation on fast-spiking parvalbumin-positive interneurons is deemed important for the …

Go to article

Roles Of Oxidative Stress And Dna Methylation In Cigarette Smoking-Induced Accelerated Acute Myeloid Leukemia Progression, Mary Figueroa Aug 2022

Roles Of Oxidative Stress And Dna Methylation In Cigarette Smoking-Induced Accelerated Acute Myeloid Leukemia Progression, Mary Figueroa

Dissertations and Theses (Open Access)

Acute myeloid leukemia (AML) is a commonly diagnosed cancer in smokers. When current or former smokers have AML, they have worse survival compared to never smoking patients. This has been observed clinically for decades, but then it is unknown how smoking leads to worsened AML survival. Smoking causes oxidative stress and altered DNA methylation that persists for decades in peripheral blood mononuclear cells, but these changes from smoking have not been evaluated in the context of AML. We hypothesize that smoking-induced molecular changes, including altered DNA methylation associated with poor AML prognosis, promote AML. We developed a novel model to …

Go to article

Dibutyl Amine Detection, Quantification, And Removal With Iron(Ii)Tetrasulfophthalocyanine (Fetspc), Kyle Bittner Aug 2022

Dibutyl Amine Detection, Quantification, And Removal With Iron(Ii)Tetrasulfophthalocyanine (Fetspc), Kyle Bittner

Electronic Theses and Dissertations

Pesticide testing is of practical interest in various areas of today’s world due to their prevalence and toxicity. These areas include agriculture, environmental, chemical plants, and many others. Herbicides, like Roundup, contain secondary amines such as glyphosate. The ability to detect secondary amines could offer a method for glyphosate detection in agricultural and environmental samples. Secondary amines can interact with metal complexes through electron charge transfer. Such interactions can cause a change in the metal’s electron configuration and energy state and can be seen in the UV-Vis spectrum. Metal phthalocyanines (MPc’s) and other organometallic complexes have been of interest for …

Go to article

Pharmacological Interventions For The Treatment And Control Of Shivering In Adult Patients Undergoing Elective Surgery Under Regional Anaesthesia: A Systematic Review And Meta-Analysis, Malika Hameed, Naureen Akber Ali, Khalid Ahsan, Mohsin Nazir Aug 2022

Pharmacological Interventions For The Treatment And Control Of Shivering In Adult Patients Undergoing Elective Surgery Under Regional Anaesthesia: A Systematic Review And Meta-Analysis, Malika Hameed, Naureen Akber Ali, Khalid Ahsan, Mohsin Nazir

Department of Anaesthesia

Intraoperative shivering is quite common after regional anaesthesia, which not only increases the total body oxygen requirement but also causes discomfort to the patients. The aim of this systematic review is to determine the effectiveness of pharmacological agents administered intra-operatively for treating shivering in adult patients who are undergoing elective surgery under regional (i.e., central neuraxial) anaesthesia so that an optimal choice of an agent can be recommended for clinical application. A literature search was carried out using PubMed, Cochrane Library, CINAHL databases, and hand searches to identify relevant studies. After literature screening and information extraction, a systematic review was …

Go to article

Subchronic Dermal Toxicity Study Of Tithonia Diversifolia (Hemsley) A. Gray Gel Formulation In Wistar Rats, Muflihah Rizkawati, Mae Sri Hartati Wahyuningsih, Setyo Purwono, Dwi Aris Agung Nugrahaningsih, Abdul Karim Zulkarnain Aug 2022

Subchronic Dermal Toxicity Study Of Tithonia Diversifolia (Hemsley) A. Gray Gel Formulation In Wistar Rats, Muflihah Rizkawati, Mae Sri Hartati Wahyuningsih, Setyo Purwono, Dwi Aris Agung Nugrahaningsih, Abdul Karim Zulkarnain

The Thai Journal of Pharmaceutical Sciences

Background: Tithonia diversifolia has been widely developed as an anticancer therapy. Our previous study before showed that T. diversifolia was able to inhibit cell proliferation and collagen accumulation of keloid fibroblasts and decrease the index of rabbit scar hypertrophy. The acute dermal toxicity study of T. diversifolia gel formulation did not show toxic effect for 14 days and the LD50 was estimated more than 2%. However, toxicity data subchronic dermal toxicity study was not available for this T. diversifolia gel formulation. Objectives: Our study aimed to evaluate the subchronic dermal toxicity of T. diversifolia gel formulation in rats. Materials and …

Go to article

Preparation And Stability Of Fluocinolone Acetonide Premicroemulsion Concentrates And Microemulsions For Oral Lichen Planus Treatment, W. Muangsiri, P. Chukaewrungroj, Pornpen Werawatganone Aug 2022

Preparation And Stability Of Fluocinolone Acetonide Premicroemulsion Concentrates And Microemulsions For Oral Lichen Planus Treatment, W. Muangsiri, P. Chukaewrungroj, Pornpen Werawatganone

The Thai Journal of Pharmaceutical Sciences

Purpose: Fluocinolone acetonide (FA) preparations were developed in the forms of premicroemulsion concentrates and microemulsions and their stabilities were evaluated. Materials and Methods: A pseudoternary diagram of clove oil, surfactant mixture (containing polysorbate80: Polyethylene glycol 400 [PEG400] at the ratio of 2:1), and water was constructed for the formulation of FA premicroemulsion concentrates and microemulsions. Physical properties and chemical stabilities of the preparations were monitored in the absence and presence of three antioxidants. Their beyond-use dates were determined. Results and Discussion: The premicroemulsion concentrates and microemulsions containing polysorbate 80, PEG400, and clove oil successfully improved FA solubility. Average diameters of …

Go to article

Design, Development, And Characterization Of Brinzolamide And Brimonidine Tartrate Nanoemulsion For Ophthalmic Drug Delivery, Bhavin R. Choradiya, Sanjay B. Patil Aug 2022

Design, Development, And Characterization Of Brinzolamide And Brimonidine Tartrate Nanoemulsion For Ophthalmic Drug Delivery, Bhavin R. Choradiya, Sanjay B. Patil

The Thai Journal of Pharmaceutical Sciences

Aim: The current investigation work sums up the enumerating improvement and depiction of brinzolamide and brimonidine tartrate ophthalmic nanoemulsion giving widened helpful effect and improved visual penetration for treating glaucoma. Methodology: Nanoemulsion was formulated using polysorbate 80, castor oil and glycerol using the continuous emulsification technique. Preliminary batches were screened subject to in vitro medication release, globule size, zeta potential, and stability with regards to accelerated and long time. Nanoemulsions were evaluated for ex vivo optical irritancy using the hen’s egg chorioallantois membrane test model. Results: Screened nanoemulsion batches showed a low mean globule width (<220 nm), higher penetrability (>75%) in comparison with …

Go to article

A New Antidiabetic Polyherbal Formulation For Diabetes, Sadish Kumar Shanmugam, Praveen Kumar Gaur, Deepak Kumar Aug 2022

A New Antidiabetic Polyherbal Formulation For Diabetes, Sadish Kumar Shanmugam, Praveen Kumar Gaur, Deepak Kumar

The Thai Journal of Pharmaceutical Sciences

Background: Synergism is a well-known concept in Herbal therapies. Polyherbal aqueous extract (PH-AE) containing Gymnema sylvestre (GS), Momordica charantia, Syzygium cumini, and Mangifera indica was evaluated for Antidiabetic activity. Objective: In our continuous research, an attempt has been made to explore GS aqueous extract (GS-AE) and its Polyherbal composite for diabetes to achieve greater efficacy. Methods: The antidiabetic activity was assessed in Streptozotocin induced diabetic rats and histopathological changes in Pancreas were documented after screening acute toxicity of both extracts. Results: Chromatographic separation and identification of GS-AE revealed the presence of Saponins and glycosides, which have also been confirmed in …

Go to article

Diversity And Lipolytic Activity Of Lactic Acid Bacteria Isolated From Fermented Foods And Plant Materials In Thailand, Sujitra Techo, Nattakorn Kuncharoen, Somboon Tanasupawat Aug 2022

Diversity And Lipolytic Activity Of Lactic Acid Bacteria Isolated From Fermented Foods And Plant Materials In Thailand, Sujitra Techo, Nattakorn Kuncharoen, Somboon Tanasupawat

The Thai Journal of Pharmaceutical Sciences

Lactic acid bacteria (LAB) originated from fermented foods, are generally known to possess the lipolytic activity which provides the desirable flavor of the products. However, the researches on their lipolytic activity are limited. Therefore, LAB with lipolytic activity derived from traditional fermented foods and plants in Thailand were isolated and identified based on the phenotypic characteristics and 16S rRNA gene sequences. The isolates were identified as Lactiplantibacillus pentosus (four isolates), Lactiplantibacillus plantarum (three isolates), Limosilactobacillus fermentum (four isolates), Enterococcus hirae (two isolates), and each isolate of Lactiplantibacillus paraplantarum, Companilactobacillus tucceti, Companilactobacillus farciminis, Lacticaseibacillus porcinae, Lactobacillus amylovorus, Pediococcus pentosaceus, and Enterococcus …

Go to article

Complexity Of Implementing Harm Reduction Services In Community Hospitals: A Two-Phase Qualitative Study, Kanittha Nimsakul, Puckwipa Suwannaprom, Siritree Suttajit Aug 2022

Complexity Of Implementing Harm Reduction Services In Community Hospitals: A Two-Phase Qualitative Study, Kanittha Nimsakul, Puckwipa Suwannaprom, Siritree Suttajit

The Thai Journal of Pharmaceutical Sciences

Objective: Regardless of effective harm reduction services (HRS) in Thanyarak Hospital, difficulties exist while implementing them in community hospitals. This study aimed to investigate the complexities of HRS implementation in two community hospitals in Mae Hong Son. Methods: Phase 1, in-depth interviews were conducted with 21 participants to investigate the complexity of HRS dissemination. An interview guide was developed from the seven domains of the Non-adoption, Abandonment, Scale-up, Spread, and Sustainability framework, and thematic analysis was used. Phase 2 involved two rounds of a Delphi technique with 17 experts to evaluate the HRS’s complexity level (complex, complicated, simple). Results: Although …

Go to article

The Successful Treatment Of Brevundimonas Diminuta Using Ceftriaxone, In A Patient On Continuous Ambulatory Peritoneal Dialysis: A Case Report And Literature Review, Sukrit Kanchanasurakit, Natnicha Woranithipokin, Piyakamol Teeranaew, Natthawee Kaewrattanapatthama, Chotirat Nakaranurack Aug 2022

The Successful Treatment Of Brevundimonas Diminuta Using Ceftriaxone, In A Patient On Continuous Ambulatory Peritoneal Dialysis: A Case Report And Literature Review, Sukrit Kanchanasurakit, Natnicha Woranithipokin, Piyakamol Teeranaew, Natthawee Kaewrattanapatthama, Chotirat Nakaranurack

The Thai Journal of Pharmaceutical Sciences

Brevundimonas diminuta (B. diminuta) is found in the health-care environment and in the community. At present, there are few reports of infections caused by this microorganism, especially in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). A 44-year-old woman undergoing CAPD was diagnosed with a B. diminuta infection. Ceftriaxone was given both intravenously and intraperitoneally. After treatment with ceftriaxone, the peritoneal dialysis fluid white cell count, neutrophil count, and symptoms improved. To the best of our knowledge, this is the first case report of a B. diminuta infection in a patient had undergoing CAPD in Thailand

Go to article

Impact Of Clinical Pharmacist Intervention On Medication Adherence In Patients With Cardiovascular Disease, S. Lavanya, Netal Patel, Arnav Purani, Kajal Patel Aug 2022

Impact Of Clinical Pharmacist Intervention On Medication Adherence In Patients With Cardiovascular Disease, S. Lavanya, Netal Patel, Arnav Purani, Kajal Patel

The Thai Journal of Pharmaceutical Sciences

Background: Cardiovascular diseases (CVDs) are a category of heart and blood vessel disorders that include coronary disorders, cerebrovascular diseases, rheumatic pain, and other conditions. One of the major risk factors for CVDs is high blood pressure (BP). Furthermore, it is poorly managed due to a lack of understanding of hypertension, a lack of proper primary care, and a lack of follow-up. The patient education improves the patient’s response to the disease and its management and their quality of life. Objectives: The objectives of this study were to evaluate the effect of clinical pharmacist intervention by the provision of patient counseling, …

Go to article

Development And Optimization Of Polyherbal Formulation For Antiurolithiatic Activity Using Box Behnken Statistical Design, Tejal Gandhi, Vaidehi Patel, Saloni Dalwadi, Vaishali Thakkar Aug 2022

Development And Optimization Of Polyherbal Formulation For Antiurolithiatic Activity Using Box Behnken Statistical Design, Tejal Gandhi, Vaidehi Patel, Saloni Dalwadi, Vaishali Thakkar

The Thai Journal of Pharmaceutical Sciences

Background: The objective of the present investigation was to design and evaluate the antiurolithiatic activity of extract of Tribulus terrestris, Bryophyllum pinnatum, and Cyperus rotundus on ethylene glycol-induced urolithiasis in Wistar albino rats using Box Behnken Design. To induce urolithiasis, 0.75% w/v ethylene glycol was administered orally to the rats for 28 days. Cystone 750 mg/kg was selected as the reference standard as a preventive dose. On the 28th day, urine discharged in 24 h was collected and subjected for estimation of various biochemical parameters which were evaluated using urine, serum, and kidney homogenate. The kidneys were also sectioned and …

Go to article

Antioxidant Status, Antihyperlipidemic Activity, And Serum Electrolyte Levels In Dexamethasone-Induced Oxidative Stress In Wistar Rats Treated With Vitamin E, Idara Asuquo Okon, Justin Atiang Beshel, Daniel Udofia Owu Aug 2022

Antioxidant Status, Antihyperlipidemic Activity, And Serum Electrolyte Levels In Dexamethasone-Induced Oxidative Stress In Wistar Rats Treated With Vitamin E, Idara Asuquo Okon, Justin Atiang Beshel, Daniel Udofia Owu

The Thai Journal of Pharmaceutical Sciences

Objectives: Dexamethasone (Dex) is an anti-inflammatory drug with serious side effects. The aim of this study was to investigate, antioxidants status, antihyperlipidemic activity, and serum electrolyte levels of rats treated with Vitamin E in Dex-induced oxidative stress. Materials and Methods: Wistar rats of both sexes were assigned to four groups (n = 6). The control group was fed with standard rat feed and water, while Dex group received 30 μg/kg of Dex. Vitamin E group received 300 IU/kg of vitamin E, while Dex + Vitamin E group received 30 μg/kg of Dex and 300 IU/kg of vitamin E. After 14 …

Go to article

Silymarin And Oral Cancer: A Review On Clinical And Analytical Reports, Ramya Jonnalagadda, C. Vinodhini Aug 2022

Silymarin And Oral Cancer: A Review On Clinical And Analytical Reports, Ramya Jonnalagadda, C. Vinodhini

The Thai Journal of Pharmaceutical Sciences

Oral cancer is the sixth-largest kind globally of cancer and a major health issue in India as well and affects a large population that is very vulnerable to recurrences and a lower survival rate among all the other malignancies. Milk thistle is a phytochemical herb of interest that has been used as folk medicine since ancient times. Due to its potential benefits, the pharmaceutical industrial world is widely using silymarin (an active component of milk thistle) for commercial preparations. Knowing the quantity and identity of active components is of utmost importance. Therefore, robust, accurate, and precise analytical methods are needed …

Go to article

Edible Mushrooms: An Emerging Therapeutic Of Diabetes, Nilanjan Chakraborty, Anuron Banerjee, Sudeshna Nandi, Swagata Sarkar, Krishnendu Acharya Aug 2022

Edible Mushrooms: An Emerging Therapeutic Of Diabetes, Nilanjan Chakraborty, Anuron Banerjee, Sudeshna Nandi, Swagata Sarkar, Krishnendu Acharya

The Thai Journal of Pharmaceutical Sciences

Diabetes is the third most customary non-infectious disease occurring worldwide and leads to untimely disability and mortality. This metabolic disorder is characterized by impaired insulin secretions and high blood glucose levels. Among others, type 2 diabetes is the most common. Various chemical and biochemical hypoglycemic drugs are utilized to control and treat hyperglycemia but required further interventions to reduce their toxicity and side effects on the users. Edible mushrooms have been employed from ancient times to heal many diseases as it composed of anti-oxidant, alkaloids, fibers, triterpenoids, and other phytochemicals. The bioactive secondary metabolites of mushrooms can improve insulin resistance …

Go to article

Determination Of Sugars And Amino Acids In Japanese Wine Using Core–Shell Liquid Chromatography Tandem Electrochemical Detection, Kana Yoshimura, Aiko Sano, Ryuichiro Suzuki, Shun-Ichi Mitomo, Yukiko Negishi, Toshiki Mutai, Florencio Arce Jr, Gerard Lee See, Takashi Tanikawa, Yutaka Inoue Aug 2022

Determination Of Sugars And Amino Acids In Japanese Wine Using Core–Shell Liquid Chromatography Tandem Electrochemical Detection, Kana Yoshimura, Aiko Sano, Ryuichiro Suzuki, Shun-Ichi Mitomo, Yukiko Negishi, Toshiki Mutai, Florencio Arce Jr, Gerard Lee See, Takashi Tanikawa, Yutaka Inoue

The Thai Journal of Pharmaceutical Sciences

In this study, sugars (glucose, fructose, and sucrose) and amino acids in plum and yuzu wines were quantified with a new and simple method involving an electrochemical detector (ECD) and core–shell column (S-30/70 = Styrene/divinylbenzene – 5 tetramethyldiaminohexane). Analysis was conducted under the following conditions: A column temperature (40°C), flow rate (0.3 mL/min), injection volume (20 μL), and mobile phase (0.1 mol/L NaOH). Glucose, fructose, and sucrose had retention times of 14.68 min, 16.22 min, and 19.29 min, respectively, when measured using an ECD. When the sugar content was compared among the plum wines, plum wine A had the lowest …

Go to article

Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers, Titiek Hidayati, Akrom Akrom, Sagiran Sagiran, Indrayanti Indrayanti Aug 2022

Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers, Titiek Hidayati, Akrom Akrom, Sagiran Sagiran, Indrayanti Indrayanti

The Thai Journal of Pharmaceutical Sciences

No abstract provided.

Go to article

Formulation, Characterization, And Pharmacokinetic Study Of Methoteraxate-Quercetin Loaded Nanoparticles, Gyanesh Kumar Sahu, Harish Sharma, Swarnali Das Paul, Ajazuddin, Chanchal Deep Kaur Aug 2022

Formulation, Characterization, And Pharmacokinetic Study Of Methoteraxate-Quercetin Loaded Nanoparticles, Gyanesh Kumar Sahu, Harish Sharma, Swarnali Das Paul, Ajazuddin, Chanchal Deep Kaur

The Thai Journal of Pharmaceutical Sciences

Objectives: Methotrexate (MTX) is a biopharmaceutics classification system Class IV drug having potential cytotoxic action against cancer cells. However, short half-life and poor bioavailability have limited its application. The object of this work was to entrap MTX and an herbal bioenhancer in a nanoparticle system to improve its bioavailability. Methods: We prepared the nanoparticles (NPs) by emulsion solvent evaporation method with Eudragit RLPO (ERLPO) polymer. Results: The result revealed good in vitro properties with 110 to 228 nm particle size range. The percentage of drugs released from all the batches in 72 h was within the range of 82.71 to …

Go to article

Metal Accumulation In Soils, Invertebrates, And Whiptail Lizards In The Northern Chihuahuan Desert, Allyson Benson-Pedraza Aug 2022

Metal Accumulation In Soils, Invertebrates, And Whiptail Lizards In The Northern Chihuahuan Desert, Allyson Benson-Pedraza

Open Access Theses & Dissertations

Smelting activities by the American Smelting and Refining Company (ASARCO) lead to the substantial release of metal pollution into the El Paso, Texas, and border cities region. To-date few studies have examined metal accumulation within vertebrate taxa in these areas. As reptiles are currently experiencing population declines globally for a variety of reasons including pollution, lizards were chosen to be evaluated for trace element (As, Cu, Cr, Cd, Pb, and Zn) concentrations. These metals were measured within soils, invertebrate prey items, and the livers of three species of whiptail lizards (Aspidoscelis) from the un-remediated University of Texas at El Paso …

Go to article

First Prev Next Last