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Articles 1021 - 1050 of 6953

Full-Text Articles in Pharmacology, Toxicology and Environmental Health

Effects Of B4galnt1 Expression On Metastatic Phenotype And Response To Treatment In Osteosarcoma Cell Lines, Fatemeh Zareihajiabadi Feb 2023

Effects Of B4galnt1 Expression On Metastatic Phenotype And Response To Treatment In Osteosarcoma Cell Lines, Fatemeh Zareihajiabadi

Annual Research Symposium

No abstract provided.

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A Review On The Impact Of Cannabis In Society And The Analytical Methodologies For Cannabinoids, Matt J. Vergne, Lindsey K. Reynolds, Alexus Brown, Grayson Pullias, Anna Froemming Feb 2023

A Review On The Impact Of Cannabis In Society And The Analytical Methodologies For Cannabinoids, Matt J. Vergne, Lindsey K. Reynolds, Alexus Brown, Grayson Pullias, Anna Froemming

Faculty Works

The use of plant-based medicine dates back centuries, and cannabis (Cannabis sativa) is one such plant that has been used medicinally and illicitly. Although cannabis contains hundreds of cannabinoids and other natural products, its potential medicinal use was largely ignored by modern researchers due to the legal restrictions and heavy regulations introduced in the 1930s. As restrictions on cannabis access have eased since the 1990s there is renewed interest in the research of cannabinoids and the other components in the cannabis plant. The focus of this review article is an overview of cannabis and the analytical challenges in the quality …

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Modulation Of Tlr4/Nf-Κb, Nrf2/Ho-1 And Pi3k/Akt Signaling By Cilostazol Mitigates Lipopolysaccharide-Induced Septic Acute Kidney Injury, Ahmed F. Mohamed, Helmy M. Sayed, Hala F. Zaki, Marwa M. Safar Feb 2023

Modulation Of Tlr4/Nf-Κb, Nrf2/Ho-1 And Pi3k/Akt Signaling By Cilostazol Mitigates Lipopolysaccharide-Induced Septic Acute Kidney Injury, Ahmed F. Mohamed, Helmy M. Sayed, Hala F. Zaki, Marwa M. Safar

Bulletin of Faculty of Pharmacy Cairo University

Cilostazol was investigated as a protective agent against lipopolysaccharide (LPS)-associated acute kidney damage in mice. Cilostazol (50 mg/kg/day; p.o) administered for 7 consecutive days before a single LPS dose (2 mg/kg; i.p) hampered serum creatinine and cystatin C as well as renal KIM-1 and NGAL, repressed TLR4 and MYD88 transcription as well as NF-κB p65, IL-1β and MDA content, boosted Nrf-2 mRNA expression, HO-1 activity and GSH content. This was synchronous with an upregulation of p-PI3K and p-Akt expressions. Collectively, cilostazol prevented LPS renal injury which might correspond to modulation of TLR4/NF-κB, Nrf2/HO-1 and PI3K/Akt pathways.

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Comparing The Toxicant Responses And Culturing Characteristics Of Long-Term Laboratory-Reared And Field Populations Of Ceriodaphnia Dubia, Victoria Rose Lydy Feb 2023

Comparing The Toxicant Responses And Culturing Characteristics Of Long-Term Laboratory-Reared And Field Populations Of Ceriodaphnia Dubia, Victoria Rose Lydy

Student Theses and Dissertations

Ceriodaphnia dubia is an EPA-recommended organism used in regulatory toxicity testing of surface waters and commercial chemicals. They are often cultured for extended periods in the laboratory with little knowledge of how it impacts subsequent generations. This thesis investigated if C. dubia cultured for an extended period were representative of three recently-collected field populations by comparing their culturing characteristics and sensitivities to toxicants. Comparative chronic toxicity tests with sodium chloride, the neonicotinoid insecticide thiamethoxam, and mixtures of the two toxicants measured differences in sensitivities among the laboratory and field cultures, specifically in the variability of responses. For culturing characteristics, the …

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Leveraging Bio-Inspired Molecules For Cancer Theranostics, Douglas S. Macpherson Feb 2023

Leveraging Bio-Inspired Molecules For Cancer Theranostics, Douglas S. Macpherson

Dissertations, Theses, and Capstone Projects

A variety of molecules can be radiolabeled and delivered to a cancer site for the purposes of diagnostics and therapy. Among the most promising of tumor targeting molecules are peptides and antibodies. These bio-inspired molecules can be designed and synthesized to target and respond to cancer cells based on the properties of those cells. Matrix metalloproteinase (MMP) enzymes are over-expressed by some metastatic cancers, in which they are responsible for the degradation and remodeling of the extracellular matrix. In recent years, MMPs have emerged as promising targets for enzyme-responsive diagnostic probes because oligopeptides can be designed to be selectively hydrolyzed …

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Tris(1,3-Dichloro-2-Propyl) Phosphate Is A Metabolism-Disrupting Chemical In Male Mice, Sara Y. Ngo Tenlep, Megan L. Weaver, Jianzhong Chen, Olga A. Vsevolozhskaya, Andrew J. Morris, Cetewayo S. Rashid Feb 2023

Tris(1,3-Dichloro-2-Propyl) Phosphate Is A Metabolism-Disrupting Chemical In Male Mice, Sara Y. Ngo Tenlep, Megan L. Weaver, Jianzhong Chen, Olga A. Vsevolozhskaya, Andrew J. Morris, Cetewayo S. Rashid

Pharmacology and Nutritional Sciences Faculty Publications

Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate flame retardant. The primary TDCPP metabolite, bis(1,3-dichloro-2-propyl) phosphate (BDCPP), is detectable in the urine of over 90 % of Americans. Epidemiological studies show sex-specific associations between urinary BDCPP levels and metabolic syndrome, which is an established risk factor for type 2 diabetes, heart disease, and stroke. We used a mouse model to determine whether TDCPP exposure disrupts glucose homeostasis. Six-week old male and female C57BL/6J mice were given ad libitum access to diets containing vehicle (0.1 % DMSO) and TDCPP resulting in the following treatment groups: 0 mg/kg/day, 0.02 mg/kg/day, 1 mg/kg/day, or 100 …

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Landscape And Site Factors Drive Invasive Phragmites Management And Native Plant Recovery Across Chesapeake Bay Wetlands, Christine B. Rohal, Eric L. G. Hazelton, Eliza K. Mcfarland, Rebekah Downard, Melissa K. Mccormick, Dennis F. Whigham, Karin M. Kettenring Jan 2023

Landscape And Site Factors Drive Invasive Phragmites Management And Native Plant Recovery Across Chesapeake Bay Wetlands, Christine B. Rohal, Eric L. G. Hazelton, Eliza K. Mcfarland, Rebekah Downard, Melissa K. Mccormick, Dennis F. Whigham, Karin M. Kettenring

Watershed Sciences Student Research

Successful invasive plant management—where invaders are sufficiently reduced and diverse native plant communities recover—remains an elusive goal for land managers. The site- and landscape-scale drivers of variable management outcomes and vegetation recovery are poorly understood due to a lack of rigorous experiments that characterize longer term vegetation trends across contexts. We present the results of a five-year experiment across eight subestuaries of Chesapeake Bay, representing a gradient of watersheds with differing dominant land-use types and anthropogenic impacts, to evaluate invasive and native plant response to herbicide management. The focal invader, Phragmites australis (common reed), is one of the most aggressive …

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Exploring Gaps In City Climate Planning In The Mountain West, Joshua Padilla, Caitlin J. Saladino, William E. Brown Jr. Jan 2023

Exploring Gaps In City Climate Planning In The Mountain West, Joshua Padilla, Caitlin J. Saladino, William E. Brown Jr.

Environment

This fact sheet explores data from the 2022 Brookings Institution report by Joseph W. Kane, Adie Tomer, Caroline George, and Jamal Russell Black called “Not according to plan: Exploring gaps in city climate planning and the need for regional action." The original report analyzes decarbonization plans for 50 of the largest U.S. cities and comparatively ranks each plan using a point system of 5 categories. This fact sheet focuses on Mountain West cities (Denver, CO; Phoenix, AZ; Las Vegas, NV; Salt Lake, UT; and Albuquerque, NM) included in the original study.

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Bazedoxifene, Parth M. Raina, Mayur Parmar Jan 2023

Bazedoxifene, Parth M. Raina, Mayur Parmar

HPD Articles

No abstract provided.

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Romosozumab, Kristina Krupa, Mayur Parmar, Linda F. Delo Jan 2023

Romosozumab, Kristina Krupa, Mayur Parmar, Linda F. Delo

HPD Articles

No abstract provided.

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Abaloparatide, Miis Akel, Mayur Parmar Jan 2023

Abaloparatide, Miis Akel, Mayur Parmar

HPD Articles

No abstract provided.

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The Effects Of Salinity And Acetaminophen On The Aquatic Snail Physa Acuta, Michelle Sackey-Ansah, Megan Mackey, Daniel Elias, Jason Doll, Alyssa Brookhart Jan 2023

The Effects Of Salinity And Acetaminophen On The Aquatic Snail Physa Acuta, Michelle Sackey-Ansah, Megan Mackey, Daniel Elias, Jason Doll, Alyssa Brookhart

Journal of the South Carolina Academy of Science

Pharmaceuticals are increasingly detected in water bodies, and their presence can negatively impact aquatic organisms. This effect can be amplified when combined with increasing salinity in freshwater ecosystems. Acetaminophen is a widely used analgesic that is commonly found in river, streams, and waters where it is discharged directly. Therefore, organisms present in these locations (e.g., insects, snails, amphibians, and fish) are likely to be affected by acetaminophen. In this study, we determined the effects of elevated salinity (0.68 g/L), acetaminophen (500 µg/L) and combined elevated salinity (0.68 g/L) and acetaminophen (500 µg/L), on the growth, reproduction, and movement of the …

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Antibody-Dependent Enhancement Activity Of A Plant-Made Vaccine Against West Nile Virus, Amber M. Paul, Haiyan Sun, Dhiraj Acharya, Huafang Lai, Junyun He, Fengwei Bai, Qiang Chen Jan 2023

Antibody-Dependent Enhancement Activity Of A Plant-Made Vaccine Against West Nile Virus, Amber M. Paul, Haiyan Sun, Dhiraj Acharya, Huafang Lai, Junyun He, Fengwei Bai, Qiang Chen

Publications

West Nile virus (WNV) causes annual outbreaks globally and is the leading cause of mosquito-borne disease in Unite States. In the absence of licensed therapeutics, there is an urgent need to develop effective and safe human vaccines against WNV. One of the major safety concerns for WNV vaccine development is the risk of increasing infection by related flaviviruses in vaccinated subjects via antibody-dependent enhancement of infection (ADE). Herein, we report the development of a plant-based vaccine candidate that provides protective immunity against a lethal WNV challenge mice, while minimizes the risk of ADE for infection by Zika (ZIKV) and dengue …

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Characterization Of Antiviral Immunity, Host Virus Interactions, And Toxicity Of Agrochemical Residues In The Western Honey Bee, Christopher Fellows Jan 2023

Characterization Of Antiviral Immunity, Host Virus Interactions, And Toxicity Of Agrochemical Residues In The Western Honey Bee, Christopher Fellows

LSU Doctoral Dissertations

Honey bee colonies have perished at an alarming rate for over 15 years. Among the multitude of threats to bee health, virus infections and agrochemical exposure appear to be major drivers of colony loss. As virus infection is among the most damaging influences on bee health, we first investigated a putative target for antiviral immunity, termed KATP channels. We previously demonstrated that pharmacologically activating KATP channels induces the production of reactive oxygen species and increases survival during infection with Israeli Acute Paralysis Virus. Here, we demonstrate that KATP modulation and ROS induction reduce virus replication and enhance …

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Exploring The Potential Of Intranasally Administered Naturally Occurring Quercetin Loaded Into Polymeric Nanocapsules As A Novel Platform For The Treatment Of Anxiety, Shady Swidan, Khaled Younis Mahmoud, Nahla Ahmed Elhesaisy, Abdelrahman Rashed, Ebram Mikhael, Mahmoud Fadl, Mahmoud Elsadek, Merna Mohamed, Merna Mostafa, Mohamed Hassan, Omar Halema, Youssef Elnemer Jan 2023

Exploring The Potential Of Intranasally Administered Naturally Occurring Quercetin Loaded Into Polymeric Nanocapsules As A Novel Platform For The Treatment Of Anxiety, Shady Swidan, Khaled Younis Mahmoud, Nahla Ahmed Elhesaisy, Abdelrahman Rashed, Ebram Mikhael, Mahmoud Fadl, Mahmoud Elsadek, Merna Mohamed, Merna Mostafa, Mohamed Hassan, Omar Halema, Youssef Elnemer

Pharmacy

Anxiety is one of the most prevalent forms of psychopathology that afects millions worldwide. It gained more importance under the pandemic status that resulted in higher anxiety prevalence. Anxiolytic drugs such as benzodiazepines have an unfavorable risk/beneft ratio resulting in a shift toward active ingredients with better safety profle such as the naturally occurring quercetin (QRC). The delivery of QRC is hampered by its low water solubility and low bioavailability. The potential to enhance QRC delivery to the brain utilizing polymeric nanocapsules administered intranasally is investigated in the current study. Polymeric nanocapsules were prepared utilizing the nanoprecipitation technique. The best …

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Soil Properties And Potassium Availability In Pullen Farm Murray, Kentucky, Ava Isaacs, Gracey Moffitt, Whitney Sides Jan 2023

Soil Properties And Potassium Availability In Pullen Farm Murray, Kentucky, Ava Isaacs, Gracey Moffitt, Whitney Sides

Posters-at-the-Capitol

One of the most important factors regarding soil and plant health is nutrient availability and fertility. Of these two factors that were mentioned available potassium is a key component. With that being said we decided that it would be beneficial to see how potassium can be traced within the soil in various locations after fertilizer is applied. There were two parts to this experiment. Part one was taking soil core samples in order to obtain various soil properties such as soil organic matter, soil water holding capacity and bulk density and observe if these properties have any effect on the …

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Phase 1a Clinical Study For Q-Griffithsin Intranasal Spray For Prevention Of Coronavirus, Megan Bezold, Kenneth Palmer, Nobuyuki Matoba, Elizabeth Cash Jan 2023

Phase 1a Clinical Study For Q-Griffithsin Intranasal Spray For Prevention Of Coronavirus, Megan Bezold, Kenneth Palmer, Nobuyuki Matoba, Elizabeth Cash

Posters-at-the-Capitol

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible virus that causes acute respiratory disease with possible long-term complications, known as coronavirus disease 2019 (COVID-19). Griffithsin (GRFT; including the oxidation-resistant variant Q-GRFT used in this study) is an algal carbohydrate-binding protein exhibiting antiviral effects against many enveloped viruses, including all major variants of SARS- CoV-2 reported to date. Q-GRFT has been recombinantly manufactured in Nicotiana benthamiana plants, thoroughly purified, and formulated as an intranasal spray designed to be developed as a non-vaccine broad-spectrum prophylactic product for acute use. This is the first-in-human, randomized, double-blind, placebo-controlled study. The …

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Access To And Utilization Of Primary Care: A Synthesis, Klaire M. Johnson Jan 2023

Access To And Utilization Of Primary Care: A Synthesis, Klaire M. Johnson

Kentucky Journal of Undergraduate Scholarship

Barriers to access and utilization of primary care affect nearly 9% of the nation’s population (USDHHS, n.d.a). These barriers are important to evaluate for members of the aging population due to increased need for health care as a result of chronic conditions and falls. Research indicates that access for the aging population is affected by a variety of factors, including: transportation, non-financial barriers, and internal factors. Issues surrounding current delivery of care, such as a workforce shortage of primary care physicians, have compounded the problem even further. While this issue has begun to be addressed through the Affordable Care Act, …

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What Is The Optimal Timing Of Embryo Biopsy For Diagnosing Genetic Abnormalities?, Nekhama Riznyk Jan 2023

What Is The Optimal Timing Of Embryo Biopsy For Diagnosing Genetic Abnormalities?, Nekhama Riznyk

The Science Journal of the Lander College of Arts and Sciences

Introduction and Purpose: This paper examines current trends in assisted reproductive technology, specifically the use of preimplantation genetic diagnosis (PGD to help in the preimplantation detection of genetic abnormalities such as monogenetic diseases and aneuploidy. PGD can be carried out in different stages, and the timing of the procedure has become one of the major issues in implementation. Three major stages of biopsy have been applied when carrying out PGD: Polar body biopsy (pre-conception), cleavage stage biopsy (3 days after conception), and blastocyst stage biopsy (6 days after conception). The purpose of the paper was to explore these stages and …

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Improving The Prediction And Management Of Intrauterine Growth Restriction, Shulamis Sadowsky Jan 2023

Improving The Prediction And Management Of Intrauterine Growth Restriction, Shulamis Sadowsky

The Science Journal of the Lander College of Arts and Sciences

Intrauterine growth restriction (IUGR) is a potentially fatal and often missed obstetric complication. The fetus is deprived of vital blood, oxygen, and nutrients due to faulty maternofetal circulation, leading to a severe lack of fetal growth. Since current prenatal testing is highly ineffective at diagnosing the condition, many babies with IUGR are negatively impacted before, during, and after birth. This paper assesses alternative and innovative detection and management methods of IUGR. Current routine prenatal care includes simple fundal height measurements to screen for IUGR. This analysis finds that other testing may increase the rate of detection of the disease. Maternal …

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Is Nanotechnology An Effective Treatment For Diabetic Wounds?, Esther Auerbach Jan 2023

Is Nanotechnology An Effective Treatment For Diabetic Wounds?, Esther Auerbach

The Science Journal of the Lander College of Arts and Sciences

Diabetes Mellitus is increasingly impacting millions of adults worldwide. Multiple complications are associated with the disease, including non-healing chronic wounds. Treatment of diabetic wounds and foot ulcers is a complex challenge, as standard treatment options are ineffective. This review focuses on the use of nanotechnology as a treatment option. Nanomaterials include inorganic and organic nanoparticles as well as nanofilms and fibers. Analysis of the benefits of these nanoparticles will be discussed which include their antimicrobial, anti-inflammatory, antioxidant, and wound healing capabilities. A critical overview of the possible bene- fits will be assessed from in vitro and in vivo studies. Overall, …

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Can Physicians Transfer Bacteria Onto Patients Through Their Neckties?, Alexandra Pinkhas Jan 2023

Can Physicians Transfer Bacteria Onto Patients Through Their Neckties?, Alexandra Pinkhas

The Science Journal of the Lander College of Arts and Sciences

Hospital-acquired infections are exacerbated by the presence of transmission agents such as bacteria on neckties. Physicians can put patients at risk of infections if bacteria contaminate their ties during their normal hospital routines. In the hospital setting, some of the most common bacteria include Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus epidermidis, Enterococcus, Streptococcus pneumoniae, Methicillin-resistant Staphylococcus aureus (MRSA) and Clostridioides difficile. Studies have shown that neckties can act as transmission agents, especially when they come into contact with patients. Additionally, the type of material used to make a necktie determines the viability of bacteria. Wearing neckties increases risk for …

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Intraoral Appliance Therapy - A Better Alternative For Apnea Than Cpap?, Bryan Teigman Jan 2023

Intraoral Appliance Therapy - A Better Alternative For Apnea Than Cpap?, Bryan Teigman

The Science Journal of the Lander College of Arts and Sciences

Obstructive sleep apnea (OSA) is a condition where there is a physiologic hindrance of airflow to the lungs, triggering the brain to interfere with the sleep cycle and awaken an individual to provide sufficient oxygen flow. For years, the continuous positive airway pressure (CPAP) machine has been the gold standard of care for patients suffering from OSA. Nonetheless, the machine has its flaws of being bulky, noisy, and other side effects, causing a low adherence rate and thus a lower relief rate of OSA symptoms. Accordingly, there have been many researchers seeking a more effective way to treat OSA, such …

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Is Intermittent Fasting A Better Option Than Continuous Calorie Restriction?, Joseph J Cynamon Jan 2023

Is Intermittent Fasting A Better Option Than Continuous Calorie Restriction?, Joseph J Cynamon

The Science Journal of the Lander College of Arts and Sciences

Intermittent fasting has become an increasingly popular diet for weight loss in the United States in the past ten years. Proponents of intermittent fasting claim that restricting calories via a fasting period yields more significant weight loss and better improvements in biomarkers for longevity than restricting calories continuously. The goal of this paper is to determine whether intermittent fasting leads to weight loss and is more beneficial than continuous calorie restriction. The paper first details the physiological processes which can occur during fasting that are theorized to render fasting advantageous. It then reviews the limited available research that experimentally compares …

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How Can We Eliminate Peanut Allergies?, Ari Weingarten Jan 2023

How Can We Eliminate Peanut Allergies?, Ari Weingarten

The Science Journal of the Lander College of Arts and Sciences

For a long time, people with peanut allergies have had to carefully read labels, carry around emergency epinephrine injections, and live in fear of accidentally consuming an otherwise benign food that could potentially kill them. Thankfully, researchers have been working on ways to alleviate the harmful effects of these allergies and perhaps even find a cure. In the Learning Early About Peanut allergy (LEAP) study performed in 2015, researchers examined whether the early introduction of peanut consumption could be used to prevent peanut allergies. According to the study, peanuts can be introduced orally to high-risk infants who are sensitized, as …

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Singer’S Voice Quality - Genetic Or Environmental Influences?, Dobra Baum Jan 2023

Singer’S Voice Quality - Genetic Or Environmental Influences?, Dobra Baum

The Science Journal of the Lander College of Arts and Sciences

This paper explores the singing voice in terms of the vocal mechanism’s key anatomical features and the physiology of the vocal function. It focuses on phonation and resonation and examines the anatomy and physiology of the vocal tract and the respiratory system. The aim is to determine whether the singer’s voice is only the product of genetics or due to environmental influences. It conducts a procedure to evaluate how singers use their voices to modify breathing, pitch, volume, and timbre through resonance shaping. It also investigates the hereditary transmission of a good singing voice, on chromosome 12q, between relatives, and …

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Full Issue: Volume 16, Number 2, Spring 2023 Jan 2023

Full Issue: Volume 16, Number 2, Spring 2023

The Science Journal of the Lander College of Arts and Sciences

Complete .pdf file of Volume 16, Number 2 of The Science Journal of the Lander College of Arts and Sciences. Published Spring 2023.

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Rheumatoid Arthritis: Traditional Drugs Vs. Alternative Medicine, Menachem Rubenstein Jan 2023

Rheumatoid Arthritis: Traditional Drugs Vs. Alternative Medicine, Menachem Rubenstein

The Science Journal of the Lander College of Arts and Sciences

Rheumatoid arthritis is a systemic autoimmune disease which is inflammatory and chronic. This disease affects the joint linings of those with this condition, which causes painful swelling. Complications of this disease can cause problems in the patients’ eyes, skin, heart, lungs, and other organs. Being that there is no cure for Rheumatoid Arthritis, different treatment approaches are aimed to reduce the current pain and to slow further damage. In this paper, we will present a summary of past and present treatments to address the best possible treatment options for Rheumatoid arthritis. We will place an added emphasis on the use …

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Alcohol Consumption And Its Effects On The Liver, Eveline Weinreb Jan 2023

Alcohol Consumption And Its Effects On The Liver, Eveline Weinreb

The Science Journal of the Lander College of Arts and Sciences

Thousands of people die each year in the United States from alcohol related deaths. Why does the metabolism of alcohol cause severe damage to the body? Ethanol enters the body in the form of wine, and other alcoholic beverages and travels through the digestive system and then to the liver where it is metabolized. There are a series of steps involved in the breakdown of ethanol, and toxic byproducts are formed such as reactive oxygen species (ROS). These oxygen radicals can lead to damaged deoxyribonucleic acid (DNA) and to the formation of adducts. Chronic alcohol consumption can lead to liver …

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Overexpression Of Abcc1 And Abcg2 Confers Resistance To Bmn-673, A Poly (Adp-Ribose) Polymerase (Parp) Inhibitors, Qiuxu Teng Jan 2023

Overexpression Of Abcc1 And Abcg2 Confers Resistance To Bmn-673, A Poly (Adp-Ribose) Polymerase (Parp) Inhibitors, Qiuxu Teng

Theses and Dissertations

Cancer remains a growing public health challenge worldwide. Although the development of chemotherapies has effectively reduced the cancer death rate and improved patients’ prognosis, the frequent occurrence of multi-drug resistance (MDR) in cancer has caused impairments on the efficacy of many structure-unrelated anticancer agents, leading to treatment failure and recurrence. One of the most common causes of MDR is the overexpression of ATP-binding cassette (ABC) transporters on cancer cell membranes, which transport anticancer drugs out of cancer cells, thereby reducing the intracellular drug concentration. BMN-673 (talazoparib) is a potent poly (ADP-ribose) polymerase (PARP) inhibitor that is approved for BRCA-mutated HER2-negative …

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