Digital Commons Network^™

Interpretable Deep Learning Reveals Spatiotemporal Mri Features Of Brain Aging That Align With Neurodegeneration, Nikhil N. Chaudhari, Owen M. Vega, Phoebe Imms, Jaron M. Kawamura, Nahian F. Chowdhury, Tamara Jafar, Andrei Irimia, Kenneth Spicer, Crystal Flynn Longmire, Jacobo Mintzer, Yaneicy Gonazalez Rojas, V. Sotelo, William Hu, Floyd Jones, Amy Saklad, Sudha Seshadri, Amy Boegel, Sydni Jenee Hill, Paul Newhouse, Rebecca Long, Campbell Long, Arthur Williams, Allison Acree, Olga Brawman-Mintzer, Chelsea Reichert, Vita Pomara, Raymundo Hernando, Nunzio Pomara, Skieff Acothley, Nadeen Elayan, Micah Ellis Slaughter

Neurology Faculty Publications

Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T₁-weighted (T₁w) MRI. By identifying MRI features unapparent to humans, DNNs can find aging-related structural alterations above and beyond cortical thickness and atrophy. Using a novel approach to DNN interpretability, we mapped brain aging progression in 25,539 cognitively normal UK Biobank adults aged 45–83 years. Cortical aging is …

Post-Approval Study 3-Year Outcomes Of The Neuroform Atlas Stent For The Treatment Of Wide-Necked Intracranial Aneurysms, Brian Jankowitz, Ashutosh P. Jadhav, Bradley Gross, Tudor G. Jovin, Abdulnasser A. Alhajeri, Justin F. Fraser, Ricardo A. Hanel, Eric Sauvageau, Amin Aghaebrahim, Donald Frei, Richard Bellon, David N. Loy, Ajit S. Puri, Adel M. Malek, Ajith J. Thomas, Gabor Toth, Demetrius Klee Lopes, R. Webster Crowley, John Reavey-Cantwell, Eugene Lin, Adnan Siddiqui, Michael J. Alexander, Ahmad Khaldi, Geoffrey P. Colby, Justin M. Caplan, Sudhakar R. Satti, Aquilla S. Turk, Alejandro M. Spiotta, Richard Klucznik, Danial K. Hallam, David Kung, Michael T. Froehler

Neurology Faculty Publications

Introduction The ATLAS trial was a prospective, multicenter, single-arm, investigational device exemption (IDE) study to evaluate the safety and effectiveness of the Neuroform Atlas Stent System for the treatment of widenecked bifurcation aneurysms. This analysis presents the 36-month follow-up data for the anterior and posterior cohorts. Methods Of the 182patients in the IDE anterior cohort, 146 consented to participate in the post-approval study (PAS) and, of the 116patients in the IDE posterior cohort, 101 consented to participate in the PAS. The primary effectiveness endpoint was core laboratory adjudicated (Raymond–Roy 1; RR1) without retreatment or parent artery stenosis (>50%) at …

Law's Shifting Circles, Ela A. Leshem

Faculty Scholarship

This Article undermines two myths in American legal history: first, that the law’s circle of moral concern has steadily expanded; and second, that legal protections have always centered on human persons. As to the first, the law contains multiple, shifting circles of moral concern, expanding along some dimensions and contracting along others. As to the second, U.S. law and the English common law on which it was based have long attributed moral status to nonhuman beings and inanimate objects.

The Article shows that U.S. legislators, judges, and advocates have for centuries treated a wide range of entities as deserving of …

Does Textualism Constrain Supreme Court Justices?, James J. Brudney, Lawrence Baum

Faculty Scholarship

A principal justification for textualism is the constraint hypothesis. Conservative Justices and leading textualist scholars contend that—in stark contrast to reliance on legislative history—focus on the ordinary meaning of enacted text leaves little room for the Justices to be policy-oriented or ideological in their interpretations. This Article represents the first systematic study probing the validity of the constraint hypothesis, one that employs both quantitative and qualitative analysis.

The Article examines the Justices’ reliance on interpretive resources in over 660 statutory decisions in the field of labor and employment, decided by the Burger Court, the Rehnquist Court, and the Roberts Court—during …

Why Are Executions Becoming Crueler?, Deborah W. Denno

Faculty Scholarship

Since the modern death penalty era, this country’s six execution methods have become crueler over time. This article details the execution procedures adopted across death penalty states up to the end of 2025, analyzing their societal and cultural underpinnings and explaining how they were implemented, including their shared flaws, unscientific origins and protocols, and reliance on untrained, unqualified, or unknown executioners. While legislatures and courts claim that states move from one technique to the next to enhance greater humaneness, history shows that such switches are primarily propelled by constitutional challenges to a state’s particular technique. In theory, rendering a state’s …

The Surveillance Of System-Adjacent Individuals, Mariam A. Hinds

Faculty Scholarship

Although the Fourth Amendment protects against “unreasonable searches and seizures,” this right is not enjoyed by all people equally. Supreme Court jurisprudence has curtailed the Fourth Amendment privacy rights of individuals under probation or parole supervision. In this line of cases, the Court concluded that the government’s interest in monitoring supervisees, reducing recidivism, and promoting public safety outweighed their reasonable expectation of privacy.

However, surveillance mechanisms like probation and parole extend the criminal legal system’s carceral gaze beyond the supervisees and peer into the bedrooms and digital lives of their families, roommates, and communities, or who this Article calls system-adjacent …

Should Statutory Interpretation And Contract Interpretation Be Harmonized?, Ethan J. Leib

Faculty Scholarship

This paper develops four case studies about how states have harmonized or separated their statutory interpretation regimes and their contract interpretation regimes.  After exploring the choices of Texas, Alaska, New York, and Alabama—all of which take different approaches to their lumping or splitting—the paper seeks to make state courts more aware of what their options are; to help states think about whether their commitments to formalism or contextualism make sense to apply in both domains; and to help them evaluate their meta-choices about whether to bring their interpretive regimes closer together or further apart.

Brokering Safety, Chinmayi Sharma, Thomas E. Kadri, Sam Adler

Faculty Scholarship

For victims of abuse, safety means hiding. Not just hiding themselves, but also their contact details, their address, their workplace, their roommates, and any other information that could enable their abuser to target them. Yet today, no number of name changes and relocations can prevent data brokers from sharing a victim’s personal information online. Thanks to brokers, abusers can find what they need with a single search, a few clicks, and a few dollars. For many victims, then, the best hope for safety lies in obscurity—that is, making themselves and their information harder to find.

This Article exposes privacy law’s …

An Empirical Study Of Malingering In Insanity Cases Across Twelve Decades, Deborah W. Denno

Faculty Scholarship

The last 120 years have seen a surge in the use of neuroscientific evidence in American criminal law cases, fueled by discoveries in brain science that have challenged the legal system’s assumptions about human thinking and culpability. One key assumption is that many defendants “malinger,” that is, feign or fake insanity or mental illness, to garner an acquittal or mitigated punishment. Likewise, when potential evidence that a defendant is malingering is introduced in court, it can have a pronounced and powerful negative effect on the defendant’s insanity claim, especially when juries and criminal justice actors are already skeptical of insanity …

Microscopic Insights On Shear Rheology Of Polyampholyte Ionomers Via Molecular Simulations, Kyle Vonscio

Williams Honors College, Honors Research Projects

Ionomers are polymers that contain a small fraction of charged groups. The ionic attraction of charged groups allows ionomers to act similarly to crosslinked polymers. Depending on the strength of electrostatic interactions and structure of the ionomers, different dynamics and rheological responses can be observed. With moderate attraction between ions, these noncovalent crosslinks can be broken when heated, allowing ionomers to flow and show the strength of a crosslinked network at low temperatures. Nonequilibrium molecular dynamics (NEMD) simulations will be performed under shear in the xy-plane and the macroscopic rheology and conformation of the polyampholyte ionomer will be determined. The …

Women's Work And Wealth: Measuring The Impact Of Incremental Liberations, 1850-1870, Hannah Kelly

Williams Honors College, Honors Research Projects

Using a two-way fixed effects difference-in-difference model, this project analyzes data from the IPUMS Full Count census for 1850, 1860, and 1870 at a state level for 48 states. Four models assess the impact of property laws on women's real property holdings, labor force participation, household types, and real property values.

By quantifying the impact of various legal reforms on women's economic empowerment, this project fills a gap in the understanding of the intersection between law, society, and women's economic agency during a transformative period in pre-industrial American history. These impacts can implicate the effectiveness of legislative measures in advancing …

A 1d Symmetric Interior Penalty Discontinuous Galerkin Solver In Rust, William Aey

Williams Honors College, Honors Research Projects

This honors project will build a 1D Symmetric Interior Discontinuous Galerkin (SIPDG) solver in Rust for Stum-Liouville type problems such as the Poisson equation, with Robin, Dirichlet, and Neumann boundary conditions. The work will cover the full pipeline: starting from the strong form of the PDE, deriving the DG weak form, implementing element and interface operators, and assembling or apply the discrete operator. Rust's safety and concurrency (e.g, via Rayon) will be used to explore serial and parallel performance. A test-driven development approach will be used to maintain a strong suite of tests. The project will result in a documented …

Determining Critical Micelle Concentrations Of Standard Surfactants And Rhamnolipids, Kathryn E. Kunz

Williams Honors College, Honors Research Projects

My proposed project will study the critical micelle concentration (CMC) of rhamnolipids using the pendant-drop and drop-weight methods. First, the critical micelle concentrations of ionic and nonionic common surfactants will be tested. Sodium Dodecyl Sulfate (SDS) will be used as an ionic surfactant and Tween 20 will be used as a nonionic surfactant. The critical micelle concentrations will be determined using the pendant-drop and drop-weight methods. The experimental results from the standard surfactants compared to their accepted values will be tested to assist with determining a more suitable approach. Completing the tests will provide a better understanding of critical micelle …

Ai-Based Porosity Detection In Babbitt Bore Turning, Kaylee Leggett, Hannah Adams Gemmell, Kaisa Shingleton

Williams Honors College, Honors Research Projects

For this project, an external company reached out to the University of Akron requesting assistance with defect detection during their vertical turning operations. As babbitt is removed in a vertical turning process, it occasionally reveals defects, mainly porosity, which can lead to costly downstream failures of the part. Current inspection techniques involve use of dye penetrant, which is time consuming, labor intensive, unergonomic, and a source of human error. The goal of the project is to create an alternative inspection method using an AI-based machine-learning model. After the turning operation, a camera is deployed to perform an in-place inspection, taking …

From Curiosity To Code: Using Ai As A Tool For Phenomenon-Based Chemistry Teaching, Allie M. Chambers

Williams Honors College, Honors Research Projects

In recent years, there has been an increased emphasis on integrating phenomena-based learning into science classrooms. This instructional approach engages students with real-world events that make scientific concepts more understandable and gives the students a personal connection to their education. However, implementing phenomena-based instruction proves to be a challenge to novice and veteran educators alike.

This project explores, through the lens of an education student, the struggle of implementing phenomena events. Starting with reflections on how lessons can be revised/ constructed to involve a phenomena event and a personal comparison of the difficulty of integrating these events without and with …

Design New Stage For Vacuum Pin On Disk, Miranda Boyd

Williams Honors College, Honors Research Projects

For my senior design project, I am redesigning the moving stage for the vacuum pin-on-disk test used in the Akron Engineering Tribology Lab. This system is used to evaluate bearings and lubricants for aerospace applications under controlled vacuum conditions. The current stage design limits flexibility when adjusting for different testing parameters, so my goal is to develop a new movable stage that allows for varying weights and loads to be applied accurately and safely. The redesigned stage will improve test efficiency, adaptability, and precision, ensuring the system can accommodate a wider range of experimental conditions and materials while maintaining compatibility …

Printer For Music Box, Chad Lewis, Caleb Murawski, Zion Smith, Bryan Tibbs

Williams Honors College, Honors Research Projects

The traditional method of creating music box sheet music involves manually punching holes into a paper strip using a hand-operated hole punch. This process involves precise knowledge of each note’s location and the ability to achieve perfect accuracy for hours.

The goal of this system is to automate this process, significantly reducing the time required while greatly improving the accuracy of the resulting music box playback. The user simply uploads a MIDI file of their choice into a user-friendly application. Here, the file is modified based on the user’s needs and sent to an automated hole-punching system to punch the …

Crashheart, Ellie Riekert, Kennady Skidmore, Madison Furino

Williams Honors College, Honors Research Projects

This project aims to develop an XR (extended reality) iPad training system to improve pediatric crash cart preparedness among nurses and clinical staff at Akron Children’s Hospital. In emergencies such as respiratory failure or shock, quick and accurate access to crash cart supplies is vital, yet opportunities for hands-on practice are limited. Current nurse training relies on PowerPoint instruction or costly physical simulations, reducing engagement and skill retention. Our interactive XR solution replicates the crash cart’s layout and contents, allowing users to practice identifying and retrieving critical items in a realistic environment without using physical supplies. The system will be …

Seat Belt Data Collection Methods: A Comparison Between States And National Guidelines, Madison R A Richards

Williams Honors College, Honors Research Projects

Thousands of fatalities related to vehicle crashes occur every year. One method to reduce fatalities is to encourage seat belt use compliance. To promote statistics regarding seat belt use, there first must be reliable data on seat belt compliance and this comes from good survey design.

This report is a comparative analysis of seat belt data collection methodologies for Ohio, Michigan, and Indiana, in addition to an evaluation of how each state aligns with standards set by the National Highway Traffic Safety Administration (NHTSA). The framework for this analysis focuses on NHTSA’s five core survey design requirements: selection of observation …

Supporting Mothers Within The Criminal Legal System: Programs In Akron And Perceptions Of “Good Motherhood”, Brynn R. Lewis

Williams Honors College, Honors Research Projects

This paper examines the programs and support systems available in Akron, Ohio, for mothers involved in the criminal legal system, including defendants, survivors, and other justice-involved individuals. Using qualitative interviews (n = 6) with professionals across courts, legal defense, community corrections, and advocacy organizations, this study examines how local institutions provide resources and support to mothers. Findings indicate that while programs aim to promote stability and rehabilitation, mothers face persistent barriers such as limited access to transportation, childcare, and communication, as well as heightened stigma tied to societal expectations of caregiving. These findings reveal that institutional support both reflects and …

Synaptic Connectivity Of Rod Bipolar Cells In The Mouse Retina: A Connectomic Analysis Using Webknossos, Harold F. Eshun

Williams Honors College, Honors Research Projects

Rod bipolar cells (RBCs) are key interneurons in the mouse retina that transmit signals from rod photoreceptors to downstream amacrine and ganglion cells under scotopic (low-light) conditions. Although their general morphology and function are well established, the fine-scale organization of their synaptic inputs and outputs remains incompletely characterized. This project aims to map the pre- and postsynaptic partners of a fully reconstructed rod bipolar cell using the Yu volume, a serial block-face electron microscopy dataset from the ventral retina of an adult wild-type mouse. Using the webKnossos platform, I identify synaptic ribbons in the axon terminals of the rod bipolar …

Security Onion Ids Case Study: Detecting And Investigating Threat Traffic Using Suricata, Zeek, And Pcap Evidence, Daryna Myroniuk

Williams Honors College, Honors Research Projects

A key component of cybersecurity is network intrusion detection, which is used to examine network traffic for any malicious activity. Many organizations deploy intrusion detection systems (IDS) but still face challenges such as validating detections, investigating alerts in a timely manner, and producing clear and repeatable evidence of what has occurred, especially when live traffic capture may be limited to risks, permissions, or privacy concerns. The goal of this project was to use Security Onion, which includes Suricata and Zeek to create and demonstrate a controllable and manageable evidence-based IDS investigation workflow. This project is focused on deploying and validating …

An Investigation Into The Potential Role Of Thioester Bonds In Prebiotic Atp Synthesis, Adam J. Ruf

Williams Honors College, Honors Research Projects

In this project I will attempt to show a potential prebiotic pathway for the synthesis of ATP. This pathway involves the use of thioester bond containing molecules, as derivatives of these bonds have been shown to exhibit enzyme-like catalytic properties. Nuclear magnetic resonance spectroscopy will be utilized to characterize each step of the pathway to ensure it is successful.

Stanislavski And Operatic Acting: What Caused The Divide Between Stanislavski’S Ideals And The Opera World?, Max Smith

Williams Honors College, Honors Research Projects

There is a difference between the realism of acting in opera and in other theatrical art forms. One reason for this might be due to theatre practitioner Konstantin Stanislavski’s ideals not being readily adopted in the opera world. Due to translation and publication issues in both the West and in the USSR, his work on opera has been largely neglected by theatre and opera historians. Certain demands of opera as an art form limit or make more difficult the ability for realism in portraying a character, but Stanislavski and others show that it is possible. A look at literature reflecting …

Defending A Soho Network Against Mitm Attacks, Braeden J. Wise

Williams Honors College, Honors Research Projects

Cybersecurity is a vast domain that consists of many threats that target sensitive information found on wired and wireless networks. One of those threats is a man-in-the-middle (MITM) attack, which involves an attacker situating themselves between a sender and a receiver to intercept or redirect network traffic. These kinds of attacks can run rampant on a small office home office (SOHO) network due to the vulnerabilities and lack of enterprise level tools. The intent of this project is to perform and defend against MITM attacks for a SOHO network. In the context of the project, three MITM attacks will be …

Analyzing Network Traffic And Data Exfiltration Via Smb In Post-Vm Escape Scenarios, Noah M. Disanza

Williams Honors College, Honors Research Projects

Virtual machines (VMs) play a crucial role in modern IT infrastructure environments by providing isolation and enhanced security, among other things, for both personal and corporate systems. VMs are heavily rely upon to safely test malware, manage infrastructure, and reduce risk to host systems. This reliance is so substantial that the idea of reducing risk to the host system is believed to be erasing risk entirely. However, this mindset has shown to be challenged time and time again by the emergence of exploits known as virtual machine escapes. These exploits allow malicious actors to break out of the virtualized environment …

Lumacurve Control System Update, Jacob Kustra, Caleb Wengerd

Williams Honors College, Honors Research Projects

The existing track heater control system used by Lumacurve has become outdated and requires frequent maintenance due to inconsistent operation and component failures. This project aims to modernize the system through the implementation of a programmable logic controller (PLC), infrared non-contact temperature sensing, and an automated pneumatic ejection mechanism.

The redesigned system improves temperature monitoring accuracy and reduces operator intervention by automatically ejecting heated plastic tracks from the heater once the desired temperature is reached. An emergency ejection subsystem is also incorporated to safely clear tracks from the heater in the event of improper operation or system faults. Additional emphasis …

Rapid Skin Stapler, Emma J. Patterson, Allison M. Milligan, Morgan E. Dunlap

Williams Honors College, Honors Research Projects

Severe burn injuries frequently require split-thickness skin grafts, with metal surgical staples serving as the current standard for fixation. While staples provide rapid and secure placement of graft material, they also introduce significant challenges. Removal is painful, time-consuming, and often requires sedation in pediatric patients, leading to added risk, resource strain, and poor patient experience. These drawbacks highlight the need for improved fixation methods that maintain graft stability while reducing procedural burden. This project applies the engineering design process to address these challenges through identification of user needs, translation into design inputs, risk assessment, and development of a prototype aimed …

The Effect Of Minimum Wage On Household Debts And Delinquencies, Payton G. Rader

Williams Honors College, Honors Research Projects

This paper examines how increases in binding minimum wages affect various types of household debts and delinquency rates. Within this paper, household debt is defined as the combined sum of auto loans, credit card debt, mortgage debt, and student loan debt. The goal of the analysis is to conclude whether minimum wage increases are contributing to America’s growing debt crisis. The answer to this question likely relies on whether or not minimum wage increases cause unemployment. This is because unemployment can contribute significantly to debt levels when unemployed people rely on credit for day-to-day transactions or payments. Traditional economic theory …

A Decade Of Programming Languages: Trends In Popularity And Influence, Jonathan C. Erb

Williams Honors College, Honors Research Projects

Programming languages play a central role in open-source software ecosystems, yet their adoption, visibility, and influence shift over time as technologies, developer communities, and industry practices evolve. The study aims to investigate long-term trends in programming-language usage on GitHub from 2014 through 2024, focusing on ten major languages that represent diverse domains and ecosystems. Using repository metadata, engagement metrics such as stars and forks, and language-level code statistics measured with cloc, the analysis will examine changes in repository creation, code contribution volume, and popularity. Since popularity remains an unsettled and multidimensional concept, part of this research involves determining how it …