Digital Commons Network^™

Biomarkers Of Multiorgan Failure In Covid-19: A Predictive Framework For Disease Severity And Clinical Outcomes, Wesam A. Nasif, Mohammed H. Mukhtar, Mohammad Althubiti, Abeer Shaker El Moursy Ali

Saudi Medical Journal

Objective: To investigate the predictive value of inflammatory, liver, renal, and cardiac biomarkers in relation to the progression of multiorgan failure (MOF) in COVID-19 patients. A primary goal was to identify which of these markers served as the most discriminative predictors of disease severity.

Methods: A retrospective cohort study was carried out between December 2020 and February 2023 to collect data from 1,803 COVID-19 patients from data records in different hospitals in Makkah, Saudi Arabia. The ROC curve analysis evaluated the diagnostic and predictive performance of selected biomarkers.

Results: Inflammatory markers such as CRP and D-dimer were evaluated, but ferritin …

Role Of Artificial Intelligence In Infectious Diseases And Antimicrobial Resistance: A Comprehensive Review On Diagnostic, Treatment, And Prevention Aspects, Naveed Ahmed, Mansoor Alghamdi

Saudi Medical Journal

Artificial intelligence (AI) plays a significant role in managing infectious diseases by enhancing diagnosis, treatment, and preventive measures. AI-assisted tools have predictive analysis ability for incoming outbreaks, including the emergence of antimicrobial resistance (AMR). AI-assisted tools facilitate the treatment methods by tailoring personalized medicine according to the specific disease history of the patient, immune response, and genetics. Advanced vaccine development by various AI-assisted in silico tools is becoming easy, leading to faster vaccine discovery and more efficient vaccine design with a more immunogenic response. Despite huge benefits, a few limitations are also encountered, including biases in algorithms, data privacy, and …

Artificial Intelligence In Radiology: Hidden Fragilities And The Path To Resilience, Mustafa S. Alhasan

Saudi Medical Journal

Radiology artificial intelligence (AI) is advancing however its adoption faces fragile foundations that threaten sustainability. Despite bold promises of efficiency and accuracy, current deployment is undermined by weaknesses in economics, evidence, infrastructure, human factors, regulation, security, and environmental impact. Nearly 90% of radiology AI studies report process metrics rather than patient outcomes, while hidden costs elevate ownership to 400% to 500% of subscription fees. Technical fragilities include 25% or greater performance loss with routine protocol or scanner shifts, compounded by vendor consolidation that has eliminated 63% of companies since 2020, creating migration costs averaging 180,000 dollars per exit. Human factor …

Childhood Obesity: Global Burden, Multifactorial Etiologies, Biological Mechanisms, And Emerging Interventions For Prevention And Management, Fahad H. Baali

Saudi Medical Journal

Childhood obesity, characterized by excessive accumulation of body fat that adversely affects health, is a global public health challenge. It affects approximately 8.2% of children and adolescents globally and contributes significantly to the burden of chronic diseases in later life. Obese children are at increased risk of developing metabolic disorder cluster, type 2 diabetes (T2D), coronary artery disease (CAD), and psychosocial complications. Increasing prevalence of childhood obesity imposes substantial economic costs and highlights the urgent need for effective prevention and management strategies. The causes of childhood obesity are multifactorial including genetic predispositions, environmental influences, dietary habits, and physical inactivity. Early …

Bleeding Avoidance Strategies In Patients With Atrial Fibrillation, Antonio Landi, Marco Valgimigli

Saudi Medical Journal

No abstract provided.

Master Any Language 100x Faster, Yoshihiko Ariizumi

Learning, Teaching, & Researching Optimization

Learn any language 100x faster with this booklet of high-speed acquisition techniques!

Mignone, Fernandez, Guarnieri: Brazilian Guitar Music After Villa-Lobos, Fabio Zanon

Soundboard Scholar

This article challenges the widespread perception of Heitor Villa-Lobos as an isolated peak in Brazilian musical culture with no natural successors. The author focuses on the composers who followed Villa-Lobos—Francisco Mignone, Oscar Lorenzo Fernandez, and Camargo Guarnieri—arguing that their works deserve far more attention in international concert life, not least their contributions to the guitar repertoire.

These twentieth-century Brazilian composers are situated within a broader historical narrative that traces the impact of European colonial models, the delayed and contested formation of musical nationalism in Brazil, and the shifting aesthetic and political conditions of the twentieth century. Analytical discussions of representative …

Hyaluronan 35 Prevents Endotoxin-Mediated Dysregulated Skeletal Muscle Proteostasis During Ethanol Exposure, Nicole Welch, Pugazhendhi Kannan, Gangarao Davuluri, Annette Bellar, Amy H. Attaway, Saurabh Mishra, Jasmin A. Cunningham, Avinash Kumar, Ryan Musich, Elif G. Ertugral, Vandana Agrawal, Isaac L. Hu, Terri J. Hartford, Noah L. Weisleder, Vidula T. Vachharajani, Chandrasekhar R. Kothapalli

Chemical & Biomedical Engineering Faculty Publications

Sarcopenia in alcohol-related liver disease (ALD) is of high clinical significance, but there are no effective treatments. Hyaluronan 35 kDa (HA35), a glycosaminoglycan polymer, modulates responses to Toll-like receptor 4 (TLR4), a lipopolysaccharide receptor, to improve hepatic and macrophage function in ALD. We evaluated skeletal muscle responses to HA35 in preclinical models of ALD. Responses to ethanol, lipopolysaccharide (LPS), and HA35 were studied in differentiated murine C2C12/human-induced pluripotent stem cell (hiPSC)-derived myotubes, and wild-type/HA receptor CD44 knockout (CD44(-/-)) mouse models of ALD (mALD). Signaling molecules and measures of protein homeostasis (proteostasis) were quantified by immunoblots, mitochondrial oxidative function was determined …

Elder Jack "Jessie" Morris, Jr.

African American Funeral Programs

Funeral program for Jack Morris, Jr. Service was held on February 7, 2026.

Learning The Game Beyond The Scoreboard, Marisa C. Atkinson

University of Mississippi News

OXFORD, Miss. – While people are watching football, selecting their fantasy teams, keeping up with the transfer portal or calling a play, statistics often form the linchpin of their analysis. Some of those statistics may have been collected by sport management students in the University of Mississippi's School of Applied Sciences.

Artificial Intelligence In Medical Ethics Education: A Descriptive Study Of Eight Models In Multiple Choice Question Generation, John Obeid, Christopher Bobier, Alex Gillham, Adam Omelianchuk, Daniel Hurst

Center for Medical Ethics and Health Policy Staff Publications

Introduction: Integrating artificial intelligence (AI) into medical education poses barriers and opportunities for medical educators. One of those opportunities is content creation for medical ethics assessment. Assessing the performance of AI in generating multiple choice questions (MCQs) in ethics that aligns with United States Medical Licensing Examination (USMLE) is important. The present study evaluates the performance of eight AI models-GPT-4 Turbo, GPT-3.5 Turbo 0125, o1 Mini, o1 Preview, GPT-4, Claude 3.5 Sonnet, Claude 3 Opus, and Gemini-in regard to the relevance, clarity, and accuracy of generated ethics-based MCQs.

Methods: Each of the eight models was tasked with generating two sets …

Impaired Arginine, Citrulline And Glutamine Metabolism In Type 2 Diabetes: Insights From A Stable Isotope Study, Mustafa Tosur, Raven A Wierzchowska-Mcnew, Nicolaas E P Deutz, Mariëlle P K J Engelen

Children’s Nutrition Research Center Staff Publications

Context: Arginine (Arg) is an important amino acid in T2D as a potent insulin secretagogue and precursor for nitric oxide (NO). Citrulline (Cit), the substrate for de novo Arg synthesis, is mostly produced from glutamine (Gln).

Objective: We aimed to investigate their metabolism in T2D using novel stable isotope tracer approach.

Methods: We studied 42 individuals (21 with T2D, 21 controls). After overnight fasting, blood samples were collected following pulse administration of stable amino acid tracers. Plasma concentrations and isotopic enrichments were measured by LC-MS/MS, and compartmental analyses were performed to calculate their whole-body production (WBP) rates and kinetics.

Results: …

Selective Reversal Of Cu-Amyloid Aggregation Monitored In Real Time By Fluorescence Anisotropy: Ni-Bme-Dach Vs Edta Benchmarks, Alyssa N. Schroeder, Eleanor K. Adams, Dane C. Frost, Erica Lopez, Jennie R. Giacomini, Marilyn R. Mackiewicz

Chemistry Faculty Publications and Presentations

Metal dyshomeostasis, particularly involving Cu2+, is increasingly recognized as a key contributor to amyloid-β (Aβ) aggregation and neurotoxicity in Alzheimer’s disease, motivating the development of chelators capable of selectively disrupting pathogenic metal-Aβ interactions without perturbing essential biological metals. Here, we employ steady-state fluorescence anisotropy as a real-time probe of TAMRA-Aβ1–42 rotational mobility to quantify metal-induced aggregation and its reversibility by two chelators with distinct selectivities: EDTA, a broad-spectrum benchmark, and Ni-bme-dach, a sulfur-rich metallodithiolate with high Cu affinity. Cu2+ induces the most significant increases in anisotropy, consistent with rapid formation of large nanoscale aggregates, while Fe3+ produces moderate aggregation and …

Regulating Reader(S): Book People V. Wong, Compelled Speech, And Sexually Explicit Library Materials In The Fifth Circuit, Gray Wood

Texas A&M Law Review

This Note analyzes the Fifth Circuit Court of Appeals’ recent holding in Book People, Inc. v. Wong, which struck down Texas Education Code Chapter 35. Passed under the 88th Texas Legislature’s READER Act in 2023, Chapter 35 instituted a mandatory rating system that required Texas book vendors to review the books they sold to district schools and open-enrollment charter schools for sexually explicit material. Book vendors banded together to oppose the law, arguing that it constituted compelled speech, a legal doctrine that has come to the forefront of First Amendment fights since the Supreme Court’s 2023 decision in 303 …

Thomasine B. Bayless

African American Funeral Programs

No abstract provided.

Project Risk Management In Ai-Enabled Systems: Managing Ethical, Privacy, And Governance Risks, Onome Cynthia Anakanire

Harrisburg University Dissertations and Theses

This research examined how Artificial intelligence (AI) has been embedded in project-based work, particularly in finance and software industries, where it enables efficiency and assists in complex decision-making. However, these innovations introduce significant ethical, privacy, and governance risks that traditional project risk management frameworks fail to adequately address. This study investigated how project managers can systematically integrate the management of these emerging risks into AI-enabled projects. Using a qualitative research design, the study drew on semi-structured interviews with project managers, compliance officers, and AI developers in finance, software and related sectors. Supplementary data included internal project documentation and risk registers. …

In The Belly Of The Beast:The Struggle For Abortion Rights And Reproductive Freedom In El Salvador, Cho, Karen Hyunbee

Santa Clara Journal of International Law

El Salvador maintains one of the most restrictive abortion regimes globally. Abortion is prohibited in all circumstances, and women who undergo the procedure may face prosecution for aggravated homicide, punishable by sentences of up to fifty years’ imprisonment. Healthcare professionals who assist with such procedures can likewise face criminal liability, with penalties of up to twelve years of imprisonment. This article concerns the case of a woman named Beatriz (surname unlisted) in El Salvador who sought an abortion in 2013 when she was medically diagnosed with a high-risk condition and an anencephalic fetus during her pregnancy. She was denied her …

Energy And Fluid Balance During A 214-Km Winter Ultraendurance Race: A Case Study, Kyle W. Wehmanen, Brent C. Ruby, Timothy C. Shriver, Michele N. Ravelli, Shalaya Kipp, John Mcdaniel, Erich Petushek, Steven J. Elmer

Michigan Tech Publications

The upper limits for total energy expenditure (TEE) and water turnover (rHO) in humans have been reported during several continuous single-day ultraendurance races (running, cycling, and triathlon). Currently, the upper limits for TEE and rHO during continuous single-day activity in cold weather (< 0 °C) remain unknown. The Arrowhead Ultra is one of the coldest ultraendurance races in North America and provides a unique opportunity to answer these questions. Racers select a bicycle, cross-country skis, or foot travel to traverse a 214-km snow-covered trail (altitude range: 345-426 m, 2,030-m elevation gain). Historically, approximately one-half of the racers complete the event. In this case study, we assessed TEE and rHO from the racer [cyclist: age: 22 yr, height: 1.84 m, body mass: 87.7 kg, and maximal oxygen consumption (V̇o): 5.0 LO·min] who won the 2025 Arrowhead Ultra (17.9 h, -13 to -1 °C) using the doubly labeled water method. Total energy and fluid intake were recorded to assess energy and fluid balance. Mean heart rate was 141 beats·min (71% of maximum heart rate). TEE was 63.9 MJ (15,273 kcal, 9.6 times basal metabolic rate) while total energy intake was 33.2 MJ (7,941 kcal). Mean carbohydrate intake was 88 g·h. Water turnover was 17.7 L, yielding a rHO/TEE ratio of 0.28 L·MJ for the race. The cyclist demonstrated high TEE and rHO that were comparable to values from other ultraendurance athletes competing in a range of temperatures (3-34°C). Notably, rHO from this cyclist was higher compared to athletes performing other ultratype endeavors in cold weather conditions (-25 to -19 °C). Our observations shed light on energy and fluid demands during continuous single-day activity in the cold and have endurance training and performance implications. In this short report, we detail new data on the upper limits of human energy expenditure (9.6 times basal metabolic rate) and water turnover (10.5 L·12 h) during continuous single-day exercise in the cold. Our results indicated elevated energy use, and impressively, water turnover comparable to exercise in warmer conditions. These findings have implications for training and endurance performance of strenuous exercise in cold weather environments.

Money And Desperation: Petruchio’S Love Language In The Taming Of The Shrew, Hannah Steck

Titan Humanitas

In The Taming of the Shrew by William Shakespeare, a young man, Petruchio, aims to tame the unmarriable Katherina. This desire to tame the “shrew” leads to physical fights, arguments, and struggles throughout the play, not only for Katherina but for Petruchio as well. Petruchio is established early on as a character who must find his own way in the world after the death of his father, therefore, perhaps his need to tame Katherina is guided by a desire besides love. Using literary analysis and close reading of the play, this paper argues that Petruchio’s motivation to tame Katherina is …

Profiting Off Of Humanity: Capitalism’S Bioinnovation In Speculative Fiction, Dana Janiec

Titan Humanitas

A deep dive in to Speculative Fiction such as Kazuo Ishiguro’s Never Let Me Go and Margaret Atwood’s Oryx and Crake regarding how Capitalism drives twisted and cruel forms of Bioinnovation for the sake of profit.

Paying The Price For Beauty Abroad: Khoula Hospital’S Experience With Complications Following Aesthetic Procedures Performed Overseas, 2013–2023, Khalifa Al Alawi, Areej Al-Mamari, Maysa Al-Maawali, Ashima Alkabi, Al-Batul Al-Mufargi, Juhaina Al Tobi, Hoor Al-Khanjari, Yasmine Al Balushi, Rawan Al Mandhari, Rafal Aljadder, Sultan Al Shaqsi

Sultan Qaboos University Medical Journal

Objective: This study aimed to evaluate the types and outcomes of complications arising from aesthetic surgeries performed abroad and subsequently managed at Khoula Hospital, Muscat, Oman. Methods: This retrospective study included patients who presented with post-aesthetic surgical complications after undergoing procedures outside Oman from January 2013 to December 2023. Data were extracted from Khoula Hospital’s electronic health records, focusing on demographics, procedures performed, types of complications and outcomes, including admissions and surgical interventions. Results: A total of 191 patients with 488 recorded encounters were included. The most common procedures done overseas were abdominoplasty (50.8%), lipectomy (29.3%) and …

Culture Lockdown: The Fear Of Cultural Appropriation In The Arts, Ellie Mcenery

Titan Humanitas

This paper examines cultural appropriation as a modern phenomenon and how it is perceived by those in the arts and humanities. It critiques cultural appropriation based on its hindering of artistic expression and by employing a deeper understanding of cultural history as argued by scholars Brian Morton and Rhiannon Giddens.

The Structure, Pathogenesis, And Inhibition Of The P53-Mdm2 Pathway, Amanda L. Brown, Xiaoying Lian, Qian Wang

Faculty Publications

The p53 tumor suppressor protein plays a central role in maintaining genomic stability by regulating cell cycle arrest, apoptosis, and DNA repair under cellular stress. Mouse double minute 2 (MDM2), an E3 ubiquitin ligase, negatively regulates p53 via direct binding and proteasomal degradation. Overexpression or amplification of MDM2 can disrupt this pathway and promote tumorigenesis, even in cancers with wild-type p53. This review outlines the structural features of MDM2, particularly its N-terminal hydrophobic pocket and C-terminal RING domain, and their roles in p53 regulation. We further examine the pathological effects of MDM2 dysregulation and SNPs linked to increased cancer risk. …

Silence Is Golden: Quiet Hours Vs. Delirium In The Picu, Chastity Gillmore-Williams, Kevin Lai, North Porter, Jade Orozco, Corrie Zuker, Bria Pierce

2025

No abstract provided.

02-17-26 Bor Hsc Committee Notice Of Meeting, Patricia Serna

HSC Committee (A subcommittee of the UNM Board of Regents)

02-17-26 BOR HSC Committee Notice of Meeting

Schwannomatosis Tumor Modeling: Progress And Prospects For Translational Research, Mackenzie S Madison, Huazhen Xu, Yarelis Gonzalez-Vargas, Marybeth G Yonk, Charee M Thompson, Hurley Haney, Danielle Babbitt, Yuhong Du, Angela C Hirbe, Nicholas M Boulis, Ren-Yuan Bai, Kecheng Lei

2020-Current year OA Pubs

BACKGROUND: Schwannomatosis (SWN) is a rare genetic condition characterized by the development of benign schwannomas along peripheral and spinal nerves, and this tumor development often results in chronic peripheral pain and significant neurological deficits. Despite surgical resection being the current standard of care for SWN-related pain, scientists are searching for accurate preclinical models that can be used for drug efficacy testing, but existing models often fail to fully recapitulate the complex genotypic diversity and tumor-nerve interface pathology seen in patients. MAIN TEXT: This review first summarizes the genotypic and phenotypic characteristics of SWN subtypes resulting from key mutations in NF2, …

Therapeutic Reprogramming Of Tumour-Associated Macrophages In Pancreatic Cancer Using A Cytotoxic Ccr2-Targeted Nanotheranostic, Vikas Kumar Somani, Xiaohui Zhang, Timothy Hung-Po Chen, Ashenafi Bulle, Sapana Bansod, Lin Li, Yutong Geng, Liang-I Kang, Gyu Seong Heo, Hannah Luehmann, Yuena Zhang, Muhammad A Saeed, Kory J Lavine, David G Denardo, Russell K Pachynski, Yongjian Liu, Kian-Huat Lim

2020-Current year OA Pubs

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) exhibits a profoundly immunosuppressive tumour microenvironment (TME) dominated by inflammatory monocytes (IMs) and tumour-associated macrophages (TAMs), which restrict adaptive immunity and drive resistance to immune checkpoint blockade (ICB). Recruitment of CCR2⁺ IMs by tumour-derived CCL2 is a central mechanism underlying TAM accumulation. Conventional gemcitabine (GEM) and small-molecule CCR2 inhibitors provide limited benefit due to poor intratumoural delivery, transient target engagement, and compensatory myeloid recruitment. METHODS: We engineered a CCR2-targeted nanotheranostic by conjugating a CCR2-binding peptide (ECL1i) and GEM onto ultrasmall copper nanoclusters (CuNCs-ECL1i-GEM; C-E-G). Therapeutic efficacy and immune remodelling were evaluated using orthotopic subcutaneous and …

Ai Integration In English Language Teaching: Exploring Efl Teachers’ Perceptions And Challenges In Saudi Universities, Waheeb Shadid Al-Biladi

UB Journal for Humanities

In response to the growing integration of Artificial Intelligence (AI) in English language education, this study explores how EFL educators in Saudi universities perceive and respond to the challenges associated with incorporating AI into their teaching practices. A quantitative study including 158 male and female EFL faculty members at Saudi institutions was executed using a standardized questionnaire to evaluate perceived barriers connected to AI and corresponding coping methods. Descriptive statistics and inferential tests were used to examine differences based on gender, teaching experience, and educational qualification. The findings indicate that educators somewhat recognize hurdles, including technological difficulties, inadequate training, and …

Paradox In The Characters Of Abdullah Thabit’S Novels: A Study In Vision And Form, Khalid Nasser Al-Jumaihi Al-Qahtani

UB Journal for Humanities

This research examines irony as an artistic and semantic mechanism that transcends the limits of apparent contradiction to express the depth of the psychological and intellectual conflicts experienced by characters within the novelistic text. In light of the intellectual and aesthetic transformations witnessed in Saudi narrative discourse, irony has emerged as one of the most effective narrative tools for uncovering the deep contradictions that govern the relationship between the individual, the self, and society. It is not merely an aesthetic device used to provoke surprise or astonishment, but rather a semantic structure that reflects a crisis-ridden consciousness caught between values …

The Impact Of Climate On Solar Panel Performance In Al-Madinah Al-Munawwarah, Mounira Matthas Al-Qahtani

UB Journal for Humanities

This study aims to identify the most important climatic elements that must be considered when designing solar panels in Al-Madinah Al-Munawwarah for the period 1995–2024, as well as the impact of monthly and annual climatic variations on the efficiency of solar panel performance. The study relies on the following climatic elements: annual radiation, temperature, relative humidity, wind, rainfall, and dust, in order to understand the relationship between climatic elements and the performance of solar panels. The study employed an analytical and applied methodology. The results indicate that Al-Madinah Al-Munawwarah enjoys high levels of solar radiation, with an overall average of …