Digital Commons Network^™

Sting-Induced Blood-Brain Barrier Opening Combined With Radiotherapy Potentiates Antitumor Response In A High-Grade Glioma Model, Shashwat Tripathi, Hinda Najem, Lisa Hurley, Ruochen Du, Crismita Dmello, Kathleen Mccortney, Peng Zhang, Craig M Horbinski, Lara Leoni, Ryan J Avery, Rimas V Lukas, Timothy L Sita, David R Raleigh, Sean Sachdev, Roger Stupp, Maciej S Lesniak, David M Ashley, Daniele Procissi, Michael A Curran, Irina Balyasnikova, Amy B Heimberger

Faculty, Staff and Student Publications

Radiation therapy (RT) is the standard of care for glioblastoma but is not curative. Triggering the cGAS/stimulator of interferon genes (STING) pathway with potent agonists, such as 8803, exerts activity across high-grade glioma preclinical models. To determine if the combination of 8803 with RT warrants consideration in the up-front treatment setting and to clarify the underlying mechanisms of therapeutic activity, C57BL/6J mice harboring intracerebral CT-2A or QPP8v gliomas were treated with RT, intratumoral 8803, or both. The treatment with the combination resulted in 80% long-term survival in the CT-2A model but not in the radiation-resistant QPP8v model. This therapeutic effect …

Automated Quantification Of Movement Qualities In The Human Upper Extremity After Stroke Using A Wearable Robot., Yoon No Gregory Hong, Kyoungsoon Kim, Sheng Li, Marcia K O'Malley, Ashish D Deshpande, Jinsook Roh

Faculty, Staff and Student Publications

Background: Stroke is a leading cause of long-term adult disability, with approximately 80% of survivors experiencing upper extremity (UE) motor impairments. Conventional tools like the Fugl-Meyer Assessment (FMA) are widely used but limited by ordinal scales and subjective visual observation. While wearable robotics offer high-resolution data, their clinical translation is hindered by a lack of standardized protocols and limited interpretability for clinical decision-making.

Objective: This study aimed to develop an objective, standardized, and clinically interpretable method to quantify UE motor qualities by integrating wearable robotic technology with traditional clinical assessment tasks.

Methods: Ten healthy individuals and ten stroke survivors performed …

How A Holistic Approach To People Of Reproductive Age Can Support Access To Preconception Care For People Living With Health Conditions: Findings From A Realist Evaluation, Heather Hopper, Kerryn Husk, Kate Maslin, Jill Shawe

School of Nursing and Midwifery

This realist evaluation explored how access to preconception care works for people with pre-existing health conditions, for whom, and in what contexts. Thirty one participants (women of reproductive age, partners, and healthcare professionals) were interviewed using qualitative realist methods. Iterative analysis refined 35 initial programme theories into 13 middle range theories. The theory reported here identifies healthcare professionals’ knowledge of sexual and reproductive health, understanding of pregnancy planning, and enquiry regarding pregnancy intention as key mechanisms. In the context of diagnosis or review, these resources support holistic and individualized preconception care, enabling improved preconception health and reduced adverse maternal and …

Artificial Intelligence In Nuclear Cardiology: Technical Perspectives, Strategic Directions, And Recommendations From An Iaea Expert Working Group, Christiane Wiefels, Luis Eduardo Juárez-Orozco, Pietro Selemo Craviolatti, Oleksandr Diahiliev, Amir Eskander, Raffaele Giubbini, Weihua Zhou, Et Al.

Michigan Tech Publications

Artificial intelligence (AI) is increasingly permeating nuclear cardiology and offers the possibility to enhance diagnostic accuracy, prognostic stratification, and operational efficiency. AI is demonstrating applicability across the imaging workflow—from individualized patient selection and adaptive image reconstruction to denoising of low-dose datasets, automated attenuation and motion correction, calcium scoring, and the integration of imaging with clinical and functional variables for enhanced diagnosis and comprehensive risk assessment. But the translational trajectory of AI in nuclear cardiology is challenged by the lag in fundamental AI knowledge among researchers and clinicians, the quality of the target data regarding heterogeneity in acquisition protocols, scanner platforms, …

Postdilation Of Evolut Transcatheter Heart Valves: Insights From Bench Testing., Ole De Backer, Ryan Stublaski, Hatem Tadros, Arif Khokhar, Gintautas Bieliauskas, Steven J Yakubov, Michael Deeb, Kendra J Grubb, John K Forrest, Michael J Reardon

Heart and Vascular Articles

No abstract provided.

Six-Year Outcomes After Transcatheter Vs Surgical Aortic Valve Replacement In Low-Risk Patients With Aortic Stenosis., John K Forrest, Steven J Yakubov, G Michael Deeb, Michael J Reardon

Heart and Vascular Articles

BACKGROUND: The Evolut Low Risk trial enrolled patients with severe aortic stenosis at low surgical risk. Annual follow-up is planned for 10 years, evaluating the composite of all-cause mortality or disabling stroke and key secondary endpoints.

OBJECTIVES: Our prespecified objective was to report the 6-year clinical outcomes of transcatheter aortic valve replacement (TAVR) vs surgery from the Evolut Low Risk trial. Given an increase in reintervention rates at 6 years, we performed additional analyses in available 7-year data.

METHODS: Low-risk patients with severe symptomatic aortic stenosis were randomized to TAVR or surgery from 2016-2019. Prespecified analyses at 6 years included …

Visual Healing In Visual Communication Design: Exploring Calm Aesthetics For The Psychological Well-Being Of Urban Society, Siti Indah Lestari, Ivo Ramadhani

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

This study investigates the concept of visual healing from a Visual Communication Design (VCD) perspective, focusing on its potential contribution to emotional comfort and psychological well-being among urban office workers. Contemporary workplace environments are increasingly characterized by prolonged screen exposure, dense visual information, and sustained cognitive demands, conditions that intensify visual fatigue and psychological strain. In this context, the study positions visual design not merely as an aesthetic practice, but as a psychologically responsive medium capable of shaping users' emotional experiences in everyday work settings. Employing a qualitative Research through Design (RtD) methodology, the study treats the design process as …

Discourses On Homosexuality And The Paradox Of The Closet In The New Life (2023) By Tom Crewe, Paramita Ayuningtyas, Shuri Mariasih Gietty Tambunan, Asri Saraswati

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

This article offers a critical examination of Tom Crewe's biographical novel The New Life (2023), focusing on its representation of homosexual subjectivity in Victorian England—a historical context defined by restrictive moral norms and punitive legal regimes that criminalised same-sex relationships. Drawing on Michel Foucault's theory of discursive power, Eve Kosofsky Sedgwick's concept of the closet, and Michael Boucai's topology of the closet, the study demonstrates that the novel portrays the closet not merely as a private site of concealment but as a complex social mechanism shaped by legal regulation, gender norms, and class-based power relations. Building on this theoretical framework, …

Adapting To Cultural Diversity At Work: A Thematic Analysis Of Resources Mobilized By Local And Posted Agricultural Workers In France, Alexandrine Ceschiutti, René Mokounkolo

The Qualitative Report

When workers have to adapt to a new culture, they develop intercultural skills as cultural intelligence (CQ), which is the ability to show an interest and act effectively in an environment characterized by cultural diversity. There has been little research on this subject in France, and studies have focused on expatriates, while acculturation also affects people from the local community. This is the case for local agricultural workers (LW), whose perceptions we compare with those of foreign posted agricultural workers (PW) in France. Our study had two aims: (a) to explore the personal resources that these workers perceive as necessary …

On-Orbit Correction Of Ecostress Radiances By Comparison With Iasi Hyperspectral Sounders, David S. Wethey, Sarah A. Woodin, Jorge Vazquez-Cuervo

Faculty Publications

Radiance data from ECOSTRESS (ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station), which is the first of a planned virtual constellation of wide-swath ultra-high-resolution thermal satellites, were used to test the concept of on-orbit cross-calibration based on the Global Space-based Inter-Calibration System (GSICS) with the Infrared Atmospheric Sounding Interferometer (IASI) as the reference. Validation of the results was performed using comparisons of corrected ECOSTRESS radiances with strictly independent data from IASI and the Cross-Track Infrared Sounder (CrIS) and with RTTOV radiative transfer simulations of clear-sky observations in iQuam (the NOAA in situ sea surface temperature quality monitor database). ECOSTRESS has …

A 682-Second X-Ray Periodicity In Ch Cygni: Evidence For A Magnetic White Dwarf, Manuel Pichardo Marcano, Thomas J. Maccarone, Liliana E. Rivera Sandoval

Physics & Astronomy Faculty Publications

Symbiotic stars are interacting binaries consisting of a red giant and typically a white dwarf (WD), which are important as potential Type Ia supernova progenitors. Despite theoretical predictions that WDs in symbiotic systems should often be magnetic, direct evidence has been elusive. We report the discovery of a 682.5 ± 7 s periodicity in the XMM–Newton X-ray light curve that we interpret as the spin period of the WD in CH Cygni. This detection provides strong evidence for a magnetic WD in CH Cygni, making it only the second WD symbiotic star with confirmed X-ray pulsations after R Aquarii. Our …

Strspy2.0: Unlocking The Potential Of Long Reads For Forensic Dna Profiling, Bupe Kapema, Nicole R Phillips, Fritz J Sedlazeck, Roxanne R Zascavage

Faculty, Staff and Students Publications

Forensic human identification relies on length-based differences in short tandem repeats (STRs) across autosomal and Y chromosomes, which require separate reactions and provide limited resolution. While next-generation sequencing offers greater discriminatory power, most platforms are expensive and restricted to traditional lab settings. Nanopore sequencing has the potential to change this with the real-time, portable MinION sequencer. However, forensic-specific tools that generate STR profiles compatible with established length-based databases are lacking. To address this, we developed STRspy2.0, which simultaneously profiles autosomal and Y-STRs using nanopore reads. STRspy2.0 produced accurate profiles for 54 multiplexed control libraries and 41 mock casework samples (blood, …

Author Correction: Intracranial Directed Connectivity Links Subregions Of The Prefrontal Cortex To Major Depression, Ben Shofty, Victoria Gates, Joshua Adkinson, Anusha B Allawala, Adrish Anand, Ron Gadot, Ricardo Najera, Hernan G Rey, Sanjay J Mathew, Kelly Bijanki, Garrett Banks, Andrew Watrous, Eleonora Bartoli, Sarah R Heilbronner, Nicole Provenza, Wayne K Goodman, Nader Pouratian, Benjamin Y Hayden, Sameer A Sheth

Faculty, Staff and Students Publications

No abstract provided.

Supercoiled Dna Recognition And Cleavage Control In Topoisomerase Vi, Curtis Beck, Qianyun Yan, Haley R Johnson, Ryan A Eckerty, Jonathan M Fogg, Matthew L Baker, Lynn Zechiedrich, James M Berger

Faculty, Staff and Students Publications

Type II topoisomerases modulate DNA supercoiling and resolve chromosome entanglements. Type IIB topoisomerases, exemplified by DNA topoisomerase VI (Top6), are used by plants and archaea to support endoreduplication and cell proliferation, respectively; homologs of Top6 further serve to initiate meiotic recombination in eukaryotes and constitute the nuclease portion of MksBEFG/Wadjet/Gabija bacterial defense systems. To understand how such factors act upon DNA, we determine structures of Top6 bound to supercoiled minicircles in cleaved and uncleaved states using single-particle electron cryo-microscopy. The structures show that Top6 binds a curved 74 bp region of the supercoiled minicircle DNA and that it cuts at …

Molecular Detection Of Genes Encoded For Biofilm Formation In Bacteria Isolated From The Oral Cavity Of Patients, Tebarek Al-Taei, Ali A. Al-Hisnawi

Karbala International Journal of Modern Science

Background: A biofilm is a collection of the microbial cells attached to the surface that are encased in a matrix of extracellular polymers. Biofilm formation creates a physical and chemical barrier that prevents antibiotics from reaching bacterial cells, resulting in treatment failure and reinfection. The present study aimed to investigate the biofilm formation in bacteria isolated from the oral cavity of patients.

Methods: In this study, 150 bacterial isolates were obtained from tooth and gum surface swabs of male and female patients of different ages who visited specialized centers and dental clinics in Babylon City after they were clinically diagnosed …

A Virtual Community Math Circle, Skona Brittain, Sayonita Ghosh Hajra, Steve Heller, Daniel Hodgins, Peter Petto, Gabriella Pinter, Lauren Rose, A. Gwinn Royal, Asmita Sodhi

Journal of Math Circles

The Julia Robinson Mathematics Festival (JRMF) Community Math Circle is free, volunteer-run, and online. We collaborate with JRMF and use their activities in our events. Started during the pandemic, the Community Math Circle continues to thrive. We have about 40 participants attending every month, typically kids aged 6 to 13, teachers, facilitators, and other adults. This article describes how our event is organized, planned, and executed, and how we train facilitators. We will also offer reflections on our successes and challenges.

Assessment Perception: Delivery Matters, Nicole Marie Arcuri Sanders, Chelsey Simmons

Journal of Counselor Preparation and Supervision

Perception shapes how individuals experience the world and guides their actions toward personal goals. In counseling, clients’ accurate understanding of assessment results is essential for informed decision-making and effective treatment engagement. Mental health clinicians have an ethical responsibility to communicate findings in ways that safeguard client welfare and empower both clients and stakeholders to collaborate in care. This conceptual manuscript introduces the BRIEF (Brief, Relevant, Interpretive, Empathetic, and Factual) Feedback Integration Framework, a structured model for delivering assessment feedback ethically and accessibly. Integrating cognitive, developmental, and cultural considerations. BRIEF provides counselors, supervisors, and educators with a practical strategy for improving …

Addressing Saintly Corrections: An Integrative, Developmental Approach To Counselor Bias Management, Travis Walker, Jennifer M. Cook

Journal of Counselor Preparation and Supervision

No person is without biases, even the most culturally adept among us. Managing biases is critical to counselors’ continued journey of understanding clients contextually and holistically. In this article, we describe two novel bias management concepts: A specific type of bias called saintly corrections and the more clinically fruitful approach of realistic corrections. We define and illustrate saintly and realistic corrections, outline a multifold approach (i.e., cognitive complexity, cultural identity development, and the multicultural orientation model) for remediating saintly corrections, and offer recommendations counselor educators can use during planned and contextual learning opportunities, including an example of a contextual …

Teaching Multicultural Counseling: A Phenomenological Exploration Of Counselor Educators’ Voices, Cameka Hazel, Paul Leheste, Raymond Blanchard

Journal of Counselor Preparation and Supervision

This study explored the perceptions of counselor educators who taught the graduate level multicultural counseling course. Six participants shared experiences, leading to four themes: personal and professional rewards, who is fit to teach? dealing with resistance and difficult conversations and limited time and class size. Implications for counselor education are discussed.

Competencies And Preparation For Addressing Poverty In Counselor Education: A Q Methodological Study, Seneka Rachel Gainer

Journal of Counselor Preparation and Supervision

This study explored the competencies needed to prepare counselors to address the systemic and relational impacts of poverty within counselor education. Using Q methodology, expert participants identified critical knowledge, skills, and awareness factors required for effective practice. Two distinct factors emerged: (1) the centrality of relational competencies such as empathy, cultural humility, and trust-building, and (2) the necessity for curriculum-wide integration of poverty-specific training and systemic advocacy. Findings highlight the need for counselor education programs to embed poverty-related competencies across curricula, foster interdisciplinary collaboration, and develop experiential and advocacy-based training models. Implications for counselor education, accreditation standards, and professional development …

Counselors’ Experiences Of The Alliance In Videoconference Supervision: The Role Of Nonverbals, John E. Trenery, Azra Karajic Siwiec, Randall L. Astramovich

Journal of Counselor Preparation and Supervision

The role of nonverbal immediacy and intimacy in shaping the supervisory alliance during videoconference-based clinical supervision is understudied. Using a generic qualitative research design, data were collected from 15 practicing counselors through semi-structured interviews. Thematic analysis identified six primary themes, highlighting both the perceived barriers and the essential role of nonverbal cues, as well as the need for amplified behaviors in video-based interactions. The findings point to significant gaps in telesupervision training and introduce a novel framework to strengthen telepresence in videoconference supervision. This study offers actionable insight for educational institutions and governing bodies, emphasizing the importance of targeted curricula …

Dismantling Racism In The Classroom: Recommendations For White Male Counselor Educators, Jason L. Vannest, Rebecca J. Vannest, Lorise D. Grey

Journal of Counselor Preparation and Supervision

In response to the historical tradition of Eurocentrism and Whiteness in counseling programs in the United States, the American Counseling Association (ACA) and the Association for Counselor Education and Supervision (ACES) have challenged their members to confront implicit bias, become allies with Black Indigenous People of Color (BIPOC), and commit to challenging racism and implicit bias. Despite these robust calls to disrupt racism and implicit bias, counselor educators - specifically White male counselor educators (WMCEs) - may wonder how to effectively take action due to their own racial identity. Several factors may contribute to WMCEs' reticence to deconstruct racism and …

The Feminist Impostor Phenomenon Approach (Fipa): A Feminist Approach To Addressing Impostor Phenomenon In Novice Counselors, Isabel Springer, Kelly Emelianchik-Key

Journal of Counselor Preparation and Supervision

Impostor Phenomenon (IP) is known to affect new professionals in health professions, yet there is little to no academic literature available on how it affects early career counselors and how it can be addressed. Novice counselors (NC) frequently experience extreme anxiety and feelings of fraudulence around their professional performance. Feminist mentorship and interventions can help alleviate IP and foster self-efficacy and confidence in new counseling professionals. The Feminist Impostor Phenomenon Approach (FIPA) consists of a three-hour workshop educating participants through a feminist lens about IP and relevant coping strategies, and subsequent weekly consciousness-raising groups where coping strategies are reinforced, and …

The Interpretive Phenomenological Analysis Of The Job Search Experiences Of International Counseling Doctoral Students In The U.S., Yi-Ju Cheng, Juleen Buser, Terry Pertuit

Journal of Counselor Preparation and Supervision

International counseling doctoral students (ICDSs) bring valuable cultural diversity to the counseling profession in the U.S. However, their transition to professional roles is complicated by cultural identity factors, limited support for career guidance, and employment barriers tied to language, immigration status, and unfamiliarity with U.S. licensing and employment resources. There is limited understanding of their job search experiences. This qualitative study, through interpretive phenomenological analysis, examines 12 ICDSs’ job search experiences in the U.S. Nine themes were identified. The findings highlight a discrepancy between the counseling profession’s stated commitment to diversity and the actual support to international students, and the …

Artificial Intelligence Literacy In Counselor Education: The Developmental Ai Literacy Framework, Leo Gonzalez Jr.

Journal of Counselor Preparation and Supervision

Artificial intelligence (AI) is transforming counselor education, yet frameworks for preparing counselors-in-training (CITs) to use AI remain limited. This article introduces the developmental AI literacy framework (DALF), a conceptual model integrating developmental theory, professional identity formation, and AI literacy. The DALF reframes AI literacy as a developmental competency comprising intentional AI use, critical evaluation, ethical engagement, and awareness of professional identity. The framework outlines three stages, including foundational awareness, reflective application, and integrated professionalization, that parallel CITs’ growth from dependence to autonomy. Pedagogical, developmental, and research implications are provided to guide ethical and reflective AI integration in counselor education.

Prediction Of Thyroid Disease Based On Machine Learning Algorithms, Tuqa Ahmed Elbillihy, Eman Abdelhalim, Mohamed Ashour, Hala B. Nafea

Mansoura Engineering Journal

Accurately diagnosing thyroid disease remains a challenge in medicine, necessitating the use of reliable computational techniques for early detection and categorization. Using a dataset of 3164 patient records, this study applies machine learning algorithms to create a computer-aided thyroid disease diagnosis system. The data set includes demographic information, clinical indicators, and thyroid function test results. To improve model performance, the study focuses on preprocessing approaches such as data cleaning, normalization, and feature selection. The use of feature engineering techniques to determine the most predictive characteristics associated with thyroid problems is highlighted. Five machine learning classifiers—Random Forest, K-Nearest Neighbors, Support Vector …

Seismic Behavior Of Slender Cable-Supported Braced Frame Structures, Aya Aboelnaga, Mohamed Mortagi, Mohamed E. El Madawy, A.H.A. Abdelrahman, M. Naguib

Mansoura Engineering Journal

This research investigates advanced strategies to enhance the seismic performance and global stability of slender steel frames by integrating cable-supported and braced systems. To address these challenges, the study develops finite element (FE) models of multi-story slender frames in SAP2000, incorporating both cable-supported configurations and diagonal bracing systems. Nonlinear time-history analyses are performed using selected earthquake ground motions to evaluate structural response, inter-story drift, and mode shape behavior. Results highlight the efficiency of cablesupported frames in controlling lateral displacements and redistributing forces, while also emphasizing the role of bracing in providing additional stiffness. The findings demonstrate that guided frames with …

Back Matter

Creative Nonfiction Magazine

No abstract provided.

Solving A Problem, Kathy Rooney

Creative Nonfiction Magazine

No abstract provided.

A Kamikaze Attitude, Ac Fraser

Creative Nonfiction Magazine

No abstract provided.