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Economic Evaluation Of Perioperative Pembrolizumab Plus Standard Of Care As Treatment For Resectable Locally Advanced Head And Neck Squamous Cell Carcinoma In The United States, Feng Qian, Arielle G Bensimon, Anjela Tzontcheva, Kimberly Benjamin, Ravindra Uppaluri, Douglas Adkins, Geoffrey Johnson, Catherine Fernan, Dandan Zheng, Yuexin Tang, Biruk Chafamo, Dominic Muston

2020-Current year OA Pubs

AIMS: In the phase 3 KEYNOTE-689 trial (NCT03765918) among patients with resectable locally advanced head and neck squamous cell carcinoma (LA HNSCC), perioperative pembrolizumab (pembrolizumab before surgery, then continued with standard-of-care [SOC] radiotherapy +/- cisplatin after surgery followed by pembrolizumab alone) significantly prolonged event-free survival vs. SOC alone, both in the intention-to-treat population and PD-L1 combined positive score (CPS) ≥1 subgroup. Perioperative pembrolizumab + SOC received Food and Drug Administration approval in June 2025 for resectable LA HNSCC expressing PD-L1 (CPS ≥ 1). The present study evaluated the cost-effectiveness of perioperative pembrolizumab + SOC versus SOC in this indication, from …

Frankenstein’S Drugs: Did Gilead Sciences’ Bahamas Tax Caper Create A Multibillion-Dollar Periodic Adjustment?, Stephen L. Curtis, Reuven S. Avi-Yonah

Articles

With about 182 million infections worldwide at the time, the potential value of a cure for the hepatitis C virus (HCV) was staggering.2 The company behind this drug, Pharmasset Inc., was a startup in Princeton, New Jersey, with 42 researchers and $127 million in the bank, churning through $66 million per year with no commercialized products and no codevelopment or commercialization partners. The “Pharmasset combo” was an extremely effective nucleotide analog that could treat HCV-infected individuals across genotypes, known as PSI-7977 (later renamed GS-7977), also called sofosbuvir, the active pharmaceutical ingredient (API) found in multiple current drugs used to treat …

Discrete Quantization On Spherical Geometries: Explicit Models, Computations, And Didactic Exposition, Mrinal Kanti Roychowdhury

School of Mathematical & Statistical Sciences Faculty Publications

This article presents a comprehensive and analytically explicit study of optimal discrete quantization on spherical geometries equipped with the geodesic metric. Focusing on highly symmetric configurations on the unit sphere 𝕊2, we investigate three explicit models of discrete uniform distributions and derive closed-form expressions for their optimal quantizers and corresponding mean square quantization errors. (I) For N equally spaced points on the equator, we obtain exact error formulas for both divisible and non-divisible cases 𝑛 ∤𝑁, demonstrating that optimal Voronoi cells form contiguous arcs with midpoint representatives. (II) For two antipodally symmetric small circles at latitudes ±𝜙0, each with M …

Autonomous Aesthetic Composition Via A Generative Model In A Robotic Control Loop, Rohit Sinha, Prathamesh Save, Kumar N. Dwarakanath

Defensive Publications Series

Automated camera systems may focus on geometric tracking without considering aesthetic composition, while certain aesthetic evaluation software may lack the physical agency to move a camera to create an improved image. Disclosed are systems and methods for a closed-loop control architecture that can integrate a mobile robotic platform, such as a drone or wheeled robot, with a generative cognitive agent. Such a system can operate through an iterative cycle where an image can be captured, the agent can provide a natural language critique and a corrective command based on a high-level subjective goal, and a local controller can translate the …

Agent-To-Agent (A2a) Artificial Intelligence (Ai) Bill Of Materials (Bom) Exchange And Policy Framework, Robert Barton, Barry Qi Yuan

Defensive Publications Series

The agent-to-agent (A2A) protocol lacks transparent, verifiable visibility into the artificial intelligence (AI) components driving counterpart behavior, such as large language models (LLMs), auxiliary agents, Model Context Protocol (MCP) servers, and downstream tools. Assessing risk, compatibility, and compliance amid dynamic runtime changes and opaque provenance becomes difficult, forcing organizations to either over-trust or restrict utility. The disclosed techniques augment the A2A protocol with an AI Bill of Materials (AI BOM) exchange that discloses component inventories, versions, provenance, and attestations; a policy engine that evaluates BOMs to approve, scope, or deny interactions; and selective disclosure to balance transparency with privacy. Sessions …

Agent-To-Agent (A2a) Agent Card Creation Through Model Context Protocol (Mcp) And Agent Skill Compilation, Robert Barton, Arjun Sambamoorthy, Yathi Udupi

Defensive Publications Series

Proposed herein are techniques for a system that automatically generates Agent-to-Agent (A2A) capability cards by scanning Model Context Protocol (MCP) servers and semantically analyzing the tool inventories of the servers. The system transforms low-level tool specifications into high-level capability descriptions through a multi-stage pipeline that extracts schemas, infers dependencies, detects relationships, clusters related tools into skills, and abstracts skills into comprehensive capabilities. The output is a standardized A2A agent card that enables efficient agent discovery and collaboration in multi-agent systems.

Sekitar Pasal 115 Ketetapan Mpr-Ri No. I/Mpr/1978, Hermawan Ps. Notodipoero, S.H.

Jurnal Hukum & Pembangunan

Abstract

Perencanaan Pemukiman Transmigrasi Sebagai Usaha Pengembangan Wilayah Serta Masalah Hukum Dalam Penyediaan Dan Penyiapan Tanahnya, Arie Sukanti Sumantri, S.H.

Jurnal Hukum & Pembangunan

Abstract

Mahkamah Agung Cegah Berubahnya Tujuan Adopsi, Detty Tangkudung, S.H.

Jurnal Hukum & Pembangunan

Abstract

Nilai Dan Fungsi Keterangan Ahli (Dokter) Terhadap Suatu Tindak Pidana Di Depan Pengadilan, B.Z. Koemolontang, S.H.

Jurnal Hukum & Pembangunan

Abstract

Arbitrase Dagang Internasional Dari Negara-Negara Asia Afrika, Prof. Dr. Mr. Sudargo Gautama

Jurnal Hukum & Pembangunan

Abstract

Strategies For Sustainable And Inclusive Outdoor Wayfinding In Healthcare Facilities: An Approach To Enhance User Experience At Kafr Alsheikh University Hospital, Egypt, Rania Abd Allateef Ghanam, Ahmed Salah El-Deep

Mansoura Engineering Journal

Outdoor wayfinding plays a critical role in shaping user experience in healthcare environments, where inadequate navigation can heighten stress and hinder timely access to care. Despite the presence of wayfinding systems in many hospitals, outdoor navigation remains underexamined and inconsistently addressed in design guidelines. This study fills this gap by investigating architectural strategies to enhance outdoor wayfinding and reduce user stress. The research focuses on Kafrelsheikh University Hospital in Egypt and applies a twophase methodology: (1) a comprehensive literature review to identify current principles, guidelines, and best practices in outdoor wayfinding, and (2) an on-site case study to assess existing …

The Impact Of Integrating Social Benefit Requirements For Urban Green Infrastructure And Place Identity Attributes To Enhance The Sense Of Place - Case Study Of Central Park, Madinaty, New Cairo City, Egypt, Ibrahim Magdi Mohammed, Rehab Abdelfatah Abdel Aziz Mahmoud

Mansoura Engineering Journal

This research develops an integrated model that links the social benefit requirements of Urban Green Infrastructure (UGI) with the non-physical attributes of Place Identity (PI) to enhance the Sense of Place (SOP) in contemporary urban environments. The need for this integration arises from limitations in current planning frameworks, which often prioritize ecological performance while overlooking cultural, perceptual, and behavioral dimensions that shape user attachment and belonging. The study adopts an inductive and synthesis-based approach to identify key UGI indicators across environmental, social, economic, and spatial dimensions, alongside PI attributes related to places’ legibility, uniqueness, publicness and territoriality, place’s identification. To …

Enhancing Thermal Energy Storage Efficiency Using Optimized Concrete Materials: A Review, Ahmed Mohamed Abbass, Ahmed M. El-Khayatt, Khaled A. Eltawil

Mansoura Engineering Journal

The increasing global energy demand and the environmental impact of fossil fuels necessitate the development of sustainable energy solutions. Solar energy is a promising alternative, but its intermittency and inefficiency limit its widespread adoption. This study explores the role of advanced concrete-based thermal energy storage systems in addressing these challenges. Key aspects examined include packing density optimization, high-temperature performance, and hydrothermal durability of concrete. The research highlights the importance of granulometric optimization, binder selection, and hydration mechanisms in enhancing concrete properties. Additionally, the effects of heat exposure on concrete durability, permeability, and mechanical strength are analyzed, with a focus on …

Optimized Thermal Management Of Cylindrical Lithium-Ion Batteries Using Circular Fins And Forced Air-Cooling, Mohamed M. Donia, Ahmed A. Hegazi, Mohamed A. Aziz, Osama Abdelrehim

Mansoura Engineering Journal

The Battery Thermal Management System (BTMS) is vital for maintaining the optimal performance, safety, and longevity of electric vehicle batteries by keeping their temperature within a desired range. This study proposes an optimized cooling solution for BTMS based on both experimental and numerical investigations. Experimental tests were performed on a single battery cell under discharging rates of 1C, 2C, 3C, and 4C using an electronic load, with thermal performance evaluated under natural convection. Numerical models simulating both forced and natural convection were developed using ANSYS 19.3, and a combined Computational Fluid Dynamics (CFD) and Response Surface Methodology (RSM) approach was …

Verification Of Offline Signature Based On A Hybrid Dense-Attention-Residual-Cnn Structure Optimized By Grey Wolf Algorithm, Zeyad T. Salim, Mahmoud M. Saafan, Eman M. El-Gendy

Mansoura Engineering Journal

Signature verification is a necessary vision task with prevalent use in securing realworld applications. Offline signature is a popular type that needs to efficacious approach to be checked due to the depending on the paper time and the written tool. The progress in intelligent algorithms participates in supporting simple way authentication-based signatures. In this research work, an offline signature verification (OSV) based on an optimized and costumed convolutional neural network(CNN) infrastructure is suggested. The CNN is costumed by integrating residual, dense, and attention mechanisms, then optimized by applying a grey wolf optimization(GWO) algorithm. The system is trained and tested with …

Membuat Undang-Undang Perubahan Sosial Di Negara Yang Sedang Membangun Undang-Undang Perkawinan Indonesia Yang Baru Diteliti Kembali, June S. Katz, Ronald S. Katz

Jurnal Hukum & Pembangunan

Abstract

Penahanan Tidak Sah Dan Pembebanan Ganti Rugi, Putu Putra

Jurnal Hukum & Pembangunan

Abstract

Perjanjian Perdamaian Sebagai Lembaga Hukum Untuk Menyelesaikan Masalah Tertumpuknya Perkara Di Mahkamah Agung, Riduan Syahrani, S.H.

Jurnal Hukum & Pembangunan

Abstract

Merenungkan Kembali Susunan Mpr, Harmaily Ibrahim, S.H.

Jurnal Hukum & Pembangunan

Abstract

Pembahasan Prasaran Prof. Soebekti Mengenai Sistim Hukum Nasional Yang Akan Datang, Purnadi Purbacaraka, S.H.

Jurnal Hukum & Pembangunan

Abstract

Beberapa Pemikiran Mengenai Sistem Hukum Nasional Yang Akan Datang, Ghs I. Tobing

Jurnal Hukum & Pembangunan

Abstract

Masalah Penegakan Hukum Dan Kesadaran Hukum, Dr. Soerjono Soekanto, S.H., M.A.

Jurnal Hukum & Pembangunan

Abstract

Laporan Lengkap Promosi Doktor Satjipto Rahardjo, S.H., Erman Radjagukguk, Budiman B. Sagala

Jurnal Hukum & Pembangunan

Abstract

Rumah Flat Diatur Dengan Sistem Condominium, Hartono S.H.

Jurnal Hukum & Pembangunan

Abstract

Pengembilan/Pengumpulan Batu Di Areal Kawasan Hutan Jawa Dan Madura Serta Sebuah Pendapat, Emmanuel Rahajaan, S.H.

Jurnal Hukum & Pembangunan

Abstract

Penggunaan Dasar-Dasar Analisa Kausal Dalam Penelitian Sosiologi Hukum Yang Non Doktriner, Ronny Hanitijo Soemitro, S.H.

Jurnal Hukum & Pembangunan

Abstract

Pensyaratan (Reservation) Dalam Perjanjian Internasional, Sri Setianingsih Suwardi, S.H.

Jurnal Hukum & Pembangunan

Abstract

Sistim Hukum Nasional Yang Akan Datang, Prof. Soebekti S.H.

Jurnal Hukum & Pembangunan

Abstract

Assessing The Geomechanical Modelling Of Underground Reservoir For Co₂ Storage Trapping Mechanisms, Bonavian Hasiholan, Mohammed Ali Farea, Elhassan Mostafa Abdallah, Sami Abdelrahman M. Yagoub, Yasir Mukhtar

Mathematical Modelling and Numerical Simulation with Applications

Effective carbon dioxide (CO₂) storage is essential for mitigating climate change amid increasing global greenhouse gas emissions. This study investigates the influence of geomechanics on CO₂ storage performance within carbon capture and storage (CCS), focusing on structural, residual, and solubility trapping mechanisms using a fully coupled modeling framework. Two numerical models, with and without geomechanical effects, are developed to evaluate impacts on reservoir behavior, CO₂ migration, and trapping efficiency. Each mechanism is analyzed separately and within an integrated framework to assess their combined contributions. Results indicate that geomechanical coupling increases reservoir pressure, reduces CO₂ flow velocity, enhances migration control, and …