Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 85501 - 85530 of 5153635

Full-Text Articles in Entire DC Network

A211: Ai-Driven Strategic Frameworks For Sport Event Propagation Under Media Affordance Theory, Wenqian Yao, Jingwang Zhang Jan 2026

A211: Ai-Driven Strategic Frameworks For Sport Event Propagation Under Media Affordance Theory, Wenqian Yao, Jingwang Zhang

International Journal of Physical Activity and Health

The advancement of intelligent technology has transformed interaction models across communication ecosystems, encompassing production, dissemination, and consumption. Exemplified by the Paris Olympics’ 180+ intelligent communication domains, “AI + Sports” has emerged as an industry paradigm. This study employs media affordance theory to analyze AI’s transformative role in sports communication and associated ethical challenges, offering insights for cultivating a robust digital sports ecosystem. Method: This study investigates the application pathways of artificial intelligence in 20 major sports events held between 2000 and 2024. Data on application frequency, audience feedback, and other relevant metrics w collected to analyze the impact patterns of …

Go to article

A212: Experimental Study On The Kdl Physical Education Curriculum Promoting Preschoolers’ Gross Motor Development, Zhen Li, Xiao Niu, Normah Binti Jusoh, Yong Liu, Zhongji Hao Jan 2026

A212: Experimental Study On The Kdl Physical Education Curriculum Promoting Preschoolers’ Gross Motor Development, Zhen Li, Xiao Niu, Normah Binti Jusoh, Yong Liu, Zhongji Hao

International Journal of Physical Activity and Health

Early childhood is a critical stage for the development of fundamental motor skills, with gross motor skills being the primary focus. Effective development of gross motor skills lays a foundation for learning complex movements during adolescence. Research confirmed that gross motor skills also directly affect Preschoolers’ perceptual, cognitive, and social adaptability development. This study explores the effectiveness of the "KDL Physical Education and Health Curriculum" in promoting gross motor skills development in preschoolers, aiming to enhance their overall health. From September to December 2024, 167 Preschoolers from primary, middle, and senior classes at Yijing Road Kindergarten in Chongqing Liangjiang New …

Go to article

A213: Somatosensory Interactive Technology On Postural Balance In Children With Developmental Coordination Disorder: A Systematic Review, Changhui Peng, Lei Zhang, Xueping Wu, Xingyu Shi Jan 2026

A213: Somatosensory Interactive Technology On Postural Balance In Children With Developmental Coordination Disorder: A Systematic Review, Changhui Peng, Lei Zhang, Xueping Wu, Xingyu Shi

International Journal of Physical Activity and Health

Developmental coordination disorder (DCD) is a neurodevelopmental disorder characterized by motor coordination impairments and motor learning difficulties. Compared with typically developing children, children with DCD often exhibit deficits in postural control, strength, and cardiorespiratory fitness. This study used a systematic review method to review the relevant evidence of video-game interventions in children with DCD, aiming to explore the mechanisms of somatosensory interaction technology on balance ability of children with DCD, and provide evidence-based recommendations for parents, teachers, and rehabilitation therapists. A PICO framework was constructed to systematically search Chinese and English literature on the intervention of video games on balance …

Go to article

A208: Application Of Artificial Intelligence In Posture Correction, Jiaqi Wu Jan 2026

A208: Application Of Artificial Intelligence In Posture Correction, Jiaqi Wu

International Journal of Physical Activity and Health

In the modern fast-paced life, poor postures are extremely common, leading to many health problems such as neck pain and back pain. Posture correction is of great significance for maintaining physical health, and the rise of artificial intelligence (AI) technology has opened a new path for posture correction. Posture correction means using specific means to restore and maintain the correct body posture. This study aims to systematically review the application of AI in the field of posture correction, clarify its advantages, limitations, and future development trends. A comprehensive search was carried out in domestic and foreign authoritative databases for research …

Go to article

A220: Work Memory Of Adhd Children: A Network Meta-Analysis Of The Effects Of Different Exercise Modalities, Bingjian Dai, Xuewen Wang, Shuxin Chen, Dongfei Liu Jan 2026

A220: Work Memory Of Adhd Children: A Network Meta-Analysis Of The Effects Of Different Exercise Modalities, Bingjian Dai, Xuewen Wang, Shuxin Chen, Dongfei Liu

International Journal of Physical Activity and Health

Physical exercise, spanning from early childhood to adulthood, exerts positive influences on cognitive function. This study employed systematic review, network meta-analysis, and traditional meta-analysis to investigate the interventional effects of exercise on working memory in children with Attention Deficit Hyperactivity Disorder (ADHD). Relevant literature was retrieved from multiple databases. After screening and data extraction, study quality was assessed using the Cochrane Risk of Bias Tool. Meta-analysis, sensitivity analysis, and publication bias analysis were conducted using Review Manager 5.4 and Stata 18.0 to evaluate the impact of exercise on working memory in children with ADHD Among 1,296 screened studies, 49 met …

Go to article

A218: Efficacy Of Kinesio Tape For Plantar Fasciitis: A Systematic Review And Meta-Analysis, Tingting Mo, Xinlong Zhang, Shilun Hou Jan 2026

A218: Efficacy Of Kinesio Tape For Plantar Fasciitis: A Systematic Review And Meta-Analysis, Tingting Mo, Xinlong Zhang, Shilun Hou

International Journal of Physical Activity and Health

Plantar fasciitis is one of the most common causes of heel pain in adults and is a very common musculoskeletal system disorder. The incidence of plantar fasciitis is relatively high among sports enthusiasts, especially those involved in high-intensity, high-impact sports. Kinesio tape has the functions of relieving pain, correcting muscle function, and increasing body sensation. Currently, kinesio tape has been gradually applied to the treatment of the disease, but its effectiveness is unclear. The aim of this review is to assess how kinesio tape interventions affect pain and ankle and foot function in patients with plantar fasciitis. PubMed, Scopus, Web …

Go to article

A226: The Application And Exploration Of An Ai Agent In Physical Education Teaching, Yali Si, Sumei Yu Jan 2026

A226: The Application And Exploration Of An Ai Agent In Physical Education Teaching, Yali Si, Sumei Yu

International Journal of Physical Activity and Health

With the rapid development of artificial intelligence technology, AI-Agent, as a new type of educational technology tool, has gradually attracted widespread attention. As a system based on generative large-scale intelligent models, AI-Agent possesses core capabilities such as environmental perception, autonomous decision-making, and complex task execution. In the field of physical education, this technology holds significant application potential, particularly in personalized teaching, multimodal data processing, and enhancing teaching efficiency. However, current research on the application of AI agents in physical education is relatively scarce. This study explores the application of AI-Agent in physical education, analyzes its advantages, and investigates methods for …

Go to article

A227: Eliminate Or Evolve: Digital Transformation Of Paris 2024 Olympics Under Olympic Ai Agenda, Tong Zheng Jan 2026

A227: Eliminate Or Evolve: Digital Transformation Of Paris 2024 Olympics Under Olympic Ai Agenda, Tong Zheng

International Journal of Physical Activity and Health

The International Olympic Committee (IOC) has been promoting sports digitalization since the early 2000s, with the Olympic Agenda 2020 and the Olympic AI Agenda in 2024 providing strategic frameworks for this transformation. This paper examines how digital and AI technologies were applied at the 2024 Paris Olympics, the first Games guided by the exploration of impact on the Olympic movement and global sports landscape. Method: Using literature reviews and case studies from academic platforms like CNKI, WanFang, and Web of Science, this study analyzes digital transformation examples at the Paris 2024 Olympic Games. AI empowering the Olympics under the "Agenda" …

Go to article

A228: Preservation And Dissemination Of Taijiquan Culture In Digital Perspective, Songqi Wang, Bin Yan Jan 2026

A228: Preservation And Dissemination Of Taijiquan Culture In Digital Perspective, Songqi Wang, Bin Yan

International Journal of Physical Activity and Health

One of China’s most iconic cultural traditions has increasingly gained: Taijiquned global recognition: Taijiquned. However, rapid digitalization has significantly changed young people's cultural preferences and participation habits, posing challenges to traditional methods of cultural preservation, which often fail to resonate with youth, creating a noticeable disconnect. This study examines the potential of digital communication—especially short videos, livestreaming, and social media—to preserve and disseminate Taijiquan culture through interactive, youth-oriented methods. Specifically, it empirically explores whether digital media strategies effectively improve younger generations’ cultural awareness, participation motivation, and cultural identity, aiming to provide practical insights for digital heritage protection. A randomized controlled …

Go to article

A224: 15–17-Year-Old Student Swimmers Undergoing High-Altitude Training On Water Load Characteristics, Jiayi Lyu, Yuqi Wang, Xinyi Li Jan 2026

A224: 15–17-Year-Old Student Swimmers Undergoing High-Altitude Training On Water Load Characteristics, Jiayi Lyu, Yuqi Wang, Xinyi Li

International Journal of Physical Activity and Health

With the continuous improvement of swimming competition level, high-altitude training, as a scientific and effective training method, has received attention from swimmers. Both professional teams and amateur sports schools give widespread attention to high-altitude training. The purpose of this study is to explore the characteristics of the three-week high-altitude training load of 15-17 male student swimmers and analyze whether it is effective for competition results. Ten male student swimmers (national level one or above) aged 15-17 years old were selected as the subjects and underwent a three-week high-altitude training at an altitude of 1900 meters. Method: The research method uses …

Go to article

A207: Ai Era And Sports Equity: A Sociological Perspective, Jieqi Shi Jan 2026

A207: Ai Era And Sports Equity: A Sociological Perspective, Jieqi Shi

International Journal of Physical Activity and Health

This study explores the impact of artificial intelligence (AI) on sports equity and inclusion, focusing on its use in training, officiating, and talent selection. AI includes technologies like AI-driven training tools and systems, such as VAR. While AI can enhance access to sports resources, it may also worsen existing inequalities. The goal is to examine how AI influences fairness in sports and promotes inclusion, particularly in university sports, while considering its effects on athlete development, decision-making, and fan engagement across social groups. A qualitative approach was used to examine AI in university sports. Participants include sports students, faculty, coaches, and …

Go to article

A225: Applications Of Digitalization, Ai, And Big Data In Sports Science Research And Practice, Yixiao Zhang, Yue Xu, Zhihua Yin Jan 2026

A225: Applications Of Digitalization, Ai, And Big Data In Sports Science Research And Practice, Yixiao Zhang, Yue Xu, Zhihua Yin

International Journal of Physical Activity and Health

The rapid advancement of digitization, artificial intelligence (AI), and big data has revolutionized various industries. In the field of sports and exercise science, these technologies provide comprehensive insights into athlete performance, injury prevention, and personalized training (Smith & Johnson, 2022; Lee, 2021). However, the benefits and applications of these technologies in sports and exercise science remain understudied. Therefore, this study provides a systematic literature review of the impact and applications of digitization, AI, and big data in sports and exercise science. The search strategy followed the PEO framework and the PRESS checklist. Five databases were used for searching: ACM Digital …

Go to article

A232: The Voice-Inclusive Physical Education Class: Primary School Physical Education Teaching Mode Under New Curriculum Standards, Qing Luan Jan 2026

A232: The Voice-Inclusive Physical Education Class: Primary School Physical Education Teaching Mode Under New Curriculum Standards, Qing Luan

International Journal of Physical Activity and Health

Current physical education classes in primary schools face a lot of challenges, such as the low student participation, a dull class environment, and a lack of students’ voice, which has a negative impact on teaching effect and students’ physical and mental health. This study employed the action research method to organize the physical education classes in primary school based on the New Curriculum Standards. The study encouraged primary school students to actively express their understanding and feelings about physical education activities and guided them to enthusiastically participate in the design of teaching content and activities to construct the “voice-inclusive” physical …

Go to article

A234: The Challenge Of Physical Education Teachers In Primary And Secondary Schools, Ning Li, Jialin Liu Jan 2026

A234: The Challenge Of Physical Education Teachers In Primary And Secondary Schools, Ning Li, Jialin Liu

International Journal of Physical Activity and Health

Physical health in primary and secondary schools is the foundation for students' comprehensive development, and school sports are an important way to promote students' physical health. The implementation effect of school physical education largely depends on the professional competence and educational ability of physical education teachers. The problems faced by physical education teachers in the new era: the number and structure of physical education teachers; Challenges in teaching philosophy and abilities; The conflict between teaching pressure and the system; the disconnect between professional competence and training needs. Countermeasure: Optimize the construction of the physical education teacher team; Promote the reform …

Go to article

A021: Analysis Of The Impact Of Ski Diagonal Stride Technique On Rehabilitation Treatment Effects, Xinming Tang Jan 2026

A021: Analysis Of The Impact Of Ski Diagonal Stride Technique On Rehabilitation Treatment Effects, Xinming Tang

International Journal of Physical Activity and Health

The ski diagonal stride technique is a crucial component in cross-country skiing, engaging complex muscle coordination, enhancing cardiopulmonary function, and improving balance. In the realm of rehabilitation, traditional methods often face limitations. This study is dedicated to exploring how the physiological factors associated with this technique affect the rehabilitation treatment outcomes. By doing so, it aims to optimize rehabilitation strategies and ultimately enhance patients' physical capabilities and quality of life. Method: Eighty patients between the ages of 30 and 60, all in need of lower-limb rehabilitation, were evenly distributed into an experimental group and a control group. The experiment was …

Go to article

A036: “The Champion Gene” Actn3 And Cold Adaptation: An Environmental Regression Model And Systematic Review, Mingrui Wang, Mi Zhou, Jianchun Weng, Longtianjiao Liu, Xiaoyu Jiang, Lijun Shi Jan 2026

A036: “The Champion Gene” Actn3 And Cold Adaptation: An Environmental Regression Model And Systematic Review, Mingrui Wang, Mi Zhou, Jianchun Weng, Longtianjiao Liu, Xiaoyu Jiang, Lijun Shi

International Journal of Physical Activity and Health

The ACTN3 R577X (rs1815739) genetic polymorphism is a significant research topic in sports genetics, with the XX genotype exhibiting a marked geographical gradient in different populations worldwide. The frequency of the XX genotype is notably higher in cold, high-latitude regions compared to tropical areas (e.g., Sweden 25%, Russia 14.2%, while Kenya 1%). These phenomena suggest that the ACTN3 R577X polymorphism may be closely related to cold adaptation. This study aims to analyze the evolutionary mechanisms, molecular regulation, and potential application of the ACTN3 R577X polymorphism in winter sports talent selection. Using the genomic database Ensemble and the WWF terrestrial ecoregion …

Go to article

A053: Research On Adolescent Obesity Experience, Zhenfei Zhu Jan 2026

A053: Research On Adolescent Obesity Experience, Zhenfei Zhu

International Journal of Physical Activity and Health

The alarming prevalence of overweight and obesity among adolescents has emerged as a significant public health challenge. Since the World Health Organization (WHO) identified obesity as a global health priority in 2018, it has evolved from an individual concern to a medical condition requiring intervention, with profound implications for both individuals and society. Adolescent obesity is intricately linked to various aspects of health, including social, emotional, behavioral, and cultural dimensions. There is a notable lack of qualitative research on obesity experiences in China. Conducting qualitative studies to explore the life experiences, motivations, and physical activity patterns of students can deepen …

Go to article

Methods For Radiation-Sparing Navigation In Endovascular And Spine Surgery, William Ross Warner Jan 2026

Methods For Radiation-Sparing Navigation In Endovascular And Spine Surgery, William Ross Warner

Dartmouth College Ph.D Dissertations

Modern surgical navigation systems improve procedural accuracy, limit complications, and can reduce reliance on intraoperative ionizing radiation, yet their adoption remains uneven across surgical domains. Informed by clinical immersion, this thesis identifies and addresses two unmet needs revealed through contrasting image-guidance practices in endovascular and spine surgery, where existing guidance techniques are costly, intermittent, or fundamentally limited. Specifically, these needs include (1) the absence of radiation-sparing navigation techniques for endovascular procedures, which rely heavily on 2D x-ray angiography, and (2) the need for dynamic registration methods in open spine surgery, where navigation accuracy can degrade after initial registration and intraoperative …

Go to article

Clear Cell Hidradenoma: A Review Of Reported Cases, George Ladas, Christopher Stewart, Peter A. Khoury, Adam Kramer, Charles Harper, Pear Sukarom, Niritta Patel, Patricia Palanca, Gursuraj Grewal, Suporn Sukpraprut-Braaten Jan 2026

Clear Cell Hidradenoma: A Review Of Reported Cases, George Ladas, Christopher Stewart, Peter A. Khoury, Adam Kramer, Charles Harper, Pear Sukarom, Niritta Patel, Patricia Palanca, Gursuraj Grewal, Suporn Sukpraprut-Braaten

Student Publications

Clear cell hidradenoma (CCH) is an extremely rare benign adnexal skin tumor originating from eccrine sweat glands. The purpose of this systematic review is to analyze and demonstrate trends in the location, occurrence, and presentation of CCH as well as its ability to present in advanced disease states. This study identified 460 case reports published from 1979 through 2022 through PubMed searches. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were tightly adhered to. The search keywords were “acrospiroma” and “clear cell hidradenoma.” Investigators reviewed the articles and extracted the following information: demographics; medical history and medications; anatomic …

Go to article

Perceptions Of Defund The Police, Russell F. Cooper Jan 2026

Perceptions Of Defund The Police, Russell F. Cooper

Doctoral Dissertations and Projects

This research delves into contemporary literature on the Defund the Police movement in the United States, a significant force shaping law enforcement practices and the future landscape of policing and criminal justice. Stemming from the aftermath of the 2020 George Floyd protests, this movement has spurred transformations in policing methodologies and resource distribution. With its expansion across the nation, law enforcement agencies are grappling with high turnover rates and a dwindling pool of qualified applicants. The Defund the Police movement, originally aimed at abolishing police departments due to perceived systemic issues, underscores the need for progressive law enforcement reforms, particularly …

Go to article

A Qualitative Exploration Of Global Remote Leadership, Melissa Morrison Jan 2026

A Qualitative Exploration Of Global Remote Leadership, Melissa Morrison

Doctoral Dissertations and Projects

Leaders of organizations have faced many changes with respect to remote work. As face-to-face interactions decrease, the opportunities and challenges of technological and digital advancement further the complexity of remote work. Leaders serve as prominent figures who use remote technology to communicate and interact with employees that report to them. The relationship between remote work and the development of meaningful social interactions remains largely unexplored (Clark et al., 2018). This phenomenological study explored the described experiences of remote leaders, the role that identity development plays in the success of leadership remote work, how their identity development impacts their well-being and …

Go to article

Women, Religion, And Education In North Carolina: How The Feminization Theory Applies From The Nineteenth Century To Present Day, Jennifer Lauren Walker Jan 2026

Women, Religion, And Education In North Carolina: How The Feminization Theory Applies From The Nineteenth Century To Present Day, Jennifer Lauren Walker

Doctoral Dissertations and Projects

In the state of North Carolina southern traditions run deep. The strong foundation of religion and family have been a constant in this state. However, not everything about this state’s history has been equal or fair, especially in the case of women and education. It would take the Progressive era for the feminization of southern life and culture to work its way into the lifestyle found amongst North Carolina residents. Women across the state would lay witness to the changes that both feminization and religion brought into their lives. Education would be one major factor that played into the equation …

Go to article

Exploring The Counselor Identities Of Latina Counselors Through The Lens Of Their Familial, Cultural, And Religious Contexts: A Phenomenological Study, Samuel Landa Jan 2026

Exploring The Counselor Identities Of Latina Counselors Through The Lens Of Their Familial, Cultural, And Religious Contexts: A Phenomenological Study, Samuel Landa

Doctoral Dissertations and Projects

Developing a counselor identity is an essential component of becoming a counselor. There are several factors influencing the developmental process. Though there are several studies that explore the topic of counselor identity development, the research on what this process entails for Latina counselors is limited. Thus, this transcendental phenomenological qualitative study explores how family, culture, and religion influence the counselor identity development of Latina counselors. This study utilized Schlossberg’s transition theory (1981) to observe how these factors become evident in the first year of their Council for Accreditation of Counseling and Related Educational Program (CACREP) and how they influenced their …

Go to article

Robert Saunders V. Vitalcare Health Strategies Llc Jan 2026

Robert Saunders V. Vitalcare Health Strategies Llc

2026 Decisions

USDC for the District of Delaware

Go to article

Usa V. Nicole Schuster Jan 2026

Usa V. Nicole Schuster

2026 Decisions

USDC for the Eastern District of Pennsylvania

Go to article

Usa V. Leroy Irvin Jan 2026

Usa V. Leroy Irvin

2026 Decisions

USDC for the Western District of Pennsylvania

Go to article

Falls Prevention In A Psychiatric Setting, Albert Koroma Jan 2026

Falls Prevention In A Psychiatric Setting, Albert Koroma

Walden Dissertations and Doctoral Studies

The project is a staff education initiative designed to improve the knowledge of psychiatric mental health clinicians regarding fall prevention. The gap in practice was the staff’s knowledge deficit in fall prevention. The staff’s knowledge deficits result in inconsistent prevention strategies. The practice-focused question guiding the project was: Among psychiatric mental health clinicians, does participation in an evidence-based fall prevention education program increase knowledge of fall prevention strategies as compared to pre- to post-education? The purpose of the project was to improve clinician knowledge of psychiatric-specific fall risks and evidence-based prevention strategies. The analytical strategies utilized in the project included …

Go to article

Egfr Inhibitor-Resistant Lung Cancers Exhibit Collateral Sensitivity To A Covalent, Cysteine-Independent Keap1 Oligomerizing Molecular Bridge, Christopher F Bassil, Kerry Dillon, Gray R Anderson, Benjamin Mayro, Kayleigh N Askin, Peter S Winter, Stefan Harry, Samuel Gruber, Tierney M Hall, Jacob P Hoj, Christian Cerda-Smith, Haley M Hutchinson, Shane T Killarney, Ava Heffernan, Caroline Teddy, Katherine R Singleton, Li Qin, Kévin Jubien-Girard, Cécile Favreau, Guillaume Robert, Barr Tivon, Ella Livnah, Nir London, Rachid Benhida, Patrick Auberger, Ann Marie Pendergast, Liron Bar-Peled, David M Lonard, Anthony R Martin, Alexandre Puissant, Kris C Wood Jan 2026

Egfr Inhibitor-Resistant Lung Cancers Exhibit Collateral Sensitivity To A Covalent, Cysteine-Independent Keap1 Oligomerizing Molecular Bridge, Christopher F Bassil, Kerry Dillon, Gray R Anderson, Benjamin Mayro, Kayleigh N Askin, Peter S Winter, Stefan Harry, Samuel Gruber, Tierney M Hall, Jacob P Hoj, Christian Cerda-Smith, Haley M Hutchinson, Shane T Killarney, Ava Heffernan, Caroline Teddy, Katherine R Singleton, Li Qin, Kévin Jubien-Girard, Cécile Favreau, Guillaume Robert, Barr Tivon, Ella Livnah, Nir London, Rachid Benhida, Patrick Auberger, Ann Marie Pendergast, Liron Bar-Peled, David M Lonard, Anthony R Martin, Alexandre Puissant, Kris C Wood

Faculty, Staff and Students Publications

Targeted therapies have revolutionized cancer care. Unfortunately, most patients develop refractory, multifocal resistance to these therapies within a matter of months. Here, we demonstrate that the evolution of resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer endows cells with hypersensitivity to a PAINS-like small molecule, MCB-613. Systematic proteomic, functional genomic, and biochemical studies revealed that MCB-613 binds KEAP1 in a covalent, cysteine-independent fashion, acting as a divalent molecular bridge that relies upon lysine residues in the KEAP1 dimerization domain to join monomers of KEAP1 together. Oligomerization of KEAP1 by MCB-613 sets into motion a fatal cascade of KEAP1 …

Go to article

Ophiobolin A Impacts Mitochondrial Redox Biology In An Epithelial-Mesenchymal Transition (Emt)-Specific Manner, Haleigh N Parker, Yongfeng Tao, Jenna Tobin, Kayla L Haberman, Samantha Davis, Emily York, Alysia Martinez, Nobuyuki Matsumoto, Jaquelin Aroujo, Jun Hyoung Park, Bernd Zechmann, Benny Abraham Kaipparettu, Angela Boari, Christie M Sayes, Antonio Evidente, Alexander Kornienko, Benjamin Cravatt, Daniel Romo, Joseph H Taube Jan 2026

Ophiobolin A Impacts Mitochondrial Redox Biology In An Epithelial-Mesenchymal Transition (Emt)-Specific Manner, Haleigh N Parker, Yongfeng Tao, Jenna Tobin, Kayla L Haberman, Samantha Davis, Emily York, Alysia Martinez, Nobuyuki Matsumoto, Jaquelin Aroujo, Jun Hyoung Park, Bernd Zechmann, Benny Abraham Kaipparettu, Angela Boari, Christie M Sayes, Antonio Evidente, Alexander Kornienko, Benjamin Cravatt, Daniel Romo, Joseph H Taube

Faculty, Staff and Students Publications

Breast cancer progression is facilitated by the epithelial to mesenchymal transition (EMT), generating cancer cells with enhanced metastatic capacity and resistance to chemotherapeutics. The fungus-derived sesterterpenoid natural produce compound, ophiobolin A (OpA), possesses nanomolar cytotoxic activity and a high therapeutic index, although its molecular targets and mechanism of action are not well characterized. Herein, we utilized a model of mammary epithelial cells and breast cancer cell lines with and without EMT features to characterize the mechanism of selectivity towards EMT(+) cells by OpA. Proteins interacting with OpA in EMT(+) cells, including mitochondrial glutathione transporter SLC25A40, were identified through via mass …

Go to article

Progress And Challenges In Profiling Protein-Rna And Protein-Associated Rna-Rna Interactions, Zhuoyi Song, Eric L Van Nostrand Jan 2026

Progress And Challenges In Profiling Protein-Rna And Protein-Associated Rna-Rna Interactions, Zhuoyi Song, Eric L Van Nostrand

Faculty, Staff and Students Publications

RNA binding proteins (RBPs) play essential roles in post-transcriptional gene regulation by interacting with a wide range of RNA targets. In addition to regulating RNA processing via individual RBP-RNA interactions, there is a growing appreciation of the regulatory impact of protein-associated RNA-RNA interactions that include both well-studied examples of small regulatory RNAs (e.g. microRNAs, snRNAs, snoRNAs, piRNAs) guiding ribonucleoprotein complexes to their targets as well as structured RNA elements defining the interaction landscape for an RBP. To elucidate the full scope of RBP-RNA interactions, CLIP ( crosslinking and immunoprecipitation)-based methods have emerged as powerful tools. Even with the wide application …

Go to article

First Prev Next Last