Digital Commons Network^™

2026 Byu Law Review Masthead

BYU Law Review

No abstract provided.

In Situ And Operando Microscopy Studies On Lithium Metal Anodes: A Review, Ian Lindsey, Cameron Mondl, Xiangbo Meng

Mechanical Engineering Faculty Publications and Presentations

Lithium metal is regarded as an ultimate anode for rechargeable batteries, ascribed to its extremely high capacity. Its implementation can remarkably boost the energy density of the resultant lithium metal batteries. However, it is very challenging to commercialize lithium metal anodes, primarily due to the intertwined nature of the formation of a solid electrolyte interphase (SEI) and the growth of lithium dendrites. To understand these issues and therefore develop technical solutions, various instrumental techniques have been employed. This review highlights the most recent advancements of in situ and operando microscopy studies that are critical for investigating and addressing the issues …

No. 111 An Order Amending Executive Order No. 110 To Provide Emergency Transportation Repairs, Bill Lee

Executive Orders

No abstract provided.

No. 110 An Order To Provide Relief In Anticipation Of Severe Winter Weather, Bill Lee

Executive Orders

No abstract provided.

Targeting Smpdl3b To Ameliorate Radiation- And Cisplatin-Induced Renal Toxicity, Youssef Zeidan

All Publications

Kidney toxicity remains a major dose-limiting complication of radiation therapy and platinum-based chemotherapy, yet the molecular determinants of renal susceptibility and resilience to these genotoxic treatments are incompletely understood. Podocytes are particularly vulnerable to such insults, and emerging evidence implicates lipid dysregulation in podocyte injury. This study investigated the role of sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B), a podocyte-enriched lipid-modulating enzyme, in radiation- and cisplatin-induced nephrotoxicity. Using a doxycycline-inducible, podocyte-specific SMPDL3B transgenic mouse model, renal injury was assessed following focal kidney irradiation, cisplatin administration, or their combination through functional assays, histopathology, ultrastructural analysis, immunofluorescence, and targeted lipidomics. Combined radiation and cisplatin …

Obesity And Long Covid: Intersecting Epidemics?, Michael Gottlieb, Huihui Yu, Ji Chen, Erica S. Spatz, Nicole L. Gentile, Rachel E. Geyer, Michelle Santangelo, Caitlin Malicki, Kristyn Gatling, Kelli N. O'Laughlin, Kari A. Stephens, Joann G. Elmore, Lauren E. Wisk, Michelle L'Hommedieu, Robert M. Rodriguez, Juan Carlos C. Montoy, Ralph C. Wang, Kristin L. Rising, Efrat Kean, Jonathan W. Dyal, Mandy J. Hill, Arjun K. Venkatesh, Robert A. Weinstein, Inspire Group

Jefferson Center for Connected Care Faculty Papers

BACKGROUND: Obesity affects over 10% of the world population and has significant public health implications. With rising recognition of the long-term effects of Long COVID (LC) coupled with new agents to facilitate weight loss, it is critical to understand the influence of obesity on LC. This study assessed the association of obesity with rates of LC and degree of LC-related mental and physical health outcomes among participants up to three years after initial infection.

METHODS: This was a cross-sectional, multisite study of participants with SARS-CoV-2 infection from 12/11/2020–8/29/2022, with data collected through 4/2/2024. Surveys included validated tools for physical and …

2026 January 22 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Operating On Thin Margins: The Cost Of Providing New Hampshire Child Care, Tyrus Parker, Jess Carson

Carsey Publications

In this primer, authors Tyrus Parker and Jess Carson summarize available data on the cost of operating a child care program in New Hampshire. Using data from a 50-state cost calculator as well as three local child care programs, the authors find that despite high child care costs for families, tuition alone is largely insufficient revenue for program operation. As a result, child care program operators must make difficult tradeoffs around program offerings, program quality, and compensation for educators. The authors call for rigorous data collection and modeling to support planning a sustainable financial model for the Granite State’s early …

Spurious Elevations Of Chromogranin A In The Setting Of Autoimmune Metaplastic Atrophic Gastritis, Elizabeth Jose, Ariana Ambrosio, Jesse F. Simon, Jeffrey H. Schneider

Student Publications

Autoimmune metaplastic gastritis (AMAG) is a form of autoimmune gastritis that is characterized by the immune system’s attack on gastric parietal cells, leading to chronic inflammation. Gastric neuroendocrine tumors (GNETs) are rare neoplasms that can develop in the gastrointestinal tract in the presence of AMAG. This case presents a 69-year-old female who presented with dyspepsia, and on subsequent endoscopic evaluation, she was found to have AMAG in the context of elevated levels of serum chromogranin A (CgA) and gastrin, suggestive of a GNET. Despite an extensive diagnostic workup, including imaging, colonoscopy, small bowel follow-through, capsule study, and oncology workup, no …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Association Between The 2022 Aha/Acc/Hfsa Heart Failure Staging And Cardiovascular And Kidney Outcomes In Patients With Diabetes And Kidney Disease: A Post Hoc Analysis Of The Scored Randomized Controlled Trial, Ayodele Odutayo, Deepak L Bhatt, Vikas S Sridhar, Michael Szarek, Christopher P Cannon, Lawrence A Leiter, Darren K Mcguire, Julia B Lewis, Renato D Lopes, Benjamin M Scirica, Kausik K Ray, Michael J Davies, Phillip Banks, Manon Girard, Subodh Verma, Jacob A Udell, Bertram Pitt, Ph Gabriel Steg, David Z I Cherney

Faculty, Staff and Student Publications

Background: The 2022 American Heart Association/American College of Cardiology/Heart Failure Society of America heart failure (HF) classification incorporates cardiac biomarkers to identify early risk of HF. The HF stages may also guide the prognosis and management of cardiovascular and kidney-related events.

Methods: SCORED (Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk) was a randomized trial in diabetes with kidney disease comparing sotagliflozin versus placebo on cardiovascular death, HF hospitalizations, and urgent HF visits. SCORED participants were grouped by HF stage post hoc. Stage A: no …

Single-Photon Emission Computed Tomography Functional Liver Imaging To Facilitate Reirradiation For Liver Malignancies: A Phase I Trial, Enoch Chang, Emma B Holliday, Janio Szklaruk, William D Erwin, Ethan B Ludmir, Sonal S Noticewala, Prajnan Das, Albert C Koong, Bruce D Minsky, Grace L Smith, Gabriel O Sawakuchi, Rachael M Martin-Paulpeter, Joshua S Niedzielski, Luis A Perles, Sam Beddar, Veronica S Valino, Joshua L Nguyen, Kanwal P S Raghav, Milind Javle, Ahmed O Kaseb, Arvind N Dasari, Michael J Overman, Christine M Parseghian, Bruno C Odisio, Armeen Mahvash, Joshua D Kuban, Shu-En Shen, Xin S Wang, Aashish C Gupta, Mais M Al Taie, Kristy K Brock, Ching-Wei D Tzeng, Jean-Nicolas Vauthey, Franklin C L Wong, Eugene J Koay

Faculty, Staff and Student Publications

Background & aims: This phase I trial evaluated the safety of hypofractionated liver reirradiation (reRT) with preferential sparing of functional liver identified by technetium-99m sulfur colloid single-photon emission computed tomography (Tc-99m SC SPECT; hereafter SPECT) for patients previously treated with external beam radiotherapy or transarterial radioembolization.

Methods: A 3+3 design evaluated the safety of two escalating SPECT-based functional liver volumetric dose constraints. Dose-limiting toxicities (DLTs), liver segment volumes, and MRI functional liver imaging score, relative liver enhancement, and elastography were assessed.

Results: Thirteen patients were enrolled from 2018 to 2021. Median reRT gross tumor volume was 61 cm3 (range 1-677 …

The Gene Encoding Ornithine Decarboxylase For Putrescine Biosynthesis Is Essential For The Viability Of Fusobacterium Nucleatum, Shiqi Xu, Bibek G C, Alex Phan, Chenggang Wu

Faculty, Staff and Student Publications

Fusobacterium nucleatum is a Gram-negative anaerobe associated with periodontitis and colorectal cancer. It secretes putrescine, a polyamine that promotes biofilm formation by oral co-colonizers and enhances the proliferation of cancer cells. However, the physiological importance of putrescine for F. nucleatum itself remains unexplored. Here, we show that putrescine biosynthesis, mediated by the ornithine decarboxylase gene oda, is essential for F. nucleatum viability. Deletion of oda was only possible when a functional copy was provided in trans, and CRISPR interference of oda expression resulted in complete growth defects. The essentiality of oda was conserved across multiple subspecies. Supplementation with …

Disease-Specific And Overall Survival For Patients With Lacrimal Gland Adenoid Cystic Carcinoma In Recent Decades, Bita Esmaeli, Zhouxuan Li, Tracy J Lu, Hila Goldberg, Jing Ning, James Matthew Debnam, Steven Jay Frank, Renata Ferrarotto

Faculty, Staff and Student Publications

Purpose: To evaluate the presenting symptoms, and the overall survival (OS) and disease-specific survival (DSS) in patients with lacrimal gland adenoid cystic carcinoma (LGACC).

Methods: This retrospective single-centre cohort study included all consecutive patients with LGACC treated by the primary author from November 1998 through August 2024. Demographic data, presenting symptoms, the histological subtype of LGACC, type of surgical treatment, adjuvant radiotherapy or chemotherapy, T category at presentation and survival data were reviewed. Correlations between histological subtypes, T-category, type of surgery (eye sparing vs orbital exenteration), and DSS and OS were analysed.

Results: 52 patients had a median age of …

Cdk2 Inhibitor Blu-222 Synergizes With Cdk4/6 Inhibitors In Drug Resistant Breast Cancers Through P21/P27 Induction, Linjie Luo, Yan Wang, Tuyen Bui, Xiaoting Jiang, Mei-Kuang Chen, Xiayu Rao, Sepideh Mohammadhosseinpour, Mi Li, Serena Kim, Rachel Y Kim, Saba Kamaliasl, Carmen W Ulizio, Spyros Tsavachidis, Juliana Navarro-Yepes, Nicole M Kettner, Hannah Wingate, Funda Meric-Bernstam, Kelly K Hunt, Jing Wang, Kerrie Faia, Khandan Keyomarsi

Faculty, Staff and Student Publications

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard first-line treatment for hormone receptor-positive, HER2-negative (HR+/HER2-) metastatic breast cancer, but resistance inevitably develops. In triple-negative breast cancer (TNBC), the efficacy of CDK4/6i remains uncertain. Our study shows that the selective CDK2 inhibitor BLU-222, while effective alone, enhances synergistic activity when combined with CDK4/6i in resistant HR+/HER2- and TNBC models, leading to increased apoptosis and cell cycle arrest. In vivo, combining BLU-222 with palbociclib or ribociclib produced significant antitumor activity across eight resistant models, driving durable tumor regression and prolonged survival. Mechanistically, BLU-222, alone or with palbociclib, upregulated …

Prehospital Transfusion Strategies In Haemorrhagic Shock, Brian Burns, Brodie Nolan, Ian Ferguson, Michael Peddle, Christopher Partyka, Geoff Healy, Stacy Shackelford, Bryan Cotton

Faculty, Staff and Student Publications

Background: Massive transfusion protocols are established in-hospital practices for managing haemorrhagic shock, yet critical bleeding accounts for up to 40% of trauma deaths, with half occurring before hospital arrival. This has driven interest in prehospital transfusion, a concept originating in military settings where early blood product administration during prolonged evacuations demonstrated significant survival benefits. Despite compelling military evidence showing improved 24-h and 30-day survival with prehospital transfusion, civilian adoption faces substantial challenges. Global interest in this domain is increasing, particularly in regions with trauma populations remote from immediate access to major trauma centres.

Main body: Current prehospital transfusion strategies have …

Cdk2 Inhibitor Blu-222 Synergizes With Cdk4/6 Inhibitors In Drug Resistant Breast Cancers Through P21/P27 Induction, Linjie Luo, Yan Wang, Tuyen Bui, Xiaoting Jiang, Mei-Kuang Chen, Xiayu Rao, Sepideh Mohammadhosseinpour, Mi Li, Serena Kim, Rachel Y Kim, Saba Kamaliasl, Carmen W Ulizio, Spyros Tsavachidis, Juliana Navarro-Yepes, Nicole M Kettner, Hannah Wingate, Funda Meric-Bernstam, Kelly K Hunt, Jing Wang, Kerrie Faia, Khandan Keyomarsi

Faculty, Staff and Student Publications

Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard first-line treatment for hormone receptor-positive, HER2-negative (HR+/HER2-) metastatic breast cancer, but resistance inevitably develops. In triple-negative breast cancer (TNBC), the efficacy of CDK4/6i remains uncertain. Our study shows that the selective CDK2 inhibitor BLU-222, while effective alone, enhances synergistic activity when combined with CDK4/6i in resistant HR+/HER2- and TNBC models, leading to increased apoptosis and cell cycle arrest. In vivo, combining BLU-222 with palbociclib or ribociclib produced significant antitumor activity across eight resistant models, driving durable tumor regression and prolonged survival. Mechanistically, BLU-222, alone or with palbociclib, upregulated …

University Medical City Annual Research Day Oman, Convention And Exhibition Centre, 24Th September 2025, Sultan Qaboos University

Sultan Qaboos University Medical Journal

No abstract provided.

Utah Women In The Workplace: Entrepreneurship, Workforce Development, Stem Fields, And Leadership Development, Susan R. Madsen, April Townsend

Marketing and Strategy Faculty Publications

During the fall of 2023, Utah Women & Leadership Project (UWLP) researchers conducted a statewide study to establish a baseline for public perceptions related to the awareness, understanding, and attitudes about challenges that Utah women and girls face. In early 2024, we published 20 short research summaries¹ that shared the results of this comprehensive study (see Nos. 9–28). Next, in the fall of 2024, we administered this survey, with slight changes, around the state of Utah for the second time. Six comprehensive research white papers were then published on the results (see Nos. 11, 12, 13, 14, 16, and …

Kenyon Collegian - January 22, 2026

The Kenyon Collegian

No abstract provided.

Long-Term Changes In Relative Humidity And Soil Wetness: Implications On Agriculture And Environmental Sustainability In Western Himalaya, Ashwani Ashwani, Pankaj Kumar

Journal of Environmental Science and Sustainable Development

Long-term climate changes in humidity and soil wetness in the cold deserts of the Western Himalaya are still not well researched. Understanding the long-term trends of relative humidity (RH) and soil moisture is crucial in high-altitude, cold desert regions for effective agricultural management and environmental sustainability. The study was conducted in a part of the western Himalaya, which is an ecologically fragile zone with a highly sensitive agricultural region that is vulnerable to climatic variations. A comprehensive study was conducted to evaluate the spatiotemporal variability of RH and soil wetness by means four techniques: Mann-Kendall, Modified Mann-Kendall, Sen’s slope estimator, …

Talent & Culture Feedback Form, Alison Coleman

UNH Cooperative Extension

No abstract provided.

Synergistic Anti-Tumor Activity Of Ciclopirox Olamine And Metformin In Triple-Negative Breast Cancer, Yakun Wu, Hui Lyu, Congcong Tan, Margaret E. Larsen, Shou Ching Tang, Shile Huang, Bolin Liu

School of Graduate Studies Faculty Publications

No abstract provided.

Ureilite Meteorite Petrofabrics: Evolution And Formation Deformational Conditions, Benjamin Botwe Agyemang

Dissertations and Theses

This thesis examines the origin and development of crystallographic fabrics in ureilites, which are primitive achondritic meteorites interpreted as residues of partial melting from a differentiated parent body. In this study, we evaluate three fabric-forming mechanisms: gravitational cumulate crystallization, shock-induced deformation, and flow alignment associated with melt extraction and convective stirring. A quantitative Electron Backscatter Diffraction (EBSD) analysis was conducted on six ureilitic meteorites to assess olivine Lattice Preferred Orientation (LPO), Shape Preferred Orientation (SPO), the connection between SPO and LPO, and other deformation metrics, including Grain Orientation Spread (GOS), and Crystal Rotation Axis (CRA). Our results suggest that most …

Cross-Ancestry Comparison Of Aptamer And Antibody Protein Measures, Jayna C Nicholas, Daniel H Katz, Usman A Tahir, Catherine L Debban, Francois Aguet, Thomas Blackwell, Russell P Bowler, K Alaine Broadaway, Jingsha Chen, Clary B Clish, Josef Coresh, Elaine Cornell, Daniel E Cruz, Rajat Deo, Margaret F Doyle, Peter Durda, Lynette Ekunwe, James S Floyd, Dipender Gill, Xiuqing Guo, Ron C Hoogeveen, Craig Johnson, Leslie A Lange, Yun Li, Alisa Manning, James B Meigs, Michael Y Mi, Josyf C Mychaleckyj, Nels C Olson, Katherine A Pratte, Brucy M Psaty, Alexander P Reiner, Peifeng Ruan, Magdalena Sevilla-Gonzalez, Amil M Shah, Quan Sun, Russell P Tracy, Jia Wen, Alexis C Wood, James G Wilson, Kristin L Young, Bing Yu, Mary R Rooney, Ani Manichaikul, Ruth Dubin, Karen L Mohlke, Stephen S Rich, Jerome I Rotter, Peter Ganz, Robert E Gerszten, Kent D Taylor, Laura M Raffield

Faculty, Staff and Student Publications

Measures from affinity-proteomics platforms often correlate poorly, challenging interpretation of protein associations with genetic variants and phenotypes. Here, we examine 2157 proteins measured on both SomaScan 7k and Olink Explore 3072 across 1930 participants with genetic similarity to European, African, East Asian, and Admixed American ancestry references. Inter-platform correlation coefficients for these 2157 proteins follow a bimodal distribution (median r = 0.30). We evaluate protein measure associations with genetic variants, and find approximately 25-30% of the signals on each platform are likely driven by protein-altering variants. We highlight 80 proteins that correlate differently across ancestry groups likely in part due …

The Effect Of Fluorides In The Tio2(B) Anode On The Hydrogen Evolution Reaction In Aqueous Electrolytes, Khoi-Nguyen Nguyen, Lam Hoang Nguyen, Jozel John Salvacion, Nam Huu Nhat Nguyen, Samuel Ming Tuk Yeung, Seung Woo Lee, Liat Rosenfeld, Chengyu Song, Dahyun Oh

Faculty Research, Scholarly, and Creative Activity

For aqueous lithium-ion batteries (A-LIBs), the hydrogen evolution reaction (HER) poses a significant challenge, as it competes with the primary electrochemical processes of the anode, resulting in capacity loss and reduced cycling stability. In this study, we investigate the use of fluorine-based additives in anodes to mitigate HER in LIBs with aqueous electrolytes including low or high amounts of salt (water-in-salt electrolytes (WiSE)). We synthesized and incorporated three distinct materials into TiO2(B) anodes: aluminum fluoride (AlF3), lithium fluoride (LiF), and 1H,1H,2H, 2H-perfluorooctyltriethoxysilane (FAS) using a solution-based method. Among these fluorides containing composite anodes, FAS containing anodes delayed HER onset potentials …

Single-Cell Atlas Of Human Lung Aging Identifies Cell Type Dyssynchrony And Increased Transcriptional Entropy, Ruben De Man, John E Mcdonough, Taylor S Adams, Fadi Nikola, Reina Rangel, Sabina Anderson, Edward P Manning, Juan Cala Garcia, Benjamin Moss, Alan Waich, Fernando Poli, Rafael Cardenas, Cristian Coarfa, Qi Song, Ziv Bar-Joseph, Bart M Vanaudenaerde, Wim A Wuyts, Laura Niklason, Micha Sam B Raredon, Xiting Yan, Ivan O Rosas, Naftali Kaminski

Faculty, Staff and Students Publications

Age is a major risk factor for lung disease. We characterized the changing cellular, transcriptional, and genomic landscape of human lung aging using single-cell RNA sequencing. We find that lung aging is cell-type dyssynchronous, with alveolar epithelial and endothelial cells exhibiting the greatest transcriptional changes. Among alveolar epithelial cells, aging is associated with a decreased relative proportion of surfactant-expressing SPChigh AT2 cells. Among alveolar capillary cells, we observed loss of differentiation and capillary function. Analysis of somatic mutations called from single-cell data revealed an increase with aging, with alveolar epithelial and endothelial cell types exhibiting greater mutation burdens. Transcriptional entropy …

Cover And Contents

Turkish Journal of Earth Sciences

No abstract provided.

Geochemical Characteristics And Ree Potential Of Red Soils In The Seydişehir–Akseki Region (Türkiye), Muazzez Çeli̇k Karakaya, Necati̇ Karakaya, Aydin Rüşen, Cem Saraç

Turkish Journal of Earth Sciences

The karst-type bauxite deposits located in southwestern Türkiye represent the most significant bauxite resources in the country. Surrounding these bauxite deposits are widespread red soil deposits of varying sizes, developed over lithologically diverse rocks. This study aims to investigate the origin of these red soils, which were examined in two distinct groups based on their spatial relationship to the underlying geology. The first group of red soils is found on or within the fractures of karstic limestones, while the second group is primarily located in proximity to ophiolitic rocks. The investigation focused on the physical properties, as well as the …

Abic-Based Surficial Density Model Of Türkiye And Tectonic Implications, İlki̇n Özsöz

Turkish Journal of Earth Sciences

This study presents a surficial density model of Türkiye derived from the Akaike Bayesian Information Criterion (ABIC) inversion of terrestrial gravity data. By regularizing the gravity field through spatial smoothness constraints, the ABIC method yields optimal Bouguer reduction densities that reflect lateral variations in tectonic architecture, lithological heterogeneity, and upper crustal structure. Over 52,000 georeferenced observations reveal surficial densities ranging from 2.20 to 4.00 g/cm³, with a statistically robust mean of 2.669 ± 0.002 g/cm³ (95% confidence interval), suitable for precision gravity reduction and geodynamic applications. The derived density field delineates key tectonic domains across the Anatolian lithosphere, including extensional …