Digital Commons Network^™

"Role Of Preoperative Echocardiography In Resource-Limited Settings And Delayed Patient Care", Zamanali Khakhar, Shamshudin Mohammedali, Sayed Karar

General Surgery, East Africa

Preoperative echocardiography has long been used as an effective diagnostic tool in the preoperative assessment of surgical candidates. In elderly patients, hip fractures represent a critical medical emergency with a high risk of complications that can occur if not addressed promptly. Unnecessary preoperative investigations may lead to delays and potentially compromise the quality of patient care. The motivation to evaluate the utility of preoperative echocardiography in select clinical scenarios, particularly in low- and middle-income countries (LMICs) where resources are limited, arose from the case of a 72-year-old female who presented to a tertiary hospital in Nairobi, Kenya, with a right-sided …

Breast Cancer Awareness And Preferences For Screening Messaging On Menstrual Hygiene Products In Ghana And Tanzania, Tingting Mo, Elisabeth Msoka, Clement Narh, Blandina Mmbaga, Modesta Mitao, Getrude Mshana, Janeth Kiwia, Huruma Sapheli, Frank Baiden, Miriam Mutebi

General Surgery, East Africa

Background Menstrual hygiene products (MHPs) may offer a high-reach, frequent, long-lasting yet underutilized channel for health education, particularly in low-resource settings. This study aimed to explore women’s breast health awareness (BHA) and their attitudes towards and preferences for BHA messages on MHPs.

Methods Women aged 18–49 years in Ghana and Tanzania (n = 438; 216 Ghana, 222 Tanzania), stratified by age and urban/rural setting, completed a questionnaire assessing socio-demographics, BHA, and preferences for BHA messages with MHP. BHA was assessed with an adapted 31-item Breast Cancer Awareness Measure Tool covering 4 domains: breast cancer signs and symptoms, confidence, skills, and …

Table Of Contents (V. 67, No. 4)

William & Mary Law Review

No abstract provided.

Unacceptable In Any Era: The Unusual And Unconstitutional Effort To Criminalize Sleeping While Homeless, Joseph W. Mead, Shelby Calambokidis

William & Mary Law Review

Grants Pass, Oregon, effectively made it a crime for some of its homeless residents to sleep—a universal and unavoidable biological necessity. In a 2024 decision, the Supreme Court held that the Eighth Amendment’s Cruel and Unusual Punishments Clause posed no obstacle to this law, but it emphasized that other constitutional provisions could place important limits on how cities treat their homeless residents.

This Article argues that modern laws criminalizing sleeping— especially when no shelter is available—represent an unprecedented and unconstitutional departure from centuries of American legal tradition. Tracing the evolution of vagrancy, poor relief, and settlement laws from the Statute …

A Study Of Awareness Of Antiseptics And Disinfectant Use Among Allied Health Sciences Students And Interns Of A Tertiary Care Hospital, Pooja M, Puneeth A, Sharmi Nm

Digital Journal of Clinical Medicine

Background:

Antiseptics and disinfectants are among the most vital tools in infection prevention and control (IPC), especially in healthcare settings where the risk of hospital-acquired infections (HAIs) remains a significant concern. This study aims to assess the awareness and knowledge of antiseptics and disinfectants among Allied Health Sciences (AHS) students and interns, identify knowledge gaps at different stages of training, and recommend educational interventions.

Methods:

This was a cross-sectional, questionnaire-based study conducted among 1st to 3rd-year AHS students and interns at a tertiary care hospital. Data were collected using a validated questionnaire via a Google form after obtaining approval from …

Morphea With Seronegative Inflammatory Arthritis And Normal Acute Phase Reactants: A Case Report, Balakrishnan Navaneethakrishnan, Mahabaleshwar Mamadapur

Digital Journal of Clinical Medicine

Localised scleroderma, also known as morphea, is an immune-mediated fibrosing disorder that primarily affects the skin and subcutaneous tissues. While traditionally considered purely a cutaneous disease, extracutaneous manifestations (especially inflammatory arthritis) are increasingly being appreciated. The combined presence of morphea and inflammatory arthritis is rare and can be difficult to diagnose, particularly when inflammatory markers and serological testing are non-contributory.

Case Summary : We describe a 41-year-old woman with long-standing biopsy-proven morphea who over 2 years developed chronic, asymmetric inflammatory arthritis of the left wrist and hand small joints. On examination, she had active synovitis with restricted movements of her …

Pseudo-Hallucinations: A Diagnostic Conundrum, Dr Sankram Nayak, Manju Aswath, Vathsalya S. Gowda

Digital Journal of Clinical Medicine

Background:

Pseudohallucinations are vivid, hallucination-like experiences that are internal, recognized as unreal. Distinguishing from true hallucinations remains a diagnostic challenge.

Case-report

33-year-old female with family history of psychosis presented with 10-year duration of delusion of infidelity and auditory experiences, with normal Biopsychosocial functioning. She had multiple psychiatric consultations, diagnosed as paranoid schizophrenia, treated with  various antipsychotics, ECT, current prescription of clozapine(350mg) with clozapine induced seizure.  Reported that her husband was emotionally unavailable. She described the voices in her head which were non-threatening, praising her for having qualities of an ideal-wife.  They were constant companions giving her solace and hence refrained …

Lunch & Learn Webinar Series, Katie Prentice

TMC Library Newsletter (2015-)

We are so excited to bring this series to you and look forward to seeing you in 2026!

Check our institutional repository for presentation and resources guides of archived classes since 2025.

Behavioral Health Resources At The Tmc Library, Joanne Romano

TMC Library Newsletter (2015-)

No abstract provided.

Cultural Policy Beyond Economy: Democratising Access To The Arts Through Cultural Policy In Singapore, Su Fern Hoe

Research Collection School of Social Sciences

Across the globe, governments have released cultural policies that aim to justify public expenditure on the arts through democratising access to the arts to the wider population. Singapore is no exception. This article critically examines the role of cultural policy in expanding access to the arts in Singapore. More specifically, this article will demonstrate how cultural policy in Singapore has traditionally and consistently adopted a democratisation of culture approach to broaden access to develop arts audiences. Through an analysis of cultural policy documents and statistical data on arts attendance and attitudes in Singapore, this article will highlight some of the …

Does Ict Use As A Strategic Response To Globalization Matter For Sme Performance In Nigeria? Mediating Roles Of Entrepreneurial Orientation, Strategic Agility, And Organizational Resilience, Uzoma H. Ononye

Journal of Global Business Insights

This study examined the effect of information and communication technology (ICT) use on small and medium-sized enterprise (SME) performance with a focus on the mediating roles of entrepreneurial orientation, strategic agility, and organizational resilience. Cross-sectional data were collected from 298 SMEs in Lagos, Nigeria, using a questionnaire based on previously validated measurement scales. Partial least squares modelling was applied to test the hypothesized five-factor model. The results demonstrate that ICT use, in response to globalization, exerts a significant and positive effect on SME performance. However, this effect is fully mediated by entrepreneurial orientation, strategic agility, and organizational resilience. The analysis …

Evaluating The Printability And Digestibility Of 3d-Printed Pea-Sorghum Protein Gels, Sorour Barekat, Ali Ubeyitogullari

Food Science Faculty Publications and Presentations

This study explored the 3D printability and digestibility of pea and sorghum protein gels as novel plant-based bioinks. First, 25 % sorghum protein gel (SPG25) and 15–25 % pea protein gels were prepared, and the effect of extruders’ nozzle size on printability was evaluated. Samples produced at the optimized conditions were then used for analyzing particle size, microstructure, secondary structure, and in vitro digestibility. Pea protein gel at 20 % (w/w) (PPG20) and SPG25 showed ideal rheological properties, including shear-thinning behavior and rapid recovery. Dual-nozzle 3D printing was optimized at a nozzle diameter of 0.52 mm and a speed of …

The Health Of Latinos In Massachusetts: Inequality In Health Behaviors And Chronic Health Conditions, Phillip Granberry, Alejandro Alvarez, Florita Coto Tristán

Gastón Institute Publications

This report provides a portrait of adult Latino health in Massachusetts by exploring and describing selected social indicators and health outcomes. This report is a companion to a 2021 report on Latino children in the state, which found that Latino children are more likely to have asthma, be overweight, and show symptoms of anxiety and depression, and less likely to be engaged in physical activity when compared to Non-Latino children. The foregoing findings suggested that Latino children are not developing in an environment that promotes health behaviors compared to Non-Latinos in Massachusetts.v The collective health of Latinos is said group …

Latinos In Massachusetts: Puerto Ricans, Phillip Granberry, Florita Coto Tristán, Melissa Colón

Gastón Institute Publications

As part of the Gastón Institute’s 2025 Latinos in Massachusetts series, we present here a profile of Puerto Ricans, the largest Latino population in the state. This report analyzes Public Use Microdata Sample (PUMS) data from the 2023 American Community Survey (ACS), conducted by the U.S. Census Bureau. Our descriptive analysis uses both household- and individual-level data to estimate population size and percentages and to compare Puerto Ricans to Other Latinos and Non-Latinos in the state.

Seeking Traditional Health Practitioners And Use Of Complementary/Alternative Medicines In The Management Of Movement Disorders In Africa: A Multicenter Continental Study, Ali Shalash, Tamer Roushdy, Samia Sassi, Oluwadamilola Ojo, Yusuf Jamnagerwalla, Ahmed Sheikh, Yasser Mecheri, Maouly Fall, Juzar Hooker, Dilraj Sokhi

Internal Medicine, East Africa

Background Traditional health practitioners (THP) and complementary and alternative medicines (CAM) play a well-recognized role in Africa. However, their role in treating movement disorders (MD) remains poorly studied.

Objective This large multicenter continental study aimed to investigate the prevalence of seeking and consulting THPs and using CAMs among people with MDs in different African countries and the associated factors of their use.

Methods This study involved 12 sites within 11 African countries. We developed and distributed a structured questionnaire that documented frequency, attitudes, beliefs, and factors related to patients' engagement with THPs and use of CAMs.

Results We surveyed 1158 …

Estimating Population Structure Using Epigenome-Wide Methylation Data, Ziqing Wang, Kent D Taylor, Jerome I Rotter, Stephen S Rich, Yinan Zheng, Lifang Hou, Xiuqing Guo, Jan Bressler, Laura M Raffield, Yongmei Liu, Robert Kaplan, Donald M Lloyd-Jones, Alanna C Morrison, Myriam Fornage, Bruce M Psaty, Jennifer A Brody, Tamar Sofer

The Brown Foundation: Institute of Molecular Medicine

Population stratification is one of the source of inflation in epigenome-wide association studies (EWAS) when not properly accounted for. To address this, we developed methylation population scores (MPSs) to predict genetic principal components (GPCs) using a feature selection approach. We used multi-ethnic DNA methylation data from Illumina EPIC arrays across five cohorts, including MESA (n = 929), CARDIA (n = 1123), JHS (n = 1365), ARIC (n = 2338), and HCHS/SOL (n = 1475), randomly splitting participants into training (85%) and test (15%) sets. Within each cohort, associations between GPCs and CpG sites were estimated using linear regression adjusting for …

Human-Centered Design Of Patient Interviews: Capturing The Experiences Of Patients Recovering From Emergency Abdominal Surgery, Jenna L Marquard, Christie L Martin, Elizabeth C Wick, Amanda C Trofholz, Matthew S Loth, Suhyun Park, Genevieve B Melton

The Brown Foundation: Institute of Molecular Medicine

Objectives: Recognizing the challenges of at-home recovery following a truncated presurgical pathway for emergency laparotomy (EL) patients, we sought to identify barriers and facilitators to optimal recovery. This study aimed to develop a human-centered interview guide to capture the experiences of patients recovering at home after EL.

Methods: We employed an iterative human-centered design (HCD) approach to interview guide development, structured across 3 cycles. Each cycle refined the interview guide based on mock interviews and feedback from an interdisciplinary team. In cycle 1, we focused on creating a patient-centered, understandable guide. In cycle 2, we introduced a preinterview survey to …

Diversity And Immune Dynamics Of Choroid Plexus Macrophages Are Shaped By Distinct Developmental Origins, Siling Du, Khai M Nguyen, Alina Ulezko Antonova, Jose L Fachi, Patrick Fernandes Rodrigues, Alice Verdiani, Martina Molgora, Igor Smirnov, Jasmin Herz, Tornike Mamuladze, Jennifer Ponce, Amanda Swain, Mattia Bugatti, Susan Gilfillan, Marina Cella, William Vermi, Jonathan Kipnis, Marco Colonna, Simone Brioschi

The Brown Foundation: Institute of Molecular Medicine

The choroid plexus forms a key barrier and signaling interface between the brain and peripheral circulation, yet its immune landscape remains incompletely understood. Using single-cell transcriptomics combined with lineage and spatial tracing methods, we identified three biologically distinct populations of choroid plexus macrophages, defined by differential expression of CD163, MHCII or CD9. These subsets arise from separate hematopoietic waves, occupy distinct anatomical niches and differentially rely on CSF1 and IL-34 for survival. We found that TGFβ signaling is essential to maintain their tissue-specific identities, and deletion of Tgfbr2 in these cells induces broad phenotypic reprogramming. During neuroinflammation, choroid plexus macrophages …

Glutamatergic Dysfunction Of Astrocytes In Paraventricular Nucleus Of Thalamus Contributes To Adult Anxiety Susceptibility In Adolescent Ethanol Exposed Mice, Aubrey Bennett, Hyunjung Kim, David Thomas, Peter Biggs, Roxan Ara, Asamoah Bosomtwi, Seungwoo Kang

The Brown Foundation: Institute of Molecular Medicine

Repeated ethanol exposure during adolescence increases adult anxiety risk, but the underlying mechanisms remain unclear. The paraventricular nucleus of the thalamus (PVT) has been considered a hub for controlling anxiety and is affected by experiences from early life. Thus, this study investigated how adolescent intermittent repeated ethanol exposure (AIE) affects the PVT activities and anxiety-related behaviors in adulthood. We found that AIE triggers anxiety-like behaviors and parallelly exhibited elevated firing rates and increased calcium signaling in the PVT neurons compared to control counterpart mice. Chemogenetic inhibition of PVT neurons reduced anxiety-like behaviors in AIE-treated animals, confirming PVT's role in adolescent …

Lipids Grease The Chain Of Cancer Progression, Joseph Rupert, Pham Hong Anh Cao, Daniel E Frigo, Mikhail G Kolonin

The Brown Foundation: Institute of Molecular Medicine

The role of lipids in cancer progression has become a fervent area of exploration. The crosstalk of tumors with adipose tissue is a complex but well-regulated orchestration of signaling pathways, lipid transporters, and enzymes. They regulate fatty acid synthesis, their deposition into lipid droplets (LDs) as triglycerides, induction of lipolysis, shuttling lipids across cells, and their systemic trafficking, modification, and catabolism. For the latter, lipid oxidation has emerged as a metabolic process of particular clinical importance. Products of lipid processing can become secondary messengers, contribute to reactive oxygen species (ROS) generation, stimulate the production of antioxidants, and, if left unchecked, …

Neutralization Of Sars-Cov-2 By Igm-14 Via Engagement Of Two Distinct Spike Epitopes, Yan Wang, Yanping Hu, Zhiqiang Ku, Jason Yeung, Jing Zou, Michael Woodson, Nikolai S Prokhorov, Ekaterina S Knyazhanskaya, Haiqing Zhao, Michael B Sherman, Zhiqiang An, Stephen F Carroll, Pei-Yong Shi, Petr G Leiman, Xuping Xie

The Brown Foundation: Institute of Molecular Medicine

Engineered immunoglobulin M (IgM) antibodies typically exhibit superior neutralization potency and avidity compared to their parental IgG counterparts, primarily due to multivalent binding to repeated epitopes on a targeting antigen. In this study, we characterize the neutralization breadth and mechanism of action of IgM-14, a previously reported intranasally deliverable antibody targeting SARS-CoV-2. IgM-14 demonstrates remarkably potent antiviral activity against all pre-Omicron variants but significantly reduced efficacy against Omicron BA.1, and complete loss of activity against the later subvariant JN.1. Resistance selection identified two key mutations in the receptor-binding domain (RBD), G476D and F486P, which disrupt IgM-14 binding and confer strong …

Severe Bilateral Retinal Degeneration Following A Twenty-Six-Year Pentosan Polysulfate Sodium Exposure: A Case Report., Aaron T. Zhao, Turner D. Wibbelsman, Martin Calotti, Collin J Richards, Tamara R. Vrabec

Wills Eye Hospital Papers

PURPOSE: To describe an advanced case of pentosan polysulfate sodium (PPS)-associated retinopathy with extensive macular and peripheral retinal involvement following prolonged high-dose exposure.

OBSERVATIONS: An 86-year-old male presented with bilateral hand motion visual acuity and a 26-year history of PPS use (400mg daily, ∼3769g cumulative dose) for treatment of interstitial cystitis. Fundus examination revealed widespread retinal degeneration characterized by confluent nummular patches of retinal atrophy in a radial distribution from the optic nerves. Ocular coherence tomography (OCT) demonstrated severe outer retinal disorganization, and fundus autofluorescence (FAF) showed extensive RPE loss and absence of the Robson Holder ring. Genetic testing excluded …

Diabetes Equity In Lehigh Valley: Recruitment For A National Diabetes Prevention Program Train The Trainer Model, Miguel Chuidian Md, Autumn Kieber-Emmons Md, Mph, Rachel Apiolaza, Carolyn Peterseim Md

Department of Family Medicine

No abstract provided.

Incarcerated Or Detained Persons Litigation Notes, Arthur S. Leonard

Other Publications

No abstract provided.

Dental Rankings: Relevant Or A Psychological Rollercoaster?, Stuart L. Segelnick Dds, Ms

The New York State Dental Journal

It may take a village of dentists honing in on their own rankings to reverse the profession’s downward trend.

Kenya’S Path To Building A National System To End Female Genital Mutilation: A Learning Paper On Securing The Anti-Fgm Law, Establishing The Anti-Fgm Board And Sustaining The National Response, Shukri Gesod

Sexual and Reproductive Health, Rights, and Choices

Drawing on in-depth key informant interviews with three former or current government officials, this learning paper responds to the following questions:

1. How did Kenya establish a standalone legal framework on female genital mutilation (FGM)?
2. How was the political and wider support needed to advance the legislation built?
3. How was the Anti-FGM Board established and made operational?
4. How was the Anti-FGM Board sustained across political and institutional change?

Learnings from the government officials accounts are used to trace the history of Kenya’s anti-FGM response, and have been documented as lessons for other countries to apply toward their end-FGM efforts.

Bundled Guidance Types And Changes In Expected Volatility, Thaddeus Neururer, George Papadakis

University Research

We examine how different types of bundled managerial guidance affect uncertainty levels around earnings announcements. To measure changes in uncertainty, we use both changes in implied volatilities and methods that decompose the implied volatility term structure. Unlike prior studies, we find little evidence that earnings guidance is associated with investor uncertainty. Our results instead indicate that other forms of bundled guidance are associated with lower uncertainty levels. Revenue, capital expenditure, and earnings before interest, taxes, depreciation, and amortization guidance are strongly associated with reductions in investor uncertainty, even when firms provide earnings guidance.

Improving Equity Within The Holistic Admission Process Through Race-Neutral Holistic Review: A Before And After Cross-Sectional Study, Megan Eikenberry, Kylie Scott, Jaime González, Josh Subialka, Lacey Frankland, Patrice Ayala, Mark Kargela, Byron Russell

Physical Therapy Faculty Publications

Introduction: The US Physical therapist (PT) workforce lacks racial and ethnic diversity, which may contribute to health disparities. Holistic review (HR) admission methods may improve workforce diversity by evaluating applicants' academic metrics, experiences, and personal attributes. Holistic review processes must adapt following the 2023 Supreme Court ruling prohibiting race-based admission criteria.

Review of literature: Holistic review criteria are program-specific and align with institutional and programmatic goals. While HR is shown to improve student body diversity, most PT education programs heavily emphasize academic metrics, which may disadvantage racial and ethnic minority (REM) applicants from acceptance. This study examines the racial and …

Implementation Barriers And Change Management Considerations In Deploying A Literature-Informed, Respiratory Therapy–Driven Copd Care Bundle With Ehr-Based Readmission Risk Stratification, Yusuf Aboul-Nasr, David M. Richardson Md

USF-LVHN SELECT

No abstract provided.

Mogad-Associated Optic Neuritis: Is It A Pain?, Anchal Shukla, Tejasvi Paturu, Amber Mcpherson, Raymond Schneider, Angela Aungst, Mitchelle Drucker, Natalie Moreo

USF-LVHN SELECT

No abstract provided.