Digital Commons Network^™

Identification Of Slc3a2 As A Potential Therapeutic Target Of Ferroptosis In Bladder Cancer, Qi Yang, Dewang Zhou, Aaron Beasley, Yujun Liu, Zeqin Yan, Hu Fang, Yuqing Li, Elin S. Gray

Research outputs 2022 to 2026

Bladder cancer (BC) represents the most prevalent malignancy within the urinary system. Mounting evidence underscores the critical involvement of ferroptosis in cancer pathogenesis; Consequently, this study delves into its molecular underpinnings and therapeutic potential specifically in BC. Methods: We analyzed gene expression profiles from The Cancer Genome Atlas (TCGA) and the Gene Expression Om-nibus (GEO) repositories. Ferroptosis-related genes (FRGs) were selected from the FerrDb database. Utilizing systematic bioinformatics analyses, we identify differentially expressed and prognostic FRGs and construct an FRGs prognostic model. Combined with protein-protein interaction (PPI) analysis, solute carrier family 3 member 2 (SLC3A2) was selected for further study. …

Circumferential Resection Of The Right Atrium To Excise Angiosarcoma, Chadi Nahal, Nicholas Borden, Majid Chammas, Thomas Steen, Cristiano Faber

Student Publications

Background

Cardiac angiosarcomas are rare, with no established treatment guidelines. There is limited reporting of large cardiac angiosarcomas requiring extensive atrial resection and reconstruction, and limited data on outcomes after resection with positive margins.

Case Summary

A 51-year-old man with multiple comorbidities was diagnosed with nonmetastatic 7.1 × 5.6 × 4.9 cm primary cardiac angiosarcoma in the right atrium extending into the superior vena cava. The mass was circumferentially resected with reconstruction of the right atrium using bovine pericardial patch. Histopathology confirmed a grade II spindle cell variant angiosarcoma with positive margins. Subsequent management included chemotherapy, targeted therapy, and radiotherapy …

Workforce Economic Inclusion And Stability In The United States And United Kingdom: Summary Findings, Mathieu Despard, Stephen Roll, Kristian Fuzi, Adele Atkinson, Louise Overton

Center for Social Development Research

Through a partnership between the Center for Social Development (CSD) at Washington University in St. Louis (United States) and the Centre on Household Savings and Asset Management (CHASM) at the University of Birmingham (United Kingdom),the Workforce Economic Inclusion and Mobility (WEIM) project has explored a host of issues affecting low-wage workers and their families in the United States and the United Kingdom. CSD and CHASM analyzed survey datasets from their respective countries to produce a set of insights regarding the challenges low-wage workers and their families face. This Research Summary discusses and synthesizes key findings organized by cross-cutting themes to …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

A Robust Convnext-Based Framework For Efficient, Generalizable, And Explainable Brain Tumor Classification On Mri, Kirti Pant, Pijush Kanti Dutta Pramanik, Zhongming Zhao

Faculty, Staff and Student Publications

Background: Accurate and dependable brain tumor classification from magnetic resonance imaging (MRI) is essential for clinical decision support, yet remains challenging due to inter-dataset variability, heterogeneous tumor appearances, and limited generalization of many deep learning models. Existing studies often rely on single-dataset evaluation, insufficient statistical validation, or lack interpretability, which restricts their clinical reliability and real-world deployment.

Methods: This study proposes a robust brain tumor classification framework based on the ConvNeXt Base architecture. The model is evaluated across three independent MRI datasets comprising four classes-glioma, meningioma, pituitary tumor, and no tumor. Performance is assessed using class-wise and aggregate metrics, including …

Kdm4a Promotes Nepc Progression Through Regulation Of Myc Expression, Celia Sze Ling Mak, Ming Zhu, Jie Fu, Xin Liang, Xiaoxuan Wang, Fei Yuan, Feng Wang, Anh G Hoang, Xingzhi Song, Peter Shepherd, Derek Liang, Jessica Suh, Jordan Contreras, Thisawin Dang, Cindy Yan, Brandon Figueroa, Mathias Mazzocco, Athena Luo, Bijeta Pradhan, Jiwon Park, Mirrah Bashir, Miao Zhang, Eric Metzger, Roland Schüle, Abhinav K Jain, Ellen Karasik, Daniel Frigo, Barbara A Foster, Min Gyu Lee, Paul Corn, Christopher J Logothetis, Ana Aparicio, Nora Navone, Patricia Troncoso, Zhi Tan, Jianhua Zhang, Sue-Hwa Lin, Guocan Wang

Faculty, Staff and Students Publications

Neuroendocrine prostate cancer (NEPC) is a highly aggressive and lethal subtype of prostate cancer (PCa) that often emerges in response to androgen receptor pathway inhibitors (ARPIs), which are widely used in treating metastatic castration-resistant and hormone-sensitive prostate cancer. The incidence of NEPC is increasing, yet effective therapeutic strategies remain limited due to an incomplete understanding of its molecular drivers. Through transcriptomic analyses of human prostate tumor samples, we identified the histone lysine demethylase KDM4A as uniquely overexpressed in human and mouse NEPC compared to prostate adenocarcinoma. Functional validation demonstrated that KDM4A is a key regulator of NEPC progression and a …

A Systematic Review Of Cyber Risk Analysis Approaches For Wind Power Plants, Muhammad Arsal, Tamer Kamel, Hafizul Asad, Asiya Khan

School of Engineering, Computing and Mathematics

Wind power plants (WPPs), as large-scale cyber–physical systems (CPSs), have become essential to renewable energy generation but are increasingly exposed to cyber threats. Attacks on supervisory control and data acquisition (SCADA) networks can cause cascading physical and economic impacts. The systematic synthesis of cyber risk analysis methods specific to WPPs and cyber–physical energy systems (CPESs) is a need of the hour to identify research gaps and guide the development of resilient protection frameworks. This study employs a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol to review the state of the art in this area. Peer-reviewed studies published …

Students’ Motivation For Online Learning Of English As A Second Language Through The Lens Of The Self-Determination Theory, Wajeeh Daher, Ahlam Anabousy, Ahmad Amer, Nael Issa

Higher Learning Research Communications

Learning English as a second language (ESL) can be challenging for students, so it is essential to keep them motivated. One way to motivate students is through electronic programs (e-programs) that can enhance their motivation to learn. This research examined student learning motivation through the lens of the self-determination theory (SDT), with 39 preparatory-year students participating and learning in a blended context. Nine students were interviewed regarding their motivation to learn English using the electronic program, and both quantitative and qualitative research methods were used to examine participants’ motivation to learn English in that context. The quantitative results indicated that …

Esg And Firm Performance In China: The Moderating Role Of Firm Size And Covid-19, Peng Dan

Student Works (2020-2029)

This study examines the relationship between Environmental, Social, and Governance (ESG) performance and firm performance in China's A-share listed companies, with a particular focus on the moderating roles of firm size and the COVID-19 pandemic. Drawing on stakeholder theory, the research investigates whether ESG activities contribute positively to firm performance, and how this relationship varies with firm size and during crisis periods. The sample consists of Chinese A-share firms from 2019 to 2023, a period that includes the COVID-19 pandemic. After data processing, there are a total of 14,186 observations over the five-year period. Firm performance is measured using both …

Finding Debtor’S Counsel, Anthony Casey, Emma Lotts

BYU Law Review

In this Essay, we explore the question of how to assess the independence of debtor’s counsel in Chapter 11. The question has arisen in recent high-profile bankruptcy cases, attracting renewed attention from commentators. We examine these cases and revisit the unique role that debtor’s counsel serves.

From this analysis, a few guiding principles emerge for determining independence and managing conflicts that may arise. First, consistent with the rules outside of bankruptcy, sophisticated parties are capable of waiving conflicts and should be free to do so when their interests alone are affected by the conflict. Second, the possibility of conflicts—both real …

The Cortico-Cortical And Subcortical Circuits Of The Human Brain Language Centers Including The Dual Limbic And Language Functioning Fiber Tracts, Arash Kamali, Nithya P Narayana, Anastasia Loiko, Anusha Gandhi, Paul E Schulz, Nitin Tandon, Manish N Shah, Vinodh A Kumar, Larry A Kramer, Jay-Jiguang Zhu, Haris Sair, Roy F Riascos, Khader M Hasan

Faculty, Staff and Student Publications

Background/Objectives: In recent years, MRI-based diffusion-weighted tractography techniques have uncovered additional white matter pathways that have significant roles in language processing and production. In this review, we aim to outline the major language centers of the brain and major language pathways along with association tracts that serve dual roles in both the language and limbic systems. According to the current dual-stream model of language processing, the brain's language network is organized into a dorsal stream, responsible for mapping sound to articulation, and a ventral stream, which maps sound to meaning.

Materials and Methods: The literature cited in this …

A Comparison Of The Effectiveness Of Salmonella-Shigella (Ss) Agar And Xylose Lysine Deoxycholate (Xld) Agar In Supporting The Growth Of Salmonella Sp. And Shigella Sp., Ika Ningsih, Kharisma Winnie Chryssantium Tiro

Indonesian Journal of Medical Chemistry and Bioinformatics

Diarrheal diseases caused by Salmonella sp. and Shigella sp. are among the most significant public health challenges worldwide, especially among children. To identify these bacteria, Salmonella-Shigella (SS) and Xylose Lysine Deoxycholate (XLD) agar media are used, which are selective and differential for Salmonella sp. and Shigella sp. Although these media share similar properties and functions for growing Salmonella sp. and Shigella sp., results from previous studies differ from those obtained in tests conducted by the Department of Microbiology, Faculty of Medicine, University of Indonesia. This laboratory-based experimental study used serial dilution with three replicates (triplicate). Based on SNI 2897 of …

Interseeding Cover Crops Into Corn In The Intermountain West, Matt Yost, Jenae Dean, Michael Pace, Tony Richards, Andrew Wallace, Jacob Hadfield, Steven Hines, Cody Zesiger, Jody Gale, Rhonda Miller, Earl Creech, Matt Palmer

All Current Publications

Interseeding cover crops into corn may provide many benefits, such as weed suppression, nitrogen fixation from legume covers, and, most importantly, soil cover and forage for livestock after corn harvest. It also has the potential to negatively impact corn production if competition with covers for water and nutrients is too high. The purpose of this guide is to discuss recent research and experience with interseeding cover crops in the Intermountain West.

Isu Symphony Orchestra Concerto-Aria Competition Finals: January 28, 2026, Illinois State University School Of Music

School of Music Programs

This is the ninety-first program of the 2025-2026

Center for the Performing Arts

January 28, 2026

Wednesday Evening

7:00 p.m.

Michael Bowe ’91 And Heidi Goldsmith ’21 On Brithem Llp And The Art Of Trial Advocacy, Jennifer Bancamper

NYLS Community News

No abstract provided.

Defining The Heterogeneous Molecular Landscape Of Lung Cancer Cell Responses To Epigenetic Inhibition, Chuwei Lin, Catherine M Sniezek, Christopher D Mcgann, Rashmi Karki, Ross M Giglio, Benjamin A Garcia, José L Mcfaline-Figueroa, Devin K Schweppe

2020-Current year OA Pubs

Epigenetic inhibitors exhibit powerful antiproliferative and anticancer activities. However, cellular responses to small-molecule epigenetic inhibition are heterogeneous and dependent on factors such as the genetic background and metabolic state of cells, as well as on-/off-target engagement of individual small-molecule compounds. The molecular study of the extent of this heterogeneity often measures changes in a single cell line. To more comprehensively profile the effects of small-molecule perturbations and their influence on heterogeneous cellular responses, we present a molecular resource based on the quantification of chromatin, proteome, and transcriptome remodeling due to histone deacetylase inhibitors (HDACi) in non-isogenic cell lines. Through quantitative …

Designing Inclusive Newborn Sequencing Research: Insights From Parents In Underrepresented Communities, Maya C Del Rosario, Sheyenne A Walmsley, Barbara W Harrison, Crystal T Stephens, Bethany Zettler, Greysha Rivera-Cruz, Priyal Agrawal, Amy Brower, Stephanie Chigbu, Kurt D Christensen, Casie A Genetti, Richetta Givens, Nina B Gold, Inez V Reeves, Isabella Schichter, Habib Shariat, Sandra Simon, Hadley Stevens Smith, Melissa Uveges, Robert C Green, Ingrid A Holm, Stacey Pereira

Center for Medical Ethics and Health Policy Staff Publications

Background: It is essential that studies of genomic sequencing (GS) in newborns and children include individuals from under-represented racial and ethnic groups (URG) to ensure future applications are equitably implemented. We conducted interviews with parents from URG to better understand their perspectives on GS research, develop strategies to reduce barriers to enrollment, and facilitate research participation.

Methods: Semi-structured interviews with 50 parents from URG.

Results: Nearly all parents said they would be interested in participating in an infant GS study. Parents were interested in participating in GS research for reasons including clinical utility, personal utility, and/or family health benefits. Deterrents …

Mast Cells Promote Pathology And Susceptibility In Tuberculosis, Ananya Gupta, Vibha Taneja, Javier Rangel-Moreno, Nilofer Naqvi, Abhimanyu, Yun Tao, Mushtaq Ahmed, Kuldeep Singh Chauhan, Daniela Trejo-Ponce De Leon, Gustavo Ramírez-Martínez, Luis Jiménez-Alvarez, Cesar Luna-Rivero, Joaquin Zuniga, Deepak Kaushal, Shabaana A Khader

2020-Current year OA Pubs

Tuberculosis (TB), caused by the bacterium

Spartan Daily, January 28, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 3

The Effects Of Ovine-Derived Reinforced Tissue Matrix Surrounding Silicone-Based Implants In A Rat Prepectoral Reconstruction Model, Sai L Pinni, Cameron Martin, Nicholas Fadell, Xiaochao Xia, Evan Marsh, Lauren Schellhardt, Xiaowei Li, Matthew D Wood, Justin M Sacks

2020-Current year OA Pubs

Silicone-based implants have been widely used in breast reconstruction but have also been associated with poorly understood complications, including pathologic foreign body responses such as capsular contracture. In this study, we leveraged 3D-printing technology to generate silicone-based implants in a novel, anatomically relevant, prepectoral rat model. We used this model to evaluate the response to an extracellular matrix-based product: ovine-derived reinforced tissue matrix (RTM). Two-piece negative molds were developed through computer-aided design and 3D-printed. The molds were filled with various polydimethylsiloxane mixtures and dip-coated to fabricate implants. Implant material characterization revealed that the implants retained the original 3D-printed mold shape …

Study Of The Spatial Effect Of Geothermal On Surface Water Quality (Case Study Of Ci Pamatutan Watershed, Parakansalak Sub-District), Fauzan Abdurrahman Masykur, Prasetiawan Pras, M. Rafli Ariq Rianputra, Nesya Desfarivana Umaya, Vanesa Kelly Gabriela, Mangapul Parlindungan Tambunan, Supriatna Supriatna

Jurnal Geografi Lingkungan Tropik (Journal of Geography of Tropical Environments)

Geothermal plays an important role in affecting surface water quality with both positive and negative effects. It becomes an efficient renewable energy source in generating electricity without producing harmful gases. However, the presence of geothermal affects the quality of surface water in a watershed. This research is focused on the Mount Salak geothermal area which has volcanic and tectonic activity. Parameters such as electrical conductivity (measured in millisiemens/cm) were used to measure the content of minerals and dissolved compounds in the water. Total Dissolved Solids (TDS) measured in ppt is used to quantify dissolved solids, while water acidity (pH) indicates …

Business Communication Barriers In An Export-Oriented Company: A Case Study Of Pt. Xyz, Sartika Ekadyasa, Arius Krypton

Jurnal Administrasi Bisnis Terapan

This study examines business communication barriers faced by PT. XYZ, an export-oriented company engaged in international business cooperation. Using a qualitative case study approach, data were collected through observation, in-depth interviews, documentation, and literature review. The findings indicate that business communication is influenced by multiple interrelated barriers, including socio-anthro-psychological, technical, and ecological factors, which affect communication effectiveness during coordination, negotiation, and relationship management with foreign business partners. These barriers shape the quality of mutual understanding, trust, and operational efficiency in cross-border interactions. The study highlights the importance of integrated communication strategies that address social, cultural, psychological, technical, and environmental dimensions …

The Role Of Digital Service Development By Bumdes Kuala Dua In Enhancing The Local Economy, Siti Fatimah, Fahmi -. Fahmi, Radityo Kusumo Santoso, Feriska Ajeng Anantri

Jurnal Vokasi Indonesia

Digital transformation has become an important instrument for strengthening local economies in rural areas, particularly through the role of village economic institutions. Village Owned Enterprises (BUMDes) hold a strategic position in integrating digitalization into business management and community empowerment. This study aims to analyze the role of BUMDes Kuala Dua in the development of digital services as a strategy for enhancing the local economy and to formulate a model for strengthening village-based digital economic institutions. The study employs a qualitative approach using a descriptive analytical method. Data were collected through in-depth interviews, participatory observation, and document analysis involving the management …

Labour-Time In The Dot.Com Bubble: Marxist Approaches, Frederick Harry Pitts

Fast Capitalism

No abstract provided.

Violent Media, Guns, And Mental Illness: The Three Ring Circus Of Causal Factors For School Massacres, As Related In Media Discourse, Jaclyn Schildkraut, Glenn W. Muschert

Fast Capitalism

No abstract provided.

Wmd Transformations: When Did An Rpg Become A Wmd?, Binoy Kampmark

Fast Capitalism

No abstract provided.

The Role Of Marketing In The Infantilization Of The Postmodern Adult, Jacopo Bernardini

Fast Capitalism

No abstract provided.

Against Speed Cosmopolitanism Towards The Slow University, Jeremy Hunsinger

Fast Capitalism

No abstract provided.

Public Access: For Socially Relevant Knowledge Production And A Democratic Cybersphere, Joshua Sbicca, Robert Todd Perdue

Fast Capitalism

No abstract provided.

Beyond Dystopian Education In A Neoliberal Society, Henry A. Giroux

Fast Capitalism

No abstract provided.