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The Powerful Teacher: A Power Hypothesis For The Benefits Of Learning-By-Teaching, Sarah Shi Hui Wong, Stephen Lim Feb 2026

The Powerful Teacher: A Power Hypothesis For The Benefits Of Learning-By-Teaching, Sarah Shi Hui Wong, Stephen Lim

Research Collection School of Social Sciences

Why does teaching others enhance one's learning? This study advanced a novel power hypothesis of learning-by-teaching: When assuming the role of a teacher, students experience a heightened sense of power in influencing others, which increases their own learning. University students (N = 242) studied a scientific text using one of three learning methods: notetaking, explaining, or teaching. The notetaking group prepared to be tested and wrote study notes about the topic; the explaining group prepared to explain and wrote an explanation about the topic as how they would write a textbook for their peers; the teaching group prepared to teach …


Derivation Of An Updated Brief Multivariable Prediction Model To Detect Panic-Related Anxiety In Emergency Department Patients With Cardiopulmonary Complaints, Sharon C. Sung, Felicia J. L. Ang, Arul Earnest, Leslie E. C. Lim, Shreshtha Jolly, Gilaine Rui Ng, A. John Rush, Marcus E. H. Ong Feb 2026

Derivation Of An Updated Brief Multivariable Prediction Model To Detect Panic-Related Anxiety In Emergency Department Patients With Cardiopulmonary Complaints, Sharon C. Sung, Felicia J. L. Ang, Arul Earnest, Leslie E. C. Lim, Shreshtha Jolly, Gilaine Rui Ng, A. John Rush, Marcus E. H. Ong

Research Collection School of Social Sciences

Background Patients with panic related-anxiety (i.e., panic attacks or panic disorder) frequently present to emergency departments (EDs) with cardiopulmonary complaints but are often undiagnosed, which can lead to recurrent visits and prolonged distress. This study aimed to derive a new symptom-based multivariable diagnostic prediction model to detect panic-related anxiety in ED patients with cardiopulmonary symptoms.Methods We conducted a single-blind prospective derivation study over 15 months in the ED of a major tertiary hospital in Singapore. Patients presenting with symptoms of palpitations, chest pain, dizziness, or difficulty breathing were assessed using the Structured Clinical Interview for DSM Disorders (SCID) to diagnose …


Secondary School Students' Engagement In Learning Activities: Validation Of A Short Scale, Feliciano Henriques Veiga, Zi Yang Wong, Johnmarshall Reeve, Shane Jimerson, Antonio Leite, Joan Perales, Sonia Valente, Isabel Martinez Feb 2026

Secondary School Students' Engagement In Learning Activities: Validation Of A Short Scale, Feliciano Henriques Veiga, Zi Yang Wong, Johnmarshall Reeve, Shane Jimerson, Antonio Leite, Joan Perales, Sonia Valente, Isabel Martinez

Research Collection School of Social Sciences

Student engagement is a multidimensional construct strongly associated with learning outcomes and academic success. However, its measurement remains challenging, as existing instruments often conflate engagement in learning activities with engagement in the school community. In addition, brief measures are scarce despite their increasing value, and most available instruments do not incorporate agentic engagement. Assessing student engagement in learning activities is, therefore, crucial for monitoring academic progress, identifying students at risk of dropping out, and predicting academic success. This study aimed to validate the 12-item Secondary School Student Engagement in Learning Activities: Short Scale, adapted from a higher education measure, which …


How Consistent Friendlike Conversation With Ai Companions Influences Our Attitudes And Perceptions Toward Ai: An Exploratory Experiment, Qi Hui Jerlyn Ho, Meilan Hu, Adalia Yin Hui Goh, Emma Jane Pragasam, Andree Hartanto Feb 2026

How Consistent Friendlike Conversation With Ai Companions Influences Our Attitudes And Perceptions Toward Ai: An Exploratory Experiment, Qi Hui Jerlyn Ho, Meilan Hu, Adalia Yin Hui Goh, Emma Jane Pragasam, Andree Hartanto

Research Collection School of Social Sciences

Despite skepticism and distrust in artificial intelligence (AI), it is increasingly integrated into daily life, with its potential benefits drawing interest. Yet little is known about the attitudinal and psychological effects of human–AI interactions, and whether consistent interactions with AI chatbots can change users’ attitudes and perceptions. Our within-subjects experiment (N = 52) investigated how five days of socially oriented, friendlike interactions with an AI chatbot, versus a journaling control, influenced changes in attitudes and perceptions of AI. Participants’ attitudes towards AI, trust, perceived empathy, anthropomorphism, animacy, likeability, perceived intelligence and safety, dependency, and exploratory well-being indicators were recorded. Results …


Examining The Effects Of Viewing Nature And Animal Smartphone Wallpapers On Affect, Behaviour, And Cognition: A Randomised Cross-Over Trial, Nadyanna M. Majeed, Nicole R. Y. Chen, Adalia Y. H. Goh, Meilan Hu, Kenneth J. J. Koh, Yuolmae H. G. Ang, Andree Hartanto Feb 2026

Examining The Effects Of Viewing Nature And Animal Smartphone Wallpapers On Affect, Behaviour, And Cognition: A Randomised Cross-Over Trial, Nadyanna M. Majeed, Nicole R. Y. Chen, Adalia Y. H. Goh, Meilan Hu, Kenneth J. J. Koh, Yuolmae H. G. Ang, Andree Hartanto

Research Collection School of Social Sciences

This study aims to investigate the effects of different smartphone lock screen wallpapers on weekly perceived well-being, procrastination, and productivity in young adults. Through a pre-registered within-subject experiment, 60 participants were exposed to three smartphone wallpaper conditions: nature, animal, and neutral (control). Each participant experienced each condition over three weeks, with the order of conditions counterbalanced. Using Frequentist and Bayesian analyses, we did not find any differences between conditions across the pre-registered confirmatory outcomes (i.e., life satisfaction, positive affect, negative affect, stress, productivity, and procrastination). Exploratory outcomes related to lock screen engagement, however, revealed some meaningful effects. Animal-themed smartphone wallpapers …


Prediction Of Methane Gas By Using Hyperspectral Imageries And Remote Sensing Techniques, Aysha Ali Alhajeri Feb 2026

Prediction Of Methane Gas By Using Hyperspectral Imageries And Remote Sensing Techniques, Aysha Ali Alhajeri

Theses

Greenhouse gases is important for sustaining life on earth as well as in mitigating climate change. Methane (CH4) is considered as one of the most important critical gases for the global climate change and have significant influences on our life. Accordingly, the prediction of this greenhouse gas emissions is very important for avoiding the climate change effects and to maintain environmental sustainability. The objective of this study is to explore the potential applications for remote sensing to predict methane levels in the Earth’s atmosphere with a combination of local ground data and data from hyperspectral satellite imagery. By using hyperspectral …


Towards Enabling Environmental Social Enterprises: Two Case Studies From Egypt, Rana Emad Kamaly Feb 2026

Towards Enabling Environmental Social Enterprises: Two Case Studies From Egypt, Rana Emad Kamaly

Theses and Dissertations

Social enterprises (SEs) and environmental social enterprises (ESEs) are emerging as promising potential players in addressing global and Egyptian social and environmental challenges. Operating as a hybrid model of financial sustainability and environmental and social impact, ESEs operate through innovative business models to address community issues, waste management, and resource scarcity through financial sustainability. However, there is a lack of research on ESEs operations, challenges, and the enabling factors that can support their growth and impact. This study explores the enabling factors and challenges affecting ESEs in Egypt through qualitative research, analyzing two case studies from Egypt by conducting semi-structured …


The Impacts Of Political Leaders’ Social Capital On Policy Success: The Case Of Local Food Systems, In Hae Noh, Beomgeun Cho, April M. Roggio, Luis F. Luna-Reyes Feb 2026

The Impacts Of Political Leaders’ Social Capital On Policy Success: The Case Of Local Food Systems, In Hae Noh, Beomgeun Cho, April M. Roggio, Luis F. Luna-Reyes

Research Collection School of Social Sciences

Network approaches to collaborative leadership suggest that local leaders’ success depends on activities that connect their organization to diverse stakeholders and resources. Drawing on the literature on managerial networking and a mixed-methods approach that includes 38 semi-structured interviews and a survey of 185 New York State municipal leaders, we explore the impact of leaders’ networking efforts on food access and security in their communities. We hypothesize that different forms of leaders’ social capital (bridging, bonding, and linking) has an impact on policy success. Our results suggest that only bridging social capital has an impact on food access. We conclude with …


Anselm Küsters, The Making And Unmaking Of Ordoliberal Language. A Digital Conceptual History Of European Competition Law, Verlag Vittorio Klostermann Frankfurt Am Main 2023, Piotr Oliński Feb 2026

Anselm Küsters, The Making And Unmaking Of Ordoliberal Language. A Digital Conceptual History Of European Competition Law, Verlag Vittorio Klostermann Frankfurt Am Main 2023, Piotr Oliński

Yearbook of Antitrust and Regulatory Studies

No abstract provided.


Is History Precedent?, Allison Orr Larsen Feb 2026

Is History Precedent?, Allison Orr Larsen

Faculty Publications

It has been just over three years since the Supreme Court instructed lower courts to evaluate Second Amendment challenges by examining history and tradition. And it is no secret that the courts have struggled. This Article tackles a phenomenon that is born of that struggle. Overwhelmed by the task of evaluating historical claims, lower courts instead are turning to other judges as authorities on history. They are using what I call in this Article “historical precedents”—meaning language about history from an older decision that the subsequent judge then treats as authority, not as part of a legal rule but for …


The Free Exercise Of Religion As A Privilege, Kyron J. Huigens Feb 2026

The Free Exercise Of Religion As A Privilege, Kyron J. Huigens

Articles

In the span of a decade, the Supreme Court has restructured the Free Exercise Clause entirely. It has removed the counterweight of disestablishment; it has sought parity between religion and secularity by means of strict scrutiny analysis turning on a principle of nondiscrimination; and it has opened the way to a general exemption from secular law for the faithful by ceding the question of what counts as an exercise of religion to the faithful themselves. This Article proposes reading the free exercise of religion as a privilege in response to these changes. This privilege stands against secular law in the …


Drug Scheduling As Institutional Design, Matthew B. Lawrence, David E. Pozen Feb 2026

Drug Scheduling As Institutional Design, Matthew B. Lawrence, David E. Pozen

Faculty Scholarship

Controlled Substances Act (CSA), U.S. drug law has simultaneously fueled mass incarceration, inhibited needed access, and enabled an opioid crisis. To make better choices, this Article argues that the CSA’s institutional design must account for three distinctive features of psychoactive drugs: the prohibition problem (drug bans tend to backfire when demand is inelastic), the pharma problem (drug companies have supercharged incentives to manipulate markets and exploit consumers), and the pluralism problem (drug policy involves irreducibly political questions that no expert discipline can answer). On their own, each of these problems calls for reform to the CSA. Taken together, they call …


Does Law Constitute Society?, Jeremy K. Kessler Feb 2026

Does Law Constitute Society?, Jeremy K. Kessler

Faculty Scholarship

The resistance of capitalist inequality to legal reform has led a growing number of scholars to reconsider the explanatory virtues of Marxist legal thought. But what are those virtues? Some scholars hold that what makes Marxist legal thought special is its ability to explain the development of legal relationships in terms of the development of extra-legal relationships — specifically, the relations of production as they adapt to changes in the productive forces. Other scholars argue that this focus on the causal process by which extra-legal change (or stasis) drives legal change (or stasis) is too reductive. They contend that Marxist …


Trump V. Cook And The American Rule Of For-Cause Removal, Jane Manners, Lev Menand Feb 2026

Trump V. Cook And The American Rule Of For-Cause Removal, Jane Manners, Lev Menand

Faculty Scholarship

Halfway through oral argument in Trump v. Cook, Justice Amy Coney Barrett asked Solicitor General John Sauer when a statute authorizing an officer’s removal should be read to require process. “Why shouldn’t we do the same thing that the Shurtleff court did,” Barrett asked, “and say that, well, as we said in Shurtleff, when a statute specifies the grounds for removal, there must be notice and a hearing given?”

In response, Sauer distinguished between statutes authorizing removal for inefficiency, neglect of duty, or malfeasance in office (INM) — which he conceded require process — and statutes using the more …


Juanita B. Harden Feb 2026

Juanita B. Harden

African American Funeral Programs

Born in Millen, Georgia; Educated in Jenkins County Georgia Public School System; Early Childhood Church, Fountain Spring Baptist Church, Millen Georgia; Later moved to Miami, Florida; Relocated to Savannah, Georgia; Joined


Roland James "Stumpy" Mcclaind, Jr. Feb 2026

Roland James "Stumpy" Mcclaind, Jr.

African American Funeral Programs

No abstract provided.


Flexible Funding Authorities To Support Tribal Climate Adaptation, Monte Mills, Sydney Anderson, Lauren Young Feb 2026

Flexible Funding Authorities To Support Tribal Climate Adaptation, Monte Mills, Sydney Anderson, Lauren Young

Articles

This project is part of a policy research effort intended to support Tribes, federal agencies, and Tribal and non-Tribal organizations in addressing some of the climate adaptation barriers and needs experienced by Northwest coastal Tribes. Accessing and administering Federal funds is a significant challenge for Tribes. Existing federal funding sources are often accompanied by rigid rules that make it difficult for Tribes to flexibly allocate funds as needed, and include strict qualification criteria that limit Tribal access to funds. Short-term funding cycles can be disruptive to long-term staffing and project needs, and are often misaligned with Tribal priorities.


A Citizenship Model Of The Fourth Amendment, Danieli Evans Feb 2026

A Citizenship Model Of The Fourth Amendment, Danieli Evans

Articles

Fourth Amendment law is in disarray. In recent years, courts and scholars have questioned central aspects of Fourth Amendment doctrine—in particular, the reasonable expectations of privacy test that has governed since the 1960s. Scholars and judges have argued for abandoning this test and instead looking to private law (sub-constitutional rules governing private conduct, such as tort, property, and contract law) to determine Fourth Amendment protection.

At a moment when judges and scholars are questioning core aspects of Fourth Amendment doctrine, the time is ripe to reconsider the values Fourth Amendment law ought to serve. I advance a novel vision for …


Flips In Two-Dimensional Hypertriangulations, Herbert Edelsbrunner, Alexey Garber, Mohadese Ghafari, Teresa Heiss, Morteza Saghafian Feb 2026

Flips In Two-Dimensional Hypertriangulations, Herbert Edelsbrunner, Alexey Garber, Mohadese Ghafari, Teresa Heiss, Morteza Saghafian

School of Mathematical & Statistical Sciences Faculty Publications

We study flips in hypertriangulations of planar points sets. Here a level-k hypertriangulation of n points in the plane is a subdivision induced by the projection of a k-hypersimplex, which is the convex hull of the barycenters of the (k−1)-dimensional faces of the standard (n−1)-simplex. In particular, we introduce four types of flips and prove that the level-2 hypertriangulations are connected by these flips.


Constrained Quantization For Probability Distributions, Megha Pandey, Mrinal Kanti Roychowdhury Feb 2026

Constrained Quantization For Probability Distributions, Megha Pandey, Mrinal Kanti Roychowdhury

School of Mathematical & Statistical Sciences Faculty Publications

In this work, we extend the classical framework of quantization for Borel probability measures defined on normed spaces ℝ𝑘 by introducing and analyzing the notions of the nth constrained quantization error, constrained quantization dimension, and constrained quantization coefficient. These concepts generalize the well-established nth quantization error, quantization dimension, and quantization coefficient, which are traditionally considered in the unconstrained setting and thereby broaden the scope of quantization theory. A key distinction between the unconstrained and constrained frameworks lies in the structural properties of optimal quantizers. In the unconstrained setting, if the support of P contains at least n elements, then the …


Demographic And Other Correlates Of Non-Prescription Drug Use Among College Students During The Covid-19 Pandemic, Subi Gandhi, Sidketa Fofana, Md Rafiul Islam, Tamer Oraby Feb 2026

Demographic And Other Correlates Of Non-Prescription Drug Use Among College Students During The Covid-19 Pandemic, Subi Gandhi, Sidketa Fofana, Md Rafiul Islam, Tamer Oraby

School of Mathematical & Statistical Sciences Faculty Publications

Background and objectives: Substance use among college students in the U.S. remains a pressing concern and may have intensified during the COVID-19 pandemic due to increased stress, uncertainty, and academic disruptions. This study investigates the relationship between non-prescription drug use and various demographic, mental health, and behavioral factors among college students during the pandemic's early stages.

Methods: Data were collected through online and in-person surveys in the summer semester of 2021. Behavioral health was assessed using validated instruments: the Patient Health Questionnaire-9 (PHQ-9) for depression and the Drug Abuse Screening Test-20 (DAST-20) for substance use. Demographic and behavioral variables were …


Progressive Neuroinflammation And Deficits In Motor Function In A Mouse Model With An Epg5 Pathogenic Variant Of Vici Syndrome., Bradley Thornton, Alexandra G. Hardinger, Laramie Pence, Priyanka Prem Kumar, Nikolas Connolly, Scott J. Weir, Jay L. Vivian Feb 2026

Progressive Neuroinflammation And Deficits In Motor Function In A Mouse Model With An Epg5 Pathogenic Variant Of Vici Syndrome., Bradley Thornton, Alexandra G. Hardinger, Laramie Pence, Priyanka Prem Kumar, Nikolas Connolly, Scott J. Weir, Jay L. Vivian

Manuscripts, Articles, Book Chapters and Other Papers

Vici syndrome (VS) is a rare pediatric genetic disorder characterized by profound developmental delay, seizures, immune deficits, cardiomyopathy and progressive motor dysfunction. This devastating condition is caused by pathogenic variants in the EPG5 gene, which encodes a regulator of autophagy, leading to the accumulation of toxic intracellular material and widespread cellular dysfunction. Less-severe EPG5 pathogenic variants have recently been linked to rare familial forms of Parkinson's disease, suggesting deficits in EPG5 function drive a range of neurodegenerative disorders. Currently, there are no effective treatments for any disorders associated with pathogenic variants of EPG5. The underlying cellular mechanisms driving the progressive …


Diagnostic Challenges Of Anomalous Left Coronary Artery From The Right Pulmonary Artery., Lavina Desai, Sanket Shah, Edo Bedzra, Christopher Mathis Feb 2026

Diagnostic Challenges Of Anomalous Left Coronary Artery From The Right Pulmonary Artery., Lavina Desai, Sanket Shah, Edo Bedzra, Christopher Mathis

Manuscripts, Articles, Book Chapters and Other Papers

• ALCAPA is a rare congenital heart defect seen in about one in 300,000 live births. • ALCARPA is an even rarer subset of ALCAPA with the LCA originating from the RPA. • Few cases report ALCARPA associated with coarctation of the aorta. • Coarctation and VSD may cause PH with antegrade LCA flow. • These defects are hard to diagnose and require coronary imaging before surgery.


Analysis Of Pediatric Cervical Spine Injury Evaluation Workflow In The Emergency Department, Annie J Truelove, Megan E Gregory, Fahd A Ahmad, Sean P Pajak, Nicole C Hammer, Daniel Corwin, Leah Tzimenatos, Scott O King, Matthew Szadkowski, Martin J Herman, Julie C Leonard Feb 2026

Analysis Of Pediatric Cervical Spine Injury Evaluation Workflow In The Emergency Department, Annie J Truelove, Megan E Gregory, Fahd A Ahmad, Sean P Pajak, Nicole C Hammer, Daniel Corwin, Leah Tzimenatos, Scott O King, Matthew Szadkowski, Martin J Herman, Julie C Leonard

2020-Current year OA Pubs

OBJECTIVES: The decision to image children for cervical spine injuries (CSI), an uncommon injury with high associated morbidity and mortality, is complex. X-rays and computed tomography are often used to screen for CSI; however, radiation exposure increases lifetime cancer risk. We recently developed a CSI prediction rule to inform pediatric imaging decisions. To guide implementation, we conducted a workflow analysis of CSI screening in children after blunt trauma.

METHODS: We interviewed emergency departments (ED) and trauma clinicians at 21 hospitals following the applied cognitive task analysis task diagram, knowledge audit, and simulation interview approaches. Interviews were coded using a combined …


Effect Of Heat Stress On Jejunal Epithelial Barrier Integrity In Broilers Divergently Selected For High- And Low-Water Efficiency, Elizabeth S. Greene, Sara Orlowski, Sami Dridi Feb 2026

Effect Of Heat Stress On Jejunal Epithelial Barrier Integrity In Broilers Divergently Selected For High- And Low-Water Efficiency, Elizabeth S. Greene, Sara Orlowski, Sami Dridi

Poultry Science Faculty Publications and Presentations

Drought and water scarcity, exacerbated by global warming, are enormous threats to global food sustainability and security. Poultry, in particular, are highly impacted by adverse environmental stressors. As nutrient absorption and intestinal integrity are critical for growth and performance, understanding the impact on the broiler gastrointestinal tract is highly relevant. Here, we examined the effect of chronic cyclic heat stress (HS) on the jejunal expression profile of tight-junction, gap-junction, adherens, and desmosome genes in the 4th generation of broiler lines divergently selected for low (LWE)- and high-water efficiency (HWE). Male HWE and LWE broilers (n = 240/line) were allotted to …


Differential Validity In Fair Lending, Spencer Caro, Talia B. Gillis, Scott Nelson Feb 2026

Differential Validity In Fair Lending, Spencer Caro, Talia B. Gillis, Scott Nelson

Faculty Scholarship

Fair lending’s disparate impact doctrine aims to address lending disparities. But which disparities? Traditional fair lending has narrowly focused on equal outcomes — examining differences in loan approval rates or interest rates. However, this singular focus overlooks other dimensions of disparities that are essential for fair credit access. This article challenges the conventional emphasis on equal outcomes, demonstrating how it has failed to address deep-rooted inequalities in traditional credit allocation while also stifling innovation in machine-learning and alternative data. We argue that disparities in the validity of creditworthiness predictions — the accuracy with which a model identifies creditworthy applicants — …


Legal Reform And Cultural Resistance: Examining The Role Of Law And Custom In Ending Fgm In Egypt, Souhaila Hafez Abo Seada Feb 2026

Legal Reform And Cultural Resistance: Examining The Role Of Law And Custom In Ending Fgm In Egypt, Souhaila Hafez Abo Seada

Theses and Dissertations

This thesis examines the persistent gap between legal reform and social practice in efforts to end Female Genital Mutilation (FGM) in Egypt. Although FGM has been criminalized since 2008, with stronger penalties introduced in 2016 and 2021, the practice continues, revealing the limits of law when it operates alongside powerful social, religious, familial, and medical norms. Using a qualitative case-based approach grounded in legal pluralism and Feminist Critical Discourse Analysis, the study draws on 11 semi-structured interviews with participants from civil society, religious institutions, the legal profession, the medical sector, and communities where FGM persists, alongside legislative, demographic, and documentary …


Life-Extending Interventions Do Not Necessarily Result In Compression Of Morbidity: A Case Example Offering A Robust Statistical Approach, Deependra K Thapa, Wasiuddin Najam, Erik S Parker, Xi Rita Wang, Daniel L Smith, Ufuk Beyaztas, James F Nelson, Steven N Austad, Gary A Churchill, David B Allison Feb 2026

Life-Extending Interventions Do Not Necessarily Result In Compression Of Morbidity: A Case Example Offering A Robust Statistical Approach, Deependra K Thapa, Wasiuddin Najam, Erik S Parker, Xi Rita Wang, Daniel L Smith, Ufuk Beyaztas, James F Nelson, Steven N Austad, Gary A Churchill, David B Allison

Children’s Nutrition Research Center Staff Publications

Despite extensive research on life-extending interventions, rigorous statistical techniques to determine their impact on compression of morbidity (CoM) are rarely used. We present a case example of an analytical method for examining the effect of life-extending dietary interventions on CoM by comparing the rates of decline in vitality and survival toward the end of life. Using data from previous experimental studies in mice, we calculated the average rate of vitality decline by fitting exponential decay models to individual vitality trajectories and compared this rate with the rate of survival decline estimated from Cox proportional hazards model. The results showed that, …


Enteral And Intravenous Supplementation Of Arginine And Citrulline Fail To Prevent Necrotizing Enterocolitis In Preterm Neonatal Pigs, Caitlin Vonderohe, Julia Garcia Mancebo, Valeria Melendez Hebib, Barbara Stoll, Inka Didelija, Sarah Elefson, Mahmoud Mohammad, Brooklynn Earls, Greg Guthrie, Doug Burrin Feb 2026

Enteral And Intravenous Supplementation Of Arginine And Citrulline Fail To Prevent Necrotizing Enterocolitis In Preterm Neonatal Pigs, Caitlin Vonderohe, Julia Garcia Mancebo, Valeria Melendez Hebib, Barbara Stoll, Inka Didelija, Sarah Elefson, Mahmoud Mohammad, Brooklynn Earls, Greg Guthrie, Doug Burrin

Children’s Nutrition Research Center Staff Publications

Background: Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in preterm infants with a morality rate that approaches 50%. Arginine has been widely studied in the field of clinical nutrition as a supplement for patients experiencing critical illness because it can be metabolized into nitric oxide, an important agent for supporting immunity and microcirculation. Citrulline has received less attention but can be metabolized into arginine and has a much longer plasma half-life than arginine. We used the highly translational preterm pig model to determine the effect of intravenous and enteral supplementation of arginine and citrulline on NEC incidence in …


Nested Ecosystems Theory For Conceptualizing Brain Tumors, Lori A Forster, David H Gutmann Feb 2026

Nested Ecosystems Theory For Conceptualizing Brain Tumors, Lori A Forster, David H Gutmann

2020-Current year OA Pubs

The application of advanced multi-omic methodologies to studying brain tumors has culminated in the appreciation that these cancers function as ecosystems that depend on the interactions of a diverse collection of cell types and signals. This connectivity operates not only at the level of the cancer cell, in which variants create new growth dependencies, but also between tumor cells and the immediate tumor microenvironment, between tumor cells and cell populations residing elsewhere in the brain tissue or body, and in response to extracorporeal factors. The cellular and molecular relationships within these four interrelated strata (intracellular, extracellular, intracorporeal and extracorporeal) act …