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Expression And Purification Of A Cleavable Recombinant Fortilin From Escherichia Coli For Structure Activity Studies, Maranda S. Cantrell, Jackson D. Wall, Xinzhu Pu, Matthew Turner, Luke Woodbury, Owen M. Mcdougal, Lisa R. Warner

Chemistry and Biochemistry Faculty Publications and Presentations

Complications related to atherosclerosis account for approximately 1 in 4 deaths in the United States and treatment has focused on lowering serum LDL-cholesterol levels with statins. However, approximately 50% of those diagnosed with atherosclerosis have blood cholesterol levels within normal parameters. Human fortilin is an anti-apoptotic protein and a factor in macrophage-mediated atherosclerosis and is hypothesized to protect inflammatory macrophages from apoptosis, leading to subsequent cardiac pathogenesis. Fortilin is unique because it provides a novel drug target for atherosclerosis that goes beyond lowering cholesterol and utilization of a solution nuclear magnetic resonance (NMR) spectroscopy, structure-based drug discovery approach requires milligram …

The Complexity Of "The Hate U Give", Esosiye Alexander

Emerging Writers

"The Complexity of 'The Hate U Give'" discusses significant cultural and societal aspects of the 2018 N.A.A.C.P. award-winning film, "The Hate U Give." As part of evaluating the film, this essay analyzes the film's portrayal of police brutality in the black community, its long-term consequences, complex discussions that black adults have with youths and themselves, and how difficult it is to get justice for the victim.

The Window To The Soul, Erica Bolding

Emerging Writers

This essay surveys the idea of "tone" and all of its complexities, including a focus on its relations to mental health conditions such as depression. Intertwined with personal memoir, research, and examples from social media, the essay unravels a difficult and under-discussed issue that surrounds tone. The essay also asks unconventional questions that hope to stir readers' thinking, such as: Is raising one’s voice always bad? Are our screams telling us something else?

The Book I Never Got To Read: A Tale Of Book Censorship, Courtney Everett

Emerging Writers

From the expression of authors to sharing perceptions of the world, the use of literature has been one of the most common ways of teaching students for generations. However, with opposing viewpoints and conflicting ideas, literary censorship has continued to become an issue among communities for longer than people realize, and it brings harm to humanity over time. This essay discusses the recent conflict of banning books in communities and its affect on students.

America’S Forgotten Laborers: The World Of Enslaved Craftsmen, Zack Dow

Emerging Writers

This article examines the underrepresented world of enslaved artisans in the American south. In the minds of many, enslaved Americans were confined to unskilled plantation labor. While such labor constituted a large part of the work of the enslaved, master craftspeople go unrecognized, perpetuating an imagine of unskilled, nominal workers that undermines the accomplishments of the millions of black artisans working at the time.

Being Black In Sports, Vongai Kwenda

Emerging Writers

This essay examines how black sportspeople aren’t sheltered from racism, though they are famous and loved. In the past, black players faced segregation and more overt, aggressive forms of racism. But today, the sports world has come a long way with integration, stricter policies, and protests going global. Racism is perpetuated by racist fans online and in the stands, and sports commentators who use racial tropes rooted in biological racism. More awareness and debunking are needed. White players can take a stand in the heat of an incident to send a stronger message too. It worked in the past, so …

The Loop Of Trauma, Jayden Miller-Jones

Emerging Writers

"The Loop of Trauma" is a piece that was written in response to the various BLM protests and police attacks that took place during 2020. The author responds to memories of being shrouded in a deep depression with no sense of how to escape. After entering their English 1101 class they were finally able to properly describe the feelings. This piece covers their beliefs on mental health in the black community and how it is often shelved for a later date, a date that more often than not, never comes.

Acknowledgements And Author Biographies

Emerging Writers

This document contains acknowledgements and author biographies for Volume 5 (2022) of the Emerging Writers Journal.

Candles, Stoners, Emotions, Oh My!, Ashley Gruca

Emerging Writers

This paper focuses on the topic of our language constantly changing while using the word “lit” to show this. Analysis of examples from personal experience like yearbook signings as well as lyrics from Travis Scott songs demonstrate how a word's meaning can shift depending on its generational context.

A Bad Time To Name Your Pet: Pet Names In The Age Of Witches, Evan Velez

Emerging Writers

In early America, there were many strange superstitions about witches. Colonists looked for all sorts of forms of witchcraft “evidence”. According to The Penguin Book of Witches, the nature of pet names may have served as an unconscious form of evidence (Howe 239). While the author thought of this suggestion as a form of social logic, this essay investigates it as a phenomenon of language. Pet names had a key role in influencing negative feelings towards animals labeled as “familiars.” This affected colonists’ perceptions of an animal, and resulted in the familiar eventually becoming a hated “pet.”

Heart Hurts From Higging, Nia Pettway

Emerging Writers

This essay examines an emotion that does not have a word and offers a neologism to apply. "Higgs," the neologism in question, defines a feeling of nostalgia for the present that blends itself with a fear of moving into the future. With the word having such a timeless, yet relevant application, this essay takes readers through its creation, examples in contemporary media, as well as how implementation of the word may help users better understand the emotion it describes.

Everyone's A Critic: My Review Of The Reviewer, Jessie Rigsbee

Emerging Writers

This article is an analysis of movie critic Oliver Jones’s Avengers Endgame film review. Through the inspection of rhetorical devices, the effectiveness of the review is assessed. The evaluation determines the faults of Jones’s argument for Endgame’s place with history’s greatest film sagas.

Keeping It Real, Robin Tandongfor

Emerging Writers

This creative nonfiction essay examines a woman's transition into college after living with strict parents. She explains how she felt unprepared to protect her own body through telling the story of a date gone wrong during her freshman year of college.

Full Issue

Journal of Mathematics and Science: Collaborative Explorations

No abstract provided.

An Examination Of Factors That Support Sustainable Cultural And Curricular Change In Stem Teaching And Learning, Erica Slate Young, Peaches Hash, Sarah Schott, Jack Bookman

Journal of Mathematics and Science: Collaborative Explorations

Using a mixed-methods design, this body of work from the SUMMIT-P consortium explores possible effective conditions for the sustainable reform of STEM teaching and learning at the collegiate level. A model of catalysts for successful and sustainable change is proposed, based on five years of data collection and observations. These catalysts include institutional support, intrinsic and extrinsic motivation of faculty involved, measures of student success, institution size, prior faculty experience, faculty buy-in, and institutional culture. The discussion ends with a delve into the potential broader impacts of this work. For example, this model may help institutions better understand how to …

Non-Debt And Non-Bank Financing For Home Purchase: Promises And Risks, Shelby D. Green

American University Business Law Review

No abstract provided.

The Ab5 Experiment — Should States Adopt California’S Worker Classification Law?, Samantha Prince

American University Business Law Review

A worker's classification as either independent contractor or employee drives whether a worker is entitled to minimum wage, overtime, worker's compensation, unemployment compensation, anti-discrimination protection, National Labor Relations Act protections, and many other safety-net protections. During the COVID-19 pandemic, unemployment protections were extended to independent contractors, but this is not the norm and is not slated to continue post-pandemic. Classifying certain workers, particularly those who work in the app- based economy, is challenging, so states are looking for an answer - either through their own innovation or through that of other states. California's answer was AB5. AB5's goals were to …

Intellectual Property Investment Functions And The Legal Characteristics Of Privatization, P. Sean Morris

American University Business Law Review

This paper develops and presents the idea of intellectual property investment functions as part of a broader narrative on the privatization of international law. Using jurisprudence and private law arguments the paper charts how early investment treaties and ICSID cases interacts with intellectual property investments and then go on to show the rise of contemporary Free Trade Agreements provisions that upend the understanding of intellectual property as an investment function. The advocates of the investment principles clearly sees no objection on the application of customary international law to investment, and by extent, the investment function of intellectual property. It must …

Nfts: The Latest Technology Challenging Copyright Law's Relevance Within A Decentralized System, Rebecca Carroll

Fordham Intellectual Property, Media and Entertainment Law Journal

Non-fungible tokens (“NFTs”) redefine society’s understanding of digital ownership and transform how creators distribute original works to consumers. This unique and often misunderstood technol- ogy has the potential to yield extraordinary value for both creators and consumers. While NFTs have existed for some time now, the recent frenzy caused by several high-value sales of NFTs exposed a number of unanswered legal questions, particularly in copyright law. NFTs also raise ideological concerns over how much, if any, government oversight and regulation should exist over the “open” internet. This Note explores copyright law’s application to NFTs and seeks to address a number …

A Tale Of Four Departments: Interdisciplinary Faculty Learning Communities Informing Mathematics Education, Bryan D. Poole, Caroline Maher-Boulis, John Hearn, Jason Robinson, Patricia Mcclung, Amanda Jones

Journal of Mathematics and Science: Collaborative Explorations

As a result of the Curriculum Foundations Project and the SUMMIT-P consortium, faculty from four different departments at Lee University created a Faculty Learning Community (FLC) with the goal of improving students’ attitudes toward undergraduate mathematics courses, including students’ perception of the utility of mathematics in their lives and the feelings of anxiety that they experience in these courses. The interdisciplinary collaborations resulted in introducing novel activities and manipulatives in various mathematics courses (Introduction to Statistics, Concepts of Mathematics I and II, and Algebra for Calculus). This paper first describes the efforts of creating the inter-departmental FLC. Second, it discusses …

Neuroprosthetic Device Failure Analysis: Impact Of Shear Stress And Blood-Brain Barrier Disruption, Fatemeh Khodadadei

Wayne State University Dissertations

It has been hypothesized that physiological shear forces acting on medical devices implanted in the brain significantly accelerate the rate to device failure in patients with chronically indwelling neuroprosthetics. In hydrocephalus shunt devices, shear forces arise from cerebrospinal fluid (CSF) flow. The shunt’s unacceptably high failure rate is mostly due to obstruction with adherent inflammatory cells. Astrocytes are the dominant cell type bound directly to obstructing shunts, rapidly manipulating their activation via shear stress-dependent cytokine secretion. Here we developed a total internal reflection fluorescence microscopy (TIR-FM) combined with a microfluidic shear device chip (MSDC) for quantitative analysis and direct spatial-temporal …

Synthesis Of Molybdenum Containing Thin Films Using Organic Reducing Agents And Synthesis Of Magnesium Silyl Intermediate Complexes For Use In Atomic Layer Deposition, Michael David Overbeek

Wayne State University Dissertations

Thin films of a variety of materials have shown great potential in the fields of microelectronics, catalysis, and energy applications. Vapor deposition methods, including PVD and CVD, have been traditionally used as the primary method to deposit these thin films. However, these methods do not provide the necessary thickness uniformity and conformality needed for future uses of these thin films as they shrink to smaller dimensions. ALD provides a high degree of uniformity and conformality due to the intrinsic nature of the self-limited reaction mechanism of an ALD process.

The research herein focuses on two metals that have untapped potential …

Nonparent-Friendly Work Climate & Parental Role Value: An Updated Approach To Understanding Nonparent Work Experiences, Andrew Lutz

Wayne State University Dissertations

First, the present study entails a theoretically guided examination of relationships between nonparent-friendly organizational climate (NPFC) and important outcomes among nonparent workers. Second, the present study explores the role of social-identity theory in understanding nonparent work experiences by examining and comparing the function (i.e., moderation effect sizes) of parental role values and parental expectations (i.e., childfree status) on relationships between NPFC and outcomes including affective commitment. Third, the present study compares the relevance of NPFC and singles-friendly culture in the prediction of outcomes among nonparent workers. Lastly, the present study examines the potential role of intersectionality of nonparental role and …

Data Management Report January 2022, Tennessee. Department Of Intellectual And Developmental Disabilities

Compliance & System Data/Reports

This monthly report provides data on various aspects of the department's activities and programs.

Trends In Recurrent Clostridioides Difficile Infection In New Haven County, Chinenye Maryanne Okafor

Public Health Theses

Background: Recurrent Clostridioides difficile infection (CDI) is a cause of increased burden on the healthcare system and factors associated with this disease merit understanding. This study aimed to determine the incidence rate and to describe the factors associated with recurrent CDI cases in New Haven County from 2015 to 2020. It also examined the trends in annual recurrent CDI cases across epidemiological classes. Methods: This study utilized data from a population-based surveillance program of the Healthcare-Associated Infectious Community Interface (HAIC) Program within the Connecticut Emerging Infectious Program (CT EIP) at Yale School of Public Health which served all residents of …

Impact Of Covid-19 On The Mental Health Of Resettled Refugee Children, Joseph Lawsel Williams

Public Health Theses

Background: Mental health difficulties disproportionately impact resettled refugee children (RRC). Little is known regarding the impact between COVID-19 and RRC mental health. A mixed-methods retrospective pilot study was conducted to examine the impact of COVID-19 on RRC mental health.

Methods: Families were recruited in partnership with Elena’s Light, a refugee resettlement community-stakeholder. Participants included 20 RRC (N=11 ages 4-11; N=9 ages 11-15; equal gender distribution) from 10 families (N=6 Afghanistan; N=1 Turkey; N=1 Syria; N=2 non-disclosed) resettled to New Haven, CT before March 2019. Pre-Covid (PC) and During-Covid (DC) maternal responses for three Strength and Difficulties Questionnaire (SDQ) dimensions (Emotional, …

[Fall] Leyendas: Creepy Creatures And Other Lore, Raquel Estrada, William Flores

Library Display Posters

No abstract provided.

Cybersecurity Awareness Month, Raquel Estrada

Library Display Posters

No abstract provided.

2022 Report To The Public, Tennessee Early Intervention System, Tennessee. Department Of Intellectual And Development Disabilities

Reports to the Public

Individuals with Disabilities Education Act (IDEA) requires states to provide an annual report to the public about the performance of early intervention service (EIS programs) compared to the state’s performance on indicator targets.

Collectivistic Independence In Children's Picture Books, Andrea Badger

Children's Book Writing and Illustrating (MFA) Theses

In an individualist society, the usefulness of collectivist ideas can often be overlooked. This is potentially because individualism and collectivism have been incorrectly framed as oppositional. This thesis examines themes of individualism and collectivism in children's’ picture books by using the psychological concepts of individualism, collectivism, idiocentrism and allocentrism. Picture books examined include: The Lorax and Horton Hears a Who!, by Dr. Seuss, Swimmy, by Leo Lionni, What Do People Do All Day?, by Richard Scarry, and Rainbow Fish, by Marcus Pfister. This thesis studies how individualism and collectivism interact with each other within a story, and proposes …