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Articles 76561 - 76590 of 5207222
Full-Text Articles in Entire DC Network
Is There No Such Thing As Bad Pr? A Case Study Analysis Of Influencer Pseudo-Events, Authentic Crises, And Crises As Opportunity, And Paracrisis, Sofia Aparicio-Gallagher
Is There No Such Thing As Bad Pr? A Case Study Analysis Of Influencer Pseudo-Events, Authentic Crises, And Crises As Opportunity, And Paracrisis, Sofia Aparicio-Gallagher
USF Tampa Graduate Theses and Dissertations
There's no such thing as bad PR, and any publicity is good publicity are phrases coined by 19th-century P.T. Barnum, a showman and businessman known for his circus hoaxes (Hiergesell, 2025). The idea implies that all media attention, whether negative or positive, is beneficial to the organization or individual. The purpose of this study is to evaluate three brands; Tarte, Poppi, and Shein during a brand event to determine whether it was a pseudo-event created to gain awareness, or a genuine, unplanned crisis. Another purpose of the study was to determine if the event was used as an opportunity for …
Spin Pumping And Interfacial Anisotropy In Ultrathin Cobalt Heterostructures, Ibrahim Almuhanna
Spin Pumping And Interfacial Anisotropy In Ultrathin Cobalt Heterostructures, Ibrahim Almuhanna
USF Tampa Graduate Theses and Dissertations
Interfaces dominate the behavior of ultrathin ferromagnets, where interfacial spin-orbit coupling(SOC) can strongly influence both magnetic anisotropy and magnetization dynamics. This thesis compares how a heavy-metal interface (Pt) and a semiconducting two-dimensional transition-metal dichalcogenide (TMD) interface (MoSe2) modify the static and dynamic magnetic properties of ultrathin Co. To isolate interface-driven effects, the heterostructure architecture is kept fixed (sapphire substrate and Si3N4 cap) while only the seeding/interface layer beneath Co is varied. MoSe2 is studied in two thickness conditions (monolayer and bilayer) to test layer-dependent trends.
Layer thicknesses are determined by X-ray reflectivity. Static magnetic properties are measured by in-plane vibrating …
A Look At The Potential Impacts Of Priming Thoughts Through The Show Family Guy, Thomas Wiskoff
A Look At The Potential Impacts Of Priming Thoughts Through The Show Family Guy, Thomas Wiskoff
USF Tampa Graduate Theses and Dissertations
This study examined whether brief exposure to a death-themed episode of the adult animated show Family Guy could prime viewers to adopt less serious attitudes toward death and dying. Drawing primarily from priming theory, with supporting insights from cultivation and framing theories, the research focused on the show's unique use of magical realism and irreverent humor, particularly the personification of Death as the sarcastic Grim Reaper, to explore potential shifts in death-related attitudes. Participants (N = 100) were randomly assigned to view one of two clips from Family Guy Season 2, Episode 6 ("Death is a Bitch") with one clip …
Framing Power: The “Deep State” In Georgian Populist And Conspiratorial Rhetoric Introduction, Salome Tsetskhladze
Framing Power: The “Deep State” In Georgian Populist And Conspiratorial Rhetoric Introduction, Salome Tsetskhladze
USF Tampa Graduate Theses and Dissertations
This thesis investigates how the concept of the “deep state” is used in contemporary Georgian political communication. The term traditionally refers to hidden networks of power that function within state institutions. However, in Georgia, it has become a political narrative that interprets international criticism, delegitimizes domestic opposition, and derails political accountability. The study analyzes how this concept is constructed and mobilized in the political discourse.
The research employs a qualitative inductive-deductive thematic analysis. It examines 125 statements made by Georgian public officials between August 2024 and February 2025 referring to the “deep state.” The analysis integrates framing theory, populist communication …
Examining The Effect Of Household Socioeconomic Status And Maternal Characteristics On Child Developmental Delay In The United States, Samuel Ilori
USF Tampa Graduate Theses and Dissertations
Child developmental delay remains a pressing public health issue with lifelong implications. This study examines the association between household socioeconomic status, maternal characteristics, and child developmental delay using data from the 2023 National Survey of Children's Health (N = 35,399 female respondents). Bivariate analyses using Chi-square tests and binary logistic regression with sequential modeling were conducted. Results revealed that economic hardship, employment status, maternal mental health, maternal physical health, marital status, and race were significantly associated with child developmental delay (p<0.001). Educational level and poverty level showed no significant associations. Among mothers reporting poor mental health, 90.0% had a child with a delay, compared to 6.6% among those with good mental health. Every mother reporting poor physical health had a child with a delay, while virtually none with good or better physical health did. In the fully adjusted regression model, maternal mental and physical health remained the most powerful predictors, while economic hardship and employment status became non-significant once health was introduced, suggesting mediation. Maternal mental and physical health are the factors most strongly correlated with child developmental delay. Economic hardship matters primarily because it undermines maternal well-being. The COVID-19 pandemic likely intensified these dynamics by disrupting healthcare access and increasing economic instability. Supporting maternal health must be recognized as a fundamental strategy for promoting child development. Universal screening for maternal depression and physical health problems, integrated into pediatric and obstetric care, can identify at-risk mothers early. Policies that reduce economic hardship alleviate the chronic stress that undermines maternal health. Children thrive when their mothers are healthy.
Draft Final Phase I Pre-Design Investigation Evaluation Report Blacktail Creek Riparian Actions Butte Priority Soils Operable Unit Of The Silver Bow Creek/Butte Area Superfund Site Silver Bow County, Montana, Hydrogeologic, Inc.
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Potential And Chloride Concentration As Thresholds For Crevice Corrosion Initiation In Ss 316l, Y Shorrab, R S. Lillard
Potential And Chloride Concentration As Thresholds For Crevice Corrosion Initiation In Ss 316l, Y Shorrab, R S. Lillard
University Research
This work investigated the relationship between crevice chloride concentration ([Cl−]) and the potential necessary for initiation in stainless steel 316L (SS 316L). Real-time fluorescence measurements were used to measure [Cl−] inside SS 316L crevice assemblies as a function of bulk [Cl−] and potential. Crevice initiation at potentials slightly less than or equal to the bulk repassivation potential was associated with chloride transport, owing to passive dissolution, and an increase in the crevice [Cl−]. Once the [Cl−] within the crevice increased to the concentration necessary to initiate SS 316L pitting at the applied potential, crevice corrosion was initiated. For example, in …
Identification And Full Genome Sequencing Of Previously Unknown Sandfly-Borne Phleboviruses Using A Newly Established Capture-Based Next-Generation Sequencing Approach, Edwin O. Ogola, Inga Slothouwer, Gilbert Rotich, Anne Kopp, Armanda D. Bastos, Caroline Getugi, Julia Melchert, Terence C. Jones, Dorcus C. Omoga, Rosemary Sang, Baldwyn Torto, David P. Tchouassi, Sandra Junglen
Identification And Full Genome Sequencing Of Previously Unknown Sandfly-Borne Phleboviruses Using A Newly Established Capture-Based Next-Generation Sequencing Approach, Edwin O. Ogola, Inga Slothouwer, Gilbert Rotich, Anne Kopp, Armanda D. Bastos, Caroline Getugi, Julia Melchert, Terence C. Jones, Dorcus C. Omoga, Rosemary Sang, Baldwyn Torto, David P. Tchouassi, Sandra Junglen
All Peer-Reviewed Publications
Sandfly-borne phleboviruses cause febrile illness and neuroinvasive disease in humans. While infections are reported in the Mediterranean region, the discovery of previously unknown phleboviruses in sandflies from Kenya suggests a wider geographic distribution. Detection and characterization of novel phleboviruses are often hindered by low-quality and low-viral-load samples. We developed a capture-based target enrichment next-generation sequencing approach that showed a 99%-100% fold enrichment of viral genomes from primary material and provides a robust tool for generating complete genomes of both known and previously unknown viruses. From a collection of 15,652 sandflies in Kenya, we recovered seven complete coding sequences of Embossos, …
Heterocyclic‐Fused Squaramides: Anionophores With Antimicrobial Activity, Luke Edward Brennan, Chris Samuel Hawes, Kevin Kavanagh, Robert Brian Peter Elmes
Heterocyclic‐Fused Squaramides: Anionophores With Antimicrobial Activity, Luke Edward Brennan, Chris Samuel Hawes, Kevin Kavanagh, Robert Brian Peter Elmes
Research Outputs: 2025-Present
Antimicrobial resistance is regarded as one of the foremost public health risks of the 21st century, highlighting the need for new antimicrobial agents and chemical tools to interrogate their biological activity. Artificial transmembrane anion transporters have emerged as promising supramolecular scaffolds in this context, having demonstrated membrane activity in mammalian systems and showing growing potential in antimicrobial research. Here, we report a series of heterocycle‐fused squaramide anionophores capable of binding and transporting chloride. Several members of this series display measurable antimicrobial activity, alongside evidence of intracellular chloride modulation in bacterial cells. Taken together, these findings indicate that membrane localisation and …
Gut Microbiota Modulation Via Repeated Donor Fecal Transplantation Improves Motor And Gastrointestinal Symptoms In Drug-Naïve Parkinson’S Disease: A Randomized Phase 2 Trial, Yongkang Chen, Han Liu, Qingyong Zhu, Haiyan Tian, Chi Qin, Junfang Teng, Beisha Tang, Min Wu, Jinsheng Zeng, Erxi Wu, Xuebing Ding, Xuejing Wang
Gut Microbiota Modulation Via Repeated Donor Fecal Transplantation Improves Motor And Gastrointestinal Symptoms In Drug-Naïve Parkinson’S Disease: A Randomized Phase 2 Trial, Yongkang Chen, Han Liu, Qingyong Zhu, Haiyan Tian, Chi Qin, Junfang Teng, Beisha Tang, Min Wu, Jinsheng Zeng, Erxi Wu, Xuebing Ding, Xuejing Wang
Faculty, Staff and Students Publications
The gut-brain axis is increasingly recognized as a critical contributor to Parkinson's disease (PD) pathogenesis, yet the therapeutic impact of microbiota modulation remains unclear due to lack of clinical trials in drug-naïve patients. We conducted a randomized, double-blind, placebo-controlled phase 2 trial to evaluate the safety, tolerability, and efficacy of repeated donor fecal microbiota transplantation (dFMT) in de novo PD. FMT was administered for seven days (200 mL on days 1-3; 50 mL on days 4-7) per 4-week cycle. Seventy-two patients were randomized 1:1 to receive dFMT or autologous FMT (aFMT), and 66 completed the trial. At 35 weeks, the …
Enhancing Staff Education On Antidepressant Side Effects For Adolescents At Discharge, Mingdi Gao
Enhancing Staff Education On Antidepressant Side Effects For Adolescents At Discharge, Mingdi Gao
Walden Dissertations and Doctoral Studies
This Doctor of Nursing Practice (DNP) evidence-based staff education project aimed to improve the quality and consistency of discharge medication education for adolescents prescribed antidepressants. Adolescents are at increased risk for antidepressant-related adverse effects, including suicidal ideation, particularly during the early stages of treatment. The identified practice problem was the lack of consistent, developmentally appropriate, and culturally sensitive discharge teaching for adolescents and their families. This gap in practice contributes to poor adherence, preventable readmissions, and diminished safety outcomes. The project was guided by the PICO question: For adolescents discharged from inpatient or outpatient behavioral health care, how does a …
Staff Education On The Patient Health Questionnaire-9 (Phq-9) To Improve Depression Screening In A Mental Health Clinic, Agatha Onyemaechi Okemkpa
Staff Education On The Patient Health Questionnaire-9 (Phq-9) To Improve Depression Screening In A Mental Health Clinic, Agatha Onyemaechi Okemkpa
Walden Dissertations and Doctoral Studies
For this doctoral project, I implemented a staff education program on the Patient Health Questionnaire-9 (PHQ-9) to address depression screening practices in a mental health clinic. The practice problem addressed was limited depression screening due to a lack of education on the PHQ-9. The project aimed to answer the question: “For staff in a mental health clinic, will an educational offering on the Patient Health Questionnaire improve knowledge towards the goal of increasing screening for depression among clients?” To evaluate the outcome, a pre- and post-knowledge-based assessment using a 10-question multiple-choice test was administered to 20 staff members, and the …
Staff Education To Optimize Pain Management In Home Health Care, Marie Natacha Francis
Staff Education To Optimize Pain Management In Home Health Care, Marie Natacha Francis
Walden Dissertations and Doctoral Studies
This DNP project is a nurse-led quality improvement initiative that responds to the age-old issue of ineffective pain management in the home healthcare setting. The issue is the absence of standardization in staff education regarding pain assessment and intervention, leading to unfavorable patient outcomes and a reduced quality of life. The purpose of the project is to assess the efficacy of educational interventions delivered by nurses to enhance staff knowledge, confidence, and consistency in the management of pain procedures. The project question is: How effective are nurse-led educational interventions in improving staff knowledge and practices in pain assessment and management, …
The Appropriation Of Indigenous Land In HawaiʻI, Julie Loo
The Appropriation Of Indigenous Land In HawaiʻI, Julie Loo
Walden Dissertations and Doctoral Studies
In the transition from a monarchical to a democratic governance system in Hawaiʻi, Indigenous perspectives have not been fully integrated into land-use decision-making, resulting in mistrust, cultural marginalization, and inequitable policy outcomes. While prior researchers have examined colonization in Hawaiʻi, there is limited understanding of how Hawaiian cultural protocols may impact modern state-level decisions regarding Indigenous land use. The purpose of this qualitative ethnographic case study was to explore perceptions and lived experiences related to the cultural protocol of Kapu Aloha among Kanaka Maoli who participated in the Mauna Kea blockade and government officials involved in permitting Indigenous land for …
Staff Education To Improve Nurses’ De-Escalation Skills In Substance Abuse Treatment Settings, Joy Atufunwa
Staff Education To Improve Nurses’ De-Escalation Skills In Substance Abuse Treatment Settings, Joy Atufunwa
Walden Dissertations and Doctoral Studies
Nearly 50% of patients in substance abuse treatment settings exhibit aggressive behaviors, placing staff and other patients at risk. In the absence of structured de-escalation training, clinicians frequently rely on physical restraints or pharmacologic interventions, which contribute to staff burnout, injury, and ethical concerns. The project implemented an evidence-based staff education program to improve nurses’ knowledge, confidence, and competence in managing aggression using nonviolent de-escalation strategies. The project question guiding this initiative was: Can education improve nurses’ de-escalation skills in a substance abuse treatment setting? Using an evidence-based practice (EBP) approach and the PICO framework, the project evaluated the impact …
Quality Of Prenatal Care, Provider Preference, And Preeclampsia Among African American Women In Georgia, Lyteasha Bass
Quality Of Prenatal Care, Provider Preference, And Preeclampsia Among African American Women In Georgia, Lyteasha Bass
Walden Dissertations and Doctoral Studies
African American women experience disproportionately high rates of preeclampsia in the United States; however, the contributions of prenatal care provider type, health care access, and quality of care to this disparity were insufficiently defined. Guided by the quality health outcomes model, this quantitative case-control study used primary data to examine associations between these factors and the occurrence of preeclampsia among African American women age 18–40 who had given birth within the previous 5 years in Georgia. Descriptive statistics and binary and multinomial logistic regression analyses were conducted. Prenatal care quality was measured using the Quality of Prenatal Care Questionnaire (QPCQ), …
Enhancing Staff Knowledge And Confidence In Depression Screening Using The Patient Health Questionnaire-9, Melkamzer Chari
Enhancing Staff Knowledge And Confidence In Depression Screening Using The Patient Health Questionnaire-9, Melkamzer Chari
Walden Dissertations and Doctoral Studies
Depression is a serious public health concern affecting over 280 million people globally and leading to significant morbidity and mortality if left undetected and untreated. At the local organization, leadership identified inconsistent depression screening as a practice problem among nursing staff. Thus, the purpose of this doctor in nursing practice (DNP) project was to determine if an educational intervention focused on depression, the importance of depression screening, and the use of the Patient Health Questionnaire-9 (PHQ-9) increased knowledge and confidence among nursing staff working in a local organization. Fifteen participants volunteered to participate in the project. The average age was …
School-Based Human Service Professionals’ Perceptions Of The Relationships Between Black Families And Southern Schools, Vanessa Faye Barnhill
School-Based Human Service Professionals’ Perceptions Of The Relationships Between Black Families And Southern Schools, Vanessa Faye Barnhill
Walden Dissertations and Doctoral Studies
The experiences that Black parents had in school have been found to influence how they view and interact with schools and the challenges and barriers related to their child’s education attainment. It is important to understand school-based human service professionals’ perceptions about the relationship that Black families have with Southern schools and suggestions these professionals have about promoting better communication and understanding with Black families. The purpose of this qualitative generic study was to examine school human service professionals’ perceptions about the relationship that Black families have with schools and to gather suggestions about how they could promote communication and …
Staff Education To Improve Nurse Confidence In Managing Co-Occurring Conditions, Gloria Johnston
Staff Education To Improve Nurse Confidence In Managing Co-Occurring Conditions, Gloria Johnston
Walden Dissertations and Doctoral Studies
This Doctor of Nursing Practice (DNP) staff education project addressed a lack of confidence and training for nursing staff who care for patients with co-occurring substance use and mental health disorders. The practice problem identified at the local project site was the inconsistent care of this patient population. Addressing this gap was essential because inadequate training can reduce care quality among patients with co-occurring conditions. The practice-focused question for this project was: In nursing staff caring for patients with co-occurring mental health and substance use disorders, how does an evidence-based staff education program on integrated treatment approaches compare to standard …
Relationships Between Resource Utilization And Relapse In Rural Areas, Shane Sneddon
Relationships Between Resource Utilization And Relapse In Rural Areas, Shane Sneddon
Walden Dissertations and Doctoral Studies
In the United States, over 100,000 deaths were attributed to drug overdose in 2021. Relapse rates are higher in rural communities than in urban communities due to sociocultural barriers such as employment, limited entrainment activities, and peer pressure during social events. Previous research did not indicate whether the increase or decrease of Daily Living Assessment (DLA-20) scores have a correlation between community resource utilization and relapse. Using systems theory as the research lens, this study examined the correlation between use of community engagement resources and relapse as manifested by scores on the DLA-20. Data were collected from 100 individuals enrolled …
Emotional And Psychological Well-Being In Early Postmenopausal Women: A Phenomenological Study, Marjorie F. Leon
Emotional And Psychological Well-Being In Early Postmenopausal Women: A Phenomenological Study, Marjorie F. Leon
Walden Dissertations and Doctoral Studies
The purpose of this qualitative phenomenological study was to explore how early postmenopausal women experience and navigate emotional and psychological well-being during the postmenopausal transition. Although menopause has been widely examined as a biological process, women’s lived emotional and psychosocial experiences during the early postmenopausal period remain underexplored in psychological research. Conceptually informed by Engel’s biopsychosocial model, this study examined how biological, psychological, and social factors intersect in shaping resilience, identity, and coping during this transitional life stage. Thirteen women within 5 years of menopause onset participated in semi structured interviews. Data were analyzed using Braun and Clarke’s six-phase reflexive …
Cannabis Stigma And Symptom Management Considerations In Cancer Survivors: A Mixed-Methods Exploration Of Patient Perspectives, Sera Levy, Salimah Meghani, Brooke Worster, Colleen Kilanowski, Danielle Smith, Amy A. Case, Rebecca L. Ashare
Cannabis Stigma And Symptom Management Considerations In Cancer Survivors: A Mixed-Methods Exploration Of Patient Perspectives, Sera Levy, Salimah Meghani, Brooke Worster, Colleen Kilanowski, Danielle Smith, Amy A. Case, Rebecca L. Ashare
Department of Medical Oncology Faculty Papers
PURPOSE: This study aims to assess for indications of stigma and attitudes toward cannabis among cancer survivors (CS) who use or consider the use of cannabis.
METHODS: This study employed a convergent, parallel mixed methods design utilizing focus group and questionnaire data to assess the presence of stigma among a sample of CS (n = 23) who use (n = 10) and do not use (n = 13) cannabis to manage symptoms. CS were recruited from a multi-site observational study in the Northeast U.S. region that assesses cannabis use among oncology patients.
RESULTS: A total of 23 CS participated in …
Using A Place-Based Harms Typology To Inform Community Practice And Research: Illustrative Cases And Contexts, Jason Sawyer, Greer A. Hamilton, Amie Thurber, Amy Krings
Using A Place-Based Harms Typology To Inform Community Practice And Research: Illustrative Cases And Contexts, Jason Sawyer, Greer A. Hamilton, Amie Thurber, Amy Krings
School of Social Work Faculty Publications and Presentations
Place-based harms comprise direct threats to community wellbeing within the spaces where people live. These harms, rooted in structural and cultural violence, are codified in policies and programs that contribute to poverty, homelessness, over-policing and surveillance, and environmental injustices. This paper argues, although community practitioners are needed to work alongside communities impacted by place-based harms, there are critical tensions and tradeoffs embedded within the place-based strategies. To illustrate this, we draw from the Contested Places Typology and present cases that highlight key tensions, tradeoffs, and nuances associated with its six approaches: (1) Reparation, (2) Remembrance, (3) Regeneration, (4) Resistance, (5) …
The George-Anne Inkwell Edition, Georgia Southern University
The George-Anne Inkwell Edition, Georgia Southern University
The Inkwell
No abstract provided.
Town Hall: Gender Justice In Crimes Against Humanity Convention, Cardozo Law Institute In Holocaust And Human Rights (Clihhr)
Town Hall: Gender Justice In Crimes Against Humanity Convention, Cardozo Law Institute In Holocaust And Human Rights (Clihhr)
2026 Event Invitations
This town hall event will feature feminist experts, activists, and movements in the upcoming effort to ensure the Crimes Against Humanity treaty is gender-sensitive, intersectional, and survivor-centered.
After brief presentations by expert panelists on the process and key considerations for the treaty, the event will include an interactive session where participants can share insights, develop strategies, and mobilize to promote broad, cross-regional feminist participation at local, regional, and international levels. Join us in exploring how we can collaborate to make sure international law serves justice for women.
Ionic Liquid Pilocarpine Serves As Therapeutic Cosolvent And Permeation Enhancer For Glaucoma Medication, Ashish Trital, Lei Xu, Burhan Ates, Tzu Chen Wang, Vimalin Mani, Hu Yang
Ionic Liquid Pilocarpine Serves As Therapeutic Cosolvent And Permeation Enhancer For Glaucoma Medication, Ashish Trital, Lei Xu, Burhan Ates, Tzu Chen Wang, Vimalin Mani, Hu Yang
Chemical and Biochemical Engineering Faculty Research & Creative Works
The efficacy of hydrophobic ocular drugs is significantly hindered by their low bioavailability, for which poor water solubility is a major contributing factor. In this work, we synthesized pilocarpine-derived ionic liquid [Pilo-OEG] Cl (PO) and evaluated its cosolvent properties for the codelivery of the hydrophobic antiglaucoma drug brimonidine (BM) for glaucoma therapy. Pilocarpine was quaternized with 2-[2-(2-chloroethoxy) ethoxy] ethanol in a one-pot reaction to yield PO, and its structure was confirmed using 1H NMR and FT-IR spectroscopy methods and further characterized for its rheological property and thermal stability. The HET-CAM assay and cell viability study showed that PO was …
[Review Of] The Informational Animal: Humans, Technology, And The Competition For Reality, Katherine Roth
[Review Of] The Informational Animal: Humans, Technology, And The Competition For Reality, Katherine Roth
Library Articles and Research
A review of Alicia Wanless' The Informational Animal: Humans, Technology, and the Competition for Reality.
Gadolinium Nanoparticles: Emerging Platforms Beyond Imaging For Drug Delivery And Theranostics, Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer, Heyam Zayed, Paris Marabut, Keykavous Parang
Gadolinium Nanoparticles: Emerging Platforms Beyond Imaging For Drug Delivery And Theranostics, Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer, Heyam Zayed, Paris Marabut, Keykavous Parang
Pharmacy Faculty Articles and Research
Gadolinium nanoparticles (GdNPs) have gained increasing attention as multifunctional metal-based nanoplatforms that extend far beyond their traditional use as magnetic resonance imaging (MRI) contrast agents. Their specific magnetic properties, tunable physicochemical features, and tunable biocompatibilities with biocompatible coatings give them great potential as drug delivery and theranostic applications. They offer greater stability, lower systemic toxicity, and more surface modification options compared to molecular gadolinium chelates. The functionalized GdNPs not only show excellent properties as drug carriers for their specific indications but also serve as agents in various imaging modalities with superior therapeutic efficacy by means of radio sensitization and magnetically …
Pd-L1, Tumor Mutational Burden, And Microbiome Signatures As Predictors Of Durable Immunotherapy Response In Metastatic Lung Cancer: A Multi-Omic Cohort Study, Wei Zhang, Li Chen, Minghao Liu, Xiaoyan Huang
Pd-L1, Tumor Mutational Burden, And Microbiome Signatures As Predictors Of Durable Immunotherapy Response In Metastatic Lung Cancer: A Multi-Omic Cohort Study, Wei Zhang, Li Chen, Minghao Liu, Xiaoyan Huang
Muthanna Medical Journal
Background: Immune checkpoint inhibitors (ICIs) have significantly improved outcomes in metastatic non–small cell lung cancer (NSCLC), yet durable clinical benefit (DCB) is achieved in only a subset of patients. Established biomarkers such as PD-L1 expression and tumor mutational burden (TMB) incompletely predict response, while emerging evidence suggests that gut microbiome composition may further modulate immunotherapy efficacy. We conducted a prospective multi-center study in China to evaluate the independent and integrated predictive value of PD-L1, TMB, and microbiome signatures for durable immunotherapy response. Methods: In this prospective cohort study, 286 patients with metastatic NSCLC receiving PD-1/PD-L1 inhibitors were enrolled across three …
Structural Insights Into Host-Pathogen Interactions Of Coronaviruses And Alphaviruses, Lucas Adams
Structural Insights Into Host-Pathogen Interactions Of Coronaviruses And Alphaviruses, Lucas Adams
Arts & Sciences Graduate Student Theses and Dissertations
The co-evolution of virus and host may partly be understood in terms of “cross-recognition”; that is, as a virus evolves to recognize and infiltrate a suitable cellular environment, the host reciprocally has evolved to recognize and thwart such an invasion. While this interplay is complex, audacious structural biologists may reduce it to discrete physical interactions between the virus and specific host factors, such as cognate receptors (i.e., viral recognition of host) or antibodies (i.e., host recognition of virus). These interactions underlie basic features of viral infection, including cellular tropism and antiviral immunity, as well as critical phenomena of viral evolution, …