Digital Commons Network^™

Multimodal Imaging Reveals A Lysosomal Drug Reservoir That Drives Heterogeneous Distribution Of Parp Inhibitors, Carmen R Moncayo, Lauren Pendergast, Priyanka Verma, Et Al.

2020-Current year OA Pubs

For all drugs, effective target engagement requires sufficient intracellular concentrations of drug to be reached, but whether tumour heterogeneity impacts drug distribution and efficacy is poorly studied. Poly (ADP-ribose) polymerase (PARP) inhibitors have transformed treatment opportunities for women with high-grade serous ovarian carcinoma, but resistance remains a clinical hurdle in this highly heterogeneous tumour type. Here, we present a patient-derived explant multi-modal imaging pipeline, which demonstrates that cell-intrinsic PARP inhibitor accumulation is highly variable, both between patients and within tumours. Spatial transcriptomics reveals enrichment of apoptotic and lysosomal signatures in high-drug regions. Rucaparib, an intrinsically fluorescent PARP inhibitor, accumulates heterogeneously …

Effectiveness Of Updated 2023-2024 (Monovalent Xbb.1.5) Covid-19 Vaccination Against Sars-Cov-2 Omicron Xbb And Ba.2.86/Jn.1 Lineage Hospitalization And A Comparison Of Clinical Severity-Ivy Network, 26 Hospitals, 18 October 2023-9 March 2024, Kevin C Ma, Jennie H Kwon, Bijal Parikh, Et Al.

2020-Current year OA Pubs

BACKGROUND: Assessing variant-specific coronavirus disease 2019 (COVID-19) vaccine effectiveness (VE) and severity can inform public health risk assessments and decisions about vaccine composition. BA.2.86 and its descendants, including JN.1 (referred to collectively as "JN lineages"), emerged in late 2023 and exhibited substantial divergence from co-circulating XBB lineages.

METHODS: We analyzed patients hospitalized with COVID-19-like illness at 26 hospitals in 20 US states admitted 18 October 2023-9 March 2024. Using a test-negative, case-control design, we estimated effectiveness of an updated 2023-2024 (monovalent XBB.1.5) COVID-19 vaccine dose against sequence-confirmed XBB and JN lineage hospitalization using logistic regression. Odds of severe outcomes, including …

Multimorbidity Profiles And Severe In-Hospital Outcomes In Adults With Respiratory Syncytial Virus, Kevin C Ma, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

BACKGROUND: Adults hospitalized with acute respiratory infections, including respiratory syncytial virus (RSV), often have multiple underlying conditions. Few data are available on the combined effect of conditions on risk of severe outcomes from RSV disease.

METHODS: We enrolled adults hospitalized with RSV at 26 hospitals in 20 US states admitted January 2022-July 2024. Seventeen underlying conditions were selected after excluding those with rare prevalence (≤1%) or high pairwise correlation (≥0.7). We applied Bayesian profile regression to identify profiles of conditions associated with increased risk of RSV severe outcomes, stratifying among adults aged 18-59 and ≥60 years.

RESULTS: We analyzed data …

Dexmedetomidine On Supraventricular Tachycardia In Critical Illness: A Time-Dependent Propensity Score Matching Study, Qiaonan Zhong, Marin H Kollef, Patrick G Lyons, Andrew P Michelson

2020-Current year OA Pubs

BACKGROUND: Supraventricular tachycardia affects many critically ill patients. Dexmedetomidine, a commonly used sedative, has sympatholytic and vagotonic effects that may alter atrioventricular nodal conduction and contribute to SVT. We aim to determine the association between dexmedetomidine exposure and clinically significant supraventricular tachycardia in a heterogeneous cohort of mechanically ventilated, critically ill adults. METHODS: This retrospective cohort study included critically ill patients from 11 hospitals admitted between July 2018 and October 2022, who were intubated within 48 h of admission. The primary exposure was intravenous dexmedetomidine. The primary outcome was occurrence of clinically significant supraventricular tachycardia, defined as heart rate > 100 …

Avian Influenza Preparedness In Ghana: A Cross-Sectional Assessment Of Knowledge, Attitudes, And Practices Among Residents Of Nsawam-Adoagyiri Municipality, Eastern Region, Christopher Yaw Dumevi, George Boateng Kyei, Et Al.

2020-Current year OA Pubs

BACKGROUND: Avian influenza (AI) represents a persistent threat to public health, food security, and livelihoods in Ghana, where outbreaks of H5N1 and H9N2 have occurred. This cross-sectional study evaluated the knowledge, attitudes, and practices (KAP) related to avian influenza among residents of the Nsawam-Adoagyiri Municipality; an area characterized by intensive poultry production with the aim of delineating deficits in community-level preparedness and guiding evidence-based public health interventions. METHODS: A community-based cross-sectional study was conducted from May to July 2025 using a four-stage sampling technique. We surveyed 321 adults via structured questionnaires, evaluating socio-demographics and KAP related to AI. Scale reliability …

Factors Associated With Telemedicine Use By Cardiologists For Medicare Beneficiaries In 2022 To 2023: An Observational Study, Samantha Harris, R J Waken, Fengxian Wang, Khavya C Avula, Rishi K Wadhera, Jose F Figueroa, E John Orav, Uchenna Ofoma, Karen E Joynt Maddox

2020-Current year OA Pubs

BACKGROUND: During the COVID-19 pandemic, the Centers for Medicare and Medicaid Services created a waiver to reimburse telemedicine services. It is important to understand factors that facilitate incorporation of telemedicine into ongoing cardiovascular practice.

METHODS: This was a retrospective cohort study of telemedicine and office visits delivered by cardiologists between January 1, 2022, and December 31, 2023, for Medicare beneficiaries. We calculated the adjusted incidence rate ratio (aIRR) of telemedicine visits, representing the proportion of a physician's visits delivered by telemedicine, to identify factors associated with telemedicine use.

RESULTS: There were 23 334 physicians in our cohort; they were predominantly …

Exploring The Influence Of Environmental Motivations On Consumer Attitudes And Purchase Intentions Toward Upcycled Foods, Peng Lu, Jennifer Waldeck, Keith Weber, Hualu Zhou

Communication Faculty Articles and Research

Food loss and waste (FLW) present pressing environmental and economic challenges. Upcycling technologies provide a sustainable pathway by transforming food by-products into value-added products; however, consumer acceptance remains a critical barrier. Guided by Self-Determination Theory (SDT), this study investigates how environmental motivations influence consumers’ attitudes and purchase intentions toward milk enriched with upcycled peanut skins. Data were collected from a nationally representative sample of 1488 U.S. adults. Structural equation modeling (SEM) was employed to test hypothesized relationships among motivational constructs, and cluster analysis was used to identify consumer segments based on motivational profiles. The results show that intrinsic motivation and …

Spartan Daily, March 17, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 23

System-Level Drivers For The Adoption Of Evidence-Based Practices In Schools, Marijne Medhurst, Jen Jackson, Pru Mitchell, Romany Manuell

School and system improvement

This report outlines strategies that education system leaders can use to support the adoption of evidence-based teaching practices within schools, recognising the importance of teaching quality to lift student outcomes. It is based on an adapted systematic review of available evidence conducted by the Australian Council for Educational Research (ACER) for and in collaboration with the Australian Education Research Organisation (AERO). The report begins by identifying considerations or approaches that system leaders can apply to selecting strategies to support schools, to ensure that they are culturally reflexive, aware of contextual enablers and barriers, and aligned with the approaches evident in …

Legal Decision Biases In Gpt: A Comparison With Human Judgment, Toscane F. Bessis, Andy J. Wills, Bartosz W. Wojciechowski, Lee C. White, Emmanuel M. Pothos

School of Psychology

Legal decision-making is expected to meet high standards of consistency and rationality, yet human judgments in this domain are known to be influenced by procedural factors such as evidence order and intermediate evaluations. Recent work has shown that even legal professionals, including judges, are susceptible to such biases when assessing criminal cases. This raises a critical question: do large language models, which are increasingly proposed as decision-support tools in legal contexts, exhibit similar procedural biases—and if so, can these biases be mitigated? To address this question, we tested GPT-4o and GPT-5.2 using a controlled legal judgment task adapted from prior …

Efficacy And Safety Of Approved Cellular Therapies And Bispecific Antibodies In Solid Tumors: The Current State, Rabab Zehra Jafry, Saba Bilal Qamar, Sohaib Irfan, Muhammad Abbas Abid, Virginia Mohlere, Neha Maithel, Syed Hassan Jafri, Sanjay Awasthi, Samer Srour, Irfan A Vaziri, Muhammad Bilal Abid

Faculty, Staff and Student Publications

Cancer immunotherapy is a broad term including naked antibodies, bispecific antibodies (BsAbs), immune-checkpoint inhibitors (ICIs), chimeric antigen receptor T-cell (CAR-T) therapy, cancer vaccines, activated immune cells, and allogeneic hematopoietic cell transplantation. Recent advances in immune-engaging T-cell therapies have led to significant progress in novel treatments across various cancer types, resulting in prolonged patient survival, mainly in patients with hematologic malignancies. Several CAR T-cell constructs and BsAbs have been approved by regulatory authorities worldwide for relapsed, refractory leukemia, non-Hodgkin lymphoma, and multiple myeloma. Solid tumors are characterized by an immunosuppressive, fibroinflammatory tumor microenvironment (TME) and immune-suppressive cells, such as regulatory T-cells …

Fungal Meningitis In Us Patients Who Received Epidural Anesthesia In Matamoros, Mexico, Dallas J Smith, Elizabeth Misas, Jeremy A W Gold, Nicole Evert, Thi Dang, Emilie Prot, Simone Godwin, Julieanna Rivas, Jessica Pearson, Lori Koenecke, Nirma D Bustamante, Maria Julia Marinissen, Gabriel Garcia Rodriquez, Irma López-Martínez, Caitlyn Lutfy, Samantha Williams, Axel A Vazquez Deida, Katrina M Byrd, Julian A Villalba, Sarah Reagan-Steiner, Lindsay Parnell, Lalitha Gade, Romney M Humphries, Nathan P Wiederhold, Charles Y Chiu, Joshua A Lieberman, Anastasia P Litvintseva, Tom Chiller, Luis Ostrosky-Zeichner, Fungal Meningitis Response Team

Faculty, Staff and Student Publications

Background: Fungal meningitis outbreaks are rare and entail high mortality rates. Beginning May 2023, we investigated fungal meningitis caused by Fusarium solani species complex occurring in US patients who received epidural anesthesia in Matamoros, Mexico.

Methods: Early epidemiological information suggested US patients with suspected fungal meningitis had undergone mostly cosmetic procedures under epidural anesthesia performed in 2 Matamoros clinics. US patients known to have received surgery at these clinics during 1 January-13 May 2023 (clinic closures date) were identified and notified by public health officials. Epidemiological and clinical data were used to update diagnostic and clinical guidance for outbreak response, …

Sixty Years Of Observations And Future Projections Of Nine Declining North American Glaciers, Edward G. Josberger, Robert Shuchman, Ray H. Watkins

Michigan Tech Publications

Warming climate has greatly affected the stability of the world's glaciers. In 1957, as part of the International Geophysical Year, nine North American glaciers were surveyed in great detail so that they could serve as future benchmarks. Since their initial survey, these nine benchmark glaciers have drastically decreased in volume and areal extent. This is a direct result of global warming. However, the exact amount of their change has never been fully documented and predictions of their lifespans in the wake of continued temperature increase has never been projected. In this study, we utilized advanced satellite techniques to quantify changes …

Structural Brain Analysis In Focal Upper Limb Dystonia, Danilo Donizete De Faria, Artur José Marques Paulo, Joselisa Péres Queiroz De Paiva, Anderson M. Winkler, Vanderci Borges, Sonia Maria Azevedo Silva, Henrique Ballalai Ferraz, Patricia De Carvalho Aguiar

Human Genetics Publications

Prior structural magnetic resonance imaging (MRI) studies that investigated structural alterations in focal dystonia have reported inconsistent findings, potentially due to methodological limitations or sample heterogeneity. This work investigates gray and white matter changes in patients with upper limb dystonia using T1-weighted images and diffusion tensor imaging (DTI). Imaging data collected with MRI at 3T from 28 right-handed individuals with right upper limb dystonia and 29 healthy controls were analyzed. T1-weighted images were analyzed using FreeSurfer to examine cortical thickness, volume and area. DTI data were assessed using tract-based spatial statistics, regions of interest (ROI) analysis and probabilistic tractography. ROI …

Using Mobile Devices To Support Outdoor Stem Learning In Rural Contexts: An Embedded Mixed-Methods Study, Jayson Seaman, Amanda Bastoni, Andrew D. Coppens, Cindy L. Hartman, Courtney Lachaine, Katelyn Moscouver, Janet Gronneberg

Faculty Publications

Background: Rural youth face barriers to involvement in effective Science, Technology, Engineering, and Math (STEM) learning experiences, leading to persistent underrepresentation in STEM fields. Purpose: This study examined the feasibility of using mobile devices to engage rural youth in informal STEM learning (ISL) during free-choice, outdoor recreational activities. We assessed outcomes of a 10-month intervention related to STEM interest, identity, and future planning. Method: Fifty-four youth ages 12 to 17 completed monthly STEM challenges delivered via a mobile platform, aligned with connected learning and free-choice learning principles. Surveys measured pre/post changes in STEM supports, STEM confidence, and …

Does Early Or Timely Diagnosis Benefit People With Dementia And Their Carers? A Systematic Review, Ben Hicks, Orla Phipps, Martha Pusey, Pauline Mcdonald, Courtney-Ann Dennis, Katie Barnard, Sube Banerjee, Nicolas Farina

Peninsula Medical School

Background: Global dementia policies advocate for early or timely diagnosis, yet evidence on benefits or harms remains limited. This systematic review evaluates quantitative evidence comparing outcomes of early versus late and timely versus untimely dementia diagnoses. Methods: Following PRISMA guidelines, the protocol was registered on PROSPERO. Comprehensive searches of PsycINFO, Medline, Embase, SCOPUS, and CINAHL were conducted without date restrictions. Eligible studies defined diagnostic timing and examined associations with outcomes for people with dementia and/or carers. Quality was appraised using the QuADS tool, and data were narratively synthesised. Results: Four studies (2018–2021) met inclusion criteria, encompassing 37,341 individuals with dementia …

Decision-Making Tool For Onshore Vs. Offshore Hydrogen Production From Offshore Wind, Jessica Guichard, Robert Rawlinson-Smith, Danny Coles, Deborah Greaves

School of Engineering, Computing and Mathematics

This paper presents optimisation studies for the combination of high efficiency reversible solid oxide cells (rSOC) with offshore wind farms in the Celtic Sea. Reversible systems can be used both in electrolyser and fuel cell mode, allowing potential benefits from switching between modes depending on the instantaneous condition of the electricity and hydrogen markets. The purpose of these studies is to determine the most cost-efficient method to combine rSOC with offshore wind whilst matching electricity supply with demand. For this, a model in Python for Power System Analysis (PyPSA) is set up which optimizes production, storage and transport infrastructure for …

Investigation On The Mechanical Behavior Of Coconut Leaf Sheath And Midrib Of Coconut Leaf Reinforced Epoxy Composites, Dawit Tafesse Gebreyohannes

Faculty, Staff and Students Publications

Over the last two decades, researchers have focused on natural reinforcement composites as choice to conventional and man-made fiber composites due to their enhanced properties. While many research has studied the mechanical characteristics of renewable fiber composites, only limited work has been done on coconut fiber–based composites. In particular, no research has explored the reinforcement of two specific coconut fibers: coconut leaf sheath (CLS) and the midrib of coconut leaf (MCL). The aim of this study is to evaluate the mechanical characteristics of composites incorporated with CLS and MCL. Composite specimens were prepared by reinforcing MCL at 10%, 15% and …

Sleep Disturbances In Patients With Cushing Syndrome And Mild Autonomous Cortisol Secretion: A Cross-Sectional Study, Sarina Ahmadian, Vanessa Fell, Dana Erickson, Anina F Peersen, Sara J Achenbach, Elizabeth J Atkinson, Irina Bancos

Faculty, Staff and Students Publications

Context: The impact of active hypercortisolism on sleep is incompletely characterized. Studies report impaired sleep in patients with Cushing syndrome (CS). Patients with mild autonomous cortisol secretion (MACS) demonstrate mild nocturnal hypercortisolism that could impact sleep.

Objectives: To characterize sleep abnormalities in patients with CS and MACS using the Pittsburgh Sleep Quality Index (PSQI), identify factors associated with poor sleep, and compare sleep abnormalities in patients with MACS vs referent subjects.

Methods: We conducted a single-center cross-sectional study of adults with active CS and MACS. Clinical and biochemical severity scores for hypercortisolism were calculated. Parallelly, we enrolled referent subjects. Quality …

2026 Clinical Practice Guideline Update By The Infectious Diseases Society Of America And The Pediatric Infectious Diseases Society On The Management Of Community-Acquired Pneumonia In Infants And Children Older Than 3 Months Of Age: The Use Of Tpa And Dnase Or Tpa Alone For Fibrinolysis, Michael D Cabana, Claudia Espinosa, Todd A Florin, Jeffrey S Gerber, Michelle Gill, Debra L Palazzi, Mark Sawyer, Angela M Statile, Derek J Williams, Sheena Patel, Mark I Neuman, Samir S Shah

Faculty, Staff and Students Publications

This paper is part of a larger clinical practice guideline on the diagnosis and management of parapneumonic effusion and empyema in children, developed by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. In this report, the panel provides recommendations for intrapleural fibrinolysis with tissue plasminogen activator (tPA) alone over tPA and dornase alfa (DNase) in children (3 months to 18 years) with complicated parapneumonic effusion and empyema. The panel's recommendations are based upon evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according …

2026 Clinical Practice Guideline Update By The Infectious Diseases Society Of America And The Pediatric Infectious Diseases Society On The Management Of Community-Acquired Pneumonia In Infants And Children Older Than 3 Months Of Age: The Choice Of Chest Tube Size, Michael D Cabana, Claudia Espinosa, Todd A Florin, Jeffrey S Gerber, Michelle Gill, Debra L Palazzi, Mark Sawyer, Angela Statile, Derek J Williams, Sheena Patel, Mark I Neuman, Samir S Shah

Faculty, Staff and Students Publications

This paper is part of a larger clinical practice guideline on the diagnosis and management of parapneumonic effusion and empyema in children, developed by the Infectious Diseases Society of America. In this paper, the panel provides recommendations on the appropriate size of thoracostomy tube for drainage. The panel's recommendations are based upon evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach.

Regression Dressed As Reform: Bharatiya Nyaya Sanhita And The Shifting Contours Of Political Speech, Anushka Singh

National Law School of India Review

This paper examines the shifting contours of criminal law in relation to political speech, with a focus on Section 152 of the Bharatiya Nyaya Sanhita (BNS). It advances three arguments. First, the decolonising narrative behind deleting sedition glosses over substantive continuities between colonial and post-colonial periods, with Section 152 BNS refashioning the colonial-era bifurcation between ‘sedition’ and ‘sedition-like’ activity. The BNS provision represents a backslide in the way it converges the various legal and political connotations of sedition from colonial to contemporary times, creating a new criminal category constructed through popular political-extra-legal discourses. Second, Section 152 BNS borrows from the …

Lessons Learned: Ignazio Visco, Mercedes Cardona

Journal of Financial Crises

Ignazio Visco served as deputy director general (the equivalent of deputy governor) of the Bank of Italy during the Global Financial Crisis of 2007–09 (GFC) and as governor during the European Sovereign Debt Crisis in 2011 (SDC). During his multidecade tenure at the bank, he held several positions and served under nine prime ministers before stepping down in 2023. Although Italy had the third-largest economy in the eurozone, its banking sector had little exposure to mortgages, which resulted in its being somewhat less impacted by the GFC than other countries. However, the SDC had a severe impact. With the assistance …

Lessons Learned: Masaaki Shirakawa, Mercedes Cardona, Benjamin Hoffner

Journal of Financial Crises

Masaaki Shirakawa became governor of the Bank of Japan (BOJ) in 2008, after a long tenure at the central bank. His career spanned a series of significant crisis events in Japan’s economic history, including the economic boom in the 1980s, which was followed by a period of stagnation characterized by low GDP growth, multiple recessions, and persistent deflation. Shirakawa led the BOJ’s response during the Global Financial Crisis of 2007–09 (GFC). He also initiated the central bank’s contingency plan in response to the 2011 tsunami, earthquake, and Fukushima nuclear disaster before stepping down near the end of his term in …

Lessons Learned: Eugen Rădulescu, Benjamin Hoffner

Journal of Financial Crises

Eugen Rădulescu has worked at the National Bank of Romania (NBR) since 1990 in various roles covering monetary policy, foreign exchange, and supervision. During his tenure, he contributed to the NBR’s work to fortify Romanian’s post-communist banking laws and the operational structure of its financial system to bring it up to the European standard, enabling Romania to join the European Union (EU) in 2007. Following the Global Financial Crisis of 2007–09 (GFC), Rădulescu was named director of the NBR’s Financial Stability Department and has served in this role until June 2023,when he became senior adviser to the governor of the …

Lessons Learned: Christos Gortsos, Rosalind Z. Wiggins

Journal of Financial Crises

Christos Gortsos has been a professor of law at the National and Kapodistrian University of Athens since 2016 as well as a visiting professor of law at various other European institutions. Previously, he was a professor of international economic law and held other positions at Panteion University of Social and Political Sciences in Athens. He has taught and written extensively on European and international banking and financial law, capital markets regulation, and law and economics. From 2000 to 2017, he served as secretary of the Hellenic Bank Association. He advises the European Parliament on bank resolution and is vice president …

Black Swans And Financial Stability: A Framework For Building Resilience, Daniel J. Barth, Stacey L. Schreft

Journal of Financial Crises

This article refines the concept of black swans, typically described as highly unlikely and catastrophic events, to be internally consistent. It explores features of the financial system that prevent the eradication of black swans. The main implication is the need to enhance the financial system’s resilience to withstand unforeseen events rather than focus on past crises. The article introduces a “resilience principle” for designing official-sector policies that can achieve such goals. The principle calls for policies that are adaptable, universal, and systemic. The article provides examples of policies with these features, assuming that the official sector is not better positioned …

How The Fdic Sourced Crisis-Time Fed Funding Through The Failed Banks Of 2023, Steven Kelly

Journal of Financial Crises

During the Banking Crisis of 2023, the Federal Deposit Insurance Corporation (FDIC) had to contend with the liquidity demands of the second-, third-, and fourth-largest bank failures in US history, all in a compressed timeframe. Facing uncertainty over its liquidity needs, particularly if additional banks were to fail, and optics and political challenges over accessing its standing credit lines with the Treasury—which itself was brushing against the federal debt ceiling—the FDIC relied on two creative forms of financing itself. First, the agency kept open the Federal Reserve (Fed) loans taken on by the failed banks, eschewing its standard practice of …

Hukum Yang Harus Dipakai Dalam Perkara Arbitrase Internasional, Prof Mr. Dr. S. Gautama

Jurnal Hukum & Pembangunan

Abstract

Beberapa Sumbangan Antropologi Dalam Usaha Pengembangan Hukum Nasional, Prof Dr. T.O. Ihrom;, S.H. , M.A.

Jurnal Hukum & Pembangunan

Abstract