Digital Commons Network^™

Lipidomic Profiles Associated With Treatment Related Hepatotoxicity In Children With Acute Lymphoblastic Leukemia., Emily J Mason, Jeremy M Schraw, John P Woodhouse, M Monica Gramatges, Kevin J Williams, Baojiang Chen, Melissa B Harrell, Olga A Taylor, Michael E Scheurer, Philip J Lupo, Karen R Rabin, Joanna S Yi, Van Huynh, Steven D Mittelman, Etan Orgel, Austin Brown

Faculty, Staff and Students Publications

Introduction: Treatment for childhood acute lymphoblastic leukemia (ALL) can result in hepatotoxicity. Despite being a common complication of ALL therapy, mechanisms and biomarkers of treatment-associated hepatotoxicity (TAH) are not well described.

Methods: We conducted lipidomic profiling to identify plasma lipids associated with TAH in children receiving ALL therapy utilizing a nested case-control framework. TAH was defined as (1) transaminitis: ALT/AST ≥ CTCAE grade 3, and/or (2) conjugated hyperbilirubinemia: > 3.0 mg/dL during induction therapy or > 2.0 mg/dL post induction. A total of 90 patients (45 matched pairs) treated at Texas Children's Hospital between 2012 and 2021 were selected for lipidomic profiling, …

Spatiotemporal Histogenesis Of The Developing Human Cerebellum Reveals Dynamic Layering Of Bergmann Glia, Guanyi He, Simon Du, Henry Tan, Sri Yellampally, Anders W Erickson, Virginia Fernandez, Ferechte Encha-Razavi, Kimberley A Phillips, Christine Haberler, Nicole Amberg, Victor Borrell, Paul A Northcott, Michael D Taylor, Kathleen J Millen, Parthiv Haldipur

Faculty, Staff and Students Publications

Bergmann glia (BG) are a specialized glial population essential for cerebellar development, yet their developmental timeline and molecular identity in the human cerebellum remain poorly understood. Here, we combined detailed histopathological analysis with spatial transcriptomics and single-nucleus RNA sequencing to generate a developmental atlas of human cerebellar BG. Histology revealed that BG emerge around 11 post-conception weeks (PCW), initially serving as a scaffold for Purkinje cells (PCs) migrating into the PC layer of the cerebellar cortex. Following the establishment of a multilayered PC arrangement, BG form a distinct parallel layer separated from the PCs by the lamina dissecans (LD), with …

Assessing Working Musicians’ Perspectives Of Need And Barriers Regarding Lay Harm Reduction Efforts For Substance-Related Harm In South Carolina, Sarah Grace Frary

Faculty Publications

Background

Harm Reduction (HR) approaches applied to substance use aim to decrease the toxic consequences of overdose. The addition of xylazine and benzodiazepines to fentanyl, the primary opioid in the US drug supply, increases the likelihood of overdose. Likewise, adding fentanyl to other popular substances, such as cocaine and methamphetamine, has further driven the exponential increase in opioid and stimulant overdoses. Engaging lay community members in HR efforts may help to combat the overdose crisis. Substance use is common in live music settings, and working musicians may be uniquely positioned within “the scene” – individuals who populate specific cultural niches …

Re: Conditional Approval Letter With Comments For Butte Priority Soils Operable Unit (Bpsou) Draft Final 2026 Interim Site-Wide Surface Water Monitoring Quality Assurance Project Plan (Qapp) (Dated February 4, 2026), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Community-Associated Quinolone-Resistant And Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli Isolates Are Similar To Clinical Infection Isolates By Sequence Type And Resistome, Emily E Benedict, Wesley Agee, Tiffany Hink, Katelyn L Parrish, Kimberly A Reske, Kate Peacock, Rachel E Bosserman, Alyssa Valencia, Akshay Saluja, Elianora Ovchiyan, Olivia Arter, Kevin Jolani, Erik R Dubberke, Gautam Dantas, Jennie H Kwon

2020-Current year OA Pubs

No abstract provided.

Associations Between The Microbiome And Immune Responses To An Adenovirus-Based Hiv-1 Candidate Vaccine Are Distinct Between African And Us Cohorts, Yuhao Li, Daniel J Stieh, Lindsay Droit, Andrew Hyoungjin Kim, Rachel Rodgers, Kathie A Mihindukulasuriya, Leran Wang, Maria G Pau, Olive Yuan, Herbert W Virgin, Dan H Barouch, Megan T Baldridge, Scott A Handley

2020-Current year OA Pubs

Optimization of prophylactic vaccine regimens to elicit strong, long-lasting immunity is an urgent need highlighted by the COVID-19 pandemic. Stronger vaccine immunogenicity is frequently reported in individuals living in high-income countries compared to individuals living in low- and middle-income countries. While numerous host genetic and immune factors may influence vaccine responses, geographic restrictions to vaccine effectiveness may also be influenced by the intestinal microbiota, which modulates host immune systems. However, the potential role of the gut microbiota on responses to HIV-1 vaccines has not yet been explored. We analyzed the bacteriome by targeted 16S sequencing and the virome by virus-like …

Variable And Conserved Features Of Copy-Back Viral Genome Populations Generated De Novo During Sendai Virus Infection, Yanling Yang, Yuchen Wang, Carolina B López

2020-Current year OA Pubs

Copy-back viral genomes (cbVGs) are generated during the replication of negative-sense RNA viruses when the polymerase drops off from the genome and reattaches to the nascent strand. cbVGs have strong immunostimulatory properties and impact infection outcomes. Despite their importance, the composition and mechanisms of

Accurate Interpretation Of Within-Host Dissemination Using Barcoded Bacteria, Rachel T Giorgio, My T Le, Ting Zhang, Caitlyn L Holmes, Karthik Hullahalli

2020-Current year OA Pubs

Bacterial dissemination across tissues is a critically important process influencing infection outcomes. Monitoring within-host dissemination is challenging because conventional measures of bulk bacterial burden cannot distinguish between lineages that are shared between tissues and those that replicate locally. This limitation can be overcome using barcoded bacteria, where deep sequencing of the barcode locus and comparisons of barcodes between tissues define which lineages spread within the host. Numerous studies have used barcoded bacteria to generate high-resolution maps of dissemination. However, since multiple cells in the infectious inoculum can contain identical barcodes, inferences about dissemination can be confounded when distinct lineages from …

Hungarian Steps Towards Freedom Of Contract, Tamás Gyulavári

Comparative Labor Law & Policy Journal

Since 1992, derogations have been allowed in individual agreements in favour of employees, with minor exceptions. The labour law reform of 2012 brought about the comprehensive reform of the hierarchy of labour law sources. As for individual agreements of the parties, the Labour Code retained the traditional rule of favourability, however, with a growing number and importance of exceptions allowing in peius derogations. Section II sets the scene by explaining the legal hierarchy of labour law sources, including derogations in collective agreements, agreements of the parties, and the meaning of the “more favourable rule.” Against this background, Section III delves …

Lessons From A Scoping, Librarian-Assisted Literature Review: How Lgbtq+ People Experience Institutions Of Health, Samuel S. N. Theesfeld, Erica Schorr

Creating Healthy Work Environments (CHWE)

Those that identify as a sexual and gender minority, that is, lesbian, gay, bisexual, transgender, queer, or any other appropriate term (LGBTQ+), experience life, health, and healthcare that is rich in multiplicity. As nurses and health professionals, the narratives of our patients are indeed paramount. Whether it’s the political marginalization of gay people, the increase in U.S. domestic hate crimes, or the fragility and minority stress in which sexual minority men in Tajikistan receive healthcare, our call to understand this population remains consistent.^1-5 This call was explored by the primary author in a scoping literature review that was conducted …

Book Review: The Russian-Ukrainian War, 2023: A Second Year Of Hell And The Dawn Of Drone Warfare, Paul Andrew Lushenko

Parameters Bookshelf – Online Book Reviews

Author: John S. Harrel

Reviewed by: Paul Andrew Lushenko, professorial lecturer, Elliott School of International Affairs, The George Washington University

In the brutal second year of Russia’s invasion, Ukraine faced relentless assaults while pioneering the battlefield use of drones in a desperate bid for survival. Retired General John S. Harrel delivers a gripping account of mechanized warfare’s evolution, where unmanned aerial vehicles reshaped tactics from the trenches to the Black Sea. This vivid chronicle captures the chaos, innovation, and global reverberations of a war that redefined modern combat.

©2026 Paul Andrew Lushenko

Resilience In Young People Living With Hiv In Low To Middle-Income Countries: A Critical Review, Lily R. Bastian

Creating Healthy Work Environments (CHWE)

Background: According to the Joint United Nations Programme on HIV/AIDS (UNAIDS, 2023), 39 million people globally were living with HIV, and 1.3 million people became infected in 2022. Of those, 27% were young people (ages 15-24), including 210,000 young women and 140,000 young men. HIV is an expanding epidemic despite an overall reduction in the annual incidence percentage and the significant strides that have been made towards prevention of transmission and treatment with antiretroviral therapy (ART). Low to middle-income countries (LMICs) are especially vulnerable to the HIV/AIDs epidemic. The identification and promotion of resilience factors could play a crucial role …

The Recent Rash Of Biotechnology Risks: A Call To Fortify Force Capability, James Giordano

Strategic Insights

This commentary looks at recent incidents that highlight emerging national security risks posed by advances in biotechnology and synthetic biology. The discovery of suspicious biological materials stored in a residential facility in Reedley, California, and reports that a rare neurotoxin may have been used against Russian opposition leader Alexei Navalny illustrate how barriers to acquiring and operationalizing biological and chemical agents are declining. Tools such as gene editing, modular DNA assembly, laboratory automation, and AI-enabled biological design are expanding the range of actors capable of producing or modifying bioagents while complicating detection and attribution. Strengthened biodefense measures, including “biosecurity-by-design,” improved …

Executive Committee - Agenda, 02/17/2026, Academic Senate

Academic Senate Agendas

No abstract provided.

When Tokenized Real-World Assets Collide With Real World, Biying Cheng, David J. Reiss

Cornell Law Faculty Publications

The city of Detroit filed a public nuisance lawsuit in July of last year in the Michigan Circuit Court for the Third Judicial Circuit against Real Token, its co-founders and 165 affiliated entities, alleging building code and safety violations across over 400 Detroit residential properties.[1] RealT is a blockchain real estate platform that sells fractional interests in individual U.S. rental properties through the issuance of crypto security tokens.

On July 22, the judge issued a temporary restraining order — later converted into a preliminary injunction on Nov. 4 — barring RealT from collecting rent, pursuing evictions without a certificate of …

Stress Management And Resiliency Program For Accelerated Bsn Students In A Dedicated Education Unit, Marcela Alvarez-Lazo

Creating Healthy Work Environments (CHWE)

Background: About 12-25% of newly graduated nurses will leave nursing within the first-year post-graduation. These statistics surrounding nursing retention are alarming and are not expected to improve, as 900,000 nurses are projected to depart from nursing by the year 2027. Addressing the underlying issues are critical in making a real impact to increase retention.

Aim: This quality improvement project aims to integrate a Stress Management and Resiliency. Program for accelerated BSN nursing students. The project aims to apply a CBT-based program to increase the knowledge of principles of stress and resilience for nursing students and preceptors, decrease stress, increase resilience, …

Caregiving Experiences Of Latino And Caucasian Dementia Caregivers Amid Pandemic, Alexis Ross

Creating Healthy Work Environments (CHWE)

More than 6.7 million American older adults are diagnosed with Alzheimer’s and related dementias (Alzheimer’s Association, 2023). Caregivers for community dwelling persons living with dementia (PWD) are usually family members such as a spouse or offspring. Resources such as adult day care centers, in-home supportive services, and family support groups were widely used before the COVID-19 pandemic. Following the California ‘Stay-At-Home’ administrative order during the early pandemic, such necessary support services were forced to close.

The purpose of this study was to identify similarities and differences in caregiving experiences between Latino caregivers and non-Hispanic White caregivers of community dwelling persons …

The Effects Of Patient Care In Relation To Toxic Workplace Environments, Kayla Fitzgerald

Creating Healthy Work Environments (CHWE)

Background: Bullying in the workplace setting is a significant issue that can severely impact one’s career. Bullying can be demonstrated in several forms- such as verbal abuse, isolation, intimidation, and physical harm. Specific to nursing practice, workplace bullying is shown to have negative effects on mental health, patient care, and overall job satisfaction. While there are no definite means that organizations will take complete action towards this ongoing issue, several implementations can be instilled to reduce the incidence of workplace bullying.

Methods: In this project, studies of negative work environments, specifically workplace bullying, and patient care were critiqued and synthesized. …

Exploring The Impact Of Intersectional Identity On Maternal Morbidity/Birth Outcomes Among Afro-Latinas In Florida, Alexa Parra, Cynthia Lebron, Michaela Larson, Yue Pan, Jonell Potter, Hudson Santos

Creating Healthy Work Environments (CHWE)

Background: The “Hispanic/Latina Paradox" is a phenomenon where Latina women and their infants have perinatal and birth outcomes similar to those of White women. This is often seen as a protective mechanism that helps reduce maternal health inequities. However, this paradox overlooks the fact that there are different subgroups of Latina women, including Afro-Latinas, who are often neglected when addressing racial disparities related to perinatal birth outcomes in the US. The intersectionality of multiple minority identities may put Afro-Latinas at a disadvantage in terms of perinatal health outcomes.

Objective: Determine differences in maternal morbidity, including pregnancy-related hypertension and diabetes, and …

Screening For Postpartum Depression At A Suburban Chiropractic Clinic, Emma Stedronsky, Mary Degrote Goering

Creating Healthy Work Environments (CHWE)

Background: The pregnancy and postpartum period are crucial times to evaluate for mental health conditions. The American College of Obstetrics and Gynecology (ACOG) recommends that providers screen for perinatal and postpartum depression (PPD) at least once during pregnancy and once during the postpartum period using a validated screening tool. A chiropractic clinic in the upper Midwestern United States identified an anecdotal increase in mental health concerns in their pregnant and postpartum patient population since the COVID-19 pandemic. This project utilized interprofessional collaboration by implementing PPD screening at a chiropractic office according to the recommended guidelines using the Edinburgh Postnatal Depression …

Aiw26s: Linkedin Optimization Using Ai, Saisumedha Billapati

Paul English Applied Artificial Intelligence (AI) Institute Publications

This workshop was part of the PEAAII and SAC AI Workshop Series at the University of Massachusetts Boston. The session focused on using artificial intelligence to improve LinkedIn profiles and professional branding. Participants learned how to use AI tools to enhance summaries, keywords, and overall digital presence for career development.

Alaska Earthquake Center Quarterly Review July-September 2025, Heather Mcfarlin, Beth Grassi, Austin Holland, Nate Murphy, Elisabeth Nadin, Carolyn Parcheta, Michael West

Alaska Earthquake Center Reports

This series of technical quarterly reports from the Alaska Earthquake Center (AEC) includes detailed summaries and updates on Alaska seismicity, the AEC seismic network and stations, fieldwork, our online presence, public outreach, and lists publications and presentations by AEC staff. Multiple AEC staff members contributed to this report.

Lymphatic Pumping Failure In The Arm Precedes Dermal Backflow And Breast Cancer-Related Lymphedema, Melissa B Aldrich, Meghan E Mcwain, Simona F Shaitelman, Rian E Kuhns, John C Rasmussen, Wendy A Woodward, Sarah M Desnyder, Wenyaw Chan, Eva M Sevick-Muraca

The Brown Foundation: Institute of Molecular Medicine

Background

Breast cancer patients who undergo regional nodal irradiation therapy (RNI) following neoadjuvant chemotherapy and mastectomy or lumpectomy with axillary lymph node dissection (ALND) frequently encounter breast cancer-related lymphedema (BCRL). Early detection and treatment can significantly improve outcomes. Previously, near-infrared fluorescence lymphatic imaging (NIRF-LI) detection of dermal backflow, or retrograde lymphatic flow into initial lymphatics, was shown to precede clinical BCRL diagnosis by 8–23 months. Herein, we hypothesize that lymphatic pump failure is responsible for dermal backflow and may be a target to prevent onset of BCRL symptoms.

Methods

Arm lymphatics in 51 patients with locally advanced breast cancer were …

Front Matter, Editors Of Comparative Labor Law & Policy Journal

Comparative Labor Law & Policy Journal

Volume 45, Issue 4

Non-Waivability In Labour Law: A Foundational Principle In Transition, Guy Davidov, Cynthia Estlund

Comparative Labor Law & Policy Journal

EMPLOYMENT RIGHTS SECURED IN LEGISLATION cannot be waived by employee consent. This is almost a trite proposition, a truism that labour lawyers and students usually take for granted.

Non-Waivability In Labour Law: An Australian Perspective, Joellen Riley Munton

Comparative Labor Law & Policy Journal

Australian industrial relations laws traditionally provided detailed mandatory standards through a system of arbitrated occupation-based awards. In the years since a shift to enterprise bargaining, the system has tolerated a greater level of flexibility, even in the way that legislated minima are framed. The options for waiving otherwise mandatory standards are, however, limited by procedural protections. The Fair Work Commission maintains a supervisory role to ensure that workers are “better off overall” as a consequence of their bargains. This article explains the many ways in which Australian labour standards permit flexible application, within constraints designed to preclude exploitative practices.

The Non-Waivability Principle: Possible Derogations From Collective Bargaining And Re-Assessment Of Individual Bargaining In Assisted Procedures, Elena Gramano, Silvio Sonnati

Comparative Labor Law & Policy Journal

This article examines the evolving landscape of Italian labour law, with a focus on the principle of non-waivability and its gradual adaptation to demands for flexibility and competitiveness. Traditionally, the Italian labour law framework has been characterised by a strong non-waivability regime, which protects employees from negotiating away their rights due to inherent power imbalances vis-à-vis employers. However, recent regulatory developments have facilitated a shift towards both collective and individual agreements that allow deviations from statutory provisions, including to the detriment of employees. The article analyses the implications of this trend, exploring key regulatory models that enhance the role of …

Waiver Of Statutory Employment Rights In The United Kingdom, Hugh Collins

Comparative Labor Law & Policy Journal

The common law endorses the principle of freedom of contract, but, with few exceptions, Parliament has explicitly prevented straightforward waivers of statutory employment rights. Nevertheless, for the sake of promoting settlements of claims by employees, it is surprisingly easy for individual employees to enter into agreements to compromise claims for breach of those rights without appropriate safeguards such as independent advice and freedom from pressure. Moreover, employers’ lawyers have demonstrated considerable ingenuity in finding ways to avoid the application of employment rights either by manipulations of employment status or by seeking contractual agreements on the facts of the case that …

Relaxation Of Mandatory Rules Through Collective And Individual Agreements In Japanese Labour Law, Ryuichi Yamakawa

Comparative Labor Law & Policy Journal

This article analyses the legal situation in Japan regarding the relaxation of or deviation from mandatory regulations in labour law through collective and individual agreements. Although many statutory labour laws in Japan have a mandatory effect over individual employment contracts, several statutory provisions provide that such mandatory regulations can be relaxed through collective agreements under certain circumstances, as is the case in other industrialised countries. However, Japan’s situation is unique insofar as the relaxation is permissible through collective agreements concluded by non-union (individual) representatives of a majority of employees in the absence of union representatives who have been elected by …

Derogability By Collective Agreements In Germany And The Presumption, Eva Kocher

Comparative Labor Law & Policy Journal

The promotion of derogability clauses, which allow collective agreements to deviate from statutory protection to the detriment of employees, has been an issue in the political debate on German labour law for some 20 years. While such derogability clauses can effectively allow for flexibility at the company or sectoral level, there are differing views on their suitability for promoting collective bargaining. This article highlights the paradox of such derogability clauses: They are legitimised by the presumption of fairness that underpins collective autonomy; at the same time, they create incentives for employers that challenge the very presumption of fairness. All in …