Digital Commons Network^™

Hsp90 Activator Aha1 Drives Production Of Pathological Tau Aggregates, Chad Dickey, Lindsey Shelton, Brian Blagg, John Koren, Laura Blair

USF Patents

Disclosed herein are compounds and methods for inhibiting Aha1 for the treatment of tauopathies and neurodegenerative diseases. The Aha1 inhibitor may reduce the interaction between Aha1 and Hsp90. The Aha1 inhibitor may reduce aggregation of tau protein. The Aha1 inhibitor may include a compound selected from KU-177, KU-174, and KU-308.

System And Method For Infrastructure Restoration Plan Optimization, Tingting Zhao, Yu Zhang

USF Patents

A system and method for transportation infrastructure restoration, assuming limited budget constraints and considering unmet demand in the system for maximizing transportation system resilience is provided.

Infrastructure And Policies Supporting Physical Activity Habits: A Comparison Between The United States And Europe, Anisha Laddha

Honors College Theses

Most adults in the United States are not getting enough physical activity, and this is causing high rates of adverse health conditions such as diabetes and cardiovascular disease in the population. The rising costs of cardiovascular disease are a national problem that must be tackled from multiple perspectives. This literature review explores policies and infrastructure implemented in European countries with better health outcomes and higher physical activity levels in the population compared to the United States. The infrastructure in places such as Germany and Denmark is constructed to encourage physical activity in the form of active transportation such as walking …

Formalized Diabetes Education In A Safety-Net Clinic, Haley N. Wanic

Doctoral Dissertations & Projects

Uncontrolled diabetes mellitus in a Hispanic population can be helped through a quality improvement project focused on progressive verbal and written diabetes self-management education (DSME) Purpose of this article is to review the background, an organizational assessment, a literature review, results of the quality improvement project that took place at a safety-net clinic in the Midwest. This project included four patients and data was analyzed through descriptive statistics. Results include improved hemoglobin (Hg) A1c, minimal workflow adjustments for providers, completed microalbumins, and written education given to patients. In conclusion, the quality improvement project showed positive trends in outcome measures over …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

De-Extinction: A Hopeful Dream Or Hopeless Nightmare, Meikeila M. Kincaid

Augustana Center for the Study of Ethics Essay Contest

This is an essay about de-extinction and what we should and should not do in order to remedy this.

Segmentation Of Dna Lesions In Irradiated Mouse Brain Sections, Nicholas Cirone

Honors Capstones

The impacts of microscopy image analysis have resulted in better visualization of foci (spots) in cell nuclei. However, manual analysis of microscopy images is challenging regarding subjectivity in structure counting and identification. Recent computer algorithms have enabled cellular analysis through automatic segmentation that uses computational edges in digital images. In this project, the automatic segmentation workflow in the Zeiss Zen Blue 3.3 software was adapted to more closely reflect visualized foci in a cell. The foci represent DNA double strand breaks. The Zeiss LSM 900 microscope was used to collect maximal intensity projection images of γH2AX foci and super-resolution z-stacks …

Breaking Boundaries And Making Her Way - Journey To Commencement, Lou Tyson

Journey to Commencement

Tayler Glover fosters opportunities for women in computer science.

Acquiring Knowledge To Support Those In Need - Journey To Commencement, Cameron Smith

Journey to Commencement

Erin Bowens pursues her passion and develops skills in speech-language pathology.

Match Made In Pharmacy - Journey To Commencement, Whitney Tarp

Journey to Commencement

Nason and Shelby Wise found the perfect matches in each other and the profession.

Significance Of Α-Myosin Heavy Chain (Myh6) Variants In Hypoplastic Left Heart Syndrome And Related Cardiovascular Diseases, Melissa Anfinson, Robert H. Fitts, John W. Lough, Jeanne M. James, Pippa M. Simpson, Stephanie S. Handler, Michael E. Mitchell, Aoy Tomita-Mitchell

Manuscripts, Articles, Book Chapters and Other Papers

Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease (CHD) with complex genetic inheritance. HLHS segregates with other left ventricular outflow tract (LVOT) malformations in families, and can present as either an isolated phenotype or as a feature of a larger genetic disorder. The multifactorial etiology of HLHS makes it difficult to interpret the clinical significance of genetic variants. Specific genes have been implicated in HLHS, including rare, predicted damaging MYH6 variants that are present in >10% of HLHS patients, and which have been shown to be associated with decreased transplant-free survival in our previous studies. MYH6 (α-myosin …

Ms 171 Guide To The Texas Medical Center-Women's History Project (2013-2016), Houston Academy Of Medicine-Texas Medical Center Library

Manuscript Finding Aids

The Texas Medical Center-Women's History Project contains audio interviews and print transcriptions of the interviews with women who made contributions to the biomedical and health care fields at the Texas Medical Center. Support organizations at the nursing and medical schools of UTHealth, The University of Texas Health Science Center at Houston, began the project in 2013 with five interviews. See more at MS 171.

A Place In This World: Minority Nation-Building In Interwar Czechoslovakia, Shelby Wise

History Theses

An in-depth analysis of Slovak, German, Hungarian, Ukrainian, and Jewish minority struggles with the Czech majority within the First Czechoslovak Republic. Each minority faced their own unique set of issues with both the new government and each other due to long-standing historical grievances. These issues hindered the overall development of the new nation-state and helped usher in the Munich Crisis on the eve of WWII, which effectively ended the short life of the First Republic.

A Closer Look At The Influence Of Transformational Leadership On Teachers' Creative Work Behavior And Organizational Innovation. Understanding The Relationship Between Teacher Leadership And Student Achievement., Sarper Turker

Theses and Dissertations

The educational literature has a long history of studies focusing on relationships among a variety of variables such as leadership practices, teachers’ behaviors, and students’ educational outcomes. The behavior of leaders has been identified as a characteristic that directly influences an employee’s creative behaviors and organizational innovation. Fostering creativity in education is intended to address many concerns, such as dealing with ambiguous problems, coping with the fast-changing world, and facing an uncertain future (Parkhurst, 1999). Although creativity is essential in education, teachers have not received adequate support from school principals to enhance creativity. Transformational leadership is one of the most …

Empower You: An Adult Type 2 Diabetes Mellitus Management Program With Utilization Of A Mobile Phone Application, Kelsey Jahn

Evidence-Based Practice Project Reports

In 2018, 34.2 million Americans had diabetes and there continues to be 1.5 million Americans diagnosed with diabetes every year (ADA, 2018). Due to this increasing prevalence, self-management of type 2 diabetes mellitus (T2DM) is essential to disease management. The PICOT question for this project was: In adults with T2DM with a hemoglobin A1C (HbA1C) greater than 8% in a diabetes specialty clinic (P), what is the effect of a multimodal smartphone application (I) compared to prior nonuse of the application (C) on average blood glucose readings (O) over an 8-week period (T)? The project was completed in a large, …

Screening And Follow Up For Postpartum Depression: How To Improve Practice, Mallory Matusik

Evidence-Based Practice Project Reports

Postpartum depression (PPD) is one of the most common mental health conditions, affecting one in seven women during their reproductive years (American College of Obstetricians and Gynecologists [ACOG], 2018). The purpose of this evidence-based practice (EBP) project was to improve screening and management of PPD using the Edinburgh Postnatal Depression Scale (EPDS) screening tool and a protocol for appropriate treatment and follow up care for PPD. A protocol was created by the project leader with information on screening and diagnosis, follow up, and treatment for PPD. The protocol also included information on how to assess for suicidal and/or homicidal ideation …

Back To The Basics With Smart Goals: A Multimodal Intervention For Adults Who Have Type 2 Diabetes, Alyssa L. Snyder

Evidence-Based Practice Project Reports

Diabetes, the seventh leading cause of death in the United States (Centers for Disease Control and Prevention [CDC], 2020a) and the ninth leading cause of death worldwide (World Health Organization [WHO], 2020), has increased by 70% over the last two decades (WHO, 2020). Type 2 diabetes (T2D), the most prevalent type accounting for 90% to 95% of diagnosed cases (CDC, 2020a), affects individuals of all ages and often results in major health problems including stroke, heart attack, and kidney disease. The purpose of this patient-centered, evidence-based practice (EBP) project was to evaluate the effectiveness of a multimodal intervention on hemoglobin …

Adjusting On The Fly: Nonprofit Marketing During The Covid-19 Pandemic, Chenaire Barmore

Nonprofit and NGO Studies Student Projects

This capstone is a case study of the Rockford Area Convention and Visitors Bureau (RACVB) in an effort to assist with answering the main research question. The main question is “To what extent has COVID-19 impacted the marketing and communications of nonprofit organizations”? The mission of the RACVB is to drive quality of life and economic growth for our citizens through tourism marketing and destination development. Due to the lack of tourism during this two-year period, I was interested to see how the RACVB adjusted to this new normal in marketing the Rockford region. Over the course of two months, …

Ralph Eubanks Recognized For Reflecting Mississippi, Rebecca Lauck Cleary

University of Mississippi News

UM alumnus and visiting professor honored by Mississippi Humanities Council

Abstract Argumentation And Answer Set Programming: Two Faces Of Nelson’S Logic, Jorge Fandinno, Luis Fariñas Del Cerro

Computer Science Faculty Publications

In this work, we show that both logic programming and abstract argumentation frameworks can be interpreted in terms of Nelson’s constructive logic N4. We do so by formalising, in this logic, two principles that we call noncontradictory inference and strengthened closed world assumption: the first states that no belief can be held based on contradictory evidence while the latter forces both unknown and contradictory evidence to be regarded as false. Using these principles, both logic programming and abstract argumentation frameworks are translated into constructive logic in a modular way and using the object language. Logic programming implication and abstract argumentation …

Kraft Lignin With Improved Homogeneity Recovered Directly From Black Liquor And Its Application In Flexible Polyurethane Foams, Peng Quan, Alper Kiziltas, Akash Gondaliya, Mohsen Siahkamari, Mojgan Nejad, Xinfeng Xie

Michigan Tech Publications, Part 1

An effective method that can produce a large amount of Kraft lignin with improved homogeneity is strongly desired for Kraft lignin's high-value applications and scientific advancements. Herein, a one-pot acid-catalyzed liquefaction method was developed to recover Kraft lignin directly from black liquor. The recovery rate and properties of the recovered lignin were affected by the reaction time, reaction temperature, moisture content (MC), pH, and acid categories. The highest lignin recovery rate of 75% was achieved when the concentrated black liquor (MC = 25%) reacted with methanol at pH = 7 and 160 °C for 10 min using acetic acid as …

Walking Is Worthy: Walking For Hypertension, Ashleigh Y. Peterson

Evidence-Based Practice Project Reports

Elevated blood pressure (BP), or hypertension (HTN), can cause a cascade of detrimental effects to the body. It is associated with increased risk of stroke, angina, myocardial infarction, heart failure, peripheral artery disease, end-stage renal disease, and abdominal aortic aneurysms (Whelton et al., 2018). HTN is also a major risk factor for the development of cardiovascular disease (CVD), which is the United States’ (U.S.) leading cause of death in men and women (U.S. Preventive Services Task Force [USPSTF], 2020). The PICOT question for this project was: does an eight-week (T) structured walking program utilizing a smartwatch for step counts and …

Nursing Students' Moral Courage Development Through Incivility Simulation Education, Melissa Madden

Nursing Theses and Dissertations

Objectives: The purpose of this study was to determine if the use of an incivility simulation intervention and incivility educational module would increase nursing students’ perceived moral courage more than an incivility educational module alone.

Hypotheses: Nursing students’ moral courage scores would increase more in response to an incivility simulation intervention and educational module than for those who received the incivility educational module intervention alone.

Methods: The NLN Jeffries Simulation Theory framed the proposed intervention using a quasi-experimental pre-test-post-test comparison group design. A convenience sample of 66 students was utilized from one university across two classes. The Moral Courage …

Timeless Questions, Susan Dumais

UNH Today Archive

No abstract provided.

Nasa Grant Fuels Northern Lights Research, Kassidy Taylor

UNH Today Archive

No abstract provided.

Review Of Code Of Judicial Conduct: Ethical Campaigning (With A Special Emphasis On Inappropriate Political Activity And Canon 5), Thomas Simmons

Faculty Publications

No abstract provided.

Social Infrastructure (“Third Places”) Is Not Distributed Equally Across The U.S., Danielle Rhubart, Yue Sun, Claire Pendergrast, Shannon M. Monnat

Population Health Research Brief Series

Third places are the physical spaces in a community where people can gather to connect and share resources, support, and information. They can help support health because they promote social interaction, community trust, and resource and information sharing. This data slice shows that third places are not evenly distributed across the U.S. Results show less availability of third places per capita in neighborhoods (Census tracts) with larger shares of non-Hispanic Blacks and Hispanics and larger shares of residents in poverty. The authors also found that third places are in shorter supply in rural neighborhoods than in urban neighborhoods, with the …

The Importance Of Academic Advising During Covid-19, Justice J. Harris

Theses and Dissertations

Academic Advisors are the connection between the students and the world of college. Having an academic advisor several students appreciate because they know they have their support and want them to succeed. The study will take place at Rowan University, and it will show just how important the role of an academic advisor is and especially during COVID-19.

Graduate Student Earns Summer Internship At Library Of Congress, Edwin B. Smith

University of Mississippi News

Roger Davis Jr. is among 42 selected for distinguished program

Iv Sotalol Use In Pediatric And Congenital Heart Patients: A Multicenter Registry Study., Lindsey Malloy-Walton, Nicholas H. Von Bergen, Seshadri Balaji, Peter S. Fischbach, Jason M. Garnreiter, S Yukiko Asaki, Jeffrey P. Moak, Luis A. Ochoa, Philip M. Chang, Hoang H. Nguyen, Akash R. Patel, Christa Kirk, Ashley K. Sherman, Jennifer N. Avari Silva, J Philip Saul

Manuscripts, Articles, Book Chapters and Other Papers

Background There is limited information regarding the clinical use and effectiveness of IV sotalol in pediatric patients and patients with congenital heart disease, including those with severe myocardial dysfunction. A multicenter registry study was designed to evaluate the safety, efficacy, and dosing of IV sotalol. Methods and Results A total of 85 patients (age 1 day-36 years) received IV sotalol, of whom 45 (53%) had additional congenital cardiac diagnoses and 4 (5%) were greater than 18 years of age. In 79 patients (93%), IV sotalol was used to treat supraventricular tachycardia and 4 (5%) received it to treat ventricular arrhythmias. …