Digital Commons Network^™

Repurposing Storage: Spatial Transformation Of Self Storage, Tina Cerda

Bachelor of Architecture Theses - 5th Year

What was once confined to the attic or garage has exploded into a billion-dollar industry. Today, there are around 50,000 storage facilities nationwide. This accounts for 2.3 billion sq ft in rentable space. To give you some scale that’s 3 times the size of Manhattan. That’s enough space for all 330 million Americans to physically stand under the facilities’ rooftop at this very moment. As many Americans begin to downsize, reduce their ecological footprint, and become less mobile. The need for temporary storage during resettlement and relocation is on a decline. How will these facilities then be utilized when excessive …

Sheltered City: A Prevention For Homelessness Through Sheltered Designs, Kena Fairfax

Bachelor of Architecture Theses - 5th Year

“Nothing but stable housing fundamentally differentiates those who experience homelessness and those who don’t, and all people deserve the human right to housing (pg. 1),” quoted by the National Health Care of the Homeless Council, can serve as a driving influence in developing solutions to address homelessness. The poignant experience that homeless people shared and described serve as an inspiration to better these individuals’ lives. As a substitute, approaching homelessness in a political or financial position, this thesis is to provide solutions to shelters architecturally.

Delving into precedents, each are separated into four categories such as singular, community, group, and …

Aquatic Architecture, Jonathan Bonaparte

Bachelor of Architecture Theses - 5th Year

For centuries, mankind has been building their architectural cities near or around water. It has its advantages such as transportation, convenience for the trade routes and water survival. As the earth gets hotter every year and the ice glaciers continues to melts, the ocean sea levels will continue to rise.

Assuming that the projected sea water levels for 2050 are correct, 95% of coastal cities around the world are at risk from rising sea levels and unpredictable storm surges. The coastal cities are going to have to adapt and change its way of thinking with the encroachment of the sea. …

The Labyrinth Archetype, Zachary Chimoff

Bachelor of Architecture Theses - 5th Year

This thesis looks at the myth of the labyrinth, a philosophical metaphor for life, and creates a modern version.

Designing A Digital Electronics Lab, Ben Buckwalter

Honors Program: Senior Projects (Public)

Hardware electronics tools can be more expensive than a new learner is willing to invest resulting in a barrier to entry. Furthermore, it can be difficult for a new learner to know where to start when learning electronics. To resolve this issue, we first explore current mobile app solutions that provide free electronics tooling. Then, we propose a design for a new mobile app that contains basic function generator and oscilloscope functionality as well as the learning resources necessary in order to guide new learners in the basics of digital electronics.

A Strategic Audit Of Seaworld, Jaden Capaldi, Rachel Jendro, Jacob Mir, Sophie Newman, Tommy Wolfe

Honors Program: Senior Projects (Public)

No abstract provided.

Experimental Investigation Of The Moment-Rotation Behaviour Of Beam-Column Connections Produced Using Compressed Wood Connectors, Sameer Mehra, Conan O'Ceallaigh, Adeayo Sotayo, Zhongwei Guan, Annette M. Harte

Research Outputs: 2025-Present

The use of timber in construction in medium–high rise construction has increased in recent years largely due to the significant innovation in engineered wood products and connection technology coupled with a desire to utilise more environmentally sustainable construction materials. While engineered wood products offer a low-carbon solution to the construction industry, the widespread use of adhesive and metallic fasteners often limits the recyclability of the structural components at the end of life of the structure and it may be beneficial to reduce this where possible. To establish the possibility of an all-wood connection solution, this preliminary study examines a series …

Bi-Order Multimodal Integration Of Single-Cell Data, Jinzhuang Dou, Shaoheng Liang, Vakul Mohanty, Qi Miao, Yuefan Huang, Qingnan Liang, Xuesen Cheng, Sangbae Kim, Jongsu Choi, Yumei Li, Li Li, May Daher, Rafet Basar, Katayoun Rezvani, Rui Chen, Ken Chen

Faculty, Staff and Student Publications

Integration of single-cell multiomics profiles generated by different single-cell technologies from the same biological sample is still challenging. Previous approaches based on shared features have only provided approximate solutions. Here, we present a novel mathematical solution named bi-order canonical correlation analysis (bi-CCA), which extends the widely used CCA approach to iteratively align the rows and the columns between data matrices. Bi-CCA is generally applicable to combinations of any two single-cell modalities. Validations using co-assayed ground truth data and application to a CAR-NK study and a fetal muscle atlas demonstrate its capability in generating accurate multimodal co-embeddings and discovering cellular identity.

Central Nervous System Immune Interactome Is A Function Of Cancer Lineage, Tumor Microenvironment, And Stat3 Expression, Hinda Najem, Martina Ott, Cynthia Kassab, Arvind Rao, Ganesh Rao, Anantha Marisetty, Adam M Sonabend, Craig Horbinski, Roel Verhaak, Anand Shankar, Santhoshi N Krishnan, Frederick S Varn, Víctor A Arrieta, Pravesh Gupta, Sherise D Ferguson, Jason T Huse, Gregory N Fuller, James P Long, Daniel E Winkowski, Ben A Freiberg, Charles David James, Leonidas C Platanias, Maciej S Lesniak, Jared K Burks, Amy B Heimberger

Faculty, Staff and Student Publications

BACKGROUND

Immune cell profiling of primary and metastatic CNS tumors has been focused on the tumor, not the tumor microenvironment (TME), or has been analyzed via biopsies.

METHODS

En bloc resections of gliomas (n = 10) and lung metastases (n = 10) were analyzed via tissue segmentation and high-dimension Opal 7-color multiplex imaging. Single-cell RNA analyses were used to infer immune cell functionality.

RESULTS

Within gliomas, T cells were localized in the infiltrating edge and perivascular space of tumors, while residing mostly in the stroma of metastatic tumors. CD163⁺ macrophages were evident throughout the TME of metastatic …

Racial And Ethnic Differences In Genomic Profiling Of Early Onset Colorectal Cancer, David M Hein, Weiye Deng, Marylena Bleile, Syed Ali Kazmi, Brooke Rhead, Francisco M De La Vega, Amy L Jones, Radhika Kainthla, Wen Jiang, Brandi Cantarel, Nina N Sanford

Faculty, Staff and Student Publications

The incidence and mortality of early onset colorectal cancer (EOCRC) is rising; outcomes appear to differ by race and ethnicity. We aimed to assess differences in mutational landscape and gene expression of EOCRC by racial and ethnic groups (non-Hispanic Asian, non-Hispanic Black, non-Hispanic White, White Hispanic) using data from the American Association for Cancer Research Project GENIE (10.2) and University of Texas Southwestern, the latter enriched in Hispanic patients. All statistical tests were 2-sided. Of 1752 EOCRC patients, non-Hispanic Black patients had higher rates of KRAS mutations (60.9%; P = .001, q = 0.015), and non-Hispanic White and non-Hispanic Black …

Holistic Generations | Reshaping A City's Health, Tania Rodriguez Serrano

Bachelor of Architecture Theses - 5th Year

In Puerto Rico everything seems emptier. The more hurricanes hit us, the less opportunities there are, the more corrupt the government gets, then the more people leave. The Puerto Rican population is rapidly decreasing. The small town of Jayuya, Puerto Rico is one that seems to be very lonely these days. I scarcely see my generation and the older generation is getting left behind. Due to this the town is basically a ghost town by the time 4pm hits. If my generation leaves, then who takes care of the older generations? Who maintains the town alive? When asked these questions …

Working Modular | The Modular System That Crosses The Boundary Between Micro And Macro Offices, Enrique Brimmer

Bachelor of Architecture Theses - 5th Year

I am designing an infrastructure that helps the growth of modules in a macro scale. For example, the office typology is one that isn’t easy to change, as shown in the past. As times change and people move around, our buildings need to be able to adapt and grow with us. That is why the ability to move and change module orientation is important to the growth of a building. In the micro scale I am going to be designing unique modules that can be easily repeated to create large and small spaces. These modules will have the opportunity to …

A Kit For Kids - Revitalizing Low-Income Communities By Embracing The Younger Generation, Anirose Burge

Bachelor of Architecture Theses - 5th Year

How often do we consider the physical, emotional, and social needs of youth when determining ways to better society? When deciding actions in a community, the needs of the next generation should be put as a top priority. This thesis will research and develop ways of doing this through architecture.

This project will create a modular and transportable structure that will focus on teens ages 11-15. The structure will be developed using a kit of parts so that it can be placed onto any site while also containing a site-specific program. The program will contain three categories with subcategories to …

Pattern Differentiation And Tuning Shift In Human Sensory Cortex Underlie Long-Term Threat Memory, Yuqi You, Lucas R Novak, Kevin J Clancy, Wen Li

Faculty, Staff and Student Publications

The amygdala-prefrontal-cortex circuit has long occupied the center of the threat system 1, but new evidence has rapidly amassed to implicate threat processing outside this canonical circuit 2-4. Through non-human research, the sensory cortex has emerged as a critical substrate for long-term threat memory 5-9, underpinned by sensory cortical pattern separation/completion 10,11 and tuning shift 12,13. In humans, research has begun to associate the human sensory cortex with long-term threat memory 14,15, but the lack of mechanistic insights obscures a direct linkage. Towards that end, …

Characterization Of Retinal Function And Structure In The Mptp Murine Model Of Parkinson's Diseasecharacterization Of Retinal Function And Structure In The Mptp Murine Model Of Parkinson’S Disease, Katie K N Tran, Vickie H Y Wong, Jeremiah K H Lim, Ali Shahandeh, Anh Hoang, David I Finkelstein, Bang V Bui, Christine T O Nguyen

Faculty, Staff and Student Publications

In addition to well characterized motor symptoms, visual disturbances are increasingly recognized as an early manifestation in Parkinson's disease (PD). A better understanding of the mechanisms underlying these changes would facilitate the development of vision tests which can be used as preclinical biomarkers to support the development of novel therapeutics for PD. This study aims to characterize the retinal phenotype of a mouse model of dopaminergic dysfunction and to examine whether these changes are reversible with levodopa treatment. We use a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD to characterize the neurotoxic effects of MPTP on in vivo retinal function (electroretinography, …

Intersections Of Identity, Culture, And Curriculum On The Threshold Of A Latinx Transforming Edd Program At A Hispanic Serving Institution, Caroline A. Hesse, Laura M. Jewett

Teaching and Learning Faculty Publications

A constellation of emergent research is devoted to critiquing the institutional identities of Hispanic Serving institutions (HSIs) as primarily Hispanic-enrolling institutions and then exploring frameworks and practices aimed at transforming them into what García (2019) terms Latinx-serving institutions. The purpose of this essay is to explore the intersections of culturally relevant, responsive, and sustaining approaches and as potentially decolonizing curricular spaces of EdD program (re)design at HSIs. This essay draws from two qualitative studies exploring critical approaches to curriculum and pedagogy and program redesign in order to re-align questions about serving Latinx students toward practices of critical consciousness situated at …

Covid-19 Exposure And Health Alerts, Georgia Southern University

Covid-19 Pandemic: News & Publications (Archived)

No abstract provided.

#Golead Newsletter, Georgia Southern University

#GoLead Newsletter (2016-2023)

• Virtual Service
• Serve912
• On-Campus Service
• Off-Campus Service

Keywords, Evan Lian, Simin Saatee

Advocate GME

No abstract provided.

Floating Edge: Modular Living, Jonathan Cruz

Bachelor of Architecture Theses - 5th Year

This thesis aims to develop an alternate solution for rising sea levels. By adopting flotation technology which is successfully implemented in building on water. This thesis primary objective is to examine and discuss the relationships between floating architecture, and the possibility of a new modular way of living in these coastal areas. This thesis will also explore the technologies and processes incorporated in the foundations of floating constructions and the accessibility of the structures through well-planned grids. To develop an alternate solution for land reclamation and rising sea levels.

Ndls Communicator: Week Of 05.09.22, Notre Dame Law School

NDLS Communicator

The Latest News

• Media coverage: Supreme Court breach and the pending Supreme Court abortion case decision
• Julian Velasco promoted to full professor
• Avishalom Tor joins IBPPA advisory board
• Keith Cooper — a man whose wrongful conviction inspired the creation of the Exoneration Justice Clinic reached a $7.5 million settlement with the city of Elkhart, Indiana. Adjunct Professor Elliot Slosar is Cooper’s attorney.
• The Law School and the Law School of the Ukrainian Catholic University will host a webinar today with several panel discussions on the legal challenges posed by Russia’s invasion of Ukraine.

Commencements Law School Specific Events:

Friday, May …

Comment Letter: Butte Priority Soils Operable Unit (Bpsou) Draft Final Unreclaimed Sites Quality Assurance Project Plan (Dated April 5, 2022), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Impacts Of Covid-19 On The Experiences Of Students With Basic Needs Insecurity: Evidence From A National Survey, Allyson Cornett, Carla Fletcher

Journal of Student Financial Aid

The COVID-19 pandemic has affected college students’ basic needs, financial security, academic success, caregiving responsibilities, mental health, and more, according to the Fall 2020 Student Financial Wellness Survey (SFWS) conducted by Trellis Company. Researchers surveyed 37,936 students at 62 two- and four-year colleges and universities from October to November 2020 and found 53 percent (n=20,095) indicated one or more forms of basic needs insecurity (BNI). This brief examines data from students with BNI with a special lens on their mental health, familial responsibilities and finances, employment, and financial security. These results highlight the disparate impacts of the pandemic among basic …

Massively Parallel Identification Of Functionally Consequential Noncoding Genetic Variants In Undiagnosed Rare Disease Patients., Jasmine A. Mcquerry, Merry Mclaird, Samantha N. Hartin, John C. Means, Jeffrey J. Johnston, T Pastinen, Scott T. Younger

Manuscripts, Articles, Book Chapters and Other Papers

Clinical whole genome sequencing has enabled the discovery of potentially pathogenic noncoding variants in the genomes of rare disease patients with a prior history of negative genetic testing. However, interpreting the functional consequences of noncoding variants and distinguishing those that contribute to disease etiology remains a challenge. Here we address this challenge by experimentally profiling the functional consequences of rare noncoding variants detected in a cohort of undiagnosed rare disease patients at scale using a massively parallel reporter assay. We demonstrate that this approach successfully identifies rare noncoding variants that alter the regulatory capacity of genomic sequences. In addition, we …

Self-Determination Skills: Building A Foundation For Student Success, Mariya T. Davis, Ingrid K. Cumming, Julie D. Southward

Special Education Faculty Publications (Archived)

Among different transitions that happen in a young person’s life, transition to adulthood can be one of the most challenging. The new post-school environment requires increased self-determination, including self-awareness, self-advocacy, self-management, and other important skills that help one function as an independent adult. Because it takes time to develop and nurture self-determination skills, it is important to begin early and continue infusing self-determination into various aspects of instruction. Discussed in this article are SCORE strategies for embedding self-determination skills into classroom settings. Multiple tools and resources are provided to aid with the selection and application processes. A vignette is offered …

Georgia Southern Golf Course Newsletter, Georgia Southern University

Athletics: News & Publications

• Brandon Costlow
• Celebrating All the Mothers Out There!
• 2022 Season
• Faculty, Staff and Friends - Every Tuesday
• St9op Rushing Your Swing

Georgia Southern Golf Course Newsletter, Georgia Southern University

Athletics: News & Publications

• Brandon Costlow
• Celebrating All the Mothers Out There!
• 2022 Season
• Faculty, Staff and Friends - Every Tuesday
• St9op Rushing Your Swing

Greenhouse Gas Emissions During The Usage Phase Of Electric Vehicles In The United States, Now And In The Future, Zach Roza

Department of Environmental Studies: Undergraduate Student Theses

This is a systematic literature review and a discussion of future trends on the greenhouse gas emissions produced during the usage phase of electric vehicles in the United States now and in the future. The objective of this study was to determine the amount of greenhouse gas emissions produced during the usage phase of an electric vehicle in the US currently and what it is expected to be in the year 2050. The reason that the study was conducted was due to the harmful effects caused by global warming and how large of a role the transportation industry in the …

The Impact Of Interactions Among Native Grassland Species: A Study Of Interactions Between Two Invasive Species (Bromus Tectorum And Setaria Faberi) And Two Native Species (Helianthus Annuus And Rudbeckia Hirta), Nash Leef

Department of Environmental Studies: Undergraduate Student Theses

Allelopathy is a description of an interaction between two plant species, usually negative, that impacts their growth or germination. There has been ample data published regarding the impact of allelopathic species in agricultural settings, but little attention has been given to the potential interactions between invasive and native species. Two culprits that have employed allelopathy to great effect in agricultural settings are cheatgrass (Bromus tectorum) and giant foxtail (Setaria faberi). This study posits that allelopathic interactions, similar to those found in agriculture, are occurring between native and invasive species on the Great Plains.

A set of greenhouse trials was established …

Biodegradable Active Bio-Nanocomposite Film For The Enhanced Shelf Life Of Tomatoes, Kalpani Y. Perera, Shubham Sharma, Brendan Duffy, Amit K. Jaiswal, Swarna Jaiswal

Articles

The increased environmental pollution has led to finding sustainable solutions for non-renewable plastic-based food packaging materials. Thus, the use of biomaterial-based packaging material has become an immense trend. This work aims at developing an antimicrobial biodegradable chitosan-alginate bio-nano composite film with TiO2 nanoparticle (NPs) for food packaging applications. The film was developed by a solution casting method. The chemical, mechanical, thermal, barrier, antimicrobial, and biodegradable properties of the packaging films were evaluated. Packaging studies were performed for 15 days for cherry tomatoes. The designed packaging material had enhanced the mechanical properties with a significantly (p < 0.05) higher tensile strength of 15.76 folds and 2 fold higher elongation at break. The UV barrier properties increased by 88.6%, while the film transparency decreased by 87.23%. Molecular interaction of N-H covalent bonds was observed between alginate and chitosan together with TiO2 NPs. The developed bio-nano composite film showed antimicrobial activity against foodborne pathogens E. coli, S. aureus, S. typhi, and L. monocytogene with a log reduction of 7.08, 7.28, 6.04 & 6.02 log CFU/ml respectively at 24 hours incubation period. The film was completely biodegraded and a weight loss of 89.06% was observed in bio-nanocomposite film during the 3 months. Shelf-life estimation of cherry tomato using developed packaging films showed an increase in the shelf-life up to 8 days with stable pH, total soluble solids, and weight with no bacterial growth when packaged with prepared film. Owing to their improved mechanical, UV barrier, antibacterial, and biodegradability, the prepared active bio-nano composite packaging films could be considered a potential candidate for fruit packaging.