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Techniques To Analyze The Pathophysiology Of Aging From Induced Senescence And Sod2 Loss, Asia Davis-Castillo

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Cardiovascular disease is the leading cause of death in the United States. Cardiac function declines with age, and promotes a number of age-related disorders, including atrial fibrillation and heart failure. Mitochondrial oxidative stress has long been suspected as a primary driver of aging pathology in multiple tissues, including the heart and brain. We used several phenotypic assays to characterize chemically-induced accelerated cardiac aging, as well as two transgenic knockout models for heart and brain specific loss of superoxide dismutase (SOD2), a mitochondrial antioxidant protein.

We first accelerated aging in mice by treating with doxorubicin (DOXO), a chemotherapeutic drug. One group …

Small Molecule Compound With Indole Moiety Protects Against Alzheimer’S Disease Pathology In C. Elegans And Mammalian Cell Culture Models, Elena Battistoni

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Alzheimer's disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia in the elderly. In 2020, an estimated 5.8 million Americans 65 and older were living with Alzheimer's dementia¹. Currently, the disease has no cure, and extensive research continues to explore potential treatments. Because the pathogenesis of AD has been attributed, at least in part, to the extracellular aggregation and toxicity of the amyloid beta (Aβ) protein in the brain, discovering therapeutics that target this protein remains of interest. However, many past drug development programs and clinical trials that target Aβ aggregates have been unsuccessful. …

Exploring The Diet Dependent Role Of Oxidation Resistance 1 In Regulating Retromer Function, Enrique Carrera

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Aging has been identified as a significant risk factor to the development of several diseases, such as neurodegeneration¹. One of the most common age-related neurodegenerative diseases is Alzheimer’s Disease (AD)², which causes cognitive decline. Current treatments for AD attempt to mitigate its symptoms or delay its onset^3–5. One method that has shown promise not only for the treatment of AD, but also for increasing lifespan and healthspan overall is dietary restriction (DR)⁶, but the mechanisms by which DR mediates these effects remains unclear^7,8. We have identified the human gene Oxidation …

The Possibility Of A Land Bridge Across Nebraska In Mississippian Time, E. C. Reed

School of Natural Resources: Faculty Publications

No abstract provided.

The Berlin Wall, Abigail Hasselbrink

Prologue: A First-Year Writing Journal

No abstract provided.

Our World Is Not Getting Worse: The Overflow Of Negative News And Human Biases, Ha Doan

Prologue: A First-Year Writing Journal

No abstract provided.

Don't Call Me Tan, Maya Schaefer

Prologue: A First-Year Writing Journal

No abstract provided.

Mortality And Empathy: The Meaning In Death In Do Androids Dream Of Electric Sheep?, Sarah Kissinger

Prologue: A First-Year Writing Journal

No abstract provided.

Letter From The Prologue Editors In Chief

Prologue: A First-Year Writing Journal

No abstract provided.

Method To Support Ipsk For Wpa3 Clients As Well As Reduce Online Dictionary Attacks, Niranjan M M, Vijay Kothamasu, Nagaraj Kenchaiah

Defensive Publications Series

WPA3 was developed with the backward compatibility into consideration, i.e., if WPA3 is enabled on WPA2+PSK SSID (also called mixed mode), then both WPA3 and WPA2-only clients can associate to same SSID. This will work as long as SSID is configured to use default-PSK. In other words, if SSID is configured with iPSK, then WPA2-only clients can associate to the SSID using iPSK, but WPA3 clients fails to associate to this SSID using iPSK, as current WPA3 SAE negotiation does not consider iPSK (unique PSK per client). Also, WPA3 was introduced to combat offline dictionary attacks on WPA2+PSK by using …

Academic Senate - Minutes, 5/17/2022, Academic Senate

Academic Senate Minutes

No abstract provided.

Targeted In Vivo Drug Delivery With Focused Ultrasound, Naomi Matsuura

Nanotechnology In Medicine III: Enabling Next Generation Therapies

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Photothermal Nanoparticle-Based Approaches To Designing Immunoengineered Therapies For Cancer, Rohan Fernandez

Nanotechnology In Medicine III: Enabling Next Generation Therapies

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A Phoenix From The Ashes: Jackson Park’S Japanese Garden, Cultural Exchange, And The Endurance Of Japanese Sites After Pearl Harbor, Brittany Murphy

Asian Studies: Student Scholarship & Creative Works

Japanese gardens in the United States have a history that dates back to the World’s Fairs of the late 19th century, when Japan used the World’s Stage to project an image of itself as a powerful nation founded on both modern industrial techniques and traditional culture to compete with dominating Euro-American powers. The history of the Japanese garden in Chicago’s Jackson Park, gifted to Chicago by the Japanese government for the 1893 Columbian Exposition, tells the story of Midwesterners’ love and appreciation for the gardens while also demonstrating the implicit legacies of Executive Order 9066. The garden remained a crucial …

05-17-2022 Dr. Trisha Wald Named Associate Dean Of Swosu Everett Dobson Sbt, Southwestern Oklahoma State University

THE BARK ARCHIVE 2022

No abstract provided.

05-17-2022 Harold & Carol Wright Family Named To Swosu Planned Giving Society, Southwestern Oklahoma State University

THE BARK ARCHIVE 2022

No abstract provided.

71 Update: Email - Unifi Assessment Rubrics 5-17-22, University Of Northern Iowa. General Education Re-Envisioning Committee.

General Education Re-envisioning Committee Documents

An announcement sharing the draft rubrics for assessment of the general education program and how they will be used the first year of the program.

Benchside-To-Bedside Translation Of Novel Targets For Regulating Blood Clots In Man, Michael Holinstat

Nanotechnology In Medicine III: Enabling Next Generation Therapies

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Diffusion, Disorder And Dynamics In The Nuclear Pore Complex, Roderick Lim

Nanotechnology In Medicine III: Enabling Next Generation Therapies

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Elastomeric Droplet Generation Of Vascularized Cardiac Spheroids For The Use Of High-Throughput Drugs Screening, Jennifer Kieda, Rick Lu, Yimu Zhao, Milica Radisic, Shira Landau

Nanotechnology In Medicine III: Enabling Next Generation Therapies

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Will Reducing Drug Prices Slow Innovation?, Gregory Vaughan, Fred Ledley

Mathematical Sciences Faculty Publications

The pharmaceutical industry has long argued that high drug prices reflect the high cost of innovation and that reducing drug prices would necessarily slow the pipeline of new drugs. These arguments have been bolstered by studies of large pharmaceutical companies showing statistical associations between the projected market size or revenue for pharmaceutical products and research & development (R&D) activity. Our analysis recognizes the increasingly important role of small biopharmaceuticals in drug development , companies that typically have little revenue and negative earnings, but are now responsible for more than 40% of new drug approvals. We examine the relationship between changes …

Genetic Relationships Between Mesoamerican Ancient Populations And With American Greater Southwest And Caribbean Populations Close To Mesoamerican Borders, Angélica González-Oliver, Ernesto Garfias-Morales, Miriam Jetebel Bravo-López, María Isabel De La Cruz-Laina

Human Biology Open Access Pre-Prints

Mesoamerica is a cultural and geographic region with a northern boundary adjacent to the American Greater Southwest, meanwhile its southeastern boundary includes the Maya area, which is adjacent to the Caribbean. These regions are of interest to analyze genetic structure, ancestry and gene flow between the ancient populations. We identified the mitochondrial DNA haplogroups and haplotypes in 19 colonial and 10 pre-Columbian Maya from Xcaret and 6 Paquimé individuals. We analyzed our data together with 603 ancient individuals, 95 colonial and 502 pre-Columbian. The results show clear genetic differences between Mesoamerica, American Greater Southwest and Caribbean regions. High frequency of …

2022-05-17_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/stats/data-about-places/long-term-care-data.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …

Academic Senate - Agenda, 5/17/2022, Academic Senate

Academic Senate Agendas

No abstract provided.

Taylor, Carrie (Burnam), 1855-1917 (Sc 3639), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid and scan (Click on "Additional Files" below) for Manuscripts Small Collection 3639. Postcard advertising the spring opening, 10 February 1915, of the Mrs. A. H. Taylor Company, Bowling Green, Kentucky, inviting patrons to inspect fabrics and designs and offering samples by mail.

Fine-Scale Genetic Profile And Admixture History Of Two Hmong-Mien-Speaking Miao Tribes From Southwest China Inferred From Genome-Wide Data, Hui Tan, Rui Wang, Chuan-Chao Wang

Human Biology Open Access Pre-Prints

As the dominant indigenous minority in Southern China, Hmong-Mien speaking Miao people were thought to be the descendants of Neolithic Yangtze rice farmers. However, the fine-scale population structure and genetic profile of the Miao populations remains unclear due to the limited Miao samples from Southern China and Southeast Asia. Here, we genotyped 19 individuals from the two largest Miao tribes in Guizhou province (Southwest China) via SNP chips and co-analyzed with published available modern and ancient East Asians. We observed that studied Guizhou Miao displayed a closer genomic affinity with present-day and Neolithic-to-Iron Age Southern East Asians than with most …

Overton Pauley V. Charles Samuels, Jr.

2022 Decisions

USDC for the Western District of Pennsylvania

Deep Learning Modeling M6a Deposition Reveals The Importance Of Downstream Cis-Element Sequences., Zhiyuan Luo, Jiacheng Zhang, Jingyi Fei, Shengdong Ke

Faculty Research 2022

The N⁶-methyladenosine (m⁶A) modification is deposited to nascent transcripts on chromatin, but its site-specificity mechanism is mostly unknown. Here we model the m⁶A deposition to pre-mRNA by iM6A (intelligent m⁶A), a deep learning method, demonstrating that the site-specific m⁶A methylation is primarily determined by the flanking nucleotide sequences. iM6A accurately models the m⁶A deposition (AUROC = 0.99) and uncovers surprisingly that the cis-elements regulating the m⁶A deposition preferentially reside within the 50 nt downstream of the m⁶A sites. The m⁶A enhancers mostly …

Transcriptional Profiling Of Macrophages In Situ In Metastatic Melanoma Reveals Localization-Dependent Phenotypes And Function., Jan Martinek, Jianan Lin, Kyung In Kim, Victor G Wang, Te-Chia Wu, Michael Chiorazzi, Hannah Boruchov, Ananya Gulati, Shamreethaa Seeniraj, Lili Sun, Florentina Marches, Paul Robson, Anthony Rongvaux, Richard A Flavell, Joshy George, Jeffrey Chuang, Jacques Banchereau, Karolina Palucka

Faculty Research 2022

Modulation of immune function at the tumor site could improve patient outcomes. Here, we analyze patient samples of metastatic melanoma, a tumor responsive to T cell-based therapies, and find that tumor-infiltrating T cells are primarily juxtaposed to CD14⁺ monocytes/macrophages rather than melanoma cells. Using immunofluorescence-guided laser capture microdissection, we analyze transcriptomes of CD3⁺ T cells, CD14 ⁺ monocytes/macrophages, and melanoma cells in non-dissociated tissue. Stromal CD14⁺ cells display a specific transcriptional signature distinct from CD14⁺ cells within tumor nests. This signature contains LY75, a gene linked with antigen capture and regulation of tolerance and immunity in …

John Lesko V. Secretary Pennsylvania Departm

2022 Decisions

USDC for the Western District of Pennsylvania