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Articles 701671 - 701700 of 5157228
Full-Text Articles in Entire DC Network
Interactional Challenges For Non-Native Speakers Of English In Emergency Telephone Calls, Angela Garcia
Interactional Challenges For Non-Native Speakers Of English In Emergency Telephone Calls, Angela Garcia
Natural & Applied Sciences Faculty Publications
This paper investigates interactional challenges experienced in calls to emergency services with native English speaking (NS) call takers and non-native speaking (NNS) callers. Case studies of three problematic NNS/NS calls from a collection of emergency service calls were conducted using a conversation analytic approach. These calls were selected from publicly available recordings which were made by callers who were hearably NNS of English. The analysis shows how accents, grammatical and other linguistic choices led to related challenges in the pragmatics of communication (including procedures for sequential organization such as adjacency pairs, repair initiation, confirmation requests, presequences and story solicits). Routine …
Health Disparities In Adults With Developmental And Intellectual Disabilities, Tulsi Patel
Health Disparities In Adults With Developmental And Intellectual Disabilities, Tulsi Patel
Nursing | Senior Theses
This paper reviews literature pertaining to the treatment of people with developmental disabilities. It will emphasize the inadequacies of health care in this population. The literature that will be discussed focuses on disparities in care via proxy, sociodemographic and clinical factors associated with disparities, assessing the needs of this population, the prevalence of disabilities in rural and urban settings, and the comparison of health disparities between adults with and without developmental disabilities.
For the purpose of this paper, a few terms will be defined. Developmental disabilities (DD) will be defined as “a group of conditions due to an impairment in …
A Biological Condition Gradient For Coral Reefs In The Us Caribbean Territories: Part I. Coral Narrative Rules, Deborah Santavy, Susan K. Jackson, Benjamin Jessup, Jeroen Gerritsen, Caroline Rogers, William S. Fisher, Ernesto Weil, Alina Szmant, David Cuevas-Miranda, Brian K. Walker, Christopher Jeffrey, Patricia Bradley, David Ballantine, Loretta Roberson, Hector Ruiz-Torres, Brandi Todd, Tyler Smith, Randy Clark, Ernesto Diaz, Jorge Bauzá-Ortega, Christina Horstmann, Sandy Raimondo
A Biological Condition Gradient For Coral Reefs In The Us Caribbean Territories: Part I. Coral Narrative Rules, Deborah Santavy, Susan K. Jackson, Benjamin Jessup, Jeroen Gerritsen, Caroline Rogers, William S. Fisher, Ernesto Weil, Alina Szmant, David Cuevas-Miranda, Brian K. Walker, Christopher Jeffrey, Patricia Bradley, David Ballantine, Loretta Roberson, Hector Ruiz-Torres, Brandi Todd, Tyler Smith, Randy Clark, Ernesto Diaz, Jorge Bauzá-Ortega, Christina Horstmann, Sandy Raimondo
Marine & Environmental Sciences Faculty Articles
As coral reef condition and sustainability continue to decline worldwide, losses of critical habitat and their ecosystem services have generated an urgency to understand and communicate reef response to management actions, environmental contamination, and natural disasters. Increasingly, coral reef protection and restoration programs emphasize the need for robust assessment tools for protecting high-quality waters and establishing conservation goals. Of equal importance is the need to communicate assessment results to stakeholders, beneficiaries, and the public so that environmental consequences of decisions are understood. The Biological Condition (BCG) model provides a structure to evaluate the condition of a coral reef in increments …
Use Of Saturated Lightweight Sand To Improve The Mechanical And Microstructural Properties Of Uhpc With Fiber Alignment, Huanghuang Huang, Le Teng, Xiaojian Gao, Kamal Khayat, Fazhou Wang, Zhichao Liu
Use Of Saturated Lightweight Sand To Improve The Mechanical And Microstructural Properties Of Uhpc With Fiber Alignment, Huanghuang Huang, Le Teng, Xiaojian Gao, Kamal Khayat, Fazhou Wang, Zhichao Liu
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
This paper studied the influence of pre-saturated lightweight sand (LWS) on the mechanical and microstructural properties of UHPC cast with steel fiber alignment. The changes in hydration kinetics, porosity, nano-mechanical, and mechanical properties were studied. The LWS was used at 0–50% replacement volumes of total sand. Predominant fiber alignment was favored through a flow-induced casting method during casting of flexural prisms. Experiment results showed that the 28-d autogenous shrinkage was decreased from 450 to 275 μm/m with the LWS content increasing from 0 to 50%. The addition of 20% LWS led to maximum increases of 15%, 15%, and 20% in …
Chandra Spectral Constraints Of The Low-Metallicity Collision Ring Cartwheel Galaxy, Chloë Benton
Chandra Spectral Constraints Of The Low-Metallicity Collision Ring Cartwheel Galaxy, Chloë Benton
Physics Undergraduate Honors Theses
With the sophistication of the Chandra X-Ray Observatory, many observations of the behaviors of binary systems have been researched and studied. As an excellent example, for the low metallicity Cartwheel Galaxy, some fraction of the X-ray photons emitted from X-ray binaries have been intercepted by the detectors on the telescope and have been compiled into “events file.” When modeled properly, this data can produce insight into the behavior of the stellar populations in this object. The primary goal of this project is to use these events files to measure the X-ray properties of the X-ray binaries in the Cartwheel Galaxy …
Poem No. 127, May 2022, Huntsville Literary Association (Huntsvile, Ala.)
Poem No. 127, May 2022, Huntsville Literary Association (Huntsvile, Ala.)
POEM
The Huntsville Literary Association was founded in 1967 to provide a community for writers, readers, and artists through workshops, readings, and educational programs. One of their key contributions is the literary magazine titled POEM which showcases original writings from both established and emerging writers. This issue features poems from various writers.
The Impact Of Covid-19 On Nurse Leadership Characteristics, Karen Fowler, Leslie K. Robbins
The Impact Of Covid-19 On Nurse Leadership Characteristics, Karen Fowler, Leslie K. Robbins
Nursing Faculty Publications
Background: Nurse leaders are vital for improving nursing efficiencies and the quality of care that they provide during a crisis and its aftermath. The value of positive leadership characteristics has never been more critical than during the COVID-19 pandemic. Functioning in a crisis mode required nurse leaders to demonstrate the necessary skills for clear communication and solid leadership. Therefore, nursing leadership, especially in emergencies such as the COVID-19 pandemic, needs to be transformative in the sense that leaders are informational, motivating, and able to advance the organization, notwithstanding a global pandemic. Timely leadership research during and after COVID-19 is crucial …
Renal Angina Index As A Predictor Of Acute Kidney Injury In Critically Ill Children, Athul Shelly Kooliyath
Renal Angina Index As A Predictor Of Acute Kidney Injury In Critically Ill Children, Athul Shelly Kooliyath
Master of Medicine in Paediatrics and Child Health
Background: Acute kidney injury is associated with increased morbidity and mortality in hospitalized children. In the critically ill,DR WILLIAM M MACHARIA acute kidney injury (AKI) is prevalent and difficult to diagnose. Using conventional methods, AKI is often missed thus delaying the diagnosis up to 48 hours after initial injury. Though some biomarkers that identify AKI early have been identified, they may still be insufficient due to prohibitive costs. Renal angina index is used to identify ongoing renal injury. It is a product of the clinical state and the estimated glomerular filtration rate (eGFR) of a patient during admission to a …
Feasibiity And Acceptability Of Tele-Neurology Services At A Regional Tertiary Referral Centre: A Prospective Study., Fazal Yakub
Feasibiity And Acceptability Of Tele-Neurology Services At A Regional Tertiary Referral Centre: A Prospective Study., Fazal Yakub
Master of Medicine in Internal Medicine
Background: Neurological diseases are a leading cause of morbidity and mortality worldwide with a great burden lying in Sub-Saharan Africa. The paucity of neurologists in the region makes neurological care disproportionately inaccessible. Utility of tele-medicine is low cost, time efficient, convenient, reducing the carbon footprint and ultimately increasing health care access. Objective: We identified whether the concept of tele-neurology was feasible within our setup for patients with stable neurological diseases while establishing the cost effectiveness, efficiency, convenience and the carbon footprint burden. Methods: We conducted a prospective cross-sectional study. New patients were triaged by the neurologist based on guidelines from …
Hiv Among Cancer Patients: Prevalence And Cancer Description By Hiv Status, Diana Wambui Muturi
Hiv Among Cancer Patients: Prevalence And Cancer Description By Hiv Status, Diana Wambui Muturi
Master of Medicine in Internal Medicine
Background: Antiretroviral therapy (ART) has resulted in a higher life expectancy of persons living with Human Immunodeficiency Virus (PLHIV) leading to an aging population at risk for non-AIDS defining cancers (NADCs) rather than AIDS-defining cancers (ADCs). Identification of HIV-cancer comorbidity through diagnostic HIV testing of patients presenting for cancer care is not offered routinely. The HIV prevalence among cancer patients in Kenya is undefined. In addition, the spectrum of malignancies in PLHIV has not been well characterized outside of ADCs. Objective: Our primary objective was to determine the prevalence of HIV among patients with cancer. Secondary objectives were to determine …
Deep Learning In Sports Prediction, Fan Lee
Deep Learning In Sports Prediction, Fan Lee
Computer Science Honors Theses
Sports prediction has always been an interesting problem in the entertainment industry. Many data scientists have come out different methods on this problem. We hope to see how well a neural network model can predict an individual game outcome and the final ranking on NBA data. We examined the possibility of different unbiased deep learning models can perform as well as other mathematics methods. We were also looking for what types of data are more influential for the models. Then, we can make some assumptions on our models and the other sports prediction methods.
Fish Community Assembly At Multiple Spatial Scales In East Texas Streams, Jake R. Swanson
Fish Community Assembly At Multiple Spatial Scales In East Texas Streams, Jake R. Swanson
Electronic Theses and Dissertations
Stream communities are structured by environmental processes that vary in strength across different spatiotemporal scales. Therefore, revealing how stream fish communities are influenced by environmental gradients may clarify how communities respond to disturbance associated with anthropogenic change. I investigated the relative role environmental variables play in the processes that structure the taxonomic and functional diversity of stream fish communities, as well as historical trends in occurrence and local habitat associated with a species of greatest conservation need within east Texas. The results of this study indicate that stream sites with more habitat complexity and stability support a more taxonomically and …
Constructing An Interpretive Master Plan For The Confederate Reunion Grounds State Historic Site, Alysha M. Richardson
Constructing An Interpretive Master Plan For The Confederate Reunion Grounds State Historic Site, Alysha M. Richardson
Electronic Theses and Dissertations
The Confederate Reunion Grounds State Historic Site is owned and operated by the Texas Historical Commission. Interpretation of the site spans the 1864-1940 period and includes stories of groups that once met there for social events, including the United Confederate Veterans. In recent years, the Confederate Reunion Grounds has seen a decline in visitation as well as a reduction in staff. This capstone project focuses on creating an interpretive master plan to accommodate the change. This interpretive master plan aims to address the changes that have occurred over the past seven years and set staff goals and objectives.
Covid-19’S Effects On Mortality Salience, Death Anxiety, And Worldview Defense, Sahvannah K. Shavers
Covid-19’S Effects On Mortality Salience, Death Anxiety, And Worldview Defense, Sahvannah K. Shavers
Electronic Theses and Dissertations
Since late-2019, the world has been trying to overcome an invisible killer: COVID-19. With near constant reminders of the virus the knowledge that a tiny viral particle has potential to harm or even kill has become overwhelming for many. Terror Management Theory (TMT) suggests that when individuals are reminded of their own death people take part in culturally appropriate activities and defend their own culture as ways to alleviate this increased death anxiety. The current study aims to identify whether 1) reminders of COVID-19 prime death thoughts, 2) reminders of COVID-19 increase death anxiety, and 3) increased death anxiety from …
Brignoni-Ponce And The Establishment Of Race-Based Immigration Enforcement, Isabel Skilton
Brignoni-Ponce And The Establishment Of Race-Based Immigration Enforcement, Isabel Skilton
Washington International Law Journal
United States v. Brignoni-Ponce solidified the racist enforcement of United States immigration laws by allowing “Mexican appearance” to be a factor forming reasonable suspicion in a roving patrol. The United States Supreme Court rationalized race-based immigration enforcement by relying on erroneous immigration demographics and a misconstrued notion of serving the public interest. This comment demonstrates that the rationales provided by the Supreme Court are illogical, discriminatory, and harmful to communities of color. This comment analyzes the impacts of race-based discrimination and provides alternatives which may cabin the impact of Brignoni-Ponce. Aside from overruling Brignoni-Ponce in its entirety, a probable cause …
On Uniqueness And Stability For The Boltzmann-Enskog Equation, Martin Friesen, Barbara Ruediger, Padmanabhan Subdar
On Uniqueness And Stability For The Boltzmann-Enskog Equation, Martin Friesen, Barbara Ruediger, Padmanabhan Subdar
Faculty Publications
The time-evolution of a moderately dense gas in a vacuum is described in classical mechanics by a particle density function obtained from the Boltzmann-Enskog equation. Based on a McKean-Vlasov equation with jumps, the associated stochastic process was recently constructed by modified Picard iterations with the mean-field interactions, and more generally, by a system of interacting particles. By the introduction of a shifted distance that exactly compensates for the free transport term that accrues in the spatially inhomogeneous setting, we prove in this work an inequality on the Wasserstein distance for any two measure-valued solutions to the Boltzmann-Enskog equation. As a …
Patterns Of Choice Adaptation In Dynamic Risky Environments, E Konstantinidis, J L. Harman, C Gonzalez
Patterns Of Choice Adaptation In Dynamic Risky Environments, E Konstantinidis, J L. Harman, C Gonzalez
Faculty Publications
An important aspect of making good decisions is the ability to adapt to changes in the values of available choice options, and research suggests that we are poor at changing behavior and adapting our choices successfully. The current paper contributes to clarifying the role of memory on learning and successful adaptation to changing decision environments. We test two aspects of changing decision environments: the direction of change and the type of feedback. The direction of change refers to how options become more or less rewarding compared to other options, over time. Feedback refers to whether full or partial information about …
Zein And Lignin-Based Nanoparticles As Soybean Seed Treatment: Translocation And Impact On Seed And Plant Health, Tímea Kacsó, Eban A. Hanna, Fallon Salinas, Carlos E. Astete, Ede Bodoki, Radu Oprean, Paul P. Price, Vinson P. Doyle, Colin A.R. Bonser, Jeffrey A. Davis, Cristina M. Sabliov
Zein And Lignin-Based Nanoparticles As Soybean Seed Treatment: Translocation And Impact On Seed And Plant Health, Tímea Kacsó, Eban A. Hanna, Fallon Salinas, Carlos E. Astete, Ede Bodoki, Radu Oprean, Paul P. Price, Vinson P. Doyle, Colin A.R. Bonser, Jeffrey A. Davis, Cristina M. Sabliov
Faculty Publications
Zein nanoparticles (ZNPs) were synthesized with a cationic surfactant, didodecyldimethylammonium bromide (122.9 ± 0.8 nm, + 59.7 ± 4.4 mV) and a non-ionic surfactant, Tween 80 (118.7 ± 1.7 nm, + 26.4 ± 1.1 mV). Lignin-graft-poly(lactic-co-glycolic) acid nanoparticles (LNPs) were made without surfactants (52.9 ± 0.2 nm, − 54.9 ± 0.5 mV). Both samples were applied as antifungal seed treatments on soybeans, and their impact on germination and plant health was assessed. Treated seeds showed high germination rates (> 90% for all treatment groups), similar to the control group (100%). Root and stem lengths and the dry biomass of treated …
Evaluation Of Triple Negative Breast Cancer Tumor Matrix, Alejandra Ham
Evaluation Of Triple Negative Breast Cancer Tumor Matrix, Alejandra Ham
Honors Capstones
No abstract provided.
Examining The Relationship Between Health-Related Fitness And Motor Competence In College-Aged Students, Michael Crick
Examining The Relationship Between Health-Related Fitness And Motor Competence In College-Aged Students, Michael Crick
Honors Capstones
No abstract provided.
Gender And Regional Differences Within The Southern Subculture Of Violence, Caitlin Oconnor
Gender And Regional Differences Within The Southern Subculture Of Violence, Caitlin Oconnor
Honors Capstones
No abstract provided.
Reinforcement Learning In A Quantum Network, Roy Pace
Reinforcement Learning In A Quantum Network, Roy Pace
Honors Capstones
No abstract provided.
Impact Of Sex On Proliferation And Maturation Of Primary Isolated Myoblasts, Elsa M. Bean
Impact Of Sex On Proliferation And Maturation Of Primary Isolated Myoblasts, Elsa M. Bean
Biomedical Engineering
Peripheral arterial occlusive disease (PAOD) is caused by the buildup of atherosclerotic plaque causing restriction in blood flow in tissue, known as ischemia. It affects 8 million people in the United States and can hinder daily life through the onset of symptoms such as intermittent claudication and in extreme cases ulcers and gangrene. Surgical revascularization is not accessible to certain patient populations, such those of advanced age, highlighting a need for alternative therapies. For example, naturally occurring bypass arteries, called collateral blood vessels, can remodel and enlarge to bypass the occlusion. This process, known as arteriogenesis, has been studied as …
Establishing Pteridine Metabolism In A Progressive Isogenic Breast Cancer Cell Model – Part Ii, Lindsey Rasmussen, Zachary Foulks, Jiandong Wu, Casey Burton, Honglan Shi
Establishing Pteridine Metabolism In A Progressive Isogenic Breast Cancer Cell Model – Part Ii, Lindsey Rasmussen, Zachary Foulks, Jiandong Wu, Casey Burton, Honglan Shi
Chemistry Faculty Research & Creative Works
Introduction: Determining the biological significance of pteridines in cancer development and progression remains an important step in understanding the altered levels of urinary pteridines seen in certain cancers. Our companion study revealed that several folate-derived pteridines and lumazines correlated with tumorigenicity in an isogenic, progressive breast cancer cell model, providing direct evidence for the tumorigenic origin of pteridines. Objectives: This study sought to elucidate the pteridine biosynthetic pathway in a progressive breast cancer model via direct pteridine dosing to determine how pteridine metabolism changes with tumorigenicity. Methods: First, MCF10AT breast cancer cells were dosed individually with 15 pteridines to determine …
Reply To R Kirwan Et Al., David S. Ludwig, Belinda S. Lennerz, Jacob T. Mey
Reply To R Kirwan Et Al., David S. Ludwig, Belinda S. Lennerz, Jacob T. Mey
Division of Basic Science Faculty Publications
No abstract provided.
Oncostatin M Induces Lipolysis And Suppresses Insulin Response In 3t3-L1 Adipocytes, Jennifer L. Bailey, Hardy Hang, Anik Boudreau, Carrie M. Elks
Oncostatin M Induces Lipolysis And Suppresses Insulin Response In 3t3-L1 Adipocytes, Jennifer L. Bailey, Hardy Hang, Anik Boudreau, Carrie M. Elks
Division of Basic Science Faculty Publications
Oncostatin M (OSM) is an immune cell-derived cytokine that is upregulated in adipose tissue in obesity. Upon binding its receptor (OSMR), OSM induces the phosphorylation of the p66 subunit of Src homology 2 domain-containing transforming protein 1 (SHC1), called p66Shc, and activates the extracellular signal-related kinase (ERK) pathway. Mice with adipocyte-specific OSMR deletion (OsmrFKO) are insulin resistant and exhibit adipose tissue inflammation, suggesting that intact adipocyte OSM–OSMR signaling is necessary for maintaining adipose tissue health. How OSM affects specific adipocyte functions is still unclear. Here, we examined the effects of OSM on adipocyte lipolysis. We treated 3T3-L1 adipocytes with OSM, …
Hyperactivity Of A Midbrain Dopamine To 5-Ht Circuit Causes Anorexia, Hailan Liu, Xing Cai, Yanlin He, Yong Xu
Hyperactivity Of A Midbrain Dopamine To 5-Ht Circuit Causes Anorexia, Hailan Liu, Xing Cai, Yanlin He, Yong Xu
Division of Basic Science Faculty Publications
No abstract provided.
A D2 To D1 Shift In Dopaminergic Inputs To Midbrain 5-Ht Neurons Causes Anorexia In Mice, Xing Cai, Hailan Liu, Bing Feng, Meng Yu, Yang He, Hesong Liu, Chen Liang, Yongjie Yang, Longlong Tu, Nan Zhang, Lina Wang, Na Yin, Junying Han, Zili Yan, Chunmei Wang, Pingwen Xu, Qi Wu, Qingchun Tong, Yanlin He, Yong Xu
A D2 To D1 Shift In Dopaminergic Inputs To Midbrain 5-Ht Neurons Causes Anorexia In Mice, Xing Cai, Hailan Liu, Bing Feng, Meng Yu, Yang He, Hesong Liu, Chen Liang, Yongjie Yang, Longlong Tu, Nan Zhang, Lina Wang, Na Yin, Junying Han, Zili Yan, Chunmei Wang, Pingwen Xu, Qi Wu, Qingchun Tong, Yanlin He, Yong Xu
Division of Basic Science Faculty Publications
Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors, including feeding, but less is known about how these circuits may interact. In this study, we found that DA neurons in the mouse ventral tegmental area bidirectionally regulate the activity of 5-HT neurons in the dorsal raphe nucleus (DRN), with weaker stimulation causing DRD2-dependent inhibition and overeating, while stronger stimulation causing DRD1-dependent activation and anorexia. Furthermore, in the activity-based anorexia (ABA) paradigm, which is a mouse model mimicking some clinical features of human anorexia nervosa (AN), we observed a DRD2 to DRD1 shift of DA neurotransmission on 5-HTDRN neurons, which …
Potent Anti-Sars-Cov-2 Efficacy Of Covid-19 Hyperimmune Globulin From Vaccine-Immunized Plasma, Ding Yu, Yu Feng Li, Hong Liang, Jun Zheng Wu, Yong Hu, Yan Peng, Tao Jing Li, Ji Feng Hou, Wei Jin Huang, Li Dong Guan, Ren Han, Yan Tao Xing, Yong Zhang, Jia Liu, Lu Feng, Chun Yan Li, Xiao Long Liang, Ya Ling Ding, Zhi Jun Zhou, De Ming Ji, Fei Fei Wang, Jian Hong Yu, Kun Deng, Dong Mei Xia, De Mei Dong, Heng Rui Hu, Ya Jie Liu, Dao Xing Fu, Yan Lin He, Dong Bo Zhou, Hui Chuan Yang, Rui Jia, Chang Wen Ke, Tao Du
Potent Anti-Sars-Cov-2 Efficacy Of Covid-19 Hyperimmune Globulin From Vaccine-Immunized Plasma, Ding Yu, Yu Feng Li, Hong Liang, Jun Zheng Wu, Yong Hu, Yan Peng, Tao Jing Li, Ji Feng Hou, Wei Jin Huang, Li Dong Guan, Ren Han, Yan Tao Xing, Yong Zhang, Jia Liu, Lu Feng, Chun Yan Li, Xiao Long Liang, Ya Ling Ding, Zhi Jun Zhou, De Ming Ji, Fei Fei Wang, Jian Hong Yu, Kun Deng, Dong Mei Xia, De Mei Dong, Heng Rui Hu, Ya Jie Liu, Dao Xing Fu, Yan Lin He, Dong Bo Zhou, Hui Chuan Yang, Rui Jia, Chang Wen Ke, Tao Du
Division of Basic Science Faculty Publications
Coronavirus disease 2019 (COVID-19) remains a global public health threat. Hence, more effective and specific antivirals are urgently needed. Here, COVID-19 hyperimmune globulin (COVID-HIG), a passive immunotherapy, is prepared from the plasma of healthy donors vaccinated with BBIBP-CorV (Sinopharm COVID-19 vaccine). COVID-HIG shows high-affinity binding to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein, the receptor-binding domain (RBD), the N-terminal domain of the S protein, and the nucleocapsid protein; and blocks RBD binding to human angiotensin-converting enzyme 2 (hACE2). Pseudotyped and authentic virus-based assays show that COVID-HIG displays broad-spectrum neutralization effects on a wide variety of SARS-CoV-2 variants, …
Artemisia Dracunculus L. Ethanolic Extract And An Isolated Component, Dmc2, Ameliorate Inflammatory Signaling In Pancreatic Β-Cells Via Inhibition Of P38 Mapk, Peter Smoak, Susan J. Burke, Thomas M. Martin, Heidi M. Batdorf, Z. Elizabeth Floyd, J. Jason Collier
Artemisia Dracunculus L. Ethanolic Extract And An Isolated Component, Dmc2, Ameliorate Inflammatory Signaling In Pancreatic Β-Cells Via Inhibition Of P38 Mapk, Peter Smoak, Susan J. Burke, Thomas M. Martin, Heidi M. Batdorf, Z. Elizabeth Floyd, J. Jason Collier
Division of Basic Science Faculty Publications
Non-resolving pancreatic islet inflammation is widely viewed as a contributor to decreases in β-cell mass and function that occur in both Type 1 and Type 2 diabetes. Therefore, strategies aimed at reducing or eliminating pathological inflammation would be useful to protect islet β-cells. Herein, we described the use of 2′,4′-dihydroxy-4-methoxydihydrochalcone (DMC2), a bioactive molecule isolated from an ethanolic extract of Artemisia dracunculus L., as a novel anti-inflammatory agent. The ethanolic extract, termed PMI 5011, reduced IL-1β-mediated NF-κB activity. DMC2 retained this ability, indicating this compound as the likely source of anti-inflammatory activity within the overall PMI 5011 extract. We further …