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Investigating The Ecology And Evolution Of Normal Breast Tissues And Breast Cancer With Single Cell Genomics, Tapsi Kumar, Tapsi Kumar

Dissertations and Theses (Open Access)

There is vast cellular heterogeneity in human breast tissues, with different transcriptional programs in the stromal, epithelial, and immune components, however, it remains unclear how their reprogramming and interplay leads to the progression of invasive phenotypes such as Triple- Negative Breast cancer (TNBC). To do define the microenvironmental alterations that occur during cancer, we first established a human breast cell atlas, a reference of normal breast cell types from disease free women. We profiled 535,941 cells from 62 women and 124,024 nuclei from 20 women revealing 11 major cell types and 52 cell states that reflect different biological functions that …

Increasing Awareness Of The Risks Of Teasing In Schools Ages Seven Through Eight Years Old, Stephanie Munoz

Capstone Projects and Master's Theses

Many early elementary school children; particularly those ages five through eight years old, may not have yet developed social skills to create school relationships in a school setting. They have not developed the social skills to maintain relationships with peers. The lack of social skills creates negative impacts emotionally and mentally on five through eight year old’s. The lack of social skills can cause social anxiety that is amplified by teasing in schools. Early elementary children ages five to eight years old, may not be able to tell the difference between bullying and teasing. Teasing is intended to provoke or …

Authoring Prior Art, Joseph P. Fishman, Kristelia Garcia

Vanderbilt Law Review

Patent law and copyright law are widely understood to diverge in how they approach prior art, the universe of information that already existed before a particular innovation's development. For patents, prior art is paramount. An invention can't be patented unless it is both novel and nonobvious when viewed against the backdrop of all the earlier inventions that paved the way. But for copyrights, prior art is supposed to be virtually irrelevant. Black-letter copyright doctrine doesn't care if a creative work happens to resemble its predecessors, only that it isn't actually copied from them. In principle, then, outside of the narrow …

Nondelegation In The States, Benjamin Silver

Vanderbilt Law Review

American public law is on the precipice of a nondelegation revival. Yet scholars have largely ignored the greatest wellspring of American nondelegation law: that of the states. As a result, the nondelegation literature is badly in need of a broad and deep examination of state nondelegation. This Article takes up that task by describing the kaleidoscope of contexts in which states apply the nondelegation doctrine. Significantly, state nondelegation reaches deep into public law and covers far more than the legislature-to-agency delegations that preoccupy the discussion at the federal level. This Article analyzes this mess of state nondelegation jurisprudence, arguing that …

Psychosocial Student Adaptions To Covid-19 In Higher Education: A Mixed-Methods Approach To Covid-19 Through The Theoretical Framework Of Anomie, Grace Erika Johnson

Undergraduate Honors Thesis Collection

The COVID-19 pandemic impacted individuals and social institutions due to an abrupt and expansive change to norms and values, which are key characteristics of an anomic state. The purpose of this exploratory and descriptive study was to understand how students enrolled at residential university perceived educational and societal pressures associated with COVID-19. This research applied a mixed methods approach and relied upon three phrases of research: (1) Pilot questionnaire (n=54); (2) Qualitative interviews (n=14); and (3) Quantitative questionnaire (n=253). Findings suggested similarities in how university students responded to COVID-19 and how communities responded previously to other forms of natural disasters. …

Learning From Each Other: Peer-Reviewed Literature Searching, Heather Martin, Danielle Linden, Carrie Grinstead

Articles, Abstracts, and Reports

Background: Amidst shrinking staffing levels and expanding business, a health system library department developed a peer-learning program in order to build literature search capacity and self-efficacy amongst librarians and library support staff.

Description: Library staff are partnered and rotate monthly; pairs include those in same and different job roles and experience levels. Staff are encouraged to choose real patron clinical questions that would serve as optimal learning opportunities, reinforcing best practices in search strategy and/or database functionality or ones that are particularly challenging. Partners independently perform the other’s search then meet virtually to compare results, strategies, and debrief on lessons …

The Effects Of Metronomic And Maximum-Tolerated Dose Chemotherapy In Colorectal Cancer Angiogenesis: A Combined Approach Using Endoscopic Diffuse Reflectance Spectroscopy And Mrna Expression, Ariel Isaac Mundo Ortiz

Graduate Theses and Dissertations

Colorectal cancer (CRC) continues to be one of the most incident and deadliest types of cancer worldwide. Chemotherapy has proven effective to reduce tumor burden for CRC patients, but there are several disadvantages associated with the use of mainstay maximtolerated dose (MTD) chemotherapeutic strategies. Metronomic chemotherapy (MET) has been developed as an alternative that addresses the shortcomings of maximum-tolerated dose chemotherapy but so far its effectiveness as a neoadjuvant strategy for CRC has not been explored.

This dissertation uses a combined optics and molecular biology approach (using diffuse reflectance spectroscopy and mRNA expression) to study the changes in angiogenesis and …

Characterization Of The Influence Of A Small Molecule Inhibitor On Ras-Related Proteins Interactions, Emilio Duverna

Graduate Theses and Dissertations

The Ras superfamily of small G proteins are involved in cell-signaling processes that, if not regulated, may lead to cell multiplication, apoptosis inhibition, and tumorigenesis. They function as molecular switches, which through GTP/GDP exchange cycle, switch on or off cellular activities. Overexpression and/or hyperactivity of these proteins have been linked to many diseases including various cancers. CDC42, a member of the Rho subfamily of the Ras superfamily of small G proteins, participates in the regulation of many cellular processes including cell adhesion, mitosis, and cytoskeletal rearrangements. CDC42 binds to and activates many effector proteins including CDC42-activated kinase (ACK). Abnormal activities …

2022-May-01-Meet Joshua Trimm, University Marketing And Communication, East Tennessee State University

ETSU News

When Joshua Trimm crossed the commencement stage at East Tennessee State University less than a month ago, the person who once thought a graduate degree may not be for him conquered those fears. In June, Joshua will begin a new job at one of the largest employers in the Appalachian Highlands – Eastman Chemical Company. 

 

Joshua is from Kingsport. He attended Northeast State Community College for two years and earned an associate degree in web design. A self-described “non-traditional student” who began his collegiate journey seven years ago, Joshua said time allowed him to learn the real value of higher …

The Heart Of The Problem: An Art Gallery Installation To Foster Dialogue On Heart Disease And The Privilege Of Prevention, Olivia Eileen Heinecke

Undergraduate Honors Thesis Collection

We are cautioned constantly about various harmful diseases. However, the deadliest disease tends to be overlooked. Heart disease takes the lives of more than half a million people in the United States every year, yet there is a lack of discussion to address the epidemic at hand (Hill). This is largely due to the “blame the victim” stigma surrounding the generally preventable range of complications. While 80% of cardiovascular disease is avoidable, not every individual has the means of achieving a lifestyle necessary in averting the conditions and their symptoms. For this creative art project, I want to encourage education …

Using The Edtpa As A Model For Teacher Research And Reflective Practice: An Honors Thesis, Eva Jaeger

Undergraduate Honors Thesis Collection

Teacher research engages educators in inquiry to enhance their practice, initiate evidence-based change in their classroom and become more reflective practitioners in order to best support the learning of their students’ individual strengths and needs. The edTPA is a national teaching performance assessment that determines teachers’ effective practices as they are on the cusp of entering the educational profession. Aspiring teachers must demonstrate that they are prepared to enter the educational profession with the skills and knowledge needed to help each of their individual students learn. The edTPA was completed and submitted during the high school student teaching clinical experience, …

Stress Effects On Hydrogen Peroxide Defense Response Of Physcomitrella Patens And Mnium Cuspidatum, Caden Karl Groves

Undergraduate Honors Thesis Collection

This project investigated the importance of stresses and the immune system response of hydrogen peroxide formation within the model system Physcomitrella patens, as well as in Mnium cuspidatum. I examined the role of two hormones, abscisic acid and jasmonic acid, along with the role that drought-like conditions play in the specified defense response of hydrogen peroxide production. I hypothesized that abscisic acid would act as an antagonist and reduce hydrogen peroxide production, jasmonic acid would act as an amplifier to increase hydrogen peroxide production and increasing the sodium concentration of the liquid treatment would also act as an antagonist. These …

Parents And The Evolving Math Curriculum: Supporting One's Student In Elementary Mathematics, Kailyn Heather Scobie

Undergraduate Honors Thesis Collection

The current-day mathematics curriculum is evidently different from the traditional means of teaching math. Due to this, there exist disparities between a child’s math education and their parent or guardian’s math education. This thesis will present firsthand evidence on how these disparities affect a parent’s perception of current-day curriculum, the extent to which parents can support their child in their learning of mathematics at home, and will strive to attend to the needs of both the parents or guardians as well as students in supporting the learning of these new concepts and strategies. With this, the research question asks: What …

Is The Ivory Tower Made Of Glass?: Examining Work Experiences Of Women Faculty At Butler University, Erin Elizabeth Mahan

Undergraduate Honors Thesis Collection

The guiding research question for this study is: “What are the structural, cultural, and situational factors that affect women faculty’s experience at Butler University?” While this project focuses broadly on women as an identifying group, it also requires attention to the intersectionality of individuals’ experience as issues such as race, ethnicity, sexual orientation and disabilities are also factors shaping women’s experiences. The information from this study draws attention to the experiences that women faculty have related to their gender and potentially facilitate change starting at Butler University. This paper will discuss the experiences of women faculty at Butler University regarding …

Effects Of Intermittent Alcohol And Nicotine Cc-Consumption In C57bl/6j Mice, Presley Elizabeth Fletcher

Undergraduate Honors Thesis Collection

Two of the world’s leading causes of preventable deaths include the use of alcohol and tobacco. While independently these substances have negative consequences, they are often used in combination. For instance, those who are dependent on nicotine are more likely to engage in hazardous drinking and/or have a dependence on alcohol and vice versa. As different methods of consuming nicotine become more normalized, there is a concern of associated harmful alcohol consumption being that both substances are widely available and rewarding. The goal of the current study was to understand the relationship between nicotine and alcohol and the behavioral effects …

Through My Eyes: Lessons And Stories From The Fairways, Catherine Therese Fulton

Undergraduate Honors Thesis Collection

A caddie is a person who carries a golfer’s clubs and provides assistance during a round of golf. It is the job of a caddie to carry clubs, calculate yardages to the pin, rake bunkers and read greens. The role of the caddie has been shaped by the professional caddies seen on television carrying for PGA Tour and LPGA Tour players or in movies such as Caddyshack, Happy Gilmore and The Greatest Game Ever Played. Through the first-hand experience of a female caddie at a local country club, however, caddying is more than just the job itself. This thesis is …

Jurgen Comics Contest Newspaper And Artwork - 2022, Alyson Piccione

Jurgen Banned Art Comics Contest

Digital edition of the Jurgen Comics Contest broadsheet newspaper celebrating the 2022 Contest winners. The newspaper design and supplemental artwork was created by contest student editor Alyson Piccione. Supplemental promotional materials include poster, comic, and caricatures of historical figures who played a role in the censorship of James Branch Cabell's work Jurgen: A Comedy of Justice.

The 2022 Jurgen Comics Contest invited VCU students to explore some episode or aspect of the seizure and censorship of James Branch Cabell’s Jurgen: A Comedy of Justice in a single-page, multi-panel comic.

Habitat Preference Of F. Notatus And F. Olivaceus From A Reversed Hybrid Zone, Elizabeth Hart Williams

Honors Theses

Understanding the mechanisms driving habitat preference throughout an organism’s life opens doors to the further understanding of the origins of diversity. Two species of minnow, Fundulus notatus and Fundulus olivaceus, are ideal for ecological research on habitat preference. Ordinarily, F. notatus and F. olivaceus display habitat preferences of downstream and upstream, respectively, with minimal coexistence at confluences. However, in some drainages, these preferences are flipped, like those in the Tombigbee River basin. Members of both species were collected from the Tombigbee River, tagged with species and sex specific colored elastomer marks, and placed in either a homogeneous control or …

Medical Laboratory Science Students At The University Of Southern Mississippi Response To The Covid-19 Pandemic, Kaitlyn Mcginnis

Honors Theses

The COVID-19 pandemic has changed educators’ and students’ perspectives on virtual teaching of the laboratory sciences. This study aims to determine the perceived effects of the COVID-19 pandemic on Medical Laboratory Science (MLS) students at the University of Southern Mississippi. This study will evaluate how the changes to the instruction of the MLS curriculum and overall student mental health affected their grades and retention of academic content during and post-pandemic. The goal is to determine students’ perception of the effectiveness of virtual learning during the COVID-19 quarantine period, and whether it is a sustainable learning resource. Five students enrolled in …

Covid-19 Vaccine Hesitancy: Examining The Relationship Between Perceptions Of Covid-19 Vaccine Safety And Intention To Receive It Among African Americans In Mississippi, Tija L. Johnson

Honors Theses

In March of 2020, the World Health Organization declared a global pandemic due to the ongoing spread of SARS-CoV-2, the causative agent of COVID-19 disease. While scientific developers were seeking to understand the biochemical mechanism of SARS-CoV-2, political and public health leaders implemented non-pharmaceutical interventions, such as social distancing measures, to reduce the transmission of COVID-19. As the world began to adjust to the new realities, the race to create an effective vaccine was on. With the later development of the COVID-19 vaccine, receptiveness to the vaccine across the world varied, and in the United States, vaccine hesitancy was an …

Generation Of Baiap3 Expression Construct For Subcellular Localization And Phenotypic Rescue, Ireland Ann Little

Honors Theses

Mast cells secrete a variety of biological mediators crucial for innate and adaptive immunity. One such mediator is Tumor Necrosis Factor (TNF). TNF released from mast cells and other immune cells has been shown to elicit complex signaling pathways in target cells, resulting in the production of pro-inflammatory cytokines and/or immune cell recruitment. At the molecular level, TNF secretion/exocytosis is mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and other regulatory proteins that work together to promote the fusion between secretory granules and the plasma membrane. One regulatory protein, Munc13-4, which facilitates the priming of secretory granules, was recently …

Impacts Of Methods And Pose On Performance Of Two Modern American Football Helmets, Ta’Quoris Newsome

Honors Theses

The standardization of American football helmets began with the development of the National Operating Committee for Safety in Athletic Equipment (NOCSAE). The organization successfully developed a certification that quantifies a helmet’s ability to mitigate blunt force to prevent skull fractures; however, the ability to assure the same level of protection against concussion has been elusive. Regardless, The National Football League (NFL) and Virginia Tech University (VT) have developed blunt and rotational impact testing methodologies that aim to provide consumers with the effectiveness and safety of American football helmets through their respective ranking system. These ranking systems are intended to aid …

Two Marching Band Directors’ Insights About Their Bands’ Musical Achievement And Satisfaction In The American Deep South: A Qualitative Analysis, John Klee

Honors Theses

High School marching band is an intricate facet of music education that operates in several varieties across the United States. Depending on the style as well as many external and internal factors of a marching band, marching bands can have goals and definitions of musical achievement that can vary drastically. This qualitative study aims to assist those in the world of marching music education to better understand these distinct types of marching bands on a deeper level. The study gathered detailed perspectives of two directors in juxtaposed marching programs to a view of what drives these bands and directors to …

An Investigation Of Social Ecological Barriers To And Facilitators Of Wic Farmers Market Nutrition Program Voucher Redemption, Renata Blumberg, Emily Fowler, Yeon Bai, Pankaj Lal, Alyssa Smolen, Ilana Dubrovsky

Department of Nutrition and Food Studies Scholarship and Creative Works

In the United States, many communities lack sufficient access to fresh produce. To improve access to fresh fruits and vegetables, the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) provides eligible participants vouchers through the Farmers Market Nutrition Program (FMNP) that can be redeemed directly from farmers at markets or farm stands. However, FMNP voucher redemption rates in New Jersey remain lower than those in neighboring states. This article used the social ecological model to examine differences between FMNP participants who redeem vouchers (Redeemers) and those who do not (non-Redeemers) in the areas of: produce procurement practices and …

Culture In Disney Films: A Comparative Analysis Of Color, Composition And Rhythm, Megan Paul

Interior Design Undergraduate Honors Theses

As a student of design, I take inspiration from everything around me. The media I consume, the places I visit, and the people I meet.By choice or not, I and my generation are subject to the various forms of pop culture, film is one of them. Film is one of few art forms which combines several methods and elements of design to produce a cohesive result, as opposed to a singular medium. This forms the connection to design thinking and is the foundation for the study.

Another critical component to pop culture is the ability to reach the masses. Due …

Design For A Spectrum, Brooke Warden

Interior Design Undergraduate Honors Theses

Autism Spectrum Disorder (ASD) is a growing disorder across the world. ASD affects around 1 in every 68 children in the United States (Block, 2018). This disorder results in significant social, intellectual, and behavioral changes within a child, and create challenges for a child with ASD to learn and develop like children without ASD. No two cases of ASD are alike which is why it is called a spectrum disorder. This adds an extra challenge to designing spaces for children with ASD to inhabit and thrive. These children frequently suffer from sensory processing deficits in which they have a hard …

Bumpers College Of Agricultural, Food And Life Sciences Professional Development Opportunities And Their Impact On Perceptions Of Career Preparedness, Jessica L. Wesson

Graduate Theses and Dissertations

A student’s undergraduate education is an imperative part of developing career skills that will prepare them to transition from academia to the professional world. Experience outside of the classroom and course material taught in a formal class experience are both important. Their experiences and classes, in college, allow them to develop skills and increase their chances of being successful in the workplace (Suvedi et al., 2016).

Chickering’s Seven Vectors of Student Development were used to help explain the process of student development. A quantitative survey was sent to DBCALFS faculty, staff, and administrators, and a different quantitative survey was sent …

The Experiences Of The Transgender And Gender Diverse Community On Coming Out At The University Of Arkansas, Taylor Hubbard

Graduate Theses and Dissertations

Researching the experiences of the TGD community can help better understand the unique struggles this community may face, specifically regarding the unique experiences southeastern United States TGD individuals have encountered. We draw on previous studies regarding the entire LGBTQ+ community and the minimal research on the TGD community. There is minimal research looking specifically at the experiences college TGD students have when coming out in different aspects and the perceptions TGD individuals have about themselves as a result of their experiences coming out. We conducted a survey with 37 respondents as well as 4 qualitative interviews. We present interviews conducted …

Diffusive Dynamics Of Biological Macromolecules In The Cytoplasm Of Live Bacteria, Asmaa Sadoon

Graduate Theses and Dissertations

Bacteria are small organisms that play important roles in our bodies and in maintaining our surrounding environment. However, bacterial infections are considered as one of the health diseases that threatens the lives of humans. Resistance of bacteria to antibiotics has made treating bacterial infections more challenging. With the emergence of many developed optical techniques, it has become possible to study various biological mechanisms of molecules inside these small organisms with high resolution and precise localization. In this research, single particle tracking photoactivation localization microscopy (sptPALM) technique was used to investigate the dynamics of fluorescent histonelike nucleoid-structuring proteins (H-NS) in live …

Racial And Ethnic Composition Among Latinos In The United States (1990-2017), Sebastián Villamizar-Santamaría

Center for Latin American, Caribbean, and Latino Studies

Introduction:

This report examines the socioeconomic trends and differences among not only the four major racial and ethnic groups in the country (non-Hispanic whites, non-Hispanic blacks, Latinos, and Asians) but also within the Latino population from 1990 to 2017.

Methods:

This report uses the American Community Survey PUMS (Public Use Microdata Series) data for all years released by the Census Bureau and reorganized for public use by the Minnesota Population Center, University of Minnesota, IPUMSusa, (https://usa.ipums.org/usa/index.shtml). See Public Use Microdata Series Steven Ruggles, J. Trent Alexander, Katie Genadek, Ronald Goeken, Matthew B. Schroeder, and Matthew Sobek. Integrated Public Use Microdata …