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Noxious Cellular Injury Triggers An Oxidative Stress Gene Response, Shawyun Khoshneviszadeh

Master of Science in Integrative Biology Theses

Wound and regeneration involves a series of complex processes that can induce oxidative stress by elevating intracellular reactive oxygen species (ROS) levels. In this study, we used RNA-seq and qPCR to examine the molecular signature of Human Embryonic Kidney cells (HEK-293T) stimulated with Crotalus atrox (CA) venom. NGS data was assembled and annotated utilizing the Illumina paired-end RNA-seq approach with software packages HISAT2 and StringTie. Results showed 243 genes were differentially expressed (106 upregulated, 137 downregulated) between CA venom stimulated and non-stimulated cells (p<0.05). HEK-293T stimulated with CA venom for 4 hours showed an increase in the expression of oxidative stress response genes (e.g., TOMM6, EGR (1,2,3), HSP70 (1A, 1B), SPRY4, ETV5, and EMP1) (Fold-Change (fc) >2.0). Significantly downregulated genes were associated with many novel transcripts/proteins such as AC117378, AD000671, and AC023509. …

Female Presence Does Not Increase Testosterone But Still Ameliorates Sickness Behaviours In Male Japanese Quail, Brenna M. G. Gormally, Kaelyn Bridgette, Aubrey Emmi, Delilah Schuerman, Patricia C. Lopes

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Infections can dramatically modify animal behaviour. The extent of these changes depends on an animal's environment. It has been proposed that testosterone modulates the suppression of behavioural symptoms of sickness under certain reproductive contexts. To further understand the role played by testosterone in modulating sickness behaviours under reproductive contexts, we studied a species, the Japanese quail, in which female exposure rapidly decreases circulating testosterone in males. Males received either an immune challenge (lipopolysaccharide – LPS) or a control injection and their behaviours, mass change and testosterone levels were quantified in the presence or absence of a female. Both the presence …

Celebrating The Class Of 2022, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Celebrating Unh Manchester Class Of 2022, Kassidy Taylor

UNH Today Archive

No abstract provided.

Food Insecurity And Suicidal Behaviors Among Us High School Students*, Andrea D. Brown, Hilary Seligman, Sarah Silwa, Ellen Barnidge, Kathryn L. Krupsky, Zewiditu Demissie, Angela D. Liese

Faculty Publications

BACKGROUND: Food insecurity (FI) rates in the United States are particularly high among households with children. This research set aims to analyze if high school students experiencing FI had higher risk for mental health and suicidal behaviors.

METHODS: Using combined data from 11 states that conducted the 2017 Youth Risk Behavior Survey, a total of 26,962 and24,051 high school students were used to estimate race/ethnicity and sex-stratified prevalence ratios (PRs) from Poissonregression models. A single-question was used to measure the exposure of FI and outcomes of mental health and suicidalbehaviors.

RESULTS: Overall, 10.8% of students reported FI. Students experiencing FI …

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Und Strategic Planning Focus Group Notes: Meritorious Award Staff — May 24, 2022, University Of North Dakota

LEADS Development Documents

Notes from a May 24, 2022 UND strategic planning focus group with Meritorious Award staff. The notes capture staff perspectives on UND’s strengths, workplace culture, employee recognition, communication, collaboration, staff support, and opportunities for UND’s future.

Pharmacogenetic Review: Germline Genetic Variants Possessing Increased Cancer Risk With Clinically Actionable Therapeutic Relationships, Austin A. Saugstad, Natasha Petry, Catherine Hajek

Student Publications

As our understanding of genomics and genetic testing continues to advance, the personalization of medical decision making is progressing simultaneously. By carefully crafting medical care to fit the specific needs of the individual, patients can experience better long-term outcomes, reduced toxicities, and improved healthcare experiences. Genetic tests are frequently ordered to help diagnose a clinical presentation and even to guide surveillance. Through persistent investigation, studies have begun to delineate further therapeutic implications based upon unique relationships with genetic variants. In this review, a pre-emptive approach is taken to understand the existing evidence of relationships between specific genetic variants and available …

Quantization For A Probability Distribution Generated By An Infinite Iterated Function System, Lakshmi Roychowdhury, Mrinal Kanti Roychowdhury

School of Mathematical & Statistical Sciences Faculty Publications

Quantization for probability distributions concerns the best approximation of a d-dimensional probability distribution P by a discrete probability with a given number n of supporting points. In this paper, we have considered a probability measure generated by an infinite iterated function system associated with a probability vector on R. For such a probability measure P , an induction formula to determine the optimal sets of n-means and the nth quantization error for every natural number n is given. In addition, using the induction formula we give some results and observations about the optimal sets of n-means for all n ≥ …

Information Asymmetry In Hospitals: Evidence Of The Lack Of Cost Awareness In Clinicians, J Fabes, Ts Avşar, J Spiro, T Fernandez, H Eilers, S Evans, A Hessheimer, P Lorgelly, M Spiro, D Milliken, C Morkane, C Nettlefold, P Xiang, N Vogts, A Curell, A Torroella, A Melia, R Jackson, M Hanger, A Poole

Peninsula Medical School

Background Information asymmetries and the agency relationship are two defining features of the healthcare system. These market failures are often used as a rationale for government intervention. Many countries have government financing and provision of healthcare in order to correct for this, while health technology agencies also exist to improve efficiency. However, informational asymmetries and the resulting principal-agent problem still persist, and one example is the lack of cost awareness amongst clinicians. This study explores the cost awareness of clinicians across different settings. Methods We targeted four clinical cohorts: medical students, Senior House Officers/Interns, Mid-grade Senior Registrar/Residents, and Consultant/Attending Physicians, …

A Scoping Review Of Digital Twins In The Context Of The Covid-19 Pandemic, A Khan, M Milne-Ives, E Meinert, Ge Iyawa, Rb Jones, An Josephraj

School of Engineering, Computing and Mathematics

Background: Digital Twins (DTs), virtual copies of physical entities, are a promising tool to help manage and predict outbreaks of Covid-19. By providing a detailed model of each patient, DTs can be used to determine what method of care will be most effective for that individual. The improvement in patient experience and care delivery will help to reduce demand on healthcare services and to improve hospital management. Objectives: The aim of this study is to address 2 research questions: (1) How effective are DTs in predicting and managing infectious diseases such as Covid-19? and (2) What are the prospects and …

Climatic Backdrop For Pueblo Cultural Development In The Southwestern United States, Victor J. Polyak, Yemane Asmerom, Matthew S. Lachniet

Geoscience Faculty Research

While climatic triggers for collapse and population migrations of ancestral Pueblo communities have been proposed, little is known about the overall climatic backdrop for the entire pre-Hispanic Pueblo period (ca. 1300 to 460 B2K). Here, we report data from stalagmite HC-1, from Hidden Cave, Guadalupe Mountains, New Mexico, covering the past 3400 years, showing an interval of increased frequency of droughts from 1260 to 370 yr B2K that is coeval with the entire pre-Hispanic Pueblo period. Our record suggests that this puebloan Late Holocene climatic interval was the most arid and highly variable climatic period of the last 3400 years. …

Chapter 27: Bloch Sphere And Single-Qubit Arbitrary Unitary Gate, Hiu Yung Wong

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

Association Study Between Mucin 4 (Muc4) Polymorphisms And Idiopathic Recurrent Pregnancy Loss In A Korean Population, Ji-Hyang Kim, Han-Sung Park, Jeong-Yong Lee, Eun-Ju Ko, Young-Ran Kim, Hee-Young Cho, Woo-Sik Lee, Eun-Hee Ahn, Nam-Keun Kim

Faculty, Staff and Student Publications

Recurrent pregnancy loss (RPL) is the loss of two or more consecutive pregnancies before 20 weeks of gestational age. Our study investigated whether mucin 4 (MUC4) polymorphisms are associated with RPL. MUC polymorphisms (rs882605 C>A, rs1104760 A>G, rs2688513 A>G, rs2258447 C>T, and rs2291652 A>G) were genotyped in 374 women with RPL and 239 controls of Korean ethnicity using polymerase chain reaction-restriction fragment length polymorphism analysis and the TaqMan probe SNP genotyping assay. Differences in genotype frequencies between cases of RPL and the controls were compared. MUC4 rs882605 C>A and rs1104760 A>G polymorphisms were …

A Nickase Cas9 Gene-Drive System Promotes Super-Mendelian Inheritance In Drosophila, Víctor López Del Amo, Sara Sanz Juste, Valentino M Gantz

Faculty, Staff and Student Publications

CRISPR-based gene-drives have been proposed for managing insect populations, including disease-transmitting mosquitoes, due to their ability to bias their inheritance toward super-Mendelian rates (>50%). Current technologies use a Cas9 that introduces DNA double-strand breaks into the opposing wild-type allele to replace it with a copy of the gene-drive allele via DNA homology-directed repair. However, the use of different Cas9 versions is unexplored, and alternative approaches could increase the available toolkit for gene-drive designs. Here, we report a gene-drive that relies on Cas9 nickases that generate staggered paired nicks in DNA to propagate the engineered gene-drive cassette. We show that …

Academic Senate - Agenda, 5/24/2022, Academic Senate

Academic Senate Agendas

No abstract provided.

Addressing Engagement For Cloud-Ecosystem In A Box (Ceb), Benjamin Garlington

Theses and Dissertations

The explosion of digital and observational data is having a profound effect on the nature of scientific inquiry, requiring new approaches to manipulating and analyzing large and complex data and increasing the need for collaborative solid research teams to address these challenges. These data, along with the availability of computational resources and recent advances in artificial intelligence, machine learning software tools, and methods, can enable unprecedented science and innovation. Unfortunately, these software tools and techniques are not uniformly accessible to all communities, mainly scientists and engineers at Minority Serving Institutions (MSI). Cloud computing resources are natural channels to enhance these …

Perceived Readiness For Practice Of Senior Baccalaureate Nursing Students, Janet Kay Reagor

Dissertations

Nursing education is designed to assist students to become beginning practitioners and clinical experiences are essential to this process. As competition for clinical sites increases, educators need to establish best practices of clinical experiences. This mixed method study examined the psychometric properties of a readiness for practice tool, and explored the effects of a clinical internship experience on the perception of readiness for practice of 483 senior baccalaureate nursing students in Kansas and Missouri. Matched results from data collected twice during the semester confirmed that the clinical internship experience increased perception of readiness for practice, with the most benefit coming …

Folse Named Next President Of Ripon College, University Communications

News and Events (Discontinued Series)

No abstract provided.

Semantic Segmentation To Extract Coronary Arteries In Invasive Coronary Angiograms, Chen Zhao, Robert Bober, Haipeng Ang, Jinshan Tang, Minghao Dong, Chaoyang Zhang, Zhuo He, Weihua Zhou, Et. Al.

Michigan Tech Publications, Part 1

Accurate semantic segmentation of each coronary artery using invasive coronary angiography (ICA) is important for stenosis assessment and coronary artery disease (CAD) diagnosis. In this paper, we propose a multi-step semantic segmentation algorithm based on analyzing arterial segments extracted from ICAs. The proposed algorithm firstly extracts the entire arterial binary mask (binary vascular tree) using a deep learning-based method. Then we extract the centerline of the binary vascular tree and separate it into different arterial segments. Finally, by extracting the underlying arterial topology, position, and pixel features, we construct a powerful coronary artery segment classifier based on a support vector …

Assessing Real-World Racial Differences Among Patients With Metastatic Triple-Negative Breast Cancer In Us Community Practices, Ruoding Tan, Lourenia Cassoli, Ying Yan, Vincent Shen, Bann-Mo Day, Edith P. Mitchell

Department of Medical Oncology Faculty Papers

Objective: Real-world data characterizing differences between African American (AA) and White women with metastatic triple-negative breast cancer (mTNBC) are limited. Using 9 years of data collected from community practices throughout the United States, we assessed racial differences in the proportion of patients with mTNBC, and their characteristics, treatment, and overall survival (OS).

Methods: This retrospective study analyzed de-identified data from 2,116 patients with mTNBC in the Flatiron Health database (January 2011 to March 2020). Characteristics and treatment patterns between AA and White patients with mTNBC were compared using descriptive statistics. OS was examined using Kaplan-Meier analysis and a multivariate Cox …

Impact Of Estrogen Receptor Expression On Prognosis Of Ovarian Cancer According To Antibody Clone Used For Immunohistochemistry: A Meta-Analysis, Chun Wai Ng, Kwong-Kwok Wong

Faculty, Staff and Student Publications

Background: The prognostic value of the expression of estrogen receptor (ER) subtypes ER⍺ and ERβ in ovarian cancer has previously been evaluated by meta-analyses. However, the results are contradictory and controversial.

Methods: We conducted an updated meta-analysis with stringent inclusion criteria to ensure homogeneous studies to determine the effect of ER subtypes on ovarian cancer prognosis. Articles were retrieved by systematic search of PubMed and Web of Science for articles dated up to June 2021. Only studies with known hazard ratio (HR) and antibody clone for immunochemistry (IHC) were included. Pooled HRs with the corresponding 95% confidence intervals (CIs) were …

Cysteine Metallochemistry And Metal Binding: Quantification Of The Thermodynamic Foundations Of Cellular Homeostasis, Matthew R. Mehlenbacher

Dartmouth College Ph.D Dissertations

Metals are required for life. Many metalloproteins contain cysteine in their metal-binding site (MBS) and cysteines are unique in that they are reactive, and strongly bind certain metals, which aid in metal selectivity and specificity. Using isothermal titration calorimetry (ITC), the thermodynamic foundation for metal binding, cellular protection, and transcriptional regulation, which all utilize cysteines in their MBS, are quantified.

In bacteria there are metalloprotein pathways that actively uptake mercury, which are regulated by the metalloregulatory protein MerR. MerR de-represses the transcription of these mer proteins in a metal-dependent manner. Using ITC, the thermodynamic foundation of the negative allosteric coupling …

Mathematical Musings On The External Anatomy Of The Novel Coronavirus Part 2: Chasing After Quasi-Symmetry, Jyotirmoy Sarkar, Mamunur Rashid

Mathematics Faculty Publications

What is the shape of the novel Coronavirus which has turned our world upside down? Even though it looks dull, unattractive, and even disgusting under a microscope, creative artists have attributed to it bright colors, made it look pretty, and depicted it as a thing of beauty. What can a mathematician contribute to this effort? We take a purist’s point of view by imposing on it a quasi-symmetry and then deriving some consequences. In an idealistic world, far removed from reality but still constrained by the rules of mathematics, anyone can enjoy this ethereal beauty of the mind’s creation, beckoning …

Berenice Final Analysis: Cardiac Safety Study Of Neoadjuvant Pertuzumab, Trastuzumab, And Chemotherapy Followed By Adjuvant Pertuzumab And Trastuzumab In Her2-Positive Early Breast Cancer, Chau Dang, Michael S Ewer, Suzette Delaloge, Jean-Marc Ferrero, Ramon Colomer, Luis De La Cruz-Merino, Theresa L Werner, Katherine Dadswell, Mark Verrill, Daniel Eiger, Sriparna Sarkar, Sanne Lysbet De Haas, Eleonora Restuccia, Sandra M Swain

Duncan NRI Faculty and Staff Publications

Simple Summary

A combination of pertuzumab, trastuzumab, and chemotherapy is a standard treatment for patients with a type of breast cancer called HER2-positive. Before the BERENICE study, little was known about the safety and effectiveness of pertuzumab with trastuzumab after surgery. Cardiac safety was a particular concern, especially when the chemotherapy given before surgery included drugs called anthracyclines. BERENICE was designed to assess the cardiac safety of pertuzumab with trastuzumab before surgery in combination with two different types of anthracycline-based chemotherapies. This paper describes additional safety and effectiveness data from BERENICE after patients had undergone surgery and when they had …

Optimization Model To Support Sustainable Crop Planning For Reducing Unfairness Among Farmers, Ana Esteso, M. M.E. Alemany, Angel Ortiz, Shaofeng Liu

Plymouth Business School

Agri-food production must increase while food waste needs to be reduced for improving the position of farmers. To do so it is necessary to sustainably manage agri-food supply chains beginning with the crop planning decisions. Although the centralized approach has usually been adopted for this purpose, it can lead to unfair solutions due to inequitable distribution of profits among farmers causing their unwillingness to collaborate in the implementation of decisions made. To solve this, in this paper a novel centralized multi-objective mathematical programming model is proposed to support the sustainable crop planning definition for a region that jointly optimize three …

Electrographic Seizures In Neonates With A High Risk Of Encephalopathy, Wan-Hsuan Chen, Oi-Wa Chan, Jainn-Jim Lin, Ming-Chou Chiang, Shao-Hsuan Hsia, Huei-Shyong Wang, En-Pei Lee, Yi-Shan Wang, Cheng-Yen Kuo, Kuang-Lin Lin, On The Behalf Of The Icns Group

Faculty, Staff and Student Publications

Background: Neonatal encephalopathy is caused by a wide variety of acute brain insults in newborns and presents with a spectrum of neurologic dysfunction, such as consciousness disturbance, seizures, and coma. The increased excitability in the neonatal brain appears to be highly susceptible to seizures after a variety of insults, and seizures may be the first clinical sign of a serious neurologic disorder. Subtle seizures are common in the neonatal period, and abnormal clinical paroxysmal events may raise the suspicion of neonatal seizures. Continuous video electroencephalographic (EEG) monitoring is the gold standard for the diagnosis of neonatal seizures. The aim of …

Characteristics And Outcomes Of Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm Treated With Frontline Hcvad, Naveen Pemmaraju, Nathaniel R Wilson, Guillermo Garcia-Manero, Koji Sasaki, Joseph D Khoury, Nitin Jain, Gautam Borthakur, Farhad Ravandi, Naval Daver, Tapan Kadia, Courtney Dinardo, Elias Jabbour, Sherry Pierce, Muzaffar Qazilbash, Marina Konopleva, Hagop Kantarjian

Faculty, Staff and Student Publications

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a clinically aggressive blood cancer, often involving the skin, bone marrow, lymph nodes, and central nervous system (CNS) in 20% to 30% of patients. Despite significant progress in CD123- and BCL-2-targeted therapy, most patients are not cured without hematopoietic stem cell transplant (HSCT), and CNS relapses occur quite frequently. Combination approaches with targeted and chemotherapy agents plus incorporation of prophylactic CNS-directed therapy are urgently needed. In this setting, we sought to analyze outcomes using the cytotoxic chemotherapy backbone regimen hyperfractionated cyclophosphamide, vincristine, adriamycin, and dexamethasone (HCVAD). We conducted a retrospective analysis of patients …

Current Trends Of Research Productivity Among Students Matching At Top Ophthalmology Programs, Benjamin Zhou, Nivetha Srinivasan, Shree Nadkarni, Varun Taruvai, Amy Song, Albert S. Khouri

Journal of Academic Ophthalmology

Abstract

Importance San Francisco Match publishes no data on the research output of matched applicants to an ophthalmology residency.

Objective The aim of this study was to examine the temporal trends in publication volume by medical students who successfully matched into a top ophthalmology residency.

Methods This retrospective case series compared all residents in the top 30 ophthalmology residency programs from the class of 2022 and 2017. Publication volume from before September 15th of the residents' fourth year of medical school was recorded using PubMed and Google Scholar. We recorded total number of publications (any authorship), first/second author publications, and …

2022 Beijing Winter Olympics: Spotlight On Cardiac Metabolism, Heinrich Taegtmeyer, Vlad G Zaha, Darren K Mcguire

Faculty, Staff and Student Publications

No abstract provided.