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Articles 69331 - 69360 of 5153697
Full-Text Articles in Entire DC Network
Editorial, Julia Coffman
Why Foundations Begin Making Program-Related Investments: Evidence From Recent Adopters, Maoz (Michael) Brown
Why Foundations Begin Making Program-Related Investments: Evidence From Recent Adopters, Maoz (Michael) Brown
The Foundation Review
Why do foundations begin making program-related investments (PRIs)? This article answers that question by drawing on interviews with professionals at 36 U.S. foundations that recently began implementing PRIs.
While achieving positive impact is a central motivating factor, the study reveals it is uncommon for new PRI-makers to target impact uniquely tailored to PRIs, e.g., establishing a credit history for the recipient. Operational benefits, e.g., stretching the foundation’s financial resources, are more salient in the decision to undertake PRIs, even though such benefits are often marginal.
This article also highlights a previously underexplored but apparently significant driver of PRI adoption: the …
Philanthropic Archives And Legacy, Katherine Badertscher, Huitan Xu
Philanthropic Archives And Legacy, Katherine Badertscher, Huitan Xu
The Foundation Review
This article details an environmental scan of publicly available sources and interviews to explore the landscape of archival work in philanthropy.
There is no single guidance appropriate across the spectrum of foundations and family philanthropies. Given foundation heterogeneity, records management and archiving require tailored approaches rather than a “one-size-fits-all” solution.
The authors theorize legacy as a form of capital, embodied in records, stories, and knowledge, and present a continuum of five strategies for archiving infrastructure.
Beyond The Check: Lessons In Trust, Support, And Structure For Flexible Well-Being Grants, Martena Reed, Jennifer Marsack, Chelsey Hurt, Gladys Hairston, Karla Mendez, Tejaswini Vemuganti, Valerie Stewart, Cindy Alvarado
Beyond The Check: Lessons In Trust, Support, And Structure For Flexible Well-Being Grants, Martena Reed, Jennifer Marsack, Chelsey Hurt, Gladys Hairston, Karla Mendez, Tejaswini Vemuganti, Valerie Stewart, Cindy Alvarado
The Foundation Review
This article draws on a developmental evaluation of the Blue Cross and Blue Shield of North Carolina Foundation’s Well-Being Grants, which awarded over 100 small, flexible grants to support nonprofit staff and organizational well-being. Using surveys, interviews, focus groups, and document review, authors examined how organizations defined well-being, how they used the funds, and what factors shaped their choices.
Findings show that, while grantees valued flexibility, many relied on familiar approaches such as retreats, stipends, and team building. Long-standing compliance norms engendered caution about experimentation, even when funders encouraged it.
The authors argue that funders must pair flexible dollars with …
Beyond Need: Exploring Readiness To Implement Change As A Predictor Of Nonprofit Capacity-Building Success, Bridget Y. Samuel
Beyond Need: Exploring Readiness To Implement Change As A Predictor Of Nonprofit Capacity-Building Success, Bridget Y. Samuel
The Foundation Review
This mixed-methods exploratory study investigates whether organizational readiness to implement change predicts capacity-building success more reliably than the level of perceived need.
Using a six-factor readiness assessment measuring clear priorities, change management resources, time investment commitment, board engagement, systems infrastructure, and cash flow, data from 10 participating organizations reveal a significant correlation between readiness scores and early capacity-building outcomes.
The findings challenge three common field assumptions: that the greatest capacity-building need should drive selection, that capacity-building works uniformly across developmental stages, and that dysfunction can be addressed through “standard” capacity-building programming.
Defining Community Philanthropy: Principles And Dimensions Of A Transformative Practice, Michael D. Layton
Defining Community Philanthropy: Principles And Dimensions Of A Transformative Practice, Michael D. Layton
The Foundation Review
Community philanthropy is increasingly promoted as an alternative to institutional, top-down philanthropy, yet the term remains contested. In the Global North, it is typically associated with community foundations, while in the Global South the emphasis is on community itself.
This article offers a definition of community philanthropy as a practice rooted in context and power rather than a single institutional form. It identifies five transformative characteristics that distinguish community philanthropy from conventional giving and translates these principles into seven dimensions that can be used to identify and assess community philanthropy in practice.
For practitioners, evaluators, and funders, this framework offers …
Considering Barriers To Funding Fiscal Sponsorship: Insights From Sponsor And Project Leaders, Elliot M. Zettas, Todd L. Ely, Fredrik O. Andersson
Considering Barriers To Funding Fiscal Sponsorship: Insights From Sponsor And Project Leaders, Elliot M. Zettas, Todd L. Ely, Fredrik O. Andersson
The Foundation Review
This study explores barriers to funding fiscal sponsorship based on interviews with 68 leaders of sponsors and sponsored projects. Findings reveal that funders’ limited understanding and restrictive policies contribute to negative sentiment and reduced grant access for sponsored initiatives.
Despite fiscal sponsorship’s administrative efficiencies and mission-focused benefits, funders often perceive sponsored projects as less legitimate, misunderstand sponsor roles, and resist covering sponsor cost allocations when framed as fees. Structural complexities — such as shared EINs and geographic mismatches — further impede eligibility for funding.
This article concludes with actionable recommendations for funders and sponsors, including staff education, updated grant guidelines, …
The Future Of Purpose-Driven Work: Evaluating A Case Study Of The Hybrid: Flexible Purpose Model At The Robert Wood Johnson Foundation, Jeff Williams, Melyssa Tsai O'Brien, Trish Abalo
The Future Of Purpose-Driven Work: Evaluating A Case Study Of The Hybrid: Flexible Purpose Model At The Robert Wood Johnson Foundation, Jeff Williams, Melyssa Tsai O'Brien, Trish Abalo
The Foundation Review
This 15-month case study employed a comprehensive mixed-methods evaluation to document and assess the model across six key areas. Findings revealed the Hybrid: Flexible Purpose model preserved or improved grantmaking outcomes, enhanced staff well-being and autonomy, and expanded the diversity of the talent pool.
Challenges emerged regarding sustaining the organizational culture, fostering cross-team and informal relationships, and ensuring consistent policy implementation across teams, particularly in finding the optimal balance between stated goals and actual experiences during mandatory in-person gatherings.
Findings also documented a “hybrid coordination tax,” i.e., additional effort required to manage mixed in-person and virtual meetings and schedules.
These …
Moving Beyond Words To Action: A Practitioner’S Playbook For Achieving Collaboration Success, Tessa Lesage, Jonathan L. Romine, Jane Wei Skillern
Moving Beyond Words To Action: A Practitioner’S Playbook For Achieving Collaboration Success, Tessa Lesage, Jonathan L. Romine, Jane Wei Skillern
The Foundation Review
This article argues that foundations must shift from acting as grantmakers alone to becoming active stewards of cross-sector collaborative networks.
Drawing from more than two decades of field experience and research each, the authors outline a framework for moving from collaborative rhetoric to action, identifying four essential and interconnected actions: fueling trust, elevating purpose, nurturing networks, and strengthening stewardship.
Through case examples, the article illustrates how authentic, trust-based relationships, shared goals, and relational network leadership can drive scalable, sustainable impact.
The article offers both a compelling critique of traditional philanthropic approaches and a strategic road map for how foundations can …
Using Ai To Redirect Donor Support To Smaller Organizations, Madeleine Alegria, Brandolon Barnett
Using Ai To Redirect Donor Support To Smaller Organizations, Madeleine Alegria, Brandolon Barnett
The Foundation Review
Despite rising interest in supporting local causes, many donors continue to give to large, nationally recognized nonprofits. This reflects ongoing structural barriers such as limited nonprofit visibility, decision fatigue, and search environments that prioritize brand familiarity.
At the same time, small-dollar giving has declined for three consecutive years, highlighting the need for more transparent, accessible, and trustworthy tools to support donor decision-making (Childress, 2024; Lilly Family School of Philanthropy, 2023).
In a 2024 evaluation study, 291 U.S. donors were randomly assigned to use either the Giving Compass Guide to Good platform or general internet tools to select a new nonprofit …
Social Skill Program Development For Adults With Intellectual And Developmental Disabilities, Clayton Stapert
Social Skill Program Development For Adults With Intellectual And Developmental Disabilities, Clayton Stapert
Capstone Projects
This doctoral capstone experience (DCE) was completed at the Center for Disability Services (CDS) and focused on developing and implementing a social skills program for adults with intellectual and developmental disabilities (IDD). Many existing social skills programs focus on general or work-related skills, but there is a need for programs that help individuals apply social skills during real-life community activities. This project aimed to address that gap by creating a structured, occupation-based program within an adult day skill-building day center.
The program included education, group discussion, role-playing, and community outings to help participants practice skills such as interacting with cashiers, …
Prior Head Circumference Measurements In Infants With Older Subdural Hematomas: Did We Miss It?, Maryann Alvarez Griffis, Nancy D. Kellogg, Wouter Koek
Prior Head Circumference Measurements In Infants With Older Subdural Hematomas: Did We Miss It?, Maryann Alvarez Griffis, Nancy D. Kellogg, Wouter Koek
School of Medicine Publications
Objective: To establish whether infants with macrocephaly and non-acute subdural hematomas (SDHs) had missed opportunities for measuring fronto-occipital circumference (FOC) and obtaining neuroimaging prior to diagnosis. Macrocephaly due to SDH in infancy is initially detected by FOC measurements and/or neuroimaging, as neurologic symptoms may be subtle or missed.
Methods: Retrospective chart review of infants with macrocephaly and non-acute SDHs referred to child abuse pediatricians for suspected abusive head trauma (AHT) over an 8-year period. A study sample of 35 infants met inclusion criteria and had complete prior medical records which were reviewed for missed opportunities for earlier SDH diagnosis. Four …
Vaccination Games Of Boundedly Rational Parents Toward New Childhood Immunization, Wei Yin, Martial L. Ndeffo-Mbah, Tamer Oraby
Vaccination Games Of Boundedly Rational Parents Toward New Childhood Immunization, Wei Yin, Martial L. Ndeffo-Mbah, Tamer Oraby
School of Mathematical & Statistical Sciences Faculty Publications
Infectious diseases harm societies through disease-induced morbidity, mortality, loss of productivity, and inequality. Thus, controlling and preventing them is critical for public health and societal well-being. However, societies can hinder efforts to control the spread of diseases by failing to adhere to public health recommendations, such as through vaccine hesitancy. Various disease-transmission models have been utilized to help policymakers respond to (re)emerging outbreaks. The usefulness of such models in assessing the effectiveness of public health policies is significantly dependent on human behavior. This paper introduces a new model of parental behavior toward a new childhood immunization. The model incorporates societal …
Improvements In The Thermal Stability And Mechanical Robustness Of Holograms Recorded In Acrylamide/Polyvinyl Alcohol-Based Photopolymers Through The Use Of D-Sorbitol As A Plasticizer, Michael Murray, Aaron Byrne, Izabela Naydenova, Suzanne Martin
Improvements In The Thermal Stability And Mechanical Robustness Of Holograms Recorded In Acrylamide/Polyvinyl Alcohol-Based Photopolymers Through The Use Of D-Sorbitol As A Plasticizer, Michael Murray, Aaron Byrne, Izabela Naydenova, Suzanne Martin
Research Outputs: 2025-Present
In this work, a photopolymer formulation is presented that demonstrates significant improvements in layer hardness and temperature stability, while retaining the excellent holographic recording characteristics and ease of preparation associated with acrylamide (AA)/polyvinyl alcohol (PVA)-based photopolymers. This is achieved through the use of N-phenyl glycine as an electron donor and, for the first time, D-Sorbitol, a naturally occurring sugar-alcohol, as a plasticizer. The plasticizing effect of D-Sorbitol is demonstrated through the minimal loss of diffraction efficiency (η) observed upon UV bleaching (fixing) of 500 lines/mm gratings, which is evidence for effective mass transport during holographic recording. This solves a key …
Evaluating The Feasibility Of Blockchain Technology For Secure Voting Systems: A Systematic Mapping, Dijesh Shrestha, Shishir Poudel
Evaluating The Feasibility Of Blockchain Technology For Secure Voting Systems: A Systematic Mapping, Dijesh Shrestha, Shishir Poudel
Annual Research Symposium
Voting is central to democracy. Yet it can be vulnerable to manipulation, fraud, and limited transparency. Traditional ballot-based voting faces challenges in record-keeping and trust, while electronic voting (e-voting) struggles with data integrity and central authority control. Blockchain known for its decentralized and immutable ledger, presents a promising solution to enhance trust, transparency, and security in the voting process.
Objective: Investigate and evaluate the current state of blockchain-based voting approaches to determine feasibility, benefits, and security considerations. Research questions: (1) issues in traditional voting system and can blockchain be a solution to it; (2) what are the current solution and …
Hybrid Deep Learning For Anti-Money Laundering: Unsupervised Detection Of Emerging Schemes Via Feature Fusion And Explainable Artificial Intelligence, Cosmas Ochieng Kungu, Kennedy Senagi, Evans Omondi
Hybrid Deep Learning For Anti-Money Laundering: Unsupervised Detection Of Emerging Schemes Via Feature Fusion And Explainable Artificial Intelligence, Cosmas Ochieng Kungu, Kennedy Senagi, Evans Omondi
All Peer-Reviewed Publications
Traditional rule-based anti-money laundering (AML) transaction monitoring systems suffer from high false-positive rates and rigidity in detecting complex emerging risk. This limitation has prompted changes to the Financial Action Task Force (FATF) recommendation 16, mandating the use of advanced systems for detecting money laundering schemes in cross-border payments. This study developed a hybrid framework integrating VAE-learned behavioural latent factors, GNN-captured relational network signals, and rule-based heuristics for enhanced anomaly detection. The model was evaluated on 54,258 real-world cross-border transaction records from an East African commercial bank. The One-Class SVM, optimised via a rigorous grid search proved superior compared to Isolation …
Resurgence Of Visceral And Cutaneous Leishmaniasis In Kajiado County, Kenya: A Coordinated Response And Entomological Survey, Damaris Matoke-Muhia, Barrack O. Owino, Steve Kiplagat, Hannah N. Mwangi, Johnstone M. Ingonga, Daniel Njenga, Benny B. Septer, Mwatela Kitondo, Daniel Mwiti, Charles Magiri, Hellen Nyakundi, Juliet Onditi, Sarah Weihl, Catherine Wenger, Abhay Satoskar, Jandouwe Villinger, Shaden Kamhawi, Joseph Ndungu, Richard Wamai, Daniel K. Masiga
Resurgence Of Visceral And Cutaneous Leishmaniasis In Kajiado County, Kenya: A Coordinated Response And Entomological Survey, Damaris Matoke-Muhia, Barrack O. Owino, Steve Kiplagat, Hannah N. Mwangi, Johnstone M. Ingonga, Daniel Njenga, Benny B. Septer, Mwatela Kitondo, Daniel Mwiti, Charles Magiri, Hellen Nyakundi, Juliet Onditi, Sarah Weihl, Catherine Wenger, Abhay Satoskar, Jandouwe Villinger, Shaden Kamhawi, Joseph Ndungu, Richard Wamai, Daniel K. Masiga
All Peer-Reviewed Publications
OBJECTIVES: This study investigated emergence of visceral leishmaniasis (VL) in 2021, in Kajiado County in Kenya, representing a newly recognized region of endemic transmission. METHODS: The investigation involved community sensitization, medical camps, and entomological surveys across eight villages. We screened 100 individuals with indicative symptoms of leishmaniasis, and also carried out an entomological survey. RESULTS: We found 10 patients of VL, predominantly in children under 15. Of 22 suspected cutaneous leishmaniasis (CL) cases, eight were confirmed with Leishmania tropica. Entomological surveys identified 4781 sandflies, with Sergentomyia species being most abundant. DNA of Leishmania donovani was detected in multiple Sergentomyia species …
Proper Education, Denis Kaiser
Parkinson's Disease As A Somato-Cognitive Action Network Disorder, Jianxun Ren, Evan M Gordon, Nico U F Dosenbach, Et Al.
Parkinson's Disease As A Somato-Cognitive Action Network Disorder, Jianxun Ren, Evan M Gordon, Nico U F Dosenbach, Et Al.
2020-Current year OA Pubs
Parkinson's disease (PD) is an incurable neurological disorder that often begins insidiously with sleep disturbances and somatic symptoms, progressing to whole-body motor and cognitive symptoms
Intraocular Amyloidosis Presenting With Secondary Glaucoma: A Clinical-Pathologic Report And Literature Review, Joseph B Lin, James C Liu, Rajendra S Apte, George J Harocopos
Intraocular Amyloidosis Presenting With Secondary Glaucoma: A Clinical-Pathologic Report And Literature Review, Joseph B Lin, James C Liu, Rajendra S Apte, George J Harocopos
2020-Current year OA Pubs
PURPOSE: We describe a case of intraocular amyloidosis presenting as secondary glaucoma, highlighting the clinical presentation and pathologic correlates. We also review the medical literature on all prior reported cases and discuss the diagnostic challenges pertinent to this particular case.
OBSERVATIONS: We report the case of a 72-year-old man presenting with medically intractable elevations of intraocular pressure. On clinical examination, the anterior segment was unremarkable, but there were significant vitreous opacities. The patient underwent tube shunt surgery, and a simultaneous aqueous humor biopsy was acellular and nondiagnostic. A subsequent pars plana vitrectomy demonstrated amyloid aggregates on histology. Mass spectrometric analysis …
Increased Clinical Frailty Is Associated With Aortic-Related Mortality Following Fenestrated And Branched Endovascular Repair For Thoracoabdominal Aortic Aneurysm, Silvia Chen, Elizabeth Ramirez, Blake E Murphy, Anjali Sribalaskandarajah, Martin Bunker, Joel Kruger, Karina A Newhall, Rebecca A Sorber, Sara L Zettervall, Matthew P Sweet
Increased Clinical Frailty Is Associated With Aortic-Related Mortality Following Fenestrated And Branched Endovascular Repair For Thoracoabdominal Aortic Aneurysm, Silvia Chen, Elizabeth Ramirez, Blake E Murphy, Anjali Sribalaskandarajah, Martin Bunker, Joel Kruger, Karina A Newhall, Rebecca A Sorber, Sara L Zettervall, Matthew P Sweet
2020-Current year OA Pubs
OBJECTIVE: Clinical frailty is associated with reduced long-term survival after fenestrated and branched endovascular aortic repair (F/BEVAR). This study assesses the impact of phenotypic clinical frailty on perioperative outcomes and cause of death following F/BEVAR for thoracoabdominal aortic aneurysm.
METHODS: Patients who underwent F/BEVAR at a single institution from 2012 to 2024 were identified. The clinical frailty scale (CFS) was used to determine phenotypic frailty. Patients with a preoperative CFS of ≥4 (vulnerable) and a CFS of < 4 were compared. We used χ
RESULTS: We included 233 patients; 60 (25.8%) had a CFS of ≥4 and 173 (74.2%) had a CFS of < 4. Patients with a CFS of ≥4 were more likely to have chronic obstructive pulmonary disease (53% vs 27%) and were treated for slightly larger aneurysms (72 mm vs 68 mm; P = .04). There were no differences in symptomatic presentation, aneurysm extent, or operative complexity between patient groups. Additionally, there were no differences in perioperative complications including 30-day mortality, stroke, and spinal cord ischemia. Patients with a CFS of ≥4 had an increased length of hospitalization (11.3 days vs 6.9 days; P < .01) and were less likely to return to preoperative functional status (62.7% vs 86.1%; P < .01). The 3-year all-cause and aortic-related mortality rates were 35.2% and 5.7%, respectively. Patients with a CFS of ≥4 had a lower survival at 1 year (74% vs 89%), 3 years (39% vs 73%), and 5 years (25% vs 56%), compared with patients with a CFS of < 4 (P < .01). The most common causes of death among both groups were pulmonary comorbidities (14.0%), oncologic conditions (14.0%), cardiovascular comorbidities (11.2%), and procedure-related complications (11.2%). Patients with a CFS of ≥4 were more likely to die from aortic-related mortality (10.3% vs 5.9%; P = .02), pulmonary comorbidities (15.4 vs 13.2%; P = .04), systemic decline (7.7% vs 1.5%; P = .02), and infection (12.8% vs 7.4%; P = .03). Aortic-related mortality for the entire patient cohort was 2.2% and 5.7% at 1 year and 3 years, respectively. Aortic-related deaths among clinically frail patients were often due to an inability to tolerate further aortic operations (eg, arch repair), and secondary to follow-up nonadherence in patients with a CFS of < 4.
CONCLUSIONS: In an expanded …
Longitudinal Analysis Of Rotator Cuff Repair: Joint Kinematics And Clinical Outcomes, Sujata Khandare, Rebekah L Lawrence, Alena Jalics, Roger Zauel, Vasilios Moutzouros, Eric C Makhni, Stephanie Muh, Michael J Bey
Longitudinal Analysis Of Rotator Cuff Repair: Joint Kinematics And Clinical Outcomes, Sujata Khandare, Rebekah L Lawrence, Alena Jalics, Roger Zauel, Vasilios Moutzouros, Eric C Makhni, Stephanie Muh, Michael J Bey
2020-Current year OA Pubs
BACKGROUND: Rotator cuff repair is a common surgical procedure, but postoperative outcomes can be highly variable, and postoperative repair tissue healing remains a significant clinical challenge. Furthermore, the biomechanical effects of rotator cuff repair are not fully understood.
METHODS: Twenty-two participants scheduled for arthroscopic rotator cuff repair were evaluated preoperatively and at 3, 12, and 24 months postsurgery. The following data were recorded at each time point: glenohumeral and scapulothoracic kinematics, shoulder strength, and patient-reported measures of pain and function. Postoperative repair integrity was assessed via magnetic resonance imaging at 3 months and 24 months postsurgery.
RESULTS: At 3 months …
Piezo Mechanosensitivity In Chondrocytes Is Differentially Modulated By L-Type And T-Type Voltage-Sensitive Ion Channels, Alireza Savadipour, Gabrielle K Marushack, Robert J Nims, Jaquelin M Garcia-Castorena, Wolfgang Liedtke, Farshid Guilak
Piezo Mechanosensitivity In Chondrocytes Is Differentially Modulated By L-Type And T-Type Voltage-Sensitive Ion Channels, Alireza Savadipour, Gabrielle K Marushack, Robert J Nims, Jaquelin M Garcia-Castorena, Wolfgang Liedtke, Farshid Guilak
2020-Current year OA Pubs
OBJECTIVE: One of the primary factors contributing to OA development is altered or excessive mechanical stress on the joint, which chondrocytes sense in part through the PIEZO mechanosensitive ion channels. These channels activate signaling pathways that result in joint inflammation and cartilage degeneration. In addition to PIEZO channels, voltage-gated calcium (Ca
DESIGN: To better understand the relationship between PIEZO1 and VGCCs, we quantified porcine chondrocytes' intracellular Ca
RESULTS: In primary chondrocytes, nifedipine, an L-type VGCC blocker, reduced PIEZO1 sensitivity to both mechanical compression and pharmacological agonism, while NNC-55, a T-type VGCC blocker, increased PIEZO1 activation in response to both stimuli. …
Patient And Chondral Defect-Specific Characteristics And Associated Matrix-Induced Autologous Chondrocyte Implantation Conversion Rates Following Biopsy, Derrick M Knapik, Daniel C Touhey, S Ryan Pierson, Christopher K Bozorgmehr, Matthew V Smith, Matthew J Matava, Robert H Brophy
Patient And Chondral Defect-Specific Characteristics And Associated Matrix-Induced Autologous Chondrocyte Implantation Conversion Rates Following Biopsy, Derrick M Knapik, Daniel C Touhey, S Ryan Pierson, Christopher K Bozorgmehr, Matthew V Smith, Matthew J Matava, Robert H Brophy
2020-Current year OA Pubs
BACKGROUND: Focal chondral defects in the knee lead to swelling, discomfort, and mechanical symptoms, resulting in disability and loss of function. Matrix-induced autologous chondrocyte implantation (MACI) has emerged as a viable treatment option, with satisfactory clinical outcomes reported compared with microfracture. Patient and lesion-specific variables associated with MACI after biopsy remain largely underreported.
PURPOSE: To examine patient- and defect-specific characteristics associated with conversion to MACI after biopsy from a single institution.
STUDY DESIGN: Cohort study; Level of evidence, 3.
METHODS: A retrospective chart review of prospectively collected data from June 2018 to March 2025 was performed. Inclusion criteria included patients …
Bach2 Regulates T Cell Lineage State To Enhance Car T Cell Function, Tien-Ching Chang, Amanda Heard, John Lattin, John M Warrington, Amanda Barrett, Jack H Landmann, Yangdon Tenzin, Vishaal Ganesh, Bryant Thompson, Sadia Afrin, Deepesh Kumar Gupta, Ju-Fang Chang, Julie Ritchey, Mehmet Emrah Selli, Yu-Sung Hsu, A J Federico, Avery Horn, Michael P Meers, John F Dipersio, Nathan Singh, Et Al.
Bach2 Regulates T Cell Lineage State To Enhance Car T Cell Function, Tien-Ching Chang, Amanda Heard, John Lattin, John M Warrington, Amanda Barrett, Jack H Landmann, Yangdon Tenzin, Vishaal Ganesh, Bryant Thompson, Sadia Afrin, Deepesh Kumar Gupta, Ju-Fang Chang, Julie Ritchey, Mehmet Emrah Selli, Yu-Sung Hsu, A J Federico, Avery Horn, Michael P Meers, John F Dipersio, Nathan Singh, Et Al.
2020-Current year OA Pubs
Nearly all chimeric antigen receptors (CARs) signal in the absence of antigen, referred to as 'tonic signaling'. Tonic signaling of CARs containing 41BB domains enhances T cell fitness and function, in contrast to the exhaustion driven by CD28-containing CARs. Here we show that 41BB induces BACH2, a transcriptional regulator that directs stem and memory programs. Overexpression of BACH2 successfully prevented exhaustion but locked CAR T cells in a quiescent state. We linked BACH2 to a degradation domain to tune BACH2, enabling us to prevent exhaustion while enabling potent effector function that broadly enhanced the long-term efficacy of CAR T cells …
Nasopharyngeal Microbiome-Epigenome-Wide Association Analysis In Infants With Severe Bronchiolitis, Ryohei Shibata, Yijun Li, Anat Yaskolka Meir, Sara Javornik Cregeen, Matthew Clayton Ross, Janice A Espinola, Ashley F Sullivan, Liming Liang, Kohei Hasegawa, Carlos A Camargo, Zhaozhong Zhu
Nasopharyngeal Microbiome-Epigenome-Wide Association Analysis In Infants With Severe Bronchiolitis, Ryohei Shibata, Yijun Li, Anat Yaskolka Meir, Sara Javornik Cregeen, Matthew Clayton Ross, Janice A Espinola, Ashley F Sullivan, Liming Liang, Kohei Hasegawa, Carlos A Camargo, Zhaozhong Zhu
Faculty, Staff and Students Publications
Background: Bronchiolitis exposes infants to both acute burdens (e.g., hospitalization in cases of severe bronchiolitis) and increased risks for chronic respiratory sequelae (e.g., asthma). In severe bronchiolitis, recent evidence suggests distinct pathobiological roles of microbiota (e.g., viruses, bacteria) and host responses influenced by genetic and epigenetic factors. However, the relationship of airway microbiota with host DNA methylation (DNAm) in infants with severe bronchiolitis remains unknown.
Methods: In a multi-center prospective cohort of 504 multi-ethnic infants with severe bronchiolitis (age < 1 year), using nasopharyngeal microbiome (exposure) and blood DNAm (outcome, Infinium MethylationEPIC BeadChip, Illumina) data within 24 h of the hospitalization, we conducted microbiome-epigenome-wide association studies (mbEWAS). We examined microbiota-associated differentially methylated CpGs (mbDMCs, false discovery rate [FDR] < 0.05), regions (mbDMRs, FDR < 0.05), and DNAm age acceleration. We also determined the associations of DNAm age acceleration with asthma development by age 6 years. Furthermore, we focused on asthma-related pathogenic bacteria-Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae-for functional analyses by examining serum mbDMR-related proteins (Proseek Multiplex, Olink) and their enriched pathways (FDR < 0.10).
Results: Across 23 common taxa-observed at least in 25% of the infants, we identified 1 mbDMC (S. pneumoniae, cg16594639, chr20: 39528675) …
Application Of A Natural Language Processing Algorithm To Early Asthma Ascertainment For Adults In The Era Of Electronic Health Records, Chung-Il Wi, Thanai Pongdee, Hee Yun Seol, Sunghwan Sohn, Elham Sagheb, Bhavani Singh Agnikula Kshatriya, Shauna M Overgaard, Deepak K Sharma, Sungrim Moon, Elizabeth A Krusemark, Dave Watson, Sergio E Chiarella, Miguel A Park, Jason D Greenwood, Randy M Foss, Zhandong Liu, Meera Gupta, Carla M Davis, Wade Schulz, Hongfang Liu, Young J Juhn
Application Of A Natural Language Processing Algorithm To Early Asthma Ascertainment For Adults In The Era Of Electronic Health Records, Chung-Il Wi, Thanai Pongdee, Hee Yun Seol, Sunghwan Sohn, Elham Sagheb, Bhavani Singh Agnikula Kshatriya, Shauna M Overgaard, Deepak K Sharma, Sungrim Moon, Elizabeth A Krusemark, Dave Watson, Sergio E Chiarella, Miguel A Park, Jason D Greenwood, Randy M Foss, Zhandong Liu, Meera Gupta, Carla M Davis, Wade Schulz, Hongfang Liu, Young J Juhn
Faculty, Staff and Students Publications
Background: The natural language processing (NLP) algorithm for predetermined asthma criteria (NLP-PAC) was successfully developed and validated for automatically ascertaining pediatric asthma from electronic health record (EHRs) systems. A scalable, efficient, and automated tool for ascertaining adult asthma status from EHRs remains nonexistent.
Objective: We validated NLP-PAC enabling ascertainment and early identification of adult asthma status in their EHRs.
Methods: We applied the validated NLP-PAC to EHRs of a convenient sample (adult cohorts who participated in our previous population-based studies) in which a reference standard (ie, asthma status defined by manual chart review) is available. The performance of NLP-PAC was …
Trajectories And Predictors Of Activity Participation Among People With Parkinson Disease: A 3-Year Longitudinal Study, Moon Young Kim, Yejin Lee, Carolyn M Baum, Lisa T Connor, Chih-Hung Chang, Linda Tickle-Degnen, Erin R Foster
Trajectories And Predictors Of Activity Participation Among People With Parkinson Disease: A 3-Year Longitudinal Study, Moon Young Kim, Yejin Lee, Carolyn M Baum, Lisa T Connor, Chih-Hung Chang, Linda Tickle-Degnen, Erin R Foster
2020-Current year OA Pubs
OBJECTIVE: To investigate how participation changes over time among individuals with Parkinsondisease (PD) and identify factors influencing these changes, focusing on impairment level and social factors.
DESIGN: Secondary analysis of a 3-year prospective cohort study of social self-management of PD. Data were collected during 4 in-person assessments conducted at baseline and then annually thereafter. Multilevel modeling was used to analyze data from the 4 time points.
SETTING: Department of Occupational Therapy Research Laboratory and Department of Neurology Movement Disorder Clinic.
PARTICIPANTS: A total of 86 individuals (N = 86) with idiopathic PD (Hoehn & Yahr stages I-IV; mean age ± …