Digital Commons Network^™

Hits And Misses: Patents, Innovation, And Discovering How Not To Make A Baseball, Theodore R. Curtis

Faculty and Staff Publications & Presentations

Presentation at annual conference on the intersection of baseball, business and the liberal arts. Presentation focused on patent law and inventions relating to the development of the baseball from 1850-present.

Editorial: Engineering Nucleic Acids-Based Functional Nanomaterials, Nanodrugs, And Biosensors, Jabrane Jouha, Fengli Li, Wen-Ta Su, Chenguang Fan, Dayong Yang, Hai Xiong

Chemistry & Biochemistry Faculty Publications and Presentations

Editorial on the Research Topic: Engineering Nucleic Acids-Based Functional Nanomaterials, Nanodrugs, and Biosensors

Correlates Of Rem Sleep Without Atonia In Dream Enactment Behavior Associated With Parkinson’S Disease, Medication Use And Obstructive Sleep Apnea, Abigail Quintos, Rohin Saroya, Nisha Bagchi, Ritu G. Grewal

Student Papers, Posters & Projects

METHODS: We did a retrospective review of medical records and polysomnographic (PSG) data of patients with dream enactment behavior (DEB) from 2015 to 2020. REM sleep without atonia (RSWA) was scored according to the AASM rules, and %RSWA was calculated.

RESULTS: Thirty-six patients with DEB were analyzed. Recursive partitioning algorithm was used to determine the %RSWA that correlated with the presence or absence of Parkinson’s disease (PD). RSWA >=20% was present in 11 patients, and had the highest correlation with PD (9/11). RSWA of 2.1% to 19.9% was present in 10 patients, and had modest correlation with PD (3/10). RSWA= …

Examining How Early Career Teachers’ Experiences In Gvsu Schools Inform Future Plans, Kiel Mcqueen, Grand Valley State University

Charter School Research Reports

Studies have suggested that between 20 to 40 percent of teachers leave the profession in their first five years (Darling-Hammond & Sykes, 2003; Gray & Taie, 2015; Ingersoll 2003). Turnover tends to be higher in urban districts and schools serving students from historically marginalized communities. Increased teacher turnover is particularly problematic given the growing evidence that attrition harms schools, teachers, and students (Boyd, Lankford, Loeb, & Wyckoff, 2005; Ronfeldt, Loeb, and Wyckoff, 2013). The pandemic could intensify this problem given that the number of teachers reporting frequent job-related stress, symptoms of depression, and interest in careers outside of education have …

Consensus Embedding For Multiple Networks: Computation And Applications, Mengzhen Li, Mehmet Koyutürk

Faculty Scholarship

Machine learning applications on large-scale network-structured data commonly encode network information in the form of node embeddings. Network embedding algorithms map the nodes into a low-dimensional space such that the nodes that are “similar” with respect to network topology are also close to each other in the embedding space. Real-world networks often have multiple versions or can be “multiplex” with multiple types of edges with different semantics. For such networks, computation of Consensus Embeddings based on the node embeddings of individual versions can be useful for various reasons, including privacy, efficiency, and effectiveness of analyses. Here, we systematically investigate the …

Modelmatcher: A Scientist-Centric Online Platform To Facilitate Collaborations Between Stakeholders Of Rare And Undiagnosed Disease Research, J Michael Harnish, Lucian Li, Sanja Rogic, Guillaume Poirier-Morency, Seon-Young Kim, Kym M Boycott, Michael F Wangler, Hugo J Bellen, Philip Hieter, Paul Pavlidis, Zhandong Liu, Shinya Yamamoto

Duncan NRI Faculty and Staff Publications

Next-generation sequencing is a prevalent diagnostic tool for undiagnosed diseases and has played a significant role in rare disease gene discovery. While this technology resolves some cases, others are given a list of possibly damaging genetic variants necessitating functional studies. Productive collaborations between scientists, clinicians, and patients (affected individuals) can help resolve such medical mysteries, and provide insights into in vivo function of human genes. Furthermore, facilitating interactions between scientists and research funders, including non-profit organizations or commercial entities, can dramatically reduce the time to translate discoveries from bench to bedside. Several systems designed to connect clinicians and researchers with …

A Consistent Specification Test For Dynamic Quantile Models, Peter Horvath, Jia Li, Zhipeng Liao, Andrew J. Patton

Research Collection School Of Economics

Correct specification of a conditional quantile model implies that a particular conditional moment is equal to zero. We nonparametrically estimate the conditional moment function via series regression and test whether it is identically zero using uniform functional inference. Our approach is theoretically justified via a strong Gaussian approximation for statistics of growing dimensions in a general time series setting. We propose a novel bootstrap method in this nonstandard context and show that it significantly outperforms the benchmark asymptotic approximation in finite samples, especially for tail quantiles such as Value-at-Risk (VaR). We use the proposed new test to study the VaR …

Mami Mami, La Maternidad Como Hecho Artístico (2022), Eduardo Rodríguez Jacinto

Grado en Diseño de Moda

El presente trabajo es una reflexión sobre cómo la cultura Occidental determina el constructo de madre patriarcal. Para ello se plantea un breve recorrido sobre los principales puntos de acción, en donde la maternidad ha sido desdibujada con la reproducción, el matrimonio, la medicina o los estudios del género. Además se determina el nacimiento de la figura paterna patriarcal, al igual que mecanismos por los instaurar la represión. Así mismo, se realiza una búsqueda dentro del ámbito artístico sobre las distintas interpretaciones referentes a la maternidad que se han llevado a cabo, tanto por las mujeres artistas como trabajos masculinos, …

Frequency Of Use And Preferences For Information And Communication Technologies In Patients With Sleep Apnea: A Multicenter, Multinational, Observational Cross-Sectional Survey Study, Veronica R. Jaritos, Emanuel Vanegas, Juan Facundo Nogueira, Sebastian Leiva Agüero, Vanina Giovini, Jorge Rey De Castro, Yadira Rodríguez Reyes, José Luis Carrillo Alduenda, Pammela Torres Gittaim, Zaira Romero, Azza Sarfraz

Department of Paediatrics and Child Health

Background: Obstructive sleep apnea (OSA) is a condition characterized by repeated episodes of partial or complete obstruction of the upper airway during sleep. An accessible method to facilitate self-management education is through information and communication technologies (ICTs).
Purpose: To assess the frequency of and preferences for ICT use in patients with sleep apnea.
Methods: A multicenter, multinational, observational cross-sectional survey study was conducted between 2018 and 2019 in sleep units in different countries of Latin America, including patients of both genders older than 18 years with a diagnosis of sleep apnea. Participants were asked to complete 20 questions in a …

Climate Change And Lord Of The Rings?, Winston T. L. Chow

Research Collection College of Integrative Studies

Where did we make the ‘wrong turn’? Are we at the end of the road? Winston Chow, one of the lead authors of the 6th Assessment Report published by the Intergovernmental Panel on Climate Change (IPCC), shares his perspectives on how far down the road the world is on climate change.

Prognosticators Of Visual Acuity After Indirect Traumatic Optic Neuropathy, Alex J Wright, Joanna H Queen, Emilio P Supsupin, Alice Z Chuang, John J Chen, Rod Foroozan, Ore-Ofe O Adesina

Faculty, Staff and Student Publications

BACKGROUND: The purpose of this study is to determine whether there are radiographic and systemic clinical characteristics that can predict final visual outcomes in patients with indirect traumatic optic neuropathy (iTON).

METHODS: This study is a retrospective, multicenter case series of adult patients with iTON treated initially at large, urban, and/or academic trauma centers with follow-up at an affiliated ophthalmology clinic. In addition to detailed cranial computed tomography characteristics, demographics, systemic comorbidities, coinjuries, blood products administered, and intracranial pressure, along with other factors, were gathered. LogMAR visual acuity (VA) at the initial presentation to the hospital and up to 12 …

An Introduction To Biosimilars For The Treatment Of Retinal Diseases: A Narrative Review, Seenu M Hariprasad, Richard P Gale, Christina Y Weng, Hans C Ebbers, Mourad F Rezk, Ramin Tadayoni

Faculty, Staff and Students Publications

Biological therapies have revolutionized the treatment of disease across a number of therapeutic areas including retinal diseases. However, on occasion, such treatments may be relatively more expensive compared to small molecule therapies. This can restrict patient access and treatment length leading to suboptimal clinical outcomes. Several biosimilar candidates of ranibizumab and aflibercept are currently in development and the first biosimilar of ranibizumab received EMA approval in August and FDA approval in September 2021. Biosimilars are biological medicines that are highly similar to an already-approved biological medicine (reference product). The physicochemical and clinical similarity of a biosimilar is determined by a …

Assessing Public Health Benefits Of Replacing Freight Trucks With Cargo Cycles In Last Leg Delivery Trips In Urban Centers, Jennifer C. Hartle, Ossama (Sam) A. Elrahman, Cara Wang, Daniel A. Rodriguez, Yue Ding, Matt Mcgahan

Mineta Transportation Institute

Increased urbanization, population growth, and demand for time-sensitive deliveries means increased freight movement in cities, which contributes to emissions, noise, and safety concerns. One innovative mode gaining widespread attention for urban deliveries is cargo cycles—bicycles adapted for freight delivery. Despite the recognized potential and possible success of transporting at least 25% of freight via cycle, research remains limited. This research investigates the potential of cargo cycle delivery for last mile freight in Oakland, California, with a focus on the West Oakland neighborhood. The data collection included interviews, focus groups, vehicle field observation and counts, and traffic simulation modeling. The traffic …

Evaluation Of Sustainability Determinants To Develop A Sustainability Rating System For California Infrastructure Construction Projects, Joseph Kim, Patricia Mccarthy

Mineta Transportation Institute

This study evaluates the important sustainability determinants that affect factors’ success in meeting their sustainability goals when conducting infrastructure construction projects in California. The study implemented the online survey method to evaluate the sustainability characteristics that infrastructure industry professionals currently are aware of under the current situation in California. A data set of 25 validated survey responses is used for statistical data analysis using analysis of variables, Kruskal-Wallis tests, and two sample t-tests. The analysis results showed that the median response values for the six major sustainability categories do not show any significant difference. The results also showed that no …

Influence Of Level 1 And Level 2 Automated Vehicles On Fatal Crashes And Fatal Crash Occurrence, Hardik Gajera, Srinivas S. Pulugurtha, Sonu Mathew

Mineta Transportation Institute

Connected and automated vehicles (CAVs) are expected to improve safety by gradually reducing human decisions while driving. However, there are still questions on their effectiveness as we transition from almost 0% CAVs to 100% CAVs with different levels of vehicle autonomy. This research focuses on synthesizing literature and identifying risk factors influencing fatal crashes involving level 1 and level 2 CAVs in the United States. Fatal crashes involving level 0 vehicles—ones that are not connected and automated—were compared to minimize unobserved heterogeneity and randomness associated with the influencing risk factors. The research team used the fatal crash data for the …

Effect Of Raster Angle On Mechanical Properties Of 3d Printed Short Carbon Fiber Reinforced Acrylonitrile Butadiene Styrene, Skhandesh Srinivasan Ganesh Iyer, Ozgur Keles

Faculty Research, Scholarly, and Creative Activity

The most common additive manufacturing technique fused filament fabrication (FFF) suffers from inter-bead porosity that reduces mechanical properties. Inter-bead pores follow the raster angle, which causes anisotropic mechanical properties. Yet, the effects of raster angle on the mechanical behavior of short-carbon-fiber-reinforced (SCFR) thermoplastics are unclear. In this study, we performed tensile, flexural, and fracture toughness tests on SCFR acrylonitrile butadiene styrene (ABS). Raster angles of 0°, 15°, 30°, 45°, 60°, 75°, and 90° were investigated. Tensile strength and elastic modulus decreased by 22–35% for a change from 0° to 15°. Flexural strength and modulus were less sensitive to raster angle. …

Associations Among Romantic And Sexual Partner History And Muscle Dysmorphia Symptoms, Disordered Eating, And Appearance- And Performance-Enhancing Drugs And Supplement Use Among Cisgender Gay Men, Jason M. Nagata, Anthony M. Debenedetto, Tiffany A. Brown, Jason M. Lavender, Stuart B. Murray, Matthew R. Capriotti, Annesa Flentje, Micah E. Lubensky, Chloe J. Cattle, Juno Obedin-Maliver, Mitchell R. Lunn

Faculty Research, Scholarly, and Creative Activity

This study examined relationship status (e.g., single versus not single) and number of sexual partners in relation to muscularity- and disordered eating-related attitudes and behaviors among 1090 cisgender gay men enrolled in The PRIDE Study in 2018. Participants completed measures assessing muscle dysmorphia (MD) symptoms, disordered eating attitudes and behaviors, and appearance- and performance-enhancing drug or supplement (APEDS) use. In linear regression models adjusting for theoretically relevant covariates, neither relationship status nor number of past-month sexual partners was associated with disordered eating attitudes. In terms of MD symptoms, single (versus not single) relationship status was associated with greater appearance intolerance, …

Does Judicial Foreclosure Procedure Help Delinquent Subprime Mortgage Borrowers?, Aidong Adam Ding, Shaonan Tian, Yan Yu, Xinlei Zhao

Faculty Research, Scholarly, and Creative Activity

We conduct comprehensive analyses on whether and how the judicial foreclosure procedure helps subprime mortgage borrowers to reinstate their delinquent loans outside foreclosure liquidation. Even though the transition rates of various exit types are all higher in non-judicial states, we argue such higher rates can be mechanically driven by the faster shrinking pool of delinquent mortgages in non-judicial states over time. Based on the cumulative proportions of various exit types during a period of up to 5 years post the mortgage first become 90 days past due, we find that judicial states offer more opportunities for delinquent borrowers to reinstate …

Parental Mosaicism For Apparent De Novo Genetic Variants: Scope, Detection, And Counseling Challenges, Roni Zemet, Ignatia B Van Den Veyver, Paweł Stankiewicz

Duncan NRI Faculty and Staff Publications

The disease burden of de novo mutations (DNMs) has been evidenced only recently when the common application of next-generation sequencing technologies enabled their reliable and affordable detection through family-based clinical exome or genome sequencing. Implementation of exome sequencing into prenatal diagnostics revealed that up to 63% of pathogenic or likely pathogenic variants associated with fetal structural anomalies are apparently de novo, primarily for autosomal dominant disorders. Apparent DNMs have been considered to primarily occur as germline or zygotic events, with consequently negligible recurrence risks. However, there is now evidence that a considerable proportion of them are in fact inherited from …

Linking Online Vaccine Information Seeking To Vaccination Intention In The Context Of The Covid-19 Pandemic, Han Zheng, Shaohai Jiang, Sonny Rosenthal

Research Collection College of Integrative Studies

This study examines how online vaccine information seeking is related to vaccination intention in the United States and China during the initial stage of their coronavirus disease 2019 vaccination programs. Analysis of the pooled sample showed a positive relationship between online vaccine information seeking and vaccination intention. There was also a negative indirect effect via perceived information overload, vaccine risk perception, and negative affective response. Multigroup analysis revealed differences between the United States and China. This study highlights the bright and dark sides of online health information during a global pandemic and has practical implications for communication campaigns to promote …

Balancing Learning And Enjoyment In Serious Games: Kerbal Space Program And The Communication Mediation Model, Sonny Rosenthal, Rabindra A. Ratan

Research Collection College of Integrative Studies

When designed well, serious games can support effective learning. This study used the communication mediation model to examine the process and outcomes of playing serious games, in this case, the science-themed game, Kerbal Space Program. During a 4-h research session, 241 undergraduate students played through the game's tutorial missions and completed surveys to measure variables of interest. Results of structural equation modeling showed that game progress was positively related to self-efficacy in computer gaming (β = 0.26) and ordinary science intelligence (β = 0.13). Knowledge acquisition was positively related to game progress (β = 0.21) and positively predicted experiential attitude …

From Impacts To Dependencies: A First Global Assessment Of Corporate Biodiversity Risk Exposure And Responses, Sergio Henrique Collaço De Carvalho, Theodor Florian Cojoianu, Francisco Ascui

Research Collection College of Integrative Studies

There is growing awareness that biodiversity loss poses a significant risk to the global economy, but a lack of clarity on what this means for corporations, and how they are responding. This study provides a first quantitative assessment of biodiversity risk exposure across the world's largest listed companies, compared with their adoption of biodiversity policies, through analysis of disclosures from a sample of 11,812 companies from 2004 to 2018. We find that companies have started responding strategically to biodiversity risk, with 29% having adopted a biodiversity policy by 2018. However, around $7.2 trillion of total enterprise value remains exposed to …

Aldi++: Automatic And Parameter-Less Discord And Outlier Detection For Building Energy Load Profiles, Matias Quintana, Till Stoeckmann, Young June Park, Marian Turowski, Veit Hagenmeyer, Clayton Miller

Research Collection College of Integrative Studies

Data-driven building energy prediction is an integral part of the process for measurement and verification, building benchmarking, and building-to-grid interaction. The ASHRAE Great Energy Predictor III (GEPIII) machine learning competition used an extensive meter data set to crowdsource the most accurate machine learning workflow for whole building energy prediction. A significant component of the winning solutions was the pre-processing phase to remove anomalous training data. Contemporary pre-processing methods focus on filtering statistical threshold values or deep learning methods requiring training data and multiple hyper-parameters. A recent method named ALDI (Automated Load profile Discord Identification) managed to identify these discords using …

Whole-Exome Sequencing Reveals Damaging Gene Variants Associated With Hypoalphalipoproteinemia, Weilai Dong, Sheng Chih Jin, Et Al.

2020-Current year OA Pubs

Low levels of high density lipoprotein-cholesterol (HDL-C) are associated with an elevated risk of arteriosclerotic coronary heart disease. Heritability of HDL-C levels is high. In this research discovery study, we used whole-exome sequencing to identify damaging gene variants that may play significant roles in determining HDL-C levels. We studied 204 individuals with a mean HDL-C level of 27.8 ± 6.4 mg/dl (range: 4-36 mg/dl). Data were analyzed by statistical gene burden testing and by filtering against candidate gene lists. We found 120 occurrences of probably damaging variants (116 heterozygous; four homozygous) among 45 of 104 recognized HDL candidate genes. Those …

Assessment Of The Impact Of The Covid-19 Pandemic On Health Services Use, Kimberly J Johnson, Charles W Goss, Jeannette Jackson Thompson, Anne M Trolard, Brett B Maricque, Victoria Anwuri, Rachel Cohen, Kate Donaldson, Elvin Geng

2020-Current year OA Pubs

OBJECTIVES: The coronavirus disease of 2019 (COVID-19) pandemic declared by the World Health Organization on March 11, 2020 impacted healthcare services with provider and patient cancellations, delays, and patient avoidance or delay of emergency department or urgent care. Limited data exist on the population proportion affected by delayed healthcare, which is important for future healthcare planning efforts. Our objective was to evaluate the impact of the COVID-19 pandemic on healthcare service cancellations or delays and delays/avoidance of emergency/urgent care overall and by population characteristics.

STUDY DESIGN: This was a cross-sectional study.

METHODS: Our sample (n = 2314) was assembled through …

Association Of The Receptor For Activated C-Kinase 1 With Ribosomes In Plasmodium Falciparum, Jessey Erath, Sergej Djuranovic

2020-Current year OA Pubs

The receptor for activated C-kinase 1 (RACK1), a highly conserved eukaryotic protein, is known to have many varying biological roles and functions. Previous work has established RACK1 as a ribosomal protein, with defined regions important for ribosome binding in eukaryotic cells. In Plasmodium falciparum, RACK1 has been shown to be required for parasite growth, however, conflicting evidence has been presented about RACK1 ribosome binding and its role in mRNA translation. Given the importance of RACK1 as a regulatory component of mRNA translation and ribosome quality control, the case could be made in parasites that RACK1 either binds or does not …

Toll-Like Receptor And Cytokine Expression Throughout The Bone Marrow Differs Between Patients With Low- And High-Risk Myelodysplastic Syndromes, Luana Chiquetto Paracatu, Darlene A Monlish, Zev J Greenberg, Daniel A C Fisher, Matthew J Walter, Stephen T Oh, Laura G Schuettpelz

2020-Current year OA Pubs

Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders, the pathogenesis of which involves enhanced immune signaling that promotes or selects for mutant hematopoietic stem and progenitor cells (HSPCs). In particular, toll-like receptor (TLR) expression and signaling are enhanced in MDS, and their inhibition is an attractive therapeutic strategy. Although prior studies have reported increased expression of TLR2 and its binding partners TLR1 and TLR6 in the CD34

Escape-Noncapture Bigeminy, Lisa M. Roelle, George F. Van Hare

2020-Current year OA Pubs

No abstract provided.

Protein Proximity Networks And Functional Evaluation Of The Casein Kinase 1 Gamma Family Reveal Unique Roles For Ck1Γ3 In Wnt Signaling, Megan J. Agajanian, Frances M. Potjewyd, Brittany M. Bowman, Smaranda Solomon, Kyle M. Lapak, Dhaval P. Bhatt, Jeffery L. Smith, Dennis Goldfarb, Alison D. Axtman, Michael B. Major

2020-Current year OA Pubs

Aberrant activation or suppression of WNT/β-catenin signaling contributes to cancer initiation and progression, neurodegeneration, and bone disease. However, despite great need and more than 40 years of research, targeted therapies for the WNT pathway have yet to be fully realized. Kinases are considered exceptionally druggable and occupy key nodes within the WNT signaling network, but several pathway-relevant kinases remain understudied and "dark." Here, we studied the function of the casein kinase 1γ (CSNK1γ) subfamily of human kinases and their roles in WNT signaling. miniTurbo-based proximity biotinylation and mass spectrometry analysis of CSNK1γ1, CSNK1γ2, and CSNK1γ3 revealed numerous components of the …

An Examination Of The Sex-Specific Nature Of Nutrition Assessment Within The Nutrition Care Process: Considerations For Nutrition And Dietetics Practitioners Working With Transgender And Gender Diverse Clients, Whitney Linsenmeyer, Sarah Garwood, Jennifer Waters

2020-Current year OA Pubs

No abstract provided.