Digital Commons Network^™

Associations Of Moderate-To-Vigorous Physical Activity Timing With Type 2 Diabetes Incidence In Uk Biobank And Prevalent Glycemic Measures In Nhanes, Qiuyu Feng, Gali Albalak, Linjun Ao, Qian Xiao, Heming Wang, Jeroen H P M Van Der Velde, Jessica C Kiefte-De Jong, Martin K Rutter, Charles E Matthews, Joshua R Freeman, Ko Willems Van Dijk, Diana Van Heemst, Raymond Noordam

Faculty, Staff and Student Publications

Objective: We assessed the association between timing of moderate-to-vigorous physical activity (MVPA) with incident type 2 diabetes (T2D) and glycemic measures.

Research design and methods: Regression models were used to assess associations between accelerometer-derived MVPA timing and incident T2D in UK Biobank (UKB) (n = 84,528, prospective), prevalent diabetes, and glycemic measures in the National Health and Nutrition Examination Survey (NHANES) (n = 6,998, cross-sectional).

Results: In UKB, with early morning (0500-0959) MVPA as reference and before adjustment for total MVPA, "variable-timing" MVPA was associated with the lowest incident T2D risk; while after adjustment, afternoon-evening MVPA (1500-2400) showed the lowest …

Madwoman Makings: The Modern Girl As An Object Of Fear And Fascination In Unno Jūza’S "Mrs. Hirumi's Refrigeration Bag", Eliza Joy Mortimer

University Honors Theses

This thesis argues that Unno Jūza's 1937 short story "Mrs. Hirumi's Refrigeration Bag" uses the sensational tropes of deviant detective fiction to both stage and interrogate interwar Japanese anxieties around gender, science, and modernity. Focusing on the figure of Mrs. Hirumi—a scientifically empowered and sexually assertive female plastic surgeon who dismembers and cryogenically preserves her husband—the author reads her as a radical iteration of the Japanese Modern Girl character. By drawing on scholarship on deviant detective fiction, imperial modernity, and Kazue Harada's concept of (re)productivity, this thesis demonstrates how the short story both reproduces misogynistic criminological discourse and unsettles heteronormative …

Business Capstone Review: An Analysis Of A Local School Foundation, Emily Carlile

University Honors Theses

This capstone review thesis analyzes a school foundation in the Portland Metro Area. The capstone project was designed to conduct research to support the local school foundation, specifically the 18-35 demographic, and to increase overall funding. The project required navigating a compressed ten week timeline and coordinating a large, eleven member team to meet our client’s complex expectations. Beyond our hurdles with research, we managed multiple clients' expectations during the presentation, which were not part of the original consulting process. To maintain the project workload, we communicated with the client through a weekly email, four presentations, and a final recommendation …

Understanding The Experiences And Visibility Of Asexual People And Guiding Policy To Effectively Protect Asexuality, Lizzie Stravens

University Honors Theses

Asexuality is sexual orientation defined by those who experience little to no sexual attraction. Despite asexuality being as common as red headedness or left handedness, it has been severely overlooked in research and conversations. Because many people are not aware of the existence of asexuality, it has not been directly attacked by anti-queer campaigns. Still, there have been some recent shifts in this dynamic as asexuality becomes more visible. I conducted a linear regression on the 2022 Ace Community Survey results. I analyzed the effect of theoretically important variables on the outness of asexual respondents. Results indicated an importance on …

How Does Communication Breakdown Impact Group Cohesion Over The Lifespan Of A Team?, Hannah Dyche

University Honors Theses

Communication is one of the main determinants of whether a team or group achieves a successful outcome; when it starts to erode, the team's overall goal often erodes with it. Communication breakdown within teams directly impacts group cohesion, causing small misunderstandings to escalate into larger conflicts. Every team experiences ups and downs, but maintaining a strong foundation of communication and continually strengthening it will prevent this breakdown.

Most of the existing research on team dynamics focuses on corporate environments. By shifting the focus to a short-term academic team, this thesis shows how communication breakdown impacts group cohesion over the lifespan …

Math, And You! Math Tools Website For First-Grade Children With Instruction Provided Through Music Education, Tye Raymond

University Honors Theses

This thesis explores the conceptualization, exploration, and execution of a User Interface (UI) Design created as a supplemental mathematics education tool for grade one learners. Titled "Note Builder", this thesis project is a web design project, functioning as the prototype for a prospective website. Coding a website is a separate project; this project is comprised of the web design blueprint known as a prototype. The site uses a music-based digital reward system, which I constructed to motivate students as they explore new mathematics skills. All of the math questions used in this web design project are directly produced based on …

How Agile Became The Design Philosophy Of Ai Fishbowl Under Real-World Constraints, Jad Saad

University Honors Theses

This capstone review examines the development of AI Fishbowl, a public-facing, interactive artificial intelligence system, as a case study in how Agile methods evolve from a project management tool into a design philosophy under real-world constraints. Although the project adopted an Agile workflow early on through a Kanban-style task management approach, the initial system design and architecture were still shaped by a largely plan-first mindset. This created a mismatch between flexible process and rigid design assumptions, which became increasingly apparent as the team moved from high-level architecture into implementation.

A critical turning point occurred when early architectural plans proved difficult …

A Unified Methodological Framework For Generating Digital Twins Of Multi Class Uncrewed Systems (Uxs), Sai Raghava Pathuri

Shelby Hall Graduate Research Forum Presentations

No abstract provided.

Hyperpolypharmacy And Readmission Risk Among Medicare Beneficiaries: The Role Of Postdischarge Care, Maria Ukhanova, Linda D Highfield, Trudy M Krause, Gayla M Ferguson, Robert O Morgan

Faculty, Staff and Student Publications

Objectives: Medication reconciliation post discharge may reduce readmission risk in populations with multimorbidity and polypharmacy. We aimed to evaluate the association between hyperpolypharmacy and 30-day readmissions; determine the impact of postdischarge care on 30-day readmissions; and identify interactions among hyperpolypharmacy, postdischarge care, and 30-day readmissions in 2 Medicare populations: individuals 65 years and older and individuals of any age with a qualifying disability.

Study design: Retrospective observational study using the 5% national sample Medicare fee-for-service claims data from 2016 to 2019.

Methods: We used descriptive statistics and generalized estimating equation models adjusted for covariates to assess the relationships among hyperpolypharmacy, …

Modeling Advanced Complex And Evolutionary Systems Utilizing End-To-End (E2e) Mbse Framework, Joshua Adelabu

Shelby Hall Graduate Research Forum Posters

Modern Systems Engineering (SE) practices dearth full-cycle framework for next generation systems.

Detecting Bitstream-Level Fpga Trojans With An Snn, Kylie Arnett

Shelby Hall Graduate Research Forum Presentations

Limited research has been conducted on SNNs for FPGA Trojan detection. FPGA design is often handled by manufacturers outside the U.S. FPGA manufactures outsource production to third-party foundries. This multi-step process introduces security vulnerabilities and increases risk of Hardware Trojan insertion.

Key Questions: To what extent can an FPGA be manipulated at the bitstream level to enable or disable encryption algorithms?

Can SNNs accurately detect the presence of Trojans within an FPGA?

Ai Agent For Healthcare Education, Sudhanshu Tarale

Shelby Hall Graduate Research Forum Presentations

No abstract provided.

Proteomic Signatures Of Cardiac Dysfunction Among People With Diabetes: The Atherosclerosis Risk In Communities Study, Justin B Echouffo-Tcheugui, Chiadi E Ndumele, Jingsha Chen, Mary R Rooney, Keenan A Walker, Pascal Schlosser, Kuni Matsushita, Morgan E Grams, Christie C Ballantyne, Ron C Hoogeveen, Eric Boerwinkle, Bing Yu, Amil M Shah, Ruth F Dubin, Rajat Deo, Yue Ren, Jerome I Rotter, Kent D Taylor, Wendy S Post, Peter Ganz, Elizabeth Selvin, Josef Coresh

Faculty, Staff and Students Publications

Background: To investigate the proteomic signatures of heart failure (HF) in diabetes. The underlying mechanisms of the elevated risk of HF in diabetes are unknown.

Methods: In 10 189 ARIC study (Atherosclerosis Risk in Communities) participants free of HF (mean age 57±7 years, 56% women, 22% Black adults, 14% with diabetes), we conducted discovery and internal validation for the associations of 4955 plasma proteins with HF by diabetes status. We performed (1) Cox regression to identify proteins associated with HF by diabetes status, (2) external validation in the MESA study (Multi-Ethnic Study of Atherosclerosis, n=5233, 633 with diabetes), and (3) …

Intraoperative Blood Pressure Management In Noncardiac Surgery: A Narrative Review Based On Current Evidence, Alexandre Joosten, Michelle S Chew, Emmanuel Futier, Anatole Harrois, Matthias Jacquet-Lagreze, Matthieu Legrand, Antonio Messina, Paul S Myles, Bernd Saugel, Daniel I Sessler, Denise P Veelo, Jean-Luc Fellahi

Faculty, Staff and Student Publications

Purpose: Blood pressure is closely monitored during anaesthesia, yet the optimal intraoperative target remains uncertain. This narrative review synthesizes contemporary observational and randomized evidence and explores emerging strategies for individualized haemodynamic management.

Methods: We reviewed major observational cohort studies, randomized controlled trials (RCTs), consensus statements, and recent technological developments addressing intraoperative hypotension, MAP thresholds, and strategies to prevent perioperative organ injury in adult noncardiac surgery.

Results: Large observational datasets consistently demonstrate graded, duration-dependent associations between intraoperative MAP 60-70 mmHg and postoperative myocardial injury, acute kidney injury, and mortality . These findings have informed international recommendations to avoid MAP below 60-65 …

Polygyny Between Sharia, Custom And State Law As A Persistent Dilemma In Post-Soviet Kyrgyzstan, Zharkynbai Sebetov, Mairambek Tagaev

Occasional Papers on Religion in Eastern Europe

This article presents a comprehensive study of the century-long historical and legal evolution of state-imposed prohibitions on the institution of polygyny in Kyrgyzstan. The primary objective of the research is to evaluate the outcomes of a hundred years of repressive policies – originally classified as “crimes of daily life” (bytovye prestupleniya) during the early Soviet era–and to uncover the transformed legal paradoxes of this phenomenon today. Drawing on historical archival materials, Communist Party reports, and contemporary regulatory acts, the authors investigate the fundamental reasons why polygyny persists as a resilient “shadow” institution in Kyrgyz society despite its criminalization. Within the …

Does Ethnicity Similarity Affect Analyst Forecasts?, Zichen Tian

Dissertations and Theses Collection (Open Access)

I examine whether ethnicity similarity between sell-side analysts and corporate senior officers shapes analysts’ forecasting behavior. The baseline results show that ethnicity similarity is associated with higher forecast frequency and larger initial forecast errors. Importantly, I find that the larger initial forecast error associated with ethnicity similarity comes from overestimation and disappears for analysts’ last forecasts, consistent with bias coming from innate favoritism and dissipating as public information accumulates within the fiscal year. However, the market does not discount coethnic analysts’ first forecast revisions and reacts more strongly to their last forecast revisions within the fiscal year, suggesting that investors …

The Health Of Latinos In Massachusetts: Inequality In Health Behaviors And Chronic Health Conditions, Phillip Granberry, Alejandro Alvarez, Florita Coto Tristán

Gastón Institute Publications

This report provides a portrait of adult Latino health in Massachusetts by exploring and describing selected social indicators and health outcomes. This report is a companion to a 2021 report on Latino children in the state, which found that Latino children are more likely to have asthma, be overweight, and show symptoms of anxiety and depression, and less likely to be engaged in physical activity when compared to Non-Latino children. The foregoing findings suggested that Latino children are not developing in an environment that promotes health behaviors compared to Non-Latinos in Massachusetts.v The collective health of Latinos is said group …

Latinos In Massachusetts: Puerto Ricans, Phillip Granberry, Florita Coto Tristán, Melissa Colón

Gastón Institute Publications

As part of the Gastón Institute’s 2025 Latinos in Massachusetts series, we present here a profile of Puerto Ricans, the largest Latino population in the state. This report analyzes Public Use Microdata Sample (PUMS) data from the 2023 American Community Survey (ACS), conducted by the U.S. Census Bureau. Our descriptive analysis uses both household- and individual-level data to estimate population size and percentages and to compare Puerto Ricans to Other Latinos and Non-Latinos in the state.

A Scalable Iteration Of The Horizon Simulation Framework Using Multithreading Techniques, Jason E. Beals

Master's Theses

The Horizon Simulation Framework (HSF) occupies a unique space in the modern aerospace modeling landscape, enabling flexible, modular modeling of mission-level agent behavior through an object-oriented, hierarchical design. HSF's hallmark breadth-first search scheduling algorithm explores a "multiverse" of possible mission execution pathways, enabling exhaustive evaluation of schedule combinations against user-defined heuristics.

As aerospace systems become increasingly complex, HSF faces critical challenges in establishing verifiable, deterministic behavior. The framework's core scheduling algorithm had not undergone systematic validation, leaving questions about temporal consistency, state management correctness, and reproducibility across different program executions. Furthermore, the exponential growth of schedule combinations creates computational bottlenecks …

Dataset For Equity And Justice In Water Pricing And The Effects On Water Distribution System, Brian Barkdoll

Michigan Tech Research Data

“Equity and Justice in Water Pricing and the Effects on Water Distribution System Management” Equity and justice regarding access to potable drinking water are paramount. Municipal Water Distribution Systems supply potable water to users and are essential to public health. They comprise a complicated set of source(s), pump(s), tank(s), and pipes. The price of water to users can affect the amount of usage. To find the optimal price of water to maximize utility revenue and allow changes to the system components for capital and maintenance expenditures, network modeling using the network solver fixed was performed for 15 real MDWSs.  A …

El Leñador, March 2026, El Leñador Staff

El Leñador Newspaper

El Leñador is an English and Spanish newspaper produced by Humboldt State University students. Our staff cover and provide news to Latinx and other diverse communities on campus and in Humboldt County. We are committed to providing relevant news and expanding the representations and stories told about people of color and other marginalized groups. Our work helps create more social, political and cultural diversity in local media.

El Leñador es un periodico en español y inglés producido por estudiantes de la Universidad Estatal de Humboldt. Nuestro personal cubre y provee noticias a la comunidad Latinx y otras comunidades diversas en …

China And International Economic Dispute Settlement: Disaggregating The State, Gregory Shaffer, Ji Li, Henry S. Gao

Research Collection Yong Pung How School Of Law

Most studies take a unitary state-centric approach to assessing China’s relationship with international economic law. In contrast, we provide a more nuanced approach that assesses variation in China’s engagement. We examine the role of different Chinese state and non-state actors, considering their interests, ideological frames, institutional contexts, and relation to state power. We illustrate our analytic framework by examining China’s response to and engagement with international dispute settlement systems in three areas: international commercial arbitration, international trade dispute settlement, and investor–state arbitration. Our approach is important for global cooperation in discrete policy areas so that the West does not ‘other’ …

Recommendations For Developing A Regulatory Sandbox And A Comprehensive Legal Framework For Fintech In Vietnam - Part Ii, Sue M. Altmeyer, Phan Dang Hai

Akron Law Faculty Publications

Fintech, a product of the 4.0 revolution, has experienced rapid growth in Vietnam, attracting significant attention from investors and government agencies. In encouraging innovation, the authors write, the need for a practical legal framework to regulate fintech activities has become a critical issue. The authors believe that this new legal framework should include a regulatory sandbox, which would allow fintech startups to test their products in a controlled environment, helping to mitigate risks, foster creativity, and enhance regulatory oversight. This two-part article discusses challenges in creating and implementing a regulatory sandbox and provides recommendations for overcoming these hurdles. The first …

Seeking Traditional Health Practitioners And Use Of Complementary/Alternative Medicines In The Management Of Movement Disorders In Africa: A Multicenter Continental Study, Ali Shalash, Tamer Roushdy, Samia Sassi, Oluwadamilola Ojo, Yusuf Jamnagerwalla, Ahmed Sheikh, Yasser Mecheri, Maouly Fall, Juzar Hooker, Dilraj Sokhi

Internal Medicine, East Africa

Background Traditional health practitioners (THP) and complementary and alternative medicines (CAM) play a well-recognized role in Africa. However, their role in treating movement disorders (MD) remains poorly studied.

Objective This large multicenter continental study aimed to investigate the prevalence of seeking and consulting THPs and using CAMs among people with MDs in different African countries and the associated factors of their use.

Methods This study involved 12 sites within 11 African countries. We developed and distributed a structured questionnaire that documented frequency, attitudes, beliefs, and factors related to patients' engagement with THPs and use of CAMs.

Results We surveyed 1158 …

Estimating Population Structure Using Epigenome-Wide Methylation Data, Ziqing Wang, Kent D Taylor, Jerome I Rotter, Stephen S Rich, Yinan Zheng, Lifang Hou, Xiuqing Guo, Jan Bressler, Laura M Raffield, Yongmei Liu, Robert Kaplan, Donald M Lloyd-Jones, Alanna C Morrison, Myriam Fornage, Bruce M Psaty, Jennifer A Brody, Tamar Sofer

The Brown Foundation: Institute of Molecular Medicine

Population stratification is one of the source of inflation in epigenome-wide association studies (EWAS) when not properly accounted for. To address this, we developed methylation population scores (MPSs) to predict genetic principal components (GPCs) using a feature selection approach. We used multi-ethnic DNA methylation data from Illumina EPIC arrays across five cohorts, including MESA (n = 929), CARDIA (n = 1123), JHS (n = 1365), ARIC (n = 2338), and HCHS/SOL (n = 1475), randomly splitting participants into training (85%) and test (15%) sets. Within each cohort, associations between GPCs and CpG sites were estimated using linear regression adjusting for …

Human-Centered Design Of Patient Interviews: Capturing The Experiences Of Patients Recovering From Emergency Abdominal Surgery, Jenna L Marquard, Christie L Martin, Elizabeth C Wick, Amanda C Trofholz, Matthew S Loth, Suhyun Park, Genevieve B Melton

The Brown Foundation: Institute of Molecular Medicine

Objectives: Recognizing the challenges of at-home recovery following a truncated presurgical pathway for emergency laparotomy (EL) patients, we sought to identify barriers and facilitators to optimal recovery. This study aimed to develop a human-centered interview guide to capture the experiences of patients recovering at home after EL.

Methods: We employed an iterative human-centered design (HCD) approach to interview guide development, structured across 3 cycles. Each cycle refined the interview guide based on mock interviews and feedback from an interdisciplinary team. In cycle 1, we focused on creating a patient-centered, understandable guide. In cycle 2, we introduced a preinterview survey to …

Diversity And Immune Dynamics Of Choroid Plexus Macrophages Are Shaped By Distinct Developmental Origins, Siling Du, Khai M Nguyen, Alina Ulezko Antonova, Jose L Fachi, Patrick Fernandes Rodrigues, Alice Verdiani, Martina Molgora, Igor Smirnov, Jasmin Herz, Tornike Mamuladze, Jennifer Ponce, Amanda Swain, Mattia Bugatti, Susan Gilfillan, Marina Cella, William Vermi, Jonathan Kipnis, Marco Colonna, Simone Brioschi

The Brown Foundation: Institute of Molecular Medicine

The choroid plexus forms a key barrier and signaling interface between the brain and peripheral circulation, yet its immune landscape remains incompletely understood. Using single-cell transcriptomics combined with lineage and spatial tracing methods, we identified three biologically distinct populations of choroid plexus macrophages, defined by differential expression of CD163, MHCII or CD9. These subsets arise from separate hematopoietic waves, occupy distinct anatomical niches and differentially rely on CSF1 and IL-34 for survival. We found that TGFβ signaling is essential to maintain their tissue-specific identities, and deletion of Tgfbr2 in these cells induces broad phenotypic reprogramming. During neuroinflammation, choroid plexus macrophages …

Glutamatergic Dysfunction Of Astrocytes In Paraventricular Nucleus Of Thalamus Contributes To Adult Anxiety Susceptibility In Adolescent Ethanol Exposed Mice, Aubrey Bennett, Hyunjung Kim, David Thomas, Peter Biggs, Roxan Ara, Asamoah Bosomtwi, Seungwoo Kang

The Brown Foundation: Institute of Molecular Medicine

Repeated ethanol exposure during adolescence increases adult anxiety risk, but the underlying mechanisms remain unclear. The paraventricular nucleus of the thalamus (PVT) has been considered a hub for controlling anxiety and is affected by experiences from early life. Thus, this study investigated how adolescent intermittent repeated ethanol exposure (AIE) affects the PVT activities and anxiety-related behaviors in adulthood. We found that AIE triggers anxiety-like behaviors and parallelly exhibited elevated firing rates and increased calcium signaling in the PVT neurons compared to control counterpart mice. Chemogenetic inhibition of PVT neurons reduced anxiety-like behaviors in AIE-treated animals, confirming PVT's role in adolescent …

Lipids Grease The Chain Of Cancer Progression, Joseph Rupert, Pham Hong Anh Cao, Daniel E Frigo, Mikhail G Kolonin

The Brown Foundation: Institute of Molecular Medicine

The role of lipids in cancer progression has become a fervent area of exploration. The crosstalk of tumors with adipose tissue is a complex but well-regulated orchestration of signaling pathways, lipid transporters, and enzymes. They regulate fatty acid synthesis, their deposition into lipid droplets (LDs) as triglycerides, induction of lipolysis, shuttling lipids across cells, and their systemic trafficking, modification, and catabolism. For the latter, lipid oxidation has emerged as a metabolic process of particular clinical importance. Products of lipid processing can become secondary messengers, contribute to reactive oxygen species (ROS) generation, stimulate the production of antioxidants, and, if left unchecked, …

Neutralization Of Sars-Cov-2 By Igm-14 Via Engagement Of Two Distinct Spike Epitopes, Yan Wang, Yanping Hu, Zhiqiang Ku, Jason Yeung, Jing Zou, Michael Woodson, Nikolai S Prokhorov, Ekaterina S Knyazhanskaya, Haiqing Zhao, Michael B Sherman, Zhiqiang An, Stephen F Carroll, Pei-Yong Shi, Petr G Leiman, Xuping Xie

The Brown Foundation: Institute of Molecular Medicine

Engineered immunoglobulin M (IgM) antibodies typically exhibit superior neutralization potency and avidity compared to their parental IgG counterparts, primarily due to multivalent binding to repeated epitopes on a targeting antigen. In this study, we characterize the neutralization breadth and mechanism of action of IgM-14, a previously reported intranasally deliverable antibody targeting SARS-CoV-2. IgM-14 demonstrates remarkably potent antiviral activity against all pre-Omicron variants but significantly reduced efficacy against Omicron BA.1, and complete loss of activity against the later subvariant JN.1. Resistance selection identified two key mutations in the receptor-binding domain (RBD), G476D and F486P, which disrupt IgM-14 binding and confer strong …