Digital Commons Network^™

Draft Final Bpsou Subdrain Pump Station Remedial Design (Rd) Work Plan, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Draft Final 2022 Residential Metals Abatement Program (Rmap) Park Soil Sampling Field Sampling Plan (Fsp) Submittal #3 [Covering Koprivica Park, Mcgruff Park, Skate Park, Belmont Park, Rock Park, And Hanna Park], Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Draft Final Rmap Park Soil Sampling Field Sampling Plan (Fsp) Submittal #2 [Covering Scown Field, Cherokee Park, Copper/Emmet, West Side Subdivision Park, Chester Steele Park, And Cinders Field], Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) 2022 Revised Draft Final Unreclaimed Sites Quality Assurance Project Plan (Dated June 8, 2022), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Ripk3 Signaling Regulates Hscs During Stress And Represses Radiation-Induced Leukemia In Mice, Lei Zhang, Huacheng Luo, Hong Min Ni, Shanhui Liu, Hongyun Xing, Jun Zhang, Mark Sellin, Peter S.J. Breslin, Wei Wei, Mitchell F. Denning, William Small, Wen Xing Ding, Suming Huang, Jiwang Zhang

Biology: Faculty Publications and Other Works

Receptor-interacting protein kinase 3 (Ripk3) is one of the critical mediators of inflammatory cytokine-stimulated signaling. Here we show that Ripk3 signaling selectively regulates both the number and the function of hematopoietic stem cells (HSCs) during stress conditions. Ripk3 signaling is not required for normal homeostatic hematopoiesis. However, in response to serial transplantation, inactivation of Ripk3 signaling prevents stress-induced HSC exhaustion and functional HSC attenuation, while in response to fractionated low doses of ionizing radiation (IR), inactivation of Ripk3 signaling accelerates leukemia/lymphoma development. In both situations, Ripk3 signaling is primarily stimulated by tumor necrosis factor-α. Activated Ripk3 signaling promotes the elimination …

Up To 8-Year Follow-Up From Resonate-2: First-Line Ibrutinib Treatment For Patients With Chronic Lymphocytic Leukemia, Paul M Barr, Carolyn Owen, Tadeusz Robak, Alessandra Tedeschi, Osnat Bairey, Jan A Burger, Peter Hillmen, Steve E Coutre, Claire Dearden, Sebastian Grosicki, Helen Mccarthy, Jian-Yong Li, Fritz Offner, Carol Moreno, Cathy Zhou, Emily Hsu, Anita Szoke, Thomas J Kipps, Paolo Ghia

Faculty, Staff and Student Publications

We report long-term follow-up from the RESONATE-2 phase 3 study of the once-daily Bruton's tyrosine kinase inhibitor ibrutinib, which is the only targeted therapy with significant progression-free survival (PFS) and overall survival (OS) benefit in multiple randomized chronic lymphocytic leukemia (CLL) studies. Patients (≥65 years) with previously untreated CLL, without del(17p), were randomly assigned 1:1 to once-daily ibrutinib 420 mg until disease progression/unacceptable toxicity (n = 136) or chlorambucil 0.5-0.8 mg/kg ≤12 cycles (n = 133). With up to 8 years of follow-up (range, 0.1-96.6 months; median, 82.7 months), significant PFS benefit was sustained for ibrutinib vs chlorambucil (hazard ratio …

68ga-Labeled Benzothiazole Derivatives For Imaging Aβ Plaques In Cerebral Amyloid Angiopathy, Truc T Huynh, Yujue Wang, Karna Terpstra, Hong-Jun Cho, Liviu M Mirica, Buck E Rogers

Open Access Publications

Timely diagnostic imaging plays a crucial role in managing cerebral amyloid angiopathy (CAA)-the condition in which amyloid β is deposited on blood vessels. To selectively map these amyloid plaques, we have designed amyloid-targeting ligands that can effectively complex with

The Challenges Of Interrogating Adipose Tissue Extracellular Vesicle Functions In Physiology, Clair Crewe

Open Access Publications

No abstract provided.

Long-Run Effects Of High-Quality Pre-K: What Does Research Show?, Timothy J. Bartik

Presentations

High-quality pre-K results in long-run effects of higher educational attainment, lower crime, and higher earnings for former child participants as adults.

Examining The Preliminary Validity Of A Dynamic Assessment Of Narrative Language In Mandarin Chinese, Lok Yee Sarah Cheung

Theses and Dissertations

The purpose of this thesis was to examine the preliminary validity of a newly developed dynamic assessment of narrative language in Mandarin Chinese. Two studies are reported in this thesis. Study 1 included 31 second grade participants and Study 2 included 43 first grade participants. All participants were enrolled in a Chinese immersion program in an elementary school in Utah. A dynamic assessment of narrative language was administered to each participant in Mandarin Chinese. A teacher rating was also included in Study 1. Results indicated that the dynamic assessment investigated in this thesis demonstrated some similar characteristics with other valid …

Erosion, Backsliding, Or Abuse: Three Metaphors For Democratic Decline, Thomas Keck

Political Science - All Scholarship

Drawing on Rosalind Dixon and David Landau’s Abusive Constitutional Borrowing: Legal Globalization and the Subversion of Liberal Democracy (2021), this essay calls attention to three competing metaphors for democratic decline (democratic erosion, democratic backsliding, and abusive constitutionalism) and elaborates their implications for how supporters of liberal democracy might arrest and reverse the decline. Drawing on Richard L. Hasen’s Cheap Speech: How Disinformation Poisons Our Politics–And How to Cure It (2022), Stephen M. Feldman’s Pack the Court: A Defense of Supreme Court Expansion (2021), and the Final Report of the Presidential Commission on the Supreme Court of the United States (2021), …

Machine Learning, The Mortar Of Modernization, Vishnu Pendyala

Open Educational Resources

Machine Learning is advancing civilization and is one of the key drivers of the economy today. Machine Learning literacy may one day become essential, the way computer literacy is today. This talk intends to explain Machine Learning concepts to wider audiences by using easy-to-relate real-world analogies and serves as a refresher to those already initiated. A fundamental concept in machine learning is similarity. The dot product that is ubiquitously present in machine learning is a measure of similarity. Similarity is key to human learning as well. We learn in delta increments by comparing and contrasting with what we already know. …

Differences In Attachment, Resilience, And Negative Affect In Non-Treatment-Seeking And Treatment-Seeking Ems Professionals, Jose Carbajal, Warren Ponder, Lauren Malthaner, Kathryn Shahan, Katelyn Jetelina, Jeanine Galusha, Donna Schuman

Journal of Social, Behavioral, and Health Sciences

Emergency medical service (EMS) professionals have a stressful vocation, inarguably worsened by the COVID-19 pandemic, which affects their mental health and makes them a vulnerable population warranting further study. However, to date, no published research has compared non-treatment and treatment-seeking EMS professionals in the same greater metropolitan area. In this study, we examined differences and similarities among the non-treatment-seeking EMS professionals (n = 57) from a local EMS agency and treatment-seeking EMS personnel (n = 53) from a non-profit community treatment center on six assessment instruments that measure attachment avoidance, attachment anxiety, resilience, depression, generalized anxiety, posttraumatic stress …

History Department Newsletter, Georgia Southern University

History: News & Publications

• Chair's Message: From Dr. Carol Herringer
• What Our Faculty Are Doing...
• Students in the News

College Of Education News, Georgia Southern University

College of Education: News & Publications (2003-2023)

• EAGLE Academy Updates
• Southeast Conference on School Climate
• Center for STEM Education Challenges Girl Scout Camp goers to Solve a Mystery and Think Like Engineers

Sirpα+ Macrophages Are Increased In Patients With Fl Who Progress Or Relapse After Frontline Lenalidomide And Rituximab, Mario L Marques-Piubelli, Edwin R Parra, Lei Feng, Luisa Solis Soto, Mariana Gallardo, Sushanth Gouni, Felipe Samaniego, Mansoor Noorani, Fredrick B Hagemeister, Jason R Westin, Hun Ju Lee, Maria A Rodriguez, Sattva S Neelapu, Jillian R Gunther, Nathan H Fowler, Christopher R Flowers, Ignacio I Wistuba, Loretta J Nastoupil, Francisco Vega, Paolo Strati

Faculty, Staff and Student Publications

Limited data exist regarding the outcome of patients with follicular lymphoma (FL) who relapse or progress after frontline lenalidomide and rituximab (R2). Moreover, mechanisms of resistance to R2 in FL remain unclear, with increased protumoral macrophages suspected as a major contributory culprit to this phenomenon. This retrospective study analyzed the outcome of patients with advanced-stage FL grade 1 to 3A who relapsed or progressed after frontline R2. A multiplex immunofluorescence macrophage panel, including CD47, CD14, CD68, CD115 (also known as colony-stimulating factor 1 receptor [CSF1R]), CD163, CD172a (also known as signal regulatory protein α [SIRPα]), and CD274 (also known as …

Distributed Learning For Heterogeneous Clinical Data With Application To Integrating Covid-19 Data Across 230 Sites, Jiayi Tong, Chongliang Luo, Md Nazmul Islam, Natalie E Sheils, John Buresh, Mackenzie Edmondson, Peter A Merkel, Ebbing Lautenbach, Rui Duan, Yong Chen

2020-Current year OA Pubs

Integrating real-world data (RWD) from several clinical sites offers great opportunities to improve estimation with a more general population compared to analyses based on a single clinical site. However, sharing patient-level data across sites is practically challenging due to concerns about maintaining patient privacy. We develop a distributed algorithm to integrate heterogeneous RWD from multiple clinical sites without sharing patient-level data. The proposed distributed conditional logistic regression (dCLR) algorithm can effectively account for between-site heterogeneity and requires only one round of communication. Our simulation study and data application with the data of 14,215 COVID-19 patients from 230 clinical sites in …

Metabolic Biomarkers Assessed With Pet/Ct Predict Sex-Specific Longitudinal Outcomes In Patients With Diffuse Large B-Cell Lymphoma, Shama Jaswal, Vanessa Sanders, Priyanka Pullarkat, Stephanie Teja, Amber Salter, Marcus P Watkins, Norman Atagu, Daniel R Ludwig, Joyce Mhlanga, Vincent M Mellnick, Linda R Peterson, Nancy L Bartlett, Brad S Kahl, Todd A Fehniger, Armin Ghobadi, Amanda F Cashen, Neha Mehta-Shah, Joseph E Ippolito

2020-Current year OA Pubs

In many cancers, including lymphoma, males have higher incidence and mortality than females. Emerging evidence demonstrates that one mechanism underlying this phenomenon is sex differences in metabolism, both with respect to tumor nutrient consumption and systemic alterations in metabolism, i.e., obesity. We wanted to determine if visceral fat and tumor glucose uptake with fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) could predict sex-dependent outcomes in patients with diffuse large B-cell lymphoma (DLBCL). We conducted a retrospective analysis of 160 patients (84 males; 76 females) with DLBCL who had imaging at initial staging and after completion of therapy. CT-based relative visceral fat area …

Impact Of Web-Based Cognitive Behavioral Therapy For Insomnia On Stress, Health, Mood, Cognitive, Inflammatory, And Neurodegenerative Outcomes In Rural Dementia Caregivers: Protocol For The Nitecapp Cares And Nitecapp Shares Randomized Controlled Trial, Christina S Mccrae, Ashley F Curtis, Amelia Cottle, David B Beversdorf, Joel Shenker, Brian P Mooney, Mihail Popescu, Marilyn Rantz, Maureen Groer, Phyllis Stein, Mojgan Golzy, Melanie A Stearns, Angelynn Simenson, Neetu Nair, Meredeth A Rowe

2020-Current year OA Pubs

BACKGROUND: Chronic insomnia affects up to 63% of family dementia caregivers. Research suggests that chronic insomnia prompts changes in central stress processing that have downstream negative effects on health and mood, as well as on cognitive, inflammatory, and neurodegenerative functioning. We hypothesize that cognitive behavioral therapy for insomnia (CBT-I) will reverse those downstream effects by improving insomnia and restoring healthy central stress processing. Rural caregivers are particularly vulnerable, but they have limited access to CBT-I; therefore, we developed an accessible digital version using community input (NiteCAPP CARES).

OBJECTIVE: This trial will evaluate the acceptability, feasibility, and short-term and long-term effects …

Exploring The Impact Of Trem2 In Tumor-Associated Macrophages, Darya Khantakova, Simone Brioschi, Martina Molgora

2020-Current year OA Pubs

Tumor-associated macrophages (TAMs) represent a key component of the tumor microenvironment and are generally associated with immunosuppression and poor prognosis. TREM2 is a transmembrane receptor of the immunoglobulin superfamily expressed in myeloid cells. TREM2 has been extensively studied in microglia and neurodegenerative diseases and recently emerged as a marker of pro-tumorigenic macrophages. The accumulation of TREM2-expressing TAMs was reported across numerous cancer patients and tumor models. TREM2 genetic blockade or TREM2 targeting with antibodies resulted in improved tumor control, enhanced response to anti-PD1, and significant changes in the tumor immune landscape. Preclinical studies paved the way for an ongoing clinical …

Probabilistic Multi-Objective Inverse Analysis For Damage Identification Using Piezoelectric Impedance Measurement Under Uncertainties, Kai Zhou, Yang Zhang, Qi Shuai, Jiong Tang

Michigan Tech Publications, Part 1

Piezoelectric impedance sensing is promising for highly accurate damage identification because of its high-frequency active interrogative nature and simplicity in data acquisition. To fully unleash the potential, effective inverse analysis is needed in order to pinpoint the damage location and identify the severity. The inverse analysis, however, may be underdetermined since there exists a very large number of unknowns (i.e., locations and severity levels) to be solved in a finite element model but only limited measurements are available in actual practice. To uncover the true damage scenario, an inverse analysis strategy built upon the multi-objective optimization, which aims at matching …

Mobile-Polypnet: Lightweight Colon Polyp Segmentation Network For Low-Resource Settings, Ranit Karmakar, Saeid Nooshabadi

Michigan Tech Publications, Part 1

Colon polyps, small clump of cells on the lining of the colon, can lead to colorectal cancer (CRC), one of the leading types of cancer globally. Hence, early detection of these polyps automatically is crucial in the prevention of CRC. The deep learning models proposed for the detection and segmentation of colorectal polyps are resource-consuming. This paper proposes a lightweight deep learning model for colorectal polyp segmentation that achieved state-of-the-art accuracy while significantly reducing the model size and complexity. The proposed deep learning autoencoder model employs a set of state-of-the-art architectural blocks and optimization objective functions to achieve the desired …

O'Hara V. Board Of Directors Of The Park Ave. & Seventy-Seventh St. Corp.

All Decisions

No abstract provided.

Brookes V. 157th St. Assoc., Llc

All Decisions

No abstract provided.

Marcondes V. Fort 710 Assoc., L.P.

All Decisions

No abstract provided.

Cardenas V. 74-78 Post Ave. Hgts. Assoc. Llc

All Decisions

No abstract provided.

Preparation Of Carbon Aerogels From Polymer-Cross-Linked Xerogel Powders Without Supercritical Fluid Drying And Their Application In Highly Selective Co2adsorption, Rushi U. Soni, Vaibhav A. Edlabadkar, Daniel Greenan, Parwani M. Rewatkar, Nicholas Leventis, Chariklia Sotiriou-Leventis

Chemistry Faculty Research & Creative Works

Carbon aerogels are well-known materials for their high porosity and high surface areas. They are typically made from pyrolysis of carbonizable polymeric aerogels. Here, we report an alternative route to monolithic carbon aerogels starting from xerogel powders. Use of powders speeds up solvent exchanges along sol-gel processing, and xerogelling bypasses the supercritical fluid drying step that is needed for making polymeric aerogels. Overall, this alternative route results in time, energy, and materials efficiency in the fabrication of carbon aerogels. Specifically, polymer-cross-linked silica xerogel powders were prepared via free-radical surface-initiated polymerization of acrylonitrile (AN) on a suspension of silica particles derived …

Availability, Accessibility And Utilization Of Electronic Information Resources And Services By Staff Of Nigerian Defence Academy, Kaduna, Abdulwasiu Ahmad Ismail, Tukur Abduljabbar

Library Philosophy and Practice (e-journal)

This paper investigate the availability, accessibility of electronic resources and services and the extent to which these resources were being used by staff of Nigerian Defence Academy. The objectives of this paper were to find out types of electronic resources and services available, accessed and utilized by staff of Nigerian Defence Academy Kaduna, to find out how users access and utilize these resources, to find out the purpose of accessing and utilizing these available resources, also to find out the problems that hinder these use of these resources. A survey research method was used to conduct this study and the …

Exploring Copyright Compliance In Self-Archiving Of Scholarly Works: Nigerian Librarians’ Perspectives, Iskil Arisekola Bolaji Mr.

Library Philosophy and Practice (e-journal)

Abstract

Purpose: Low understanding and comprehension of copyright compliance have been established in the body of literature. However, there is no study to indicate the understanding of Nigerian scholars on copyright compliance in self-archiving. This study explored copyright compliance of scholarly authors in self-archiving using the perspectives of Nigerian librarians.

Design/methodology/approach: The study adopts a qualitative approach, using the semi-structured interviews to collect data from a total of twenty-one (21) participants. The interview sessions were carried out using the Zoom application, and the interview transcript was analysed using thematic analysis.

Findings: Findings showed that most of the scholarly authors view …

Indoleamine 2,3-Dioxygenase 1 Activation In Mature Cdc1 Promotes Tolerogenic Education Of Inflammatory Cdc2 Via Metabolic Communication, Marco Gargaro, Carlos G. Briseño, Prachi Bagadia, Vivek Durai, Derek J. Theisen, Sunkyung Kim, Marco Colonna, Theresa L. Murphy, Kenneth M. Murphy, Et Al.

2020-Current year OA Pubs

Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is used by cDCs in maintaining tolerance, but its role in different subsets remains unclear. At homeostasis, only mature CCR7