Digital Commons Network^™

The Role Of Smoking And Body Mass Index In Mortality Risk Assessment For Geriatric Hip Fracture Patients, Ariana T. Meltzer-Bruhn, Garrett W. Esper, Christopher G. Herbosa, Abhishek Ganta, Kenneth A. Egol, Sanjit R. Konda

2020-Current year OA Pubs

Background Smoking, obesity, and being below a healthy body weight are known to increase all-cause mortality rates and are considered modifiable risk factors. The purpose of this study is to assess whether adding these risk factors to a validated geriatric inpatient mortality risk tool will improve the predictive capacity for hip fracture patients. We hypothesize that the predictive capacity of the Score for Trauma Triage in the Geriatric and Middle-Aged (STTGMA) tool will improve. Methodology Between October 2014 and August 2021, 2,421 patients >55-years-old treated for hip fractures caused by low-energy mechanisms were analyzed for demographics, injury details, hospital quality …

Neurological Complications And Recovery Rates Of Patients With Adult Cervical Deformity Surgeries, Han Jo Kim, Yu-Cheng Yao, Christopher I. Shaffrey, Justin S. Smith, Michael P. Kelly, Munish Gupta, Todd J. Albert, Themistocles S. Protopsaltis, Gregory M. Mundis, Peter Passias, Eric Klineberg, Shay Bess, Virginie Lafage, Christopher P. Ames, International Spine Study Group

2020-Current year OA Pubs

STUDY DESIGN: Retrospective cohort study.

OBJECTIVE: This study aims to report the incidence, risk factors, and recovery rate of neurological complications (NC) in patients with adult cervical deformity (ACD) who underwent corrective surgery.

METHODS: ACD patients undergoing surgery from 2013 to 2015 were enrolled in a prospective, multicenter database. Patients were separated into 2 groups according to the presence of neurological complications (NC vs no-NC groups). The types, timing, recovery patterns, and interventions for NC were recorded. Patients' demographics, surgical details, radiographic parameters, and health-related quality of life (HRQOL) scores were compared.

RESULTS: 106 patients were prospectively included. Average age …

Gan Training Acceleration Using Frechet Descriptor-Based Coreset, Yanzhe Xu, Teresa Wu, Jennifer R. Charlton, Kevin M. Bennett

2020-Current year OA Pubs

No abstract provided.

Single-Dose Intrathecal Dorsal Root Ganglia Toxicity Of Onasemnogene Abeparvovec In Cynomolgus Monkeys, Francis Fonyuy Tukov, Keith Mansfield, Mark Milton, Emily Meseck, Kelley Penraat, Deepa Chand, Andreas Hartmann

2020-Current year OA Pubs

Intravenous onasemnogene abeparvovec is approved for the treatment of spinal muscular atrophy in children < 2 years. For later-onset patients, intrathecal onasemnogene abeparvovec may be advantageous over intravenous administration. Recently, microscopic dorsal root ganglion (DRG) changes were observed in nonhuman primates (NHPs) following intrathecal onasemnogene abeparvovec administration. To characterize these DRG findings, two NHP studies evaluating intrathecal onasemnogene abeparvovec administration were conducted: a 12-month study with a 6-week interim cohort and a 13-week study with a 2-week interim cohort. The latter investigated the potential impact of prednisolone or rituximab plus everolimus on DRG toxicity. An additional 6-month, single-dose, intravenous NHP study conducted in parallel evaluated onasemnogene abeparvovec safety (including DRG toxicity) with or without prednisolone coadministration. Intrathecal onasemnogene abeparvovec administration was well tolerated and not associated with clinical observations. Microscopic onasemnogene abeparvovec-related changes were observed in the DRG and trigeminal ganglion (TG) and included mononuclear cell inflammation and/or neuronal degeneration, which was colocalized with high vector transcript expression at 6 weeks postdose. Incidence and severity of DRG changes were generally decreased after 52 weeks compared with 6 weeks postdose. Other onasemnogene abeparvovec-related microscopic findings of axonal degeneration, mononuclear cell infiltrates and/or gliosis in the spinal cord, dorsal spinal nerve root/spinal nerves, and/or peripheral nerves were absent or found at decreased incidences and/or severities after 52 weeks. DRG and/or TG microscopic findings following intravenous onasemnogene abeparvovec dosing included minimal to slight neuronal degeneration and mononuclear cell inflammation at 6 weeks and 6 months postdose. Nervous system microscopic findings following intrathecal onasemnogene abeparvovec (≥1.2 × 10

Prophetic Eu: Prospective Identification Of Pneumonia In Hospitalized Patients In The Intensive Care Unit In European And United States Cohorts, Stephen P Bergin, Marin H Kollef, Et Al.

2020-Current year OA Pubs

BACKGROUND: The prospective identification of patients at high risk for hospital-acquired/ventilator-associated bacterial pneumonia may improve clinical trial feasibility and foster antibacterial development. In a prior study conducted in the United States, clinical criteria were used to prospectively identify these patients; however, these criteria have not been applied in a European population.

METHODS: Adults considered high risk for pneumonia (treatment with ventilation or high levels of supplemental oxygen) in the intensive care units of 7 European hospitals were prospectively enrolled from June 12 to December 27, 2017. We estimated the proportion of high-risk patients developing pneumonia according to US Food and …

Projected Effects Of Disruptions To Human Immunodeficiency Virus (Hiv) Prevention Services During The Coronavirus Disease 2019 Pandemic Among Black/African American Men Who Have Sex With Men In An Ending The Hiv Epidemic Priority Jurisdiction, Jennifer Labs, Amy S Nunn, Philip A Chan, S Bessey, Carolyn J Park, Brandon D L Marshall, Rupa R Patel, Leandro A Mena, William C Goedel

2020-Current year OA Pubs

BACKGROUND: Disruptions in access to in-person human immunodeficiency virus (HIV) preventive care during the coronavirus disease 2019 (COVID-19) pandemic may have a negative impact on our progress towards the Ending the HIV Epidemic goals in the United States.

METHODS: We used an agent-based model to simulate HIV transmission among Black/African American men who have sex with men in Mississippi over 5 years to estimate how different reductions in access affected the number of undiagnosed HIV cases, new pre-exposure prophylaxis (PrEP) starts, and HIV incidence.

RESULTS: We found that each additional 25% decrease in HIV testing and PrEP initiation was associated …

Addressing Futility: A Practical Approach, Piroska K. Kopar, Adrienne Visani, Kyler Squirrell, Douglas E. Brown

2020-Current year OA Pubs

UNLABELLED: Limiting or withdrawing nonbeneficial medical care is considered ethically responsible throughout most of critical care and medical ethics literature. Practically, however, setting limits to treatment is often challenging. We review the literature to identify best practices for using the definition of futility as an anchoring concept to aid the ethical practice of ICU clinicians.

DATA SOURCES: Source data were obtained from a PubMed literature review.

STUDY SELECTION: English language articles were chosen based on relevance to medical futility ethics, end-of-life care in the ICU, or communication and conflict mitigation strategies.

DATA EXTRACTION: Independent evaluation of selected articles for recurrent …

Is Combined Surgical Dislocation And Proximal Femoral Osteotomy A Safe Procedure For Correction Of Complex Hip Deformities?, Frank W Parilla, Jeffrey J Nepple, Gail E Pashos, Perry L Schoenecker, John C Clohisy

2020-Current year OA Pubs

Complex deformities of the hip requiring intra-articular and proximal femoral correction are challenging with regard to surgical access and complication risk. Combined surgical dislocation and proximal femoral osteotomy (SD/PFO) is a surgical strategy that provides unrestricted access to the joint with the capability for adjunctive PFO. Although providing excellent surgical access, concerns over a potentially high risk of postoperative complications remain, and published information on the safety of this technique remain scarce. In this study, we defined the early complication profile of combined surgery across 48 hips with a variety of complex deformities using a standardized, validated complication grading scheme …

Encuentros And Desencuentros: Reflections On A Latcrit Colloquium In Latin America, Joshua Price, María Lugones

Florida Journal of International Law

No abstract provided.

Multi-Voiced Society: Philosophical Nuances On Rushdie's Midnight's Children, Fred Evans

Florida Journal of International Law

No abstract provided.

How To Play Justice And Drama In Antiquity: Law And Theater In Athens As Performative Rituals, Emiliano J. Buis

Florida Journal of International Law

No abstract provided.

Race, Nation-Building And Legal Transculturation During The Haitian Unification Period (1822-1844): Towards A Haitian Perspective, Charles R. Venator Santiago

Florida Journal of International Law

No abstract provided.

Protecting The Argentine Jewish Community And Jewish Identity In Times Of Crisis: Local Efforts, Global Community, And Foreign Support, Carina J. Miller

Florida Journal of International Law

No abstract provided.

Let There Be Justice: The Double Standard Of Application Of Legal Norms, José María Monzón

Florida Journal of International Law

No abstract provided.

"Meeting The World Halfway"—The Limits Of Legal Transformation, Karin Van Marle

Florida Journal of International Law

No abstract provided.

Social Justice Advocacy In The Third Dimension: Addressing The Problem Of "Preservation-Through-Transformation", John O. Calmore

Florida Journal of International Law

No abstract provided.

Indigenous Peoples' Self-Determination And The Broken Tin Kettle Music Of Human Rights And Liberal Democracy, Dominique Legros

Florida Journal of International Law

No abstract provided.

Policy And Praxis: A Role For Latcrit "Institutional-Class Analysis" In Latin American Judicial Reform, Becky L. Jacobs

Florida Journal of International Law

No abstract provided.

Civil Disobedience On Vieques: How Nonviolence Defeated The U.S. Military, Frances Olsen

Florida Journal of International Law

No abstract provided.

Labor Law And Genetic Discrimination In Chile, Hugo Rojas

Florida Journal of International Law

No abstract provided.

Latcrit Goes International, Kevin R. Johnson

Florida Journal of International Law

No abstract provided.

"Will She Speak Or Won't She? That Is The Question": Comments On The Communal Land Rights Bill, Deon Erasmus

Florida Journal of International Law

No abstract provided.

Putting Florida Buyers On Par With International Buyers: A Cost-Benefit Analysis Of Revising Florida Statute 675.109(1)(A)(4), Eyal Berger

Florida Journal of International Law

No abstract provided.

The United Nations And Humanitarian Intervention: Building Legitimacy By Confronting Our Past—An Open Letter To Kofi Annan, Danette Zaghari-Mask, Sabina Tomshinsky, Tosha Fernandez

Florida Journal of International Law

No abstract provided.

In The Name Of National Security Or Insecurity?: The Potential Indefinite Detention Of Noncitizen Certified Terrorists In The United States And The United Kingdom In The Aftermath Of September 11, 2001, Dana Keith

Florida Journal of International Law

No abstract provided.

Universal Jurisdiction And Drug Trafficking: A Tool For Fighting One Of The World's Most Pervasive Problems, Anne H. Geraghty

Florida Journal of International Law

No abstract provided.

Turning The Corporate Inversion Transaction Right Side Up: Proposed Legislation In The 108th Congress Aims To Stamp Out Any Economic Vitality Of The Corporate Inversion Transaction, Derek E. Anderson

Florida Journal of International Law

No abstract provided.

All The Other Dirty Little Secrets: Investment Treaties, Latin America, And The Necessary Evil Of Investor-State Arbitration, Carlos G. Garcia

Florida Journal of International Law

No abstract provided.

The History, Nature, And Reach Of The Alien Tort Claims Act, Jordan J. Paust

Florida Journal of International Law

No abstract provided.

Overview, Janet Reno

Florida Journal of International Law

No abstract provided.