Digital Commons Network^™

Changes In The Morphology Of Widgeon Grass (Ruppia Maritima) With The Onset Of Reproduction And Impacts On Fish Assemblages At The Chandeleur Islands, La, Matthew Byrnes

Master's Theses

Seagrasses are important submerged coastal habitats that support nearshore communities. Ruppia maritima (widgeon grass) is a widespread species whose leaves branch extensively when reproductive. The goal of this study was to understand use of reproductive and non-reproductive R. maritima by fishes, recognizing the morphological change undergone by the plant when flowering. During the peak reproductive season in August and September 2021, R. maritima meadows at the Chandeleur Islands, LA were sampled to describe the spatial distribution and morphology of reproductive plants and investigate habitat use by fish assemblages. We assessed spatial trends in R. maritima presence and occurrence of reproduction …

Diagnostic Dilemma: Progressive Supranuclear Palsy With Parkinson’S Disease, Siddharth Tewari, Niharika Prasad

Manipal Journal of Medical Sciences

Swallow tail sign is normally present in Substantia Nigra pars compacta due to the hyperintensity of nigrosome 1 containing cells on T2*/SWI sequences. Its absence is highly indicative of Parkinson’s disease.However, nigrostriatal dopaminergic degeneration is seen in progressive supranuclear palsy as well.It is important for neurologists and radiologists to assess the patient’s symptoms and signs to be able to provide the correct diagnosis,in view of further clinical management

A Neonatal Surgeon’S Concern – Review On Neonatal Gastric Perforation, Anoush Sardesai Sadat, Mahisha Virdiana, Raj Parag Gohil, Sundeep Payyanur Thotan, Ranjani Rammohan

Manipal Journal of Medical Sciences

NGP is an uncommon phenomenon that requires skilled tackling and apt management. The pathology itself is multifactorial with prematurity as a significant risk factor. NGP may present with marked abdominal distention, respiratory distress, vomiting, failure to feed, and lethargy. The diagnosis of a pneumoperitoneum can be made by plain abdominal radiographs and management usually includes an emergency laparotomy with gastrorrhaphy. Percutaneous drainage has also shown good results and may be considered in those patients who cannot be taken up for surgery. LBW and prematurity are known to affect the prognosis and it is important to have an eagle’s eye to …

“I Did Not Sign Up For This”: Student Experiences Of The Rapid Shift From In-Person To Emergency Virtual Remote Learning During The Covid Pandemic, Jeff Kuntz, Viola Manokore

Higher Learning Research Communications

Abstract

Objectives: The main objective of this study was to explore students’ experiences of the emergency virtual remote teaching, which was implemented as a result of the COVID-19 pandemic.

Method: 439 students enrolled at a community college in Canada responded to a survey that had Likert-scale and open-ended questions. Anderson’s model for online learning was used as an analytic lens to gain insight on student experiences. Descriptive statistics were used to make meaning of the data. Thematic analysis was done on student responses to open-ended questions.

Results: Findings were organized according to Anderson’s six factors in online teaching, namely: (a) …

Application Of The Big6 Skills Model And Information Literacy Skills Of Undergraduate Students On The Use Of Electronic Resources In Nigerian Universities, Manir Abdullahi Kamba Phd, Aminu Ahmed Buba

Library Philosophy and Practice (e-journal)

The study aimed at determining the information literacy skills on the use of e-resources by undergraduate students using the Big6 information literacy skills Model. Quantitative research methodology was used, and a total 2,484 sample using Sloven’s formula was obtained from a population of 61,804 undergraduate students. A structured questionnaire was used to collect data and was analyzed using descriptive statistics. The findings revealed that the undergraduate students were aware of the information literacy programmes in the Universities (mean=3.87) and possess the necessary information literacy skills to utilize e-resources (mean=3.45). Applying the constructs of the Big6 information literacy skills Model revealed …

A Scientometric Analysis And Visualization Of The Universal Reading Motivation Studies Based On Co-Word And Co-Author, Mozhdeh Salajegheh

Library Philosophy and Practice (e-journal)

Abstract

Reading is an intellectual process that everyone for doing it, need to motivation, so that they can interrelate with the concepts of the texts that they read. Reading is the agent of wisdom and knowledge. Today is the age of information. Information is power. People who have internal motivation for reading information resources, are those who have information and change it to knowledge and knowledge is the power of readers who have internal motivation. The aim of present research is to analyze world scientific studies on reading motivation based on Scientometric and benchmarks of centrality in articles of web …

Awareness And Usage Of Electronic Resources By The Faculty Members - A Case Study, Chandran Velmurugan Dr, R Raghotham

Library Philosophy and Practice (e-journal)

This paper aimed to explore the awareness and usage of online resources by the faculty members of Vivekanandha Arts and Science College for Women, Salem. The current study is rooted in primary data which were collected from the faculty members who are working in different departments of Vivekanandha Arts and Science College for Women. A total of 200 well structured and designed questionnaires were dispersed among the faculty members and we received only 179 filled questionnaires were returned out of 200 sample of population and the total response rate was 89.5%. The results of the study was observed and found …

Moral Injury, Nurse Well-Being, And Resilience Among Nurses Practicing During The Covid-19 Pandemic, Joyce J. Fitzpatrick, Grant Pignatiello, Minjin Kim, Jin Jun, Donal P. O'Mathuna, Henry Ofori Duah, Jessica Taibl, Sharon J. Tucker

College of Nursing Faculty Research and Publications

OBJECTIVE

The aim of this study was to determine relationships between moral injury (MI), well-being, and resilience among staff nurses and nurse leaders practicing during the COVID-19 (coronavirus disease 2019) pandemic.

BACKGROUND

Attention to MI among health professionals, including nurses, increased in 2021, particularly related to the pandemic. Few studies examined MI, well-being, and resilience; even fewer provided implications for leadership/management.

METHODS

The sample included 676 RNs practicing in Ohio. The electronic survey included assessments of MI, well-being, and resilience distributed via the Ohio Nurses Association and the schools of nursing alumni Listservs.

RESULTS

There was a significant association between …

Post-Surgical Emergency After-Hours Calls: Prevalence, Concerns, And Management, Vrisiis Kofina, Drake Lindholm, Abdulkareem Harunani, Andrew R. Dentino, Maharaj Singh, Dimitris N. Tatakis

College of Nursing Faculty Research and Publications

Objective

The purpose of this study was to investigate the prevalence, nature, and management of post-surgical emergency after-hours calls in a dental school setting with predoctoral students, graduate students/residents, and faculty providers.

Methods

A patient chart review (March 2018–February 2020) for post-surgical calls through the emergency after-hours pager system was conducted at the Marquette University School of Dentistry. The total number of surgical procedures, procedure type, the timing of call, operator experience, concern, and recommendation given during the call were documented.

Results

During the review period, 83 calls (from 75 patients) were recorded after 8,487 surgical procedures (1% of procedures). …

Social And Web Presence Of Cultural Heritage Organisations In India, Harpreet Singh, Mansi Gupta

Library Philosophy and Practice (e-journal)

The present study focuses on the Social and Web presence of 27 Cultural Heritage Organisations in India. The purpose of this study is to investigate the domain authority, number of webpages, links, calculate the web impact factors and link-mentions on Social Networking Sites of the websites of Cultural Heritage Organisations and rank them accordingly. Analysing the websites of the Cultural Heritage Organisations it was found that majority of them have '.gov.in' domain name in their URLs. The study found that the highest domain authority (63) and page authority (51) was recorded by website of the Archaeological Survey of India. Indira …

Optimising Curve Fitting Techniques To Look For Standardisation Of The Analysis Of Defocus Curves Derived From Multifocal Intraocular Lenses, Elizabeth M. Law, Hd Buckhurst, Rajesh K. Aggarwal, H El‐Kasaby, Jonathan Marsden, Gary L. Shum, Pj Buckhurst

School of Health Professions

IntroductionTo establish the most appropriate curve fitting method to allow accurate comparison of defocus curves derived from intraocular lenses (IOLs).MethodsDefocus curves were plotted in five IOL groups (monofocal, extended depth of focus, refractive bifocal, diffractive bifocal and trifocal). Polynomial curves from 2nd to 11th order and cubic splines were fitted. Goodness of fit (GOF) was assessed using five methods: least squares, coefficient of determination (R2adj), Akaike information criteria (AIC), visual inspection and Snedecor and Cochran. Additional defocus steps at −2.25 D and −2.75 D were measured and compared to the calculated visual acuity (VA) values. Area under the defocus curve …

Dose-Related Effects Of Ketamine For Antidepressant-Resistant Symptoms Of Posttraumatic Stress Disorder In Veterans And Active Duty Military: A Double-Blind, Randomized, Placebo-Controlled Multi-Center Clinical Trial, Chadi G Abdallah, John D Roache, Ralitza Gueorguieva, Lynnette A Averill, Stacey Young-Mccaughan, Paulo R Shiroma, Prerana Purohit, Antoinette Brundige, William Murff, Kyung-Heup Ahn, Mohamed A Sherif, Eric J Baltutis, Mohini Ranganathan, Deepak D'Souza, Brenda Martini, Steven M Southwick, Ismene L Petrakis, Rebecca R Burson, Kevin B Guthmiller, Argelio L López-Roca, Karl A Lautenschlager, John P Mccallin, Matthew B Hoch, Alexandar Timchenko, Sergio E Souza, Charles E Bryant, Jim Mintz, Brett T Litz, Douglas E Williamson, Terence M Keane, Alan L Peterson, John H Krystal

Staff and Researcher Publications

This study tested the efficacy of repeated intravenous ketamine doses to reduce symptoms of posttraumatic stress disorder (PTSD). Veterans and service members with PTSD (n = 158) who failed previous antidepressant treatment were randomized to 8 infusions administered twice weekly of intravenous placebo (n = 54), low dose (0.2 mg/kg; n = 53) or standard dose (0.5 mg/kg; n = 51) ketamine. Participants were assessed at baseline, during treatment, and for 4 weeks after their last infusion. Primary analyses used mixed effects models. The primary outcome measure was the self-report PTSD Checklist for DSM-5 (PCL-5), and secondary outcome …

Myocardial Scintigraphy In Diagnosing Cardiac Transthyretin Amyloidosis, Marija Petrovic, Persio D Lopez, Calvin Eng, Mahjabeen Rashid

The Texas Heart Institute Journal

Myocardial scintigraphy with technetium-99m pyrophosphate is a minimally invasive technique that can distinguish between transthyretin amyloidosis (ATTR) and light-chain amyloidosis. We present a case in which it helped determine the amyloidosis type in a 74-year-old man with cardiac amyloidosis and multiple previous admissions for acute decompensated heart failure. The patient presented with increasing abdominal girth and bilateral lower extremity edema. His medical history also included atrial fibrillation, liver cirrhosis, hypertension, stage 3 chronic kidney disease, and peripheral vascular disease. We prescribed guideline-directed medical therapy for his acute decompensated heart failure with cardiorenal syndrome and his decompensated cirrhosis. Two years previously, …

Decongestion Models And Metrics In Acute Heart Failure: Escape Data In The Age Of The Implantable Cardiac Pressure Monitor, David Paniagua, Glenn N Levine, Lorraine D Cornwell, Ernesto Jimenez, Biswajit Kar, Hani Jneid, Ali E Denktas, Tony S Ma

The Texas Heart Institute Journal

The United States Food and Drug Administration restricts the use of implantable cardiac pressure monitors to patients with New York Heart Association (NYHA) class III heart failure (HF). We investigated whether single-pressure monitoring could predict survival in HF patients as part of a model constructed using data from the ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) trial.

We validated survival models in 204 patients, using all-cause 180-day mortality. Two levels of model complexity were tested: 1) a simplified 1-pressure model based on pulmonary artery mean pressure ([PAM]1P) (information obtainable from an implanted intracardiac monitor alone), …

The Role Of An Inpatient Hospice And Palliative Clinical Pharmacist In The Interdisciplinary Team, Jetavia Jones Moody, Ivy O Poon, Ursula K Braun

Center for Medical Ethics and Health Policy Staff Publications

Palliative care is a specialized health care service for individuals with serious illness at any stage and can be provided in any setting. Current national consensus developed by palliative care experts recommends the inclusion of pharmacists in an interdisciplinary team (IDT) to provide quality palliative care. However, national registry data report that less than 10% of inpatient palliative teams in the U.S. have a clinical pharmacist. Clinical pharmacists have an impactful role in palliative patients' quality of life by optimizing symptom management, deprescribing, and providing education to the palliative care team as well as patients and their families. In this …

A Novel, De Novo Intronic Variant In Pogz Causes White-Sutton Syndrome, Ashanta Merriweather, David R Murdock, Jill A Rosenfeld, Hongzheng Dai, Shamika Ketkar, Lisa Emrick, Sarah Nicholas, Richard A Lewis, Undiagnosed Diseases Network, Carlos A Bacino, Daryl A Scott, Brendan Lee, Vernon Reid Sutton, Lorraine Potocki, Lindsay C Burrage

Center for Medical Ethics and Health Policy Staff Publications

White-Sutton syndrome (WHSUS), which is caused by heterozygous pathogenic variants in POGZ, is characterized by a spectrum of intellectual disabilities and global developmental delay with or without features of autism spectrum disorder. Additional features may include hypotonia, behavioral abnormalities, ophthalmic abnormalities, hearing loss, sleep apnea, microcephaly, dysmorphic facial features, and rarely, congenital diaphragmatic hernia (CDH). We present a 6-year-old female with features of WHSUS, including CDH, but with nondiagnostic clinical trio exome sequencing. Exome sequencing reanalysis revealed a heterozygous, de novo, intronic variant in POGZ (NM_015100.3:c.2546-20T>A). RNA sequencing revealed that this intronic variant leads to skipping of exon 18. …

A Validation Framework For Somatic Copy Number Detection In Targeted Sequencing Panels, Raghu Chandramohan, Jacquelyn Reuther, Ilavarasi Gandhi, Horatiu Voicu, Karla R Alvarez, Sharon E Plon, Dolores H Lopez-Terrada, Kevin E Fisher, D Williams Parsons, Angshumoy Roy

Center for Medical Ethics and Health Policy Staff Publications

Somatic copy number alterations (SCNAs) in tumors are clinically significant diagnostic, prognostic, and predictive biomarkers. SCNA detection from targeted next-generation sequencing panels is increasingly common in clinical practice; however, detailed descriptions of optimization and validation of SCNA pipelines for small targeted panels are limited. This study describes the validation and implementation of a tumor-only SCNA pipeline using CNVkit, augmented with custom modules and optimized for clinical implementation by testing reference materials and clinical tumor samples with different classes of copy number variation (CNV; amplification, single copy loss, and biallelic loss). Using wet-bench and in silico methods, various parameters impacting CNV …

Changes In Measures Of Vestibular And Balance Function And Hippocampus Volume In Alzheimer's Disease And Mild Cognitive Impairment, Helen S Cohen, Christie M Lincoln, Valory N Pavlik, Haleh Sangi-Haghpeykar

Faculty, Staff and Students Publications

OBJECTIVE: To test the hypotheses that people with Alzheimer's disease and mild cognitive impairment have increased frequency of vestibular impairments and decreased hippocampal volume compared with healthy age-matched controls.

STUDY DESIGN: Retrospective, with some historical controls.

SETTING: Out-patient, tertiary care center.

SUBJECTS: People with mild to moderate dementia diagnosed with Alzheimer's disease and with mild cognitive impairment. Main Outcome Measures: A standard clinical battery of objective tests of the vestibular system, and screening for balance; available clinical diagnostic magnetic resonance imaging (MRIs) were reviewed and postprocessed to quantify the left and right hippocampal volumes utilizing both manual segmentation and computer …

Crispr Detection Of Circulating Cell-Free Mycobacterium Tuberculosis Dna In Adults And Children, Including Children With Hiv: A Molecular Diagnostics Study, Zhen Huang, Sylvia M Lacourse, Alexander W Kay, Joshua Stern, Jaclyn N Escudero, Brady M Youngquist, Wenshu Zheng, Debrah Vambe, Muyalo Dlamini, Godwin Mtetwa, Lisa M Cranmer, Irene Njuguna, Dalton C Wamalwa, Elizabeth Maleche-Obimbo, Donald G Catanzaro, Christopher J Lyon, Grace John-Stewart, Andrew Dinardo, Anna M Mandalakas, Bo Ning, Tony Y Hu

Faculty, Staff and Students Publications

BACKGROUND: Tuberculosis remains a leading cause of global mortality, especially for adults and children living with HIV (CLHIV) underdiagnosed by sputum-based assays. Non-sputum-based assays are needed to improve tuberculosis diagnosis and tuberculosis treatment monitoring. Our aim in this study was to determine whether ultrasensitive detection of Mycobacterium tuberculosis cell-free DNA (Mtb-cfDNA) in blood can diagnose tuberculosis and evaluate tuberculosis treatment responses.

METHODS: In this molecular diagnostics study we analysed archived serum from two patient populations evaluated for tuberculosis in Eswatini and Kenya to detect Mtb-cfDNA, analysing serum from all individuals who had both sufficient serum volumes and clear diagnostic results. …

Analysis Of An Antibiotic Stewardship Program For Asymptomatic Bacteriuria In The Veterans Affairs Health Care System, Larissa Grigoryan, Aanand D Naik, Paola Lichtenberger, Christopher J Graber, Payal K Patel, Dimitri M Drekonja, Timothy P Gauthier, Bhavarth Shukla, Anne E Sales, Sarah L Krein, John N Van, Laura M Dillon, Sylvia J Hysong, Jennifer R Kramer, Annette Walder, David Ramsey, Barbara W Trautner

Faculty, Staff and Students Publications

IMPORTANCE: Antibiotic stewardship for asymptomatic bacteriuria (ASB) is an important quality improvement target. Understanding how to implement successful antibiotic stewardship interventions is limited.

OBJECTIVE: To evaluate the effectiveness of a quality improvement stewardship intervention on reducing unnecessary urine cultures and antibiotic use in patients with ASB.

DESIGN, SETTING, AND PARTICIPANTS: This interrupted time series quality improvement study was performed at the acute inpatient medical and long-term care units of 4 intervention sites and 4 comparison sites in the Veterans Affairs (VA) health care system from October 1, 2017, through April 30, 2020. Participants included the clinicians who order or collect …

Community-Based Trial Assessing The Impact Of Annual Versus Semiannual Mass Drug Administration With Ivermectin Plus Albendazole And Praziquantel On Helminth Infections In Northwestern Liberia, Obiora A Eneanya, Lincoln Gankpala, Charles W Goss, Aaron T Momolu, Enoch S Nyan, Emmanuel B Gray, Kerstin Fischer, Kurt Curtis, Fatorma K Bolay, Gary J Weil, Peter U Fischer

2020-Current year OA Pubs

We assessed the impact of three annual vs five semiannual rounds of mass drug administration (MDA) with ivermectin plus albendazole followed by praziquantel for the control or elimination of lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminth (STH) infections and schistosomiasis in Lofa County, Liberia. The study started in 2012 and was interrupted in 2014 during the Ebola virus outbreak. Repeated cross-sectional surveys were conducted in individuals 5 years and older to measure infection markers. Wuchereria bancrofti antigenemia prevalences decreased from 12.5 to 1.2% (90% reduction) and from 13.6 to 4.2% (69% reduction) one year after three rounds of annual or five …

Sustainability In Clinical Practice: A Cross-National Comparative Study Of Nursing Students, Jennie Aronsson, Anna Anåker, Marie Elf, Janet Richardson

School of Nursing and Midwifery

BACKGROUND: Delivering health care negatively influences the environment and contributes to climate change. This study examined how nursing students in England and Sweden can make changes in clinical practice to enhance environmental sustainability. METHOD: Third-year undergraduate nursing students at English and Swedish universities responded to open-ended questions on the Sustainability Attitudes in Nursing Survey. Data were analyzed using inductive content analysis. RESULTS: Students in both countries identified lack of confidence as the main barrier to challenging unsustainable practice, followed by a resistance to change in practice. English students predominantly changed their own behavior or influenced the practice of others. Swedish …

‘You Can't Walk Through Water Without Getting Wet’ Uk Nurses’ Distress And Psychological Health Needs During The Covid-19 Pandemic: A Longitudinal Interview Study, J. Maben, A. Conolly, R. Abrams, E. Rowland, R. Harris, D. Kelly, B. Kent, K. Couper

School of Nursing and Midwifery

BackgroundPre-COVID-19 research highlighted the nursing profession worldwide as being at high risk from symptoms of burnout, post-traumatic stress disorder (PTSD) and suicide. The World Health Organization declared a pandemic on 11th March 2020 due to the sustained risk of further global spread of COVID-19. The high healthcare burden associated with COVID-19 has increased nurses’ trauma and workload, thereby exacerbating pressure on an already strained workforce and causing additional psychological distress for staff.ObjectivesThe Impact of COVID-19 on Nurses (ICON) interview study examined the impacts of the pandemic on frontline nursing staff's psychosocial and emotional wellbeing.DesignLongitudinal qualitative interview study.SettingsNurses who had completed …

Infection And Inflammation: New Perspectives On Alzheimer's Disease, Heather E Whitson, Robyn S Klein, Et Al.

2020-Current year OA Pubs

Neuroinflammation has been recognized as a component of Alzheimer's Disease (AD) pathology since the original descriptions by Alois Alzheimer and a role for infections in AD pathogenesis has long been hypothesized. More recently, this hypothesis has gained strength as human genetics and experimental data suggest key roles for inflammatory cells in AD pathogenesis. To review this topic, Duke/University of North Carolina (Duke/UNC) Alzheimer's Disease Research Center hosted a virtual symposium: "Infection and Inflammation: New Perspectives on Alzheimer's Disease (AD)." Participants considered current evidence for and against the hypothesis that AD could be caused or exacerbated by infection or commensal microbes. …

Dysmorphism And Immunodeficiency - One Of The Differential Diagnoses Is Pax1 Related Otofaciocervical Syndrome Type 2, Jdc Pereira Baptista

Peninsula Medical School

Otofaciocervical syndrome (OTFCS) is a rare condition associated with short stature, abnormal facial features and conductive hearing loss. OTFCS type 2 (OTFCS) is an autosomal recessive form of this condition with associated T cell deficiency due to biallelic variants in PAX1. We report a female child born to a consanguineous couple with homozygous PAX1 variant. She was diagnosed with T cell immunodeficiency as a neonate and underwent haematopoietic stem cell transplant with cord blood at the age of 5 months. She had facial dysmorphism including ear abnormalities and spinal deformity. We present longitudinal follow-up of the proband who has responded …

Outcomes After Intracranial Rescue Stenting For Acute Ischemic Stroke, Christine Tschoe, Joshua Osbun, Et Al.

2020-Current year OA Pubs

BACKGROUND: In cases of failed recanalization despite modern mechanical thrombectomy (MT) techniques, intracranial rescue stenting (RS) may be beneficial. However, outcomes and complications of RS relative to the natural history of ongoing emergent large vessel occlusion are unknown. To evaluate whether RS for ongoing emergent large vessel occlusion after failed MT achieves superior outcomes to the natural history of persistent emergent large vessel occlusion.

METHODS: Patients from the Stroke Thrombectomy and Aneurysm Registry who underwent RS after failed MT from 2014 to 2019 were analyzed. For outcome comparisons, patients were screened for inclusion/exclusion criteria of 3 major randomized, controlled MT …

Recurrent Transcriptional Responses In Aml And Mds Patients Treated With Decitabine, Pawan Upadhyay, Jeremy Beales, Nakul M Shah, Agata Gruszczynska, Christopher A Miller, Allegra A Petti, Sai Mukund Ramakrishnan, Daniel C Link, Timothy J Ley, John S Welch

2020-Current year OA Pubs

The molecular events responsible for decitabine responses in myelodysplastic syndrome and acute myeloid leukemia patients are poorly understood. Decitabine has a short serum half-life and limited stability in tissue culture. Therefore, theoretical pharmacologic differences may exist between patient molecular changes in vitro and the consequences of in vivo treatment. To systematically identify the global genomic and transcriptomic alterations induced by decitabine in vivo, we evaluated primary bone marrow samples that were collected during patient treatment and applied whole-genome bisulfite sequencing, RNA-sequencing, and single-cell RNA sequencing. Decitabine induced global, reversible hypomethylation after 10 days of therapy in all patients, which was …

A Staged Reconstruction Technique Utilizing Bioprosthetic Mesh Reinforcement In The Repair Of Giant Omphalocele, Annahita R. Fotouhi, Justin M. Sacks, Martin S. Keller, Kamlesh B. Patel

2020-Current year OA Pubs

No abstract provided.

Prediction Of Patient Outcomes Through Social Determinants Of Health: The Pulmonary Hypertension Association Registry (Phar) Evaluation, Dan Grinnan, Murali Chakinala, Et Al.

2020-Current year OA Pubs

Outcomes of patients with pulmonary arterial hypertension (PAH) may be associated with social determinants of health (SDOH) and other baseline patient characteristics. At present, there is no prognostic model to predict important patient outcomes in PAH based on SDOH. Utilizing information from the Pulmonary Hypertension Association Registry (PHAR), we derive a model (PHAR Evaluation or PHARE) to predict an important composite patient outcomes based on SDOH and other patient characteristics. Baseline data regarding SDOH from adult patients with PAH enrolled in the PHAR between 2015 and March 23, 2020, were included for analysis. We performed repeated measures logistic regression modeling …

Mitochondrial Rna Modifications Shape Metabolic Plasticity In Metastasis, Sylvain Delaunay, Gloria Pascual, Bohai Feng, Kevin Klann, Mikaela Behm, Agnes Hotz-Wagenblatt, Karsten Richter, Karim Zaoui, Esther Herpel, Christian Münch, Sabine Dietmann, Jochen Hess, Salvador Aznar Benitah, Michaela Frye

2020-Current year OA Pubs

Aggressive and metastatic cancers show enhanced metabolic plasticity