Digital Commons Network^™

Management Of Non-Compressible Torso Hemorrhage Of The Abdomen In Austere/Remote Environments By Non-Surgeon Using Truncal Hemorrhage Control, Donald Adams Mpas, Pa-C

Doctor of Philosophy in Translational Health Sciences Dissertations

Background: Non-compressible torso hemorrhage (NCTH) of the abdomen is a potentially preventable cause of death due to injury. Over the last 26 years, the trauma community has not developed a temporizing or definitive intervention to preserve life in patients with non-compressible torso hemorrhage of the abdomen due to trauma. Individuals who sustain survivable injuries that are associated with non-compressible torso hemorrhage of the abdomen will, on average bleed out or hemorrhage within 30 minutes of sustaining injury. Truncal hemorrhage control is the intervention this research study would implement by non-surgeons managing patients with non-compressible torso hemorrhage of the abdomen in …

Modelo De Predicción De La Demencia En Adultos Mayores De 60 Años [Dementia Prediction Model In Adults Over 60 Years Old], Maria Del Pilar Santacruz-Ortega, Maria Fernanda Cobo-Charry, Bertha Lucia Avendaño-Prieto, Silvia Mejia-Arango

School of Medicine Publications

In order to determine the contribution of the sociodemographic, psychosocial and health variables to a prediction model of dementia in the elderly population, a secondary analysis was carried out with the data from the “Health, Well-being and Aging. Bogotá, 2012”, with 2000 men and women over 60 years of age from urban and rural areas of Bogotá. To select the sample, a probabilistic, multistage, conglomerate and stratified sampling was carried out, based on the 2005 National Census. The SABE questionnaire adapted for Colombia was used. According to the level of measurement of each variable and the distribution of the data, …

Otulin's Novel Regulatory Mechanisms In Genotoxic And Inflammatory Nf-Kb Signaling, Mingqi Li

Theses and Dissertations (ETD)

Triple negative breast cancer (TNBC) is aggressive but cannot be treated with hormone therapy or molecular therapy due to the lack of a target. Chemotherapy is a systemic treatment that works by attacking rapidly growing cells, which is initially more effective for TNBC patients than those individuals with the hormone receptor-positive breast cancer. However, patients with TNBC tend to develop resistance to chemo drugs, called chemoresistance. After years of effort, the signaling pathways involved in TNBC chemoresistance are gradually revealed, including the nuclear factor-kappa B (NF-kB) pathway. Transcription factor NF-kB is widely involved in cancer development and progression, and its …

Security Simulations In Undergraduate Education: A Review, Joseph J. Simpson, Aaron Brantly

International Business and Entrepreneurship Faculty Publications

Several decades of research in simulation and gamification in higher education shows that simulations are highly effective in improving a range of outcomes for students including declarative knowledge and interest in the topic being taught. While there appears to be a broad array of options to provide education in an undergraduate setting related to security, no previous reviews have explored computer-based simulations covering all facets of security. Given the increasing importance and adoption of interdisciplinary educational programs, it is important to take stock of simulations as a tool to broaden the range of problems, perspectives, and solutions presented to students. …

Working With A Different Drummer: Transgender Or Gender Creative Children And Their Families, Deborah E. Grayson

Faculty and Staff Publications & Presentations

COURSE OVERVIEW

This experiential workshop will demonstrate how the expressive art therapies will accelerate the expression of our true selves in the LGBTQ+ community and assist their families in overcoming shame and resistance and aids in healing when it comes to grieving, understanding identity and fostering lasting relationships. We will explore current challenges as well as past and current successes.

Learning Objectives

1. Demonstrate how the expressive art therapies can accelerate the expression of the true self, assists families in overcoming shame and resistance, and aids in the healing process when it comes to grieving, understanding identity and fostering lasting relationships. …

Health Concerns Of Kentucky's Library Workforce During The Early Covid-19 Pandemic., Anita R. Hall, Brandi Duggins

Faculty and Staff Scholarship

Although research early in the pandemic primarily emphasized libraries’ pandemic response and service to patrons, more interest has developed regarding library workers and their experiences. This study seeks to understand the impacts library workers experienced from the beginning of institutions’ initial pandemic response through the end of 2020. This article focuses on a subset of the data related to the health concerns and impacts Kentucky library workers experienced during distinct phases of the early pandemic. Responses to this survey indicate that workers required to be onsite were impacted more frequently with COVID-related health concerns while all library workers experienced significant …

Effect Of Organic Acids On Co2-Rock And Water-Rock Interfacial Tension: Implications For Co2 Geo-Storage, Ahmed Al-Yaseri, Nurudeen Yekeen, Muhammad Ali, Nilanjan Pal, Amit Verma, Hesham Abdulelah, Hussein Hoteit, Mohammad Sarmadivaleh

Research outputs 2022 to 2026

A small concentration of organic acid in carbon dioxide (CO2) storage formations and caprocks could significantly alter the wettability of such formations into less water-wet conditions, decreasing the CO2-storage potential and containment security. Recent studies have attempted to infer the influence of the organic acid concentration on the wettability of rock–CO2–brine systems by measuring advancing and receding contact angles. However, no studies have investigated the influence of organic acid contamination on CO2-storage capacities from rock-fluid interfacial tension (IFT) data because solid-brine and solid-CO2 IFT values cannot be experimentally measured. Equilibrium contact angles and rock-fluid IFT datasets were used to evaluate …

Concurrent Exposure To (Acute Intermittent) Hypoxia And Hypercapnia: A Promising Therapeutic Cocktail For Neuroplasticity?, Ricardo N. O. Mesquita

Research outputs 2022 to 2026

Pioneering experiments revealed that intermittent stimulation of afferent neurons from the carotid bodies elicits long-lasting increased activity of respiratory nerves, a phenomenon known as respiratory long-term facilitation (LTF). Initially observed with episodic electrical stimulation of the carotid sinus nerve, this phenomenon was then extensively demonstrated in rodent experiments via protocols of brief, episodic exposures to periods of hypoxia (i.e. acute intermittent hypoxia; AIH). Then, the realization that AIH could be used as a therapeutic modality to induce neuroplasticity and restore both respiratory and non-respiratory motor function in rats with spinal cord injuries (SCI) motivated translation to human studies. AIH has …

Wetlands As Social Ecological Systems, And Relationality In The Policy Domain, Pierre Horwitz

Research outputs 2022 to 2026

A wetland policy perspective based on social ecological systems accepts that wetlands are part of landwaterscapes, that people are part of wetland ecosystems, and that the health of wetlands and the health of people are interdependent, evidence of the close, reciprocal and indivisible relationships between nature and culture. These relationships are storied and place-based, associated with place attachment, and are representations of relational values. They are most easily located wherever and whenever Indigenous and local peoples’ knowledge and interests are at play in wetland settings. Legal and administrative processes that recognise Chthonic law and rights for wetlands will elevate relational …

Appropriateness Of Indirect Markers Of Muscle Damage Following Lower Limbs Eccentric-Biased Exercises: A Systematic Review With Meta-Analysis, Emeric Chalchat, Anne Fleur Gaston, Keyne Charlot, Luis Peñailillo, Omar Valdés, Pierre Emmanuel Tardo-Dino, Kazunori Nosaka, Vincent Martin, Sebastian Garcia-Vicencio, Julien Siracusa

Research outputs 2022 to 2026

Purpose The aim of this review was to (1) characterize the time-course of markers of exercise-induced muscle damage (EIMD) based on the level of maximal voluntary contraction torque loss at 24-48h post-exercise (MVCloss24-48h), (2) identify factors (e.g., exercise and population characteristics) affecting the level of MVCloss24-48h, and (3) evaluate the appropriateness of EIMD markers as indicators of MVCloss24-48h. Methods Magnitude of change of each EIMD markers was normalized using the standardized mean differences method to compare the results from different studies. Time-course of EIMD markers were characterized according to three levels of MVCloss24-48h based on a clustering analysis of the …

Genomic Epidemiology Of Salmonella Typhi In Central Division, Fiji, 2012 To 2016, Mark R. Davies, Sebastian Duchene, Mary Valcanis, Aaron P. Jenkins, Adam Jenney, Varanisese Rosa, Andrew J. Hayes, Aneley Getahun Strobel, Liam Mcintyre, Jake A. Lacey, Elizabeth J. Klemm, Vanessa K. Wong, Aalisha Sahukhan, Helen Thomson, Andrew Page, Dianna Hocking, Nancy Wang, Litia Tudravu, Eric Rafai, Gordon Dougan, Benjamin P. Howden, John A. Crump, Kim Mulholland, Richard A. Strugnell

Research outputs 2022 to 2026

Background: Typhoid fever is endemic in some Pacific Island Countries including Fiji and Samoa yet genomic surveillance is not routine in such settings. Previous studies suggested imports of the global H58 clade of Salmonella enterica var Typhi (Salmonella Typhi) contribute to disease in these countries which, given the MDR potential of H58, does not auger well for treatment. The objective of the study was to define the genomic epidemiology of Salmonella Typhi in Fiji. Methods: Genomic sequencing approaches were implemented to study the distribution of 255 Salmonella Typhi isolates from the Central Division of Fiji. We augmented epidemiological surveillance and …

Offspring Conceived Through Art Have Normal Thyroid Function In Adolescence And As Young Adults, L. A. Wijs, D. A. Doherty, J. A. Keelan, V. Panicker, P. Burton, J. L. Yovich, R. J. Hart

Research outputs 2022 to 2026

STUDY QUESTION: Are there differences in thyroid function between adolescents and young adults conceived with and without ART? SUMMARY ANSWER: This study demonstrated no evidence of clinically relevant differences in thyroid function between adolescents and young adults conceived with and without ART. WHAT IS KNOWN ALREADY: Studies to date have reported an increase in subclinical hypothyroidism in offspring conceived after ART. It has been suggested that the increase in maternal estrogen (E2) after fresh embryo transfers could affect thyroid function of the offspring. Suboptimal thyroid function at a young age can cause irreversible damage to the central nervous system, which …

Traditional Chinese Poems, “The White Blossom” And “Agony Unfurls,” As Well As The Finished Parts In The Martyrdom Of Chen Zi-Ang, A Film Screenplay, And “Shadows Of Phoenixes” In Scarlet Tears On A Golden Branch, A Novel (華夏傳統詩〈素華〉與〈抽怨〉、電影劇本《陳子昂殉道記》已成之部、小說《金枝紅淚》中〈凰影〉已成之部), Xiao-Yu Chen

Student Publications

Book Description

Chen Zi-Ang (courtesy name Bo-Yu, 659–700 CE) was a medieval Chinese author, poet, scholar, twice-prisoner, and a martyr. It has been a devotion of the Daoist and the Chinese folk religions to venerate him as the Holy Land Patron of the Shu Area (Sichuan) and his hometown, Shehong. During his brief life, Chen reverently practiced the cultural-spiritual lineage of Confucianism and was a devout follower of the Daoist religion. He was also a long-term manifester of the Chinese cultural-spiritual archetype of the warrior. Earning his doctorate in 684 CE, he served in a number of minor official roles, …

Biofeedback Technologies As Extended Cognition: A Philosophical Analysis, Haesoo Park

Student Publications

Every year technologies become more sophisticated and more accessible. Some have become a seamless extension of mind, so much so that they are better understood no longer as tools, but as integral parts of how our mind works. Biofeedback devices are examples of such technologies that are increasingly used in institutional contexts and for personal use. They offer a presumed scientific and objective basis for life decisions and behavioral health interventions, as well as a promise of new forms of self-knowledge. Yet in the very design of biofeedback technologies are cultural and institutional values that are rarely critically appraised. This …

Accessing History In Gettysburg: A Study Of Accessibility Of Public History Institutions, Theodore J. Szpakowski

Student Publications

Based on field observation and interviews with staff, this paper evaluates the state of accessibility in five Gettysburg public history institutions in the summer of 2022. Evaluation criteria for field observations were determined based on a critical disability studies approach, focusing on disabled people’s accounts of these and similar institutions. The research revealed areas of success and failure in current accessibility measures, as well as ongoing projects to increase accessibility in most institutions. The rubric developed here could be refined and used as a research tool or an institutional planning tool.

Supreme Court Overruling Of Roe V. Wade Poses Danger For Lgbt Rights, Arthur S. Leonard

Other Publications

No abstract provided.

Federal Court Rules That North Carolina Violated The Constitution And Title Vii By Excluding Coverage For Gender Transition From Its Public Employee Health Plan, Arthur S. Leonard

Other Publications

No abstract provided.

Prediction Of Patient Outcomes Through Social Determinants Of Health: The Pulmonary Hypertension Association Registry (Phar) Evaluation, Dan Grinnan, Murali Chakinala, Et Al.

2020-Current year OA Pubs

Outcomes of patients with pulmonary arterial hypertension (PAH) may be associated with social determinants of health (SDOH) and other baseline patient characteristics. At present, there is no prognostic model to predict important patient outcomes in PAH based on SDOH. Utilizing information from the Pulmonary Hypertension Association Registry (PHAR), we derive a model (PHAR Evaluation or PHARE) to predict an important composite patient outcomes based on SDOH and other patient characteristics. Baseline data regarding SDOH from adult patients with PAH enrolled in the PHAR between 2015 and March 23, 2020, were included for analysis. We performed repeated measures logistic regression modeling …

Single-Dose Intrathecal Dorsal Root Ganglia Toxicity Of Onasemnogene Abeparvovec In Cynomolgus Monkeys, Francis Fonyuy Tukov, Keith Mansfield, Mark Milton, Emily Meseck, Kelley Penraat, Deepa Chand, Andreas Hartmann

2020-Current year OA Pubs

Intravenous onasemnogene abeparvovec is approved for the treatment of spinal muscular atrophy in children < 2 years. For later-onset patients, intrathecal onasemnogene abeparvovec may be advantageous over intravenous administration. Recently, microscopic dorsal root ganglion (DRG) changes were observed in nonhuman primates (NHPs) following intrathecal onasemnogene abeparvovec administration. To characterize these DRG findings, two NHP studies evaluating intrathecal onasemnogene abeparvovec administration were conducted: a 12-month study with a 6-week interim cohort and a 13-week study with a 2-week interim cohort. The latter investigated the potential impact of prednisolone or rituximab plus everolimus on DRG toxicity. An additional 6-month, single-dose, intravenous NHP study conducted in parallel evaluated onasemnogene abeparvovec safety (including DRG toxicity) with or without prednisolone coadministration. Intrathecal onasemnogene abeparvovec administration was well tolerated and not associated with clinical observations. Microscopic onasemnogene abeparvovec-related changes were observed in the DRG and trigeminal ganglion (TG) and included mononuclear cell inflammation and/or neuronal degeneration, which was colocalized with high vector transcript expression at 6 weeks postdose. Incidence and severity of DRG changes were generally decreased after 52 weeks compared with 6 weeks postdose. Other onasemnogene abeparvovec-related microscopic findings of axonal degeneration, mononuclear cell infiltrates and/or gliosis in the spinal cord, dorsal spinal nerve root/spinal nerves, and/or peripheral nerves were absent or found at decreased incidences and/or severities after 52 weeks. DRG and/or TG microscopic findings following intravenous onasemnogene abeparvovec dosing included minimal to slight neuronal degeneration and mononuclear cell inflammation at 6 weeks and 6 months postdose. Nervous system microscopic findings following intrathecal onasemnogene abeparvovec (≥1.2 × 10

Sustainability In Clinical Practice: A Cross-National Comparative Study Of Nursing Students, Jennie Aronsson, Anna Anåker, Marie Elf, Janet Richardson

School of Nursing and Midwifery

BACKGROUND: Delivering health care negatively influences the environment and contributes to climate change. This study examined how nursing students in England and Sweden can make changes in clinical practice to enhance environmental sustainability. METHOD: Third-year undergraduate nursing students at English and Swedish universities responded to open-ended questions on the Sustainability Attitudes in Nursing Survey. Data were analyzed using inductive content analysis. RESULTS: Students in both countries identified lack of confidence as the main barrier to challenging unsustainable practice, followed by a resistance to change in practice. English students predominantly changed their own behavior or influenced the practice of others. Swedish …

Elementary Principals’ Instructional Leadership Role In International Schools: The Challenges And Perceptions Of Student Grouping, Hafida Belkacem Becker

Electronic Theses and Dissertations

Globally, elementary principals have similar responsibilities and duties. Some of their obligations include clerical tasks, other managerial assignments, and instructional leadership duties. All of these jobs require attention and can be time consuming. The researcher aimed to understand the perceptions which challenge elementary principals’ beliefs about student grouping strategies and the impact on reading achievement within a network of 35 schools located around the world. Principals at these schools have the challenge of creating student groups with limited numbers of students and a wide range of abilities. At most of the schools in this network, there are only enough enrolled …

Impact Of Trauma On Truancy, Teri J. Hargrave

Electronic Theses and Dissertations

Truancy has been a rising problem in the United States for several decades. Adverse childhood experiences have also been gaining recognition as a public health concern. The problem to be addressed in this study was the effect of trauma on truancy on parents whose children had been referred to the juvenile office. This study was a quantitative study using three self-reported surveys. The surveys include the Adverse Childhood Experiences survey, posttraumatic stress survey, and a school attendance survey. The sample was 60 parents of youth who had been referred to the juvenile office during fall 2021 to spring 2022 school …

Examining The Relationship Between Burnout And Mindfulness In Government Employees: A Closer Look At Mindfulness In Positive Psychology, Simona C. Davis

Electronic Theses and Dissertations

Burnout has been an ongoing problem that negatively impacts organizations, their leaders, and employees. While burnout is a highly researched topic, there is less information on burnout and mindfulness in government employees in the United States. According to research, mindfulness, a state of being conscious or aware, has shown to improve well-being and reduce stress and burnout in employees. Previous studies showed that burnout is a common problem that can lead to negative mental, emotional, and physical outcomes. The goal of this quantitative correlational study was to determine to what extent a relationship exists between mindfulness and burnout among government …

Abusive Supervision Within The Military Ranks: A Qualitative Examination Of Positive Emotion-Focused Coping Strategies, Demetrius Mcdew

Electronic Theses and Dissertations

In this study, the researcher examined abusive supervision coping by military members. Based on social exchange theory and the power and influence theory, the researcher investigated whether veterans perceived emotional coping (avoidance, support seeking, and reframing) as strategies that mitigated stress caused by abusive supervision while they were serving in their respective military departments. Past studies have not accounted for junior officers or enlisted members; therefore, the researcher studied this lower ranking tier of personnel and discovered that the hierarchy of the military system affected their reporting of and receiving assistance in dealing with abusive supervision. Therefore, affected service members …

Exploring Teachers' Perceptions On The Fidelity Of Implementing Teaching Strategies Gold, Shucrea Yamina Victor-Cameron

Electronic Theses and Dissertations

The purpose of this qualitative case study was to assess the fidelity of implementation of the school readiness/kindergarten preparedness program and the training being used, called the Teaching Strategies GOLD®, through the perceptions of preschool teachers from a Head Start program in southeastern Florida. This study addressed the crisis with the school readiness outcomes in the state of Florida. Specifically, children are entering school underprepared for kindergarten. The Florida Kindergarten Readiness Screener data revealed failing test scores at the selected study site during the 2017–2018, 2018–2019, 2019–2020, 2020–2021, and 2021– 2022 school years. Implementing and measuring the efficacy of this …

Leading For Sustainability In School-Community Partnerships, Kimberly Renee Benavides

Electronic Theses and Dissertations

Schools receive support in the form of partnerships with organizations such as businesses, churches, and non-profits for many reasons, and such partnerships are beneficial to students and the school community. The purpose of this participatory qualitative study was to determine behaviors of elementary school principals that result in the sustainability of school-community partnerships beyond the initial year of implementation. Elementary school principals in an urban public school district in North Texas were interviewed along with leaders from their corresponding community partners to determine the role of the principal in school-community partnership work. Through an in-depth analysis of interview transcripts, the …

Reducing Inpatient Falls And Falls With Injury, Constance Leigh Cannon

Electronic Theses and Dissertations

Patient falls are a costly problem for many inpatient hospitals and are exacerbated by poor training of nursing and ancillary staff. The researcher sought to determine if there was a difference in inpatient falls and falls with injury after a hospital facility in the Southwestern United States revised its fall prevention policy, reorganized its fall prevention committee, and provided new interventions for nurses assessing patients for fall risk. In this quantitative, retrospective, comparative project, the researcher reviewed data from 2017–2020 related to the facility’s fall prevention program, including its new interventions and efforts to involve patients in their safety and …

Portraits Of Leadership In Higher Education: Directors Of Centers For Teaching And Learning Leadership Styles And Dei Practices At Four-Year Universities In The U.S., Angela K. Johnson

Electronic Theses and Dissertations

This study aimed to examine Directors of Centers for Teaching and Learning DEI practices and understanding of leadership style within their 4-year universities in the United States. Information indicates that student enrollment of students identifying as members of historically marginalized groups is increasing and that persistent descriptions of experiences related to educational barriers negatively impact learning experiences. Integrating this information into this narrative life span study and considerations of the components of leadership identity development provided themes regarding the critical practices among higher education institutional leaders. The study presented findings that described the impact of the life span factor on …

Strategies Teachers Implement That Support Mixed-Race Students In Schools In Rural Southeast Texas, Tara Michelle Marshall

Electronic Theses and Dissertations

The purpose of this qualitative case study was to describe strategies middle-school teachers implement that support mixed-race students in rural southeast Texas schools. This study is framed conceptually utilizing culturally responsive pedagogy and social emotional learning. Seven middle-school teachers were interviewed and provided artifacts to support the interviews. The primary findings identified strategies for teachers to examine their biases, intentionally plan social emotional lessons, remain open-minded and nonjudgmental, and engage in authentic professional development. Using equitable language, learning cultural norms, and being transparent to build trust with students are strategies teachers were implementing regarding equity. Supporting student organizations and identifying …

Dose-Related Effects Of Ketamine For Antidepressant-Resistant Symptoms Of Posttraumatic Stress Disorder In Veterans And Active Duty Military: A Double-Blind, Randomized, Placebo-Controlled Multi-Center Clinical Trial, Chadi G Abdallah, John D Roache, Ralitza Gueorguieva, Lynnette A Averill, Stacey Young-Mccaughan, Paulo R Shiroma, Prerana Purohit, Antoinette Brundige, William Murff, Kyung-Heup Ahn, Mohamed A Sherif, Eric J Baltutis, Mohini Ranganathan, Deepak D'Souza, Brenda Martini, Steven M Southwick, Ismene L Petrakis, Rebecca R Burson, Kevin B Guthmiller, Argelio L López-Roca, Karl A Lautenschlager, John P Mccallin, Matthew B Hoch, Alexandar Timchenko, Sergio E Souza, Charles E Bryant, Jim Mintz, Brett T Litz, Douglas E Williamson, Terence M Keane, Alan L Peterson, John H Krystal

Staff and Researcher Publications

This study tested the efficacy of repeated intravenous ketamine doses to reduce symptoms of posttraumatic stress disorder (PTSD). Veterans and service members with PTSD (n = 158) who failed previous antidepressant treatment were randomized to 8 infusions administered twice weekly of intravenous placebo (n = 54), low dose (0.2 mg/kg; n = 53) or standard dose (0.5 mg/kg; n = 51) ketamine. Participants were assessed at baseline, during treatment, and for 4 weeks after their last infusion. Primary analyses used mixed effects models. The primary outcome measure was the self-report PTSD Checklist for DSM-5 (PCL-5), and secondary outcome …