Digital Commons Network^™

Potential Treatment Identified For Bladder Cancers That Are Arid1a-Deficient, Public Relations

Browse All News

No abstract provided.

Mismatch In Local Labor Markets: How Demand Shocks To Different Occupations Affect Less- Or More-Educated Workers In Diverse Local Labor Markets, Timothy J. Bartik

Upjohn Institute Technical Reports

This paper estimates the effects on local labor market outcomes (employment rates, real wages, real earnings) of local labor demand shocks to different types of occupations. Occupations are divided into three groups, “high, middle, and low,” with occupations differing in wages paid and education credentials required. Effects are considered on both workers with less than a four-year college degree and workers with a bachelor’s degree or higher. The strongest benefits for labor market outcomes come from demand shocks to “mid jobs.” Mid-job demand shocks particularly benefit less-educated workers. High-job demand shocks often hurt labor market outcomes for less-educated workers, in …

Enhancing Interprofessional Collaboration And Interprofessional Education In Women's Health, Laura Baecher-Lind, Angela C Fleming, Rashmi Bhargava, Susan M Cox, Elise N Everett, David A Forstein, Shireen Madani Sims, Helen K Morgan, Christopher M Morosky, Celeste S Royce, Tammy S Sonn, Jill M Sutton, Scott C Graziano

2020-Current year OA Pubs

This article is from the 'To The Point' series from the Association of Professors of Gynecology and Obstetrics Undergraduate Medical Education Committee. The purpose of this review is to provide an understanding of the differing yet complementary nature of interprofessional collaboration and interprofessional education as well as their importance to the specialty of Obstetrics and Gynecology. We provide a historical perspective of how interprofessional collaboration and interprofessional education have become key aspects of clinical and educational programs, enhancing both patient care and learner development. Opportunities to incorporate interprofessional education within women's health educational programs across organizations are suggested. This is …

Hepatic Transcript Signatures Predict Atherosclerotic Lesion Burden Prior To A 2-Year High Cholesterol, High Fat Diet Challenge, Sobha Puppala, Kimberly D. Spradling-Reeves, Jeannie Chan, Shifra Birnbaum, Deborah E. Newman, Anthony G. Comuzzie, Michael Mahaney, John L. Vandeberg, Michael Olivier, Laura Cox

School of Medicine Publications

The purpose of this study was to identify molecular mechanisms by which the liver influences total lesion burden in a nonhuman primate model (NHP) of cardiovascular disease with acute and chronic feeding of a high cholesterol, high fat (HCHF) diet. Baboons (47 females, 64 males) were fed a HCHF diet for 2 years (y); liver biopsies were collected at baseline, 7 weeks (w) and 2y, and lesions were quantified in aortic arch, descending aorta, and common iliac at 2y. Unbiased weighted gene co-expression network analysis (WGCNA) revealed several modules of hepatic genes correlated with lesions at different time points of …

Risk Assessment With Low-Pass Whole-Genome Sequencing Of Cell-Free Dna Before Cd19 Car T-Cell Therapy For Large B-Cell Lymphoma, Hua-Jay J Cherng, Ryan Sun, Bryant Sugg, Russell Irwin, Haopeng Yang, Qing Deng, Nathan H Fowler, Simrit Parmar, Raphael Steiner, Fredrick Hagemeister, Ranjit Nair, Hun Ju Lee, Maria Rodriguez, Felipe Samaniego, Swaminathan P Iyer, Christopher R Flowers, Linghua Wang, Loretta J Nastoupil, Sattva S Neelapu, Sairah Ahmed, Paolo Strati, Michael R Green, Jason Westin

Faculty, Staff and Student Publications

Patients with relapsed or refractory large B-cell lymphomas (rrLBCL) can achieve long-term remission after CD19 chimeric antigen receptor T-cell therapy (CART19). However, more than half of recipients will experience treatment failure. Thus, approaches are needed to identify high-risk patients who may benefit from alternative or consolidative therapy. We evaluated low-pass whole-genome sequencing (lpWGS) of cell-free DNA (cfDNA) before CART19 as a new approach for risk stratification. We performed lpWGS on pretreatment plasma samples from 122 patients at time of leukapheresis who received standard-of-care CART19 for rrLBCL to define DNA copy number alterations (CNAs). In multivariable selection, high focal CNA score …

Tale Of Two Cities: Narrative Review Of Oxygen, Sarah Hinds, Jeong-Ho Hong, Huimahn A Choi

Faculty, Staff and Student Publications

BACKGROUND: Cerebral edema (CE) at admission is a surrogate marker of 'early brain injury' (EBI) after subarachnoid hemorrhage (SAH). Only recently has the focus on the changes in CE after SAH such as delayed resolution or newly developed CE been examined. Among several factors, an early systemic inflammatory response has been shown to be associated with CE. We investigate inflammatory markers in subjects with early CE which does not resolve, i.e., persistent CE after SAH.

METHODS: Computed tomography scans of SAH patients were graded at admission and at 7 days after SAH for CE using the 0-4 'subarachnoid hemorrhage early …

Primary Cutaneous Lymphoma: Recommendations For Clinical Trial Design And Staging Update From The Iscl, Usclc, And Eortc, Elise A Olsen, Sean Whittaker, Rein Willemze, Lauren Pinter-Brown, Francine Foss, Lawrence Schwartz, Joan Guitart, John Zic, Youn H Kim, Gary S Wood, Madeleine Duvic, Wei Ai, Michael Girardi, Alejandro Gru, Emmanuella Guenova, Emmilia Hodak, Richard Hoppe, Werner Kempf, Ellen Kim, Mary Jo Lechowicz, Pablo Ortiz-Romero, Evangelia Papadavid, Pietro Quaglino, Mark Pittelkow, H Miles Prince, Jose Antonio Sanches, Makoto Sugaya, Maarten Vermeer, Jasmine Zain, Robert Knobler, Rudolf Stadler, Martine Bagot, Julia Scarisbrick

Faculty, Staff and Student Publications

The number of patients with primary cutaneous lymphoma (PCL) relative to other non-Hodgkin lymphomas (NHLs) is small and the number of subtypes large. Although clinical trial guidelines have been published for mycosis fungoides/Sézary syndrome, the most common type of PCL, none exist for the other PCLs. In addition, staging of the PCLs has been evolving based on new data on potential prognostic factors, diagnosis, and assessment methods of both skin and extracutaneous disease and a desire to align the latter with the Lugano guidelines for all NHLs. The International Society for Cutaneous Lymphomas (ISCL), the United States Cutaneous LymphomaConsortium (USCLC), …

Towards The Geographies Of Loneliness: Interpreting The Spaces Of Loneliness In Farming Contexts, Mark Holton, Mark Riley, Gina Kallis

School of Geography, Earth and Environmental Sciences

No abstract provided.

A Comparison Of Statistical Methods For Modeling Count Data With An Application To Hospital Length Of Stay, Gustavo Fernandez, Kristina Vatcheva

School of Mathematical & Statistical Sciences Faculty Publications

Background

Hospital length of stay (LOS) is a key indicator of hospital care management efficiency, cost of care, and hospital planning. Hospital LOS is often used as a measure of a post-medical procedure outcome, as a guide to the benefit of a treatment of interest, or as an important risk factor for adverse events. Therefore, understanding hospital LOS variability is always an important healthcare focus. Hospital LOS data can be treated as count data, with discrete and non-negative values, typically right skewed, and often exhibiting excessive zeros. In this study, we compared the performance of the Poisson, negative binomial (NB), …

The Developmental Trajectories Of Children’S Reorientation To Global And Local Properties Of Environmental Geometry, Matthew G. Buckley, Luke J. Holden, Alastair D. Smith, Mark Haselgrove

School of Psychology

The way in which organisms represent the shape of their environments during navigation has been debated in cognitive, comparative, and developmental psychology. While there is evidence that adult humans encode the entire boundary shape of an environment (a global-shape representation), there are also data demonstrating that organisms reorient using only segments of the boundary that signal a goal location (a local-shape representation). Developmental studies offer unique insights into this debate; however, most studies have used designs that cannot dissociate the type of boundary-shape representation that children use to guide reorientation. Thus, we examined the developmental trajectories of children's reorientation according …

Special Issue – July/August 2023: Emerging Frontiers In Human Experience, Patient Experience Journal

Patient Experience Journal

Patient Experience Journal (PXJ) is excited to announce the call for submissions for its July/August 2023 special issue focused on exploring the emerging frontiers of human experience in healthcare. As shared in the recent PXJ article, Reexamining “Defining Patient Experience”: The human experience in healthcare: "The rapid evolution in the recognition of the humanity in healthcare has required us to view the human healthcare experience not just as a person-centered process or relationship-based encounter. It is an intricate tapestry of human interaction both in the clinical and non-clinical settings across the continuum of care and into the communities served …

Tranquility Rooms For Team Member Well-Being: Implementation During Covid-19 Pandemic, Julie A. Kennedy Oehlert, Christina M. Bowen, Holly Wei, Wendy Leutgens

Patient Experience Journal

In 2020, the COVID-19 global pandemic changed the landscape of healthcare delivery and with it the need to better address team member well-being. Aside from patients and their families, healthcare professionals were among the most affected and at high risk for suffering psychological distress, including increased stress, depression, anxiety, substance use, and post-traumatic stress disorder. Prior to COVID-19, healthcare workers were already experiencing a high rate of job burnout, depression, and suicide. The pandemic brought in sharp focus the essential and urgent need for healthcare facilities to acknowledge the importance of team member well-being and the provision of spaces such …

Caring For The Caregiver During Covid-19 Suspended Visitation, Melissa D. Rouse, Lorie K. Shoemaker, Priscilla Kyle, Chris Tenold, Whitney Anthony, Jordan White

Patient Experience Journal

During the 4th surge of COVID-19, August to November 2021, visitation was suspended in a hospital system in North Georgia. The Compassionate Connections Call Center (CCCC) was created to alleviate staff stress and to manage calls and communication. The goal of the initiative was to reduce interruptions to patient care caused by the increased number of calls to the clinical units by patients, families, loved ones and personal caregivers. The CCCC managed all incoming calls and communicated with the patient’s primary nurse through a coordinated process which limited interruptions. By caring for the caregiver, the aim was to improve the …

Teamwork That Affects Outcomes: A Method To Enhance Team Ownership, Brian Carlson, Richelle Graham, Brad Stinson, Jordan Larocca

Patient Experience Journal

Healthcare is the ultimate team sport, and this case study explores how to build teamwork across teams. The ability for nursing, environmental services and food and nutrition services to work collaboratively to benefit patients is paramount to a patients experience and outcomes. The case study describes how the work was done to build teams and then improved outcomes in both patient and employee experiences. The learnings are applicable to any team setting not just those described in this case study.

Experience Framework

This article is associated with the Staff & Provider Engagement lens of The Beryl Institute Experience Framework ( …

Global Child And Family-Centered Care Fellowship, Education And Mentorship For Pediatric Healthcare Professionals: A Literature Review, Ashley Zheng, Bobbijo Pansier

Patient Experience Journal

Child- and family-centered care (FCC) is increasingly accepted and implemented to optimize the healthcare experience for patients, their families, and healthcare professionals. Standish Foundation for Children, a 501(c)(3) non-profit, has designed and piloted a fellowship to educate pediatric healthcare professionals in FCC & psychosocial care via an inquiry and mentorship model in Tbilisis, Georgia. This review aimed to evaluate and synthesize existing literature on psychosocial and FCC mentorship for pediatric healthcare professionals in four parts: ongoing need, effects on healthcare professionals, effects on children and their families and/or caregivers, and in cross-country healthcare settings. Reviewers searched open-source databases for articles …

Understanding Patient And Caregiver Perspectives Using A Dyad Approach For Data Collection: A Systematic Review Of The Literature, Jane Loftus, Andrew Yaworsky, Diane M. Turner-Bowker, Andrew Palladino, Roger Lamoureux, Emily Love, Andreas M. Pleil

Patient Experience Journal

Treatments outside of a clinical setting may be managed independently by the pediatric patient, independently by a caregiver, or by the patient and caregiver together. Best practices for pediatric clinical outcome assessment (COA) recommend patient-reported outcome (PRO) and/or observer-reported outcome (ObsRO) measures to assess the patient experience of a condition or its treatment. However, a dyad approach where patients and caregivers can complete assessments together may be useful for assessing a shared treatment experience that may not be adequately captured by a PRO and/or an ObsRO. A systematic, targeted literature review of empirical literature was conducted to identify and describe …

Patient And Provider Experiences With Virtual Care During The Covid-19 Pandemic: A Mixed Methods Study, Mars Zhao, Hisham Elshoni, Jennifer O'Brien, Erin Barbour-Tuck, Mary Ellen Walker, Heather Dyck, Andrea Vasquez, Eric Sy, Angela Baerwald, Clara Michaels, Rejina Kamrul, Olivia Reis, Brenda Schuster, Barb Beaurivage, Adam Clay, Mark Lees, Jonathan Gamble

Patient Experience Journal

The COVID-19 pandemic prompted the rapid uptake of Virtual Care (VC). Positive patient outcomes with VC are previously reported but little is known about the experiences of patients and providers using VC during the pandemic. We aimed to describe patient and primary care provider experiences, satisfaction, perceptions, and attitudes to VC during the COVID-19 pandemic that might explain adoption of VC across the continuum of care and inform sustained uptake. We conducted a sequential explanatory mixed methods study using online surveys and virtual interviews with a convenience sample of primary care providers and patients in a Canadian province (July – …

Understanding Modern Drivers Of The Employee Experience In Healthcare, Antonio Pangallo, Tim Atwell, Kristi Roe, Adrienne Boissy

Patient Experience Journal

Employee engagement has been considered the guiding metric to convey the health, loyalty, and performance of the healthcare workforce. However, the pandemic created new challenges and stimulated deeper conversations around remote work, systemic racism, inclusivity, trust, well-being, and mental illness, which calls into question whether engagement alone is enough. Using an employee experience model deployed in other industries, we identified key drivers of six employee experience (EX) outcomes. We conducted a panel study with close to 5,000 nurses and physicians to identify and prioritize current key drivers specific to the healthcare employee experience. Relative weights analyses suggest that being treated …

Beyond Service Education: Impacting The Human Experience With Sustained Training Utilizing The Experience Model Of Communication, Jennifer S. Packard, Rebecca A. Brustad, Jane M. Hoplin, Sheila K. Stevens

Patient Experience Journal

Patients scheduling or checking in for medical appointments often share with frontline employees’ details of their stories, including their worries, prior negative experiences, and hopes. These interactions require employees to not only complete their task, but also to be mindfully present, picking up on important social cues and showing appropriate emotional congruence and empathic understanding. Based on a review of recorded patient calls, a gap was identified in the communication skills of desk and scheduling staff at this large academic medical center, and a sustained training program was created to fill this gap. The training is centered on an evolving …

Rules Of Engagement: The Role Of Mistreatment From Patients In The Nurse, Physician And Advanced Practice Provider Experience, Katherine A. Meese, Alejandra Colón-López, Aoyjai P. Montgomery, Laurence M. Boitet, David A. Rogers, Patricia A. Patrician

Patient Experience Journal

The objective of this study is to examine the incidence of reported stress due to mistreatment by patients toward clinicians and the role of mistreatment from patients along with organizational factors in clinician distress. A survey of clinicians was conducted at a large academic medical center, resulting in a final analytic sample of 1,682 physicians, nurses, advanced practice providers and clinical support staff. Nurses reported the greatest incidence of mistreatment by patients as a major stressor (18.69%), followed by Advanced Practice Providers (11.26%), Clinical Support Staff (10.36%), and Physicians (7.69%). Logistic regression analysis was conducted to determine the relationship of …

Effect Of Wearing Masks In The Hospital On Patient-Provider Interaction: “They (Providers) Need To Stay Safe For Their Family And Keep Us Safe.”, Jana L. Wardian, Mikayla Peralta, Chad Vokoun, Sarah E. Richards

Patient Experience Journal

Since March 2020 when the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic was widespread in the U.S., masks became a primary form of protection for healthcare workers when caring for patients. While wearing masks was not a new phenomenon in the health field, there is little known on how the use of them affects the patient-provider relationship. This study explored the experience of wearing masks on the patient-provider relationship in the hospital. This qualitative study involved interviews with both providers and patients at an academic hospital in the Midwest. At the time of this study, in July 2021, hospital …

Improving Workforce Experiences At United States Federally Qualified Health Centers: Exploring The Perceived Impact Of Generational Diversity On Employee Engagement, Verneda Bachus, Lihua Dishman, John W. Fick

Patient Experience Journal

This qualitative study aimed to explore a multigenerational workforce’s impact on employee engagement as perceived by Federally Qualified Health Centers’ (FQHCs) C-suite executives. It sought to answer one research question: What is the perceived impact of generational diversity on employee engagement of Federally Qualified Health Centers (FQHCs) in the United States? This cross-sectional study was national. Primary data were collected using a self-developed, two-part survey instrument: (1) eight demographic questions and (2) two open-ended, short-answer questions. Cognitive interviews, reviews by five subject matter experts, and a pilot study were completed to ensure the instrument’s validity and reliability. Demographic data were …

Views On Happiness And Mental Health: A Comparison Between Residents And Staff At A Senior Care Facility, Alexis C. Schafer, Aubrey K. Deveau, Susan E. Mason

Patient Experience Journal

Residents and staff members at a senior care facility were questioned about their views on topics related to mental health. The two groups scored similarly on a happiness questionnaire. Differences as well as similarities between residents and staff were revealed through a questionnaire addressing views on mental health, counseling, and medications. The results are discussed in terms of the relationship that develops between older adults and their care givers. We argue that the health and well-being of the residents of a senior care facility may be linked to the health and well-being of the staff. The extent to which the …

Dyad Rounding On Inpatients Admitted From Emergency Department: Rehumanizing The Patient & Clinician Experience In A Post Pandemic World, Julie Oehlert, Christine Walden, Leigh Patterson

Patient Experience Journal

Emergency departments (ED) across the country were stretched to the breaking point as a result of the COVID-19 pandemic. The chaos, fear, and uncertainty impacted the emotional, physical, and spiritual well-being of not only the patients and families but also nurses, providers, and the myriad of other clinical and non-clinical staff providing care in the ED. Compounding these challenges was the dehumanizing effects of providing care in personal protective equipment (PPE). The burnout ED teams experienced left them feeling defeated and unsure of how to reconnect with patients and families. The purpose of this narrative is to share the story …

Leveraging The Power Of Peer Support: The Story And Impact Of Team Lavender, Agnes Barden

Patient Experience Journal

As the world continues to take inventory of the wake left by the COVID-19 pandemic, healthcare organizations and leaders remain steadfast on recovery. At Northwell Health, the largest health system in New York State, employee emotional wellness remains a constant priority. Team Lavender (TL) is an interdisciplinary group of professionals dedicated to supporting colleagues during times of stress and/or hardship. Emergent and proactive TL peer support responses/activations provide a moment of pause, reflection, teamwork, and peer support. Particularly during COVID-19 pandemic and subsequent variant surges, this innovative budget-neutral approach was recognized and leveraged to promote resiliency, humanism and holistic well-being. …

Human Experience Is Not A Line Item, Jason A. Wolf

Patient Experience Journal

Our humanity is fundamentally defined in context with others, in our relationships that reinforce or bend who we are, in the interactions through which we wither or grow. It is these interactions that rest squarely at the heart of the healthcare experience. For over a decade, we have defined experience in The Beryl Institute community as the sum of all interactions, shaped by an organization’s culture that influence patient perceptions across the continuum of care. The power of the simple, yet significant nature of these words reinforces the idea that experience happens primarily at the touch point between people. …

Supporting L2 Multicast In L2vni-Only Deployments, Rajeev Kumar, Sanjay Hooda

Defensive Publications Series

Techniques are presented herein that support an optimized Layer 2 (L2) multicast capability in software-defined access (SDA) fabric environments by modifying Internet Group Management Protocol (IGMP) snooping, IGMP forwarding, and multicast forwarding behavior in such environments. Such modifications help to address multiple customer requirements where customers need multicast traffic to be forwarded at L2, especially for Internet of Things (IoT) devices. Aspects of the presented techniques encompass modifying multicast router (mrouter) learning, handling IGMP control traffic, and handling sources and receivers.

Impact Of Self And Therapists’ Evaluation Of Responses To Miracle Question And Goal: Survey Of Japanese Undergraduate And Graduate Students, Gen Takagi, Taku Hiraizumi, Kazuma Sakamoto, Miki Hagidai

Translated Abstracts

درمان فشرده راه حل محور نوعی روان درمانی است که بر مشکل تمرکز نمی‌کند بلکه بر شفاف‌سازی وضعیت هدف و گسترش استثنائات متمرکز است. هدف این مطالعه، بررسی تاثیرات ارزیابی مراجعین و درمانگران درباره شفاف‌سازی هدف درباره متغیرهایی است که در SFBT مهم تلقی می‌شوند. به طور کلی، 223 شرکت‌کننده به همه پرسشنامه‌ها پاسخ دادند و در این پژوهش شرکت کردند. نتایج این مطالعه همبستگی بین ارزیابی‌های فردی و درمانگران را برای تصورات مربوط به پرسش معجزه، ملموس بودن هدف آن و واقعیت هدف آن، نشان می‌دهد. از طرف دیگر، هیچ یک از روابط، همبستگی قدرتمندی نداشتند و این موضوع …

Fidelity Monitoring In The Solution Focused Wellness For Hiv (Sfwh) Intervention For Women, Helen T. Yates, Spencer Elise Lee

Translated Abstracts

روش‌های راه حل محور اغلب توسط پزشکان متعدد با انعطاف‌پذیری و سازگاری مختلفی درباره‌ی تنظیمات عملکردی خاص تفسیر می‌شوند (لهمن و باتون 2012). این انعطاف‌پذیری یکی از ویژگی‌هایی است که SFBT را تبدیل به رویکردی مراجع محور می‌کند و به عنوان یکی از ابعاد کلیدی موفق با نتایج مطلوب، برای مراجعان برجسته نشان داده شده است (فرانکلین و همکارانش 2017). استفاده از این رویکرد مشارکتی به دلیل استفاده SFBT از اصول ساخت‌گرایان اجتماعی در فرایند راه حل‌سازی امکان‌پذیر است (بلوند و سیمون 2015). ضمن تشویق انعطاف‌پذیری در اجرای SFBT، شناسایی اصول اساسی درمان، شامل تکنیک‌ها و ذهنیت‌های خاص، برای محققانی …

Solution-Focused Collective Action: A Response To Harry Korman, Peter De Jong, And Sara Smock Jordan, Solution-Focused Collective

Translated Abstracts

نسخه‌ی چاپ شده‌ی این مجله در جولای 2021 (شنان 2021) پاسخی به مقاله‌ی توسعه‌ی نظریه‌ی استیو دی شیزر (کورمان و همکارانش 2020) و همچنین پاسخی به جوابیه‌ی نویسندگان مقاله‌ است (کورمان و همکارانش 2021).

این نویسندگان پاسخ خود را به شرح زیر ارائه کردند: «پاسخ به گای شنان و اجماع راه حل محور». البته پاسخ گای پاسخی فردی بود و این مجموعه هیچ نقشی در نوشتن آن نداشتند (و از مطالعه‌ی مقاله‌ی او به نظر نمی‌رسد که گای چیز دیگری پیشنهاد کرده باشد). با این حال، با توجه به این که کورمان و همکارانش نظرات انتقادی در پاسخ‌شان به اظهارات …