Digital Commons Network^™

Federal Circuit Declines To Find Patent Claims Indefinite For Broad Descriptive Words (And An Ode To 1l Civil Procedure), Barbier, Janelle

Santa Clara High Technology Law Journal

FEDERAL CIRCUIT DECLINES TO FIND PATENT CLAIMS INDEFINITE FOR BROAD DESCRIPTIVE WORDS (AND AN ODE TO 1L CIVIL PROCEDURE)

Niazi Licensing Corporation v. St. Jude Medical S.C., Inc., 30 F.4th 1339 (Fed. Cir. 2022)♦

An Auto-Inhibited State Of Protein Kinase G And Implications For Selective Activation, Philipp Henning, Madoka Akimoto, Bryan Vanschouwen, Gundeep Kaur, Banumathi Sankaran, Kevin R Mackenzie, Giuseppe Melacini, Darren E Casteel, Friedrich W Herberg, Choel Kim

Faculty, Staff and Students Publications

Cyclic GMP-dependent protein kinases (PKGs) are key mediators of the nitric oxide/cyclic guanosine monophosphate (cGMP) signaling pathway that regulates biological functions as diverse as smooth muscle contraction, cardiac function, and axon guidance. Understanding how cGMP differentially triggers mammalian PKG isoforms could lead to new therapeutics that inhibit or activate PKGs, complementing drugs that target nitric oxide synthases and cyclic nucleotide phosphodiesterases in this signaling axis. Alternate splicing of PRKG1 transcripts confers distinct leucine zippers, linkers, and auto-inhibitory (AI) pseudo-substrate sequences to PKG Iα and Iβ that result in isoform-specific activation properties, but the mechanism of enzyme auto-inhibition and its alleviation …

Safety And Tolerability Of Carboplatin And Paclitaxel In Cancer Patients With Hiv (Amc-078), An Aids Malignancy Consortium (Amc) Study, Missak Haigentz, Page Moore, Milan Bimali, Timothy Cooley, Joseph Sparano, Michelle Rudek, Lee Ratner, David Henry, Juan Ramos, John Deeken, Paul Rubinstein, Elizabeth Chiao

Center for Medical Ethics and Health Policy Staff Publications

Background: Persons living with human immunodeficiency virus are an underserved population for evidence-based cancer treatment. Paclitaxel and carboplatin (PCb) is an active regimen against a variety of solid tumors, including several seen in excess in patients with HIV infection. We performed a pilot trial to evaluate the safety of full-dose PCb in people living with human immunodeficiency virus and cancer.

Methods: Eligible patients, stratified by concurrent antiretroviral therapy (ART) that included CYP3A4 inhibitors or not, received paclitaxel (175 mg/m2) in combination with carboplatin (target AUC 6) intravenously every 3 weeks for up to 6 cycles.

Results: Sixteen evaluable patients received …

Prevalence Of Human Papillomavirus Infection Among Women Born In The 1990s Vs The 1980s And Association With Hpv Vaccination In The Us, Zahed Shahmoradi, Haluk Damgacioglu, Jane Montealegre, Elizabeth Y Chiao, Keith Sigel, Kalyani Sonawane, Ashish A Deshmukh

Center for Medical Ethics and Health Policy Staff Publications

This cross-sectional study examines rates of human papillomavirus infections among a cohort of vaccinated and unvaccinated women born in the 1990s.

Using Event-Related Brain Potentials To Explore The Temporal Dynamics Of Decision-Making Related To Information Security, Robert West, Bridget Kirby, Kaitlyn Malley

Psychology and Neuroscience Faculty Publications

Insider threat from individuals operating within an organization presents a significant source of violations of information security. Our previous research has used scalp recorded event-related brain potentials (ERPs) and the Information Security Paradigm (ISP) to identify the neural correlates of decision-making processes related to violations of information security. In the current study, we sought to expand this research by examining the effects of two variables that were drawn from the broader decision-making literature (i.e., the benefactor and delay of a reward) on ERPs measured in the ISP. In the ISP we varied whether Josh—a hypothetical IT specialist—or a significant other …

Low Hanging Fruits: When Governments Look For Easy Wins & Ignore Real Priorities, Laila El Baradei

Faculty Journal Articles

No abstract provided.

Ableist Microaggressions And Well-Being: Investigating The Moderating Effect Of Coping Strategies, Whitney Morean

Clinical Psychology Dissertations

Purpose/Objective: In prior research, ableist microaggressions have previously correlated with higher depressive symptoms in samples of members of the disability community. Since well-being is more than merely the absence of distressing mental health symptoms; the present study examines the relationship between ableist microaggressions and well-being and whether different coping strategies moderate the relationship. Research Method/Design: Adults (N = 132) who self-identified as having a disability or chronic health condition that significantly impacts one or more major life activities, were recruited online to complete a survey. Measures of well-being, ableist microaggressions, coping, and depression symptoms were administered via an online …

Zigbee Wireless Sensor Networks: Performance Study In An Apartment-Based Indoor Environment, Biswajit Kumar Dash, Jun Peng

Electrical and Computer Engineering Faculty Publications

Zigbee is a very popular technology for Internet of things (IoT) networks mainly because of its low power consumption and low-cost features. It shares the unlicensed 2.4 GHz Industrial, Scientific, and Medical (ISM) radio band with other wireless networks such as Wi-Fi. Usually, Zigbee and Wi-Fi networks coexist in indoor environments for their respective applications. Hence, the coexistence introduces interference for both types of networks lowering the performance of the networks, but Zigbee suffers more significant performance losses because of its lower transmission power than Wi-Fi. Since the number of IoT devices is increasing at an unprecedented rate due to …

Eagle Insider, Georgia Southern University

Athletics: News & Publications

• The Benko Briefing
• Join the Erk Russell Fund

Eagle Insider, Georgia Southern University

Athletics: News & Publications

• The Benko Briefing
• Join the Erk Russell Fund

Feed Forward Neural Networks With Asymmetric Training, Archit Srivastava

School of Computing: Dissertations, Theses, and Student Research

Our work presents a new perspective on training feed-forward neural networks(FFNN). We introduce and formally define the notion of symmetry and asymmetry in the context of training of FFNN. We provide a mathematical definition to generalize the idea of sparsification and demonstrate how sparsification can induce asymmetric training in FFNN.

In FFNN, training consists of two phases, forward pass and backward pass. We define symmetric training in FFNN as follows-- If a neural network uses the same parameters for both forward pass and backward pass, then the training is said to be symmetric.

The definition of asymmetric training in artificial …

Brookes V. 157th St. Assoc., Llc

All Decisions

No abstract provided.

Nursing Burnout In Perspective: Conservation Of Resources Theory And The Nurse Worklife Model, Anna Trujillo

Theoretical Foundation in Advanced Practice Nursing

No abstract provided.

Nursing Burnout During The Covid-19 Pandemic, Noreen Rizvi

Theoretical Foundation in Advanced Practice Nursing

Nursing burnout continues to rise as the COVID-19 pandemic amplifies environmental stressors in the workplace. This paper explores the application of Callista Roy's adaptation model in preventing nursing burnout during the pandemic using four modes of adaptation: rolefunction, interdependence, physiological/physical, and self-concept or group identity. The presented solution to alleviate nursing burnout examines the implementation of Roy's adaptation model through proposed resiliency initiatives, leadership and management modifications, and state legislature regulation. These interventions aim to reduce anxiety, moral distress, and compassion fatigue, along with increasing support for nurses.

Implementation And Design Of E-Library System Using Qr Code And Smart Mobile Phone, Dheeraj Singh Negi

Library Philosophy and Practice (e-journal)

This paper has been show that E-library system using the QR Code and smart mobile phone implementation and design of Library digital system. In this study we found the QR code is very useful of library services and Digitization. QR code easily scan to document like a books, Journals , Library website, Library Blog, Marketing of product etc. It’s very important Technology for Library automation and networking. Library staff is easily use this technology for Quick Time and user satisfaction.”

Web Content Analysis Of State Agriculture University Library Website In Uttar Pradesh: An Evaluative Study, Kunjan Prasad Gupta ,Librarian

Library Philosophy and Practice (e-journal)

Abstract:- Objective of this article to analysis and evaluate the library web content of State agriculture university library website in Uttar Pradesh. The standard Content analysis method used for evaluating the library WebPages and draw conclusions give suggestion for betterment of library website.

Approach/Methodology: The Observation method used to evaluate state agriculture library website in Uttar Pradesh, using 80 point checklist divided in 8 approaches. Ranking of agriculture library website is based on calculation of (T3 to T10). Web Addresses of library website Access throw ICAR Website from 01 June 2022 to 30 June 2022.

Scope of the study/ Limitation: …

Information And Communication Technology (Ict) Tools For Dissemination Of Covid19 Information: A Usage Analysis Among Information Professionals In Kwara State, Kabiru Gambari Sulaiman, Qudus Ajibola Bankole

Library Philosophy and Practice (e-journal)

The paper examined the information and communication technology (ICT) tools for dissemination of covid19 information: a usage analysis among information professionals in Kwara state. The descriptive survey design was adopted. The population of the study comprised of 120 information professionals in Kwara State. Four (4) research questions guided this study. The total enumerative sampling technique was used, and questionnaire was used to collect data for this study. Data was analyzed with descriptive statistics such as simple percentages, frequency count, mean and standard deviation. The findings revealed that most of the information professional use ICT tools for dissemination of covid-19 information …

Uab Summer 2022 Graduation Ceremonies Are Aug. 12-13, Shannon Thomason

Browse All News

No abstract provided.

Expanding Cu²Re Summer Program Supports Uab Medical Students, Staff

Browse All News

No abstract provided.

Counseling Active-Duty Female Service Members Who Have Experienced Sexual Assault: A Guide For Professional Counselors, Rebekah Cole, Rebecca Cowan, Taqueena Quintana

Journal of Social, Behavioral, and Health Sciences

Sexual assault is a prevailing problem for active duty women in the United States military. We explore the unique nature of military culture and explain the military’s dual pathway process for reporting sexual assault. In addition, we describe, in depth, evidence-based theoretical approaches applicable for counselors to use in their work with female service members who are survivors of sexual assault. Finally, we discuss sexual assault resources available to military clients and the steps counselors can take to engage in advocacy for and with this population.

Search For Subsolar-Mass Binaries In The First Half Of Advanced Ligo’S And Advanced Virgo’S Third Observing Run, R. Abbott, T. D. Abbott, F. Acernese, K. Ackley, Teviet Creighton, Mario C. Diaz, Francisco Llamas, Soma Mukherjee, Volker Quetschke, Wenhui Wang

Physics & Astronomy Faculty Publications

We report on a search for compact binary coalescences where at least one binary component has a mass between 0.2  M⊙ and 1.0  M⊙ in Advanced LIGO and Advanced Virgo data collected between 1 April 2019 1500 UTC and 1 October 2019 1500 UTC. We extend our previous analyses in two main ways: we include data from the Virgo detector and we allow for more unequal mass systems, with mass ratio q≥0.1. We do not report any gravitational-wave candidates. The most significant trigger has a false alarm rate of 0.14  yr−1. This implies an upper limit on the merger rate …

Continuous Fluorescence-Based Endonuclease-Coupled Dna Methylation Assay To Screen For Dna Methyltransferase Inhibitors, Rebecca Switzer, Katie A. Ward, Jessica Medrano

Faculty Journal Articles

DNA methylation, a form of epigenetic gene regulation, is important for normal cellular function. In cells, proteins called DNA methyltransferases (DNMTs) establish and maintain the DNA methylation pattern. Changes to the normal DNA methylation pattern are linked to cancer development and progression, making DNMTs potential cancer drug targets. Thus, identifying and characterizing novel small molecule inhibitors of these enzymes is of great importance. This paper presents a protocol that can be used to screen for DNA methyltransferase inhibitors. The continuous coupled kinetics assay allows for initial velocities of DNA methylation to be determined in the presence and absence of potential …

Synthesis And Characterization Of Peek Based Functional Composites For Biomedical Applications, Sabah Javaid

Theses and Dissertations

We report the synthesis and characterization of PEEK-MAX (Ti3SiC2, Ti3AlC2,and Cr2AlC), and PEEK-MoAlB, (DDGS500 – pyrolyzed Distiller’s dried grains with soluble (DDGS)), metal (Mo) and PEEK-ceramic (Xonotlite) based PEEK composites, by hot-pressing. A systematic study was done to understand the effect of these additives on functional and mechanical properties. Initially, these composites were synthesized by hot pressing. Detailed microstructure analysis by scanning electron microscopy showed that at higher concentration (≥10 vol%), the Ti3SiC2, Ti3AlC2 and PEEK-MoAlB particles segregated at the phase boundaries and formed interpenetrating micro-networks. PEEK-Cr2AlC were well dispersed in the PEEK matrix. Microstructure study of the composites showed …

Identification Of The Nrf2 Transcriptional Network As A Therapeutic Target For Trigeminal Neuropathic Pain, Chirag Vasavda, Risheng Xu, Jason Liew, Ruchita Kothari, Ryan S Dhindsa, Evan R Semenza, Bindu D Paul, Dustin P Green, Mark F Sabbagh, Joseph Y Shin, Wuyang Yang, Adele M Snowman, Lauren K Albacarys, Abhay Moghekar, Carlos A Pardo-Villamizar, Mark Luciano, Judy Huang, Chetan Bettegowda, Shawn G Kwatra, Xinzhong Dong, Michael Lim, Solomon H Snyder

Duncan NRI Faculty and Staff Publications

Trigeminal neuralgia, historically dubbed the "suicide disease," is an exceedingly painful neurologic condition characterized by sudden episodes of intense facial pain. Unfortunately, the only U.S. Food and Drug Administration (FDA)-approved medication for trigeminal neuralgia carries substantial side effects, with many patients requiring surgery. Here, we identify the NRF2 transcriptional network as a potential therapeutic target. We report that cerebrospinal fluid from patients with trigeminal neuralgia accumulates reactive oxygen species, several of which directly activate the pain-transducing channel TRPA1. Similar to our patient cohort, a mouse model of trigeminal neuropathic pain also exhibits notable oxidative stress. We discover that stimulating the …

The Value Of In Vivo Reflectance Confocal Microscopy As An Assessment Tool In Chemotherapy-Induced Peripheral Neuropathy: A Pilot Study, Sabrina R Ramnarine, Patrick M Dougherty, Roman Rolke, Linda J Williams, Christi Alessi-Fox, Caterina Longo, Marie T Fallon

Faculty, Staff and Student Publications

Background: There is a lack of standardized objective and reliable assessment tools for chemotherapy-induced peripheral neuropathy (CIPN). In vivo reflectance confocal microscopy (RCM) imaging offers a non-invasive method to identify peripheral neuropathy markers, namely Meissner's corpuscles (MC). This study investigated the feasibility and value of RCM in CIPN.

Patients and methods: Reflectance confocal microscopy was performed on the fingertip to evaluate MC density in 45 healthy controls and 9 patients with cancer (prior, during, and post-chemotherapy). Quantification was completed by 2 reviewers (one blinded), with maximum MC count/3 × 3 mm image reported. Quantitative Sensory Testing (QST; thermal and mechanical …

Adaptation And Dosimetric Commissioning Of A Synchrotron-Based Proton Beamline For Flash Experiments, Ming Yang, Xiaochun Wang, Fada Guan, Uwe Titt, Kiminori Iga, Takeshi Takaoka, Tadashi Katayose, Masumi Umezawa, Emil Schüler, Steven Frank, Steven H Lin, Narayan Sahoo, Albert C Koong, Radhe Mohan, X Ronald Zhu

Faculty, Staff and Student Publications

Objective. Irradiation with ultra-high dose rates (>40 Gy s^-1), also known as FLASH irradiation, has the potential to shift the paradigm of radiation therapy because of its reduced toxicity to normal tissues compared to that of conventional irradiations. The goal of this study was to (1) achieve FLASH irradiation conditions suitable for pre-clinicalin vitroandin vivobiology experiments using our synchrotron-based proton beamline and (2) commission the FLASH irradiation conditions achieved.

Approach. To achieve these suitable FLASH conditions, we made a series of adaptations to our proton beamline, including modifying the spill length …

Asymmetric Synthesis Of Nortropanes Via Rh-Catalyzed Allylic Arylation

Faculty, Staff and Student Publications

Tropane derivatives are extensively used in medicine, but catalytic asymmetric methods for their synthesis are underexplored. Here, we report Rh-catalyzed asymmetric Suzuki–Miyaura-type cross-coupling reactions between a racemic N-Boc-nortropane-derived allylic chloride and (hetero)aryl boronic esters. The reaction proceeds via an unexpected kinetic resolution, and the resolved enantiopure allyl chloride can undergo highly enantiospecific reactions with N-, O-, and S-containing nucleophiles. The method was applied in a highly stereoselective formal synthesis of YZJ-1139(1), a potential insomnia treatment that recently completed Phase II clinical trials. Our report represents an asymmetric catalytic method for the synthesis of YZJ-1139(1) and related compounds.

Determining Factors In Graduate Recruitment And Preparing Students For Success, Denise Jackson, Linda Riebe, Flavio Macau

Research outputs 2022 to 2026

Purpose: This study aims to investigate graduate employer perceptions of determining factors in recruitment decisions and their preferred use of recruitment channels. This study drew on the employability capitals model to interpret findings and identify ways to better prepare higher education students for recruitment and selection. This is particularly important in declining graduate labour markets, further weakened by COVID-19. Design/methodology/approach: This study gathered data from surveying 183 Australian employers from different organisational settings. Responses were analysed using descriptive and multivariate techniques, the latter exploring variations by role type, sector and organisation size. Findings: Findings reaffirmed the criticality of students having …

Lipopolysaccharide-Induced Interferon Response Networks At Birth Are Predictive Of Severe Viral Lower Respiratory Infections In The First Year Of Life, James F. Read, Michael Serralha, Danny Mok, Barbara J. Holt, Mark Cruickshank, Yuliya V. Karpievitch, David I. Broadhurst, Peter D. Sly, Deborah H. Strickland, Stacey N. Reinke, Patrick G. Holt, Anthony Bosco

Research outputs 2022 to 2026

Appropriate innate immune function is essential to limit pathogenesis and severity of severe lower respiratory infections (sLRI) during infancy, a leading cause of hospitalization and risk factor for subsequent asthma in this age group. Employing a systems biology approach to analysis of multi-omic profiles generated from a high-risk cohort (n = 50), we found that the intensity of activation of an LPS-induced interferon gene network at birth was predictive of sLRI risk in infancy (AUC = 0.724). Connectivity patterns within this network were stronger among susceptible individuals, and a systems biology approach identified IRF1 as a putative master regulator of …

Disease-Associated Mutations Within The Yeast Dnajb6 Homolog Sis1 Slow Conformer-Specific Substrate Processing And Can Be Corrected By The Modulation Of Nucleotide Exchange Factors, Ankan K Bhadra, Michael J Rau, Jil A Daw, James A J Fitzpatrick, Conrad C Weihl, Heather L True

2020-Current year OA Pubs

Molecular chaperones, or heat shock proteins (HSPs), protect against the toxic misfolding and aggregation of proteins. As such, mutations or deficiencies within the chaperone network can lead to disease. Dominant mutations within DNAJB6 (Hsp40)-an Hsp70 co-chaperone-lead to a protein aggregation-linked myopathy termed Limb-Girdle Muscular Dystrophy Type D1 (LGMDD1). Here, we used the yeast prion model client in conjunction with in vitro chaperone activity assays to gain mechanistic insights into the molecular basis of LGMDD1. Here, we show how mutations analogous to those found in LGMDD1 affect Sis1 (a functional homolog of human DNAJB6) function by altering the structure of client …