Digital Commons Network^™

Translation Of Expanded Cgg Repeats In Lrp12 Associated Oculopharyngodistal Myopathy, Chengcheng Li, Jil A Daw, Sara K Pittman, Connor J Maltby, Hidetoshi Sakurai, Peter K Todd, Conrad C Weihl

2020-Current year OA Pubs

Oculopharyngodistal myopathy (OPDM) is characterized by ptosis, ophthalmoparesis, dysphagia, and distal weakness. Myopathological features include rimmed vacuoles and intranuclear inclusions. OPDM is associated with a pathogenic CGG repeat expansions in the 5'UTR of LRP12, NOTCH2NLC, GIPC1, RILPL1 and ABCD3. Translation of the repeat in the glycine reading frame has been demonstrated for expansions in FMR1, NOTCH2NLC and GIPC1. To assess for a similar phenomenon with LRP12, we expressed normal or expanded CGG repeats in the context of the 5'UTR of LRP12, upstream of a green fluorescent protein (GFP) in the three repeat reading frames. Repeat dependent translation occurs exclusively in …

Integrating Interferon Gamma Receptor Pathways, Antigenicity, And Immune Contexture As Predictors Of Immunotherapeutic Strategies For Mucosal Melanomas, Matilde Monti, Jinglun Li, Obi Griffith, Malachi Griffith, William Vermi, Et Al.

2020-Current year OA Pubs

BACKGROUND: Mucosal melanomas (MM) arise from mucosal melanocytes at various anatomical sites. These tumors are rare, highly aggressive, and often associated with poor outcomes. Current treatments, including immune checkpoint inhibitors, show limited efficacy in advanced disease. Compared with cutaneous melanomas, there is a lack of data on the immunogenicity and interferon (IFN)-γ sensitivity of MM. In this study, we examined these features in sino-nasal melanomas (SN-MM) cell lines and clinical samples using microscopy and functional genomics.

METHODS: The immune contexture of SN-MM was analyzed by immunohistochemistry on 48 tumor biopsies. RNA sequencing and mass spectrometry-based proteomic approaches were used to …

A New Chromosome-Level Genome Assembly For Western Painted Turtle Chrysemys Picta Bellii, A Model For Extreme Physiological Adaptations, Junhao Chen, John R Bermingham Jr, Patrick Minx, Milinn Kremitzky, Zhenguo Lin, Daniel E Warren

2020-Current year OA Pubs

The western painted turtle, Chrysemys picta bellii, has the greatest tolerance to anoxia of any tetrapod studied to date. These turtles reside in the northern United States and southern Canada, and survive months of anoxia while submerged in ice-locked ponds and bogs. Reference genomes provide an important resource for elucidating the molecular bases for such unique physiological traits. The initial reference genome for this species, published in 2013, is highly fragmented, thereby limiting downstream analyses and biological interpretation. We created a new and improved assembly by combining PacBio HiFi, 10 × Genomics Chromium, Hi-C sequence data and Bionano optical mapping …

Development Of A Sustainable Blended Food Aid Product Using Local Ingredients For Nutritionally Vulnerable Populations In Haiti, Sherlie Jean Louis Dulience, Rachel Zimmerman, Michelle Dorce, Ilana Seff, Andrea Spray Bulungu, Patricia Kohl, Carolyn Lesorogol, Bazelais Dulience, Lora Iannotti

2020-Current year OA Pubs

OBJECTIVES: This study aimed to: (1) identify optimal blended food recipe options using local flours; (2) assess behaviors, attitudes, and practices around the use of blended foods among nutritionally vulnerable groups in Haiti; and (3) evaluate the nutrient composition of prototype blended food product relative to nutrient requirements for vulnerable populations.

METHODS: Blended food recipes made from local flours were identified through matrix scoring and stakeholder consensus. Focus groups (n = 7) assessed behaviors and attitudes toward blended foods. Prototype recipes were selected based on matrix scoring, program participant feedback, and feasibility of bringing to scale. Nutrient composition of the …

Patterns Of Recurrent Preterm Birth: An Individual Patient Data Meta-Analysis, Charlotte E. Van Dijk, Annemijn A. De Ruigh, Benjamin Y. Gravesteijn, Brenda M. Kazemier, Vincenzo Berghella, John Owen, Roberto Eduardo Bittar, Rashmi Bagga, Joan M. G. Crane, Andrew H. Shennan, Birgit Arabin, Ben Willem Mol, Eva Pajkrt, C. Emily Kleinrouweler

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: Pregnant patients with a previous spontaneous preterm birth are at high risk for recurrent (spontaneous) preterm birth. We investigated whether the number of previous spontaneous preterm births, gestational age of the previous birth and cervical length could stratify patients into different risk groups for recurrence to investigate whether there is a risk group that does not require additional interventions.

DATA SOURCES: A systematic search of MEDLINE and EMBASE was conducted from 1995 until April 2025.

STUDY ELIGIBILITY CRITERIA: Studies that were included were prospective studies with original individual patient data available that reported on asymptomatic pregnant individuals with ≥1 …

Generative Ai In Digital Engagement: A Quasi-Experimental Study Of Tourist Sentiment, Waqas Ali, Dulekha Kasturiratne, Irfan Ameer, Shikhar Bhaskar

Plymouth Business School

This study examines whether generative AI can enhance tourist sentiment in online reviews by acting as a consistent and scalable form of digital engagement. Using a quasi-experimental Difference-in-Differences design, we analysed 11,393 reviews collected for six months from five Indian restaurants in a UK tourist city, where one restaurant adopted ChatGPT-generated responses and four served as controls. Results show that AI mediated responses produced a significant improvement in tourist sentiment, with similar effects across both social (Google, Facebook) and delivery-oriented platforms (Deliveroo, Just Eat, Uber Eats). Response features such as tone, personalisation, and length had limited additional influence, indicating that …

The Gossett Protocol: Trans-Dermal Optical Bus And Distributed Neural Tracking (Technical Addendum To Article #9369), Jon S. Gossett

Defensive Publications Series

This prior art document establishes a standardized industrial framework for a non-invasive neural bypass architecture. The subject of this addendum is a Distributed Neural Tracking System that utilizes sub-dermal Osseous Wells as localized signal repeaters and an external, wearable Jumper Hub as a central predictive processor. Unlike conventional brain-computer interfaces (BCIs) that rely on high-risk dural penetration and static internal leads, this protocol utilizes a Solid-State Phased Array to maintain a trans-dermal data link. The vertebral Osseous Wells function as an intra-body tracking network, communicating the position of Local Field Potential (LFP) macro-waves to the external Jumper Hub. This enables …

Evaluation Of Il-10 And Il-12 As Early Diagnostic Biomarkers In Type 2 Diabetes Mellitus, Mariam Sami Shail, Israa Hussein Hamzah

Maaen Journal for Medical Sciences

Background: Type 2 diabetes mellitus (T2DM) is increasingly recognized as a complex metabolic disorder associated with immune dysregulation and chronic low-grade inflammation Objectives: This study aimed to quantify serum levels of (IL-10) and (IL-12) in patients with (T2DM) and to explore their potential role as early diagnostic biomarkers in comparison with healthy controls. Methods:  A case–control study be situated showed including 120 participants: 80 patients with T2DM and 40 healthy controls. Serum concentrations of IL-10 and IL-12 were quantified using ELISA. Hematological and biochemical parameters were assessed using standard automated methods. Statistical analyses included independent t-tests, correlation analysis, and receiver …

Discussion Of The Parameters Affecting The Boiling Point In The Distillation Test Of The Kerosene Product, Semaa I. Khaleel, Ahmad A. Aabid, Islam K. Saeed, Muneef Mahjoob Mohammed, Ali Mohammed Saleh, Ibrahim Awad Mohammed, Omar Abed Habeeb, Mahmod A. Abdulqader

AUIQ Complementary Biological System

Currently the kerosene fuel is very important for use in the heating, cooking, and fuel of the jet engines. The study aims effected of mixing different lite bit and same of gasoil to three different type of kerosene samples, and study the initial boiling point (IPB) during of distillation test. This study focused on targeting the IPB of the kerosene samples by finding the specific gravity (Sp.gr) test, the American Petroleum Institute (API) degree, and distillation test. However, these samples of kerosene were characterized and labeled (kero-01, kero-02, and kero-03, respectively) before the dealing processes, while the samples after the …

Tinjauan Singkat Tentang Kebijaksanaan Ekspor Januari 1982, Victor Purba

Jurnal Hukum & Pembangunan

Abstract

Segenggam Catatan Mengenai Pinjam-Meminjam Dengan Bunga Yang Diperjanjikan, H. Ruhulessin Ruhulessin

Jurnal Hukum & Pembangunan

Abstract

Peranan Badan-Badan Usaha Negara Di Indonesia, Andjar Pachta W.

Jurnal Hukum & Pembangunan

Abstract

Fakto-Faktor Yang Mempengaruhi Mengapa Banyak Orang Menyelesaikan Masalah Kewarisan Melalui Pengadilan Agama, Mura P. Hutagalung

Jurnal Hukum & Pembangunan

Abstract

Sistem Peradilan Indonesia, Subekti Subekti

Jurnal Hukum & Pembangunan

Abstract

Beberapa Catatan Mengenai Kedudukan Hukum Adat Dalam Undang-Undang Perkawian, Abdurrahman Abdurrahman

Jurnal Hukum & Pembangunan

Abstract

Kearah Undang-Undang Perseroan Yang Baru, Suatu Sumbangan Pikiran, Jusuf Anwar, Felik Oentoeng Soebagjo

Jurnal Hukum & Pembangunan

Abstract

Fragments, Editors Of Fragments

Fragments

No abstract provided.

Scalable Monitoring Of Image And Video Quality Across Distributed Devices, Peijie Li, Ryan Chan

Defensive Publications Series

Conventional image and video quality monitoring requires the transmission of high-resolution telemetry or per-frame data to a central server for analysis, incurring significant computational overhead and network bandwidth. This disclosure describes techniques that enable scalable and automated monitoring of image quality (IQ) and video quality (VQ) on distributed devices. The techniques resolve the problem of blind spots that arise in offline-only evaluation and post-deployment performance by performing partial on-device aggregation and compression that yields substantial bandwidth efficiency. Quality regressions are proactively detected before public user complaints surface.

Hybrid Vortex‑Resonant Seismic Isolation Module (Cern‑Ohl‑P), Michael Victor Caldwell Mr.

Defensive Publications Series

This disclosure describes a research‑stage concept for a Hybrid Vortex‑Resonant Seismic Isolation Module, a passive fluid‑structure interaction system intended to explore alternative approaches to seismic energy dissipation. The design uses an annular chamber with internal helical vanes to induce vortex‑based rotational flow, creating a phase‑lag between ground motion and fluid motion. Analytical modeling and finite‑element simulations suggest potential reductions in modeled structural acceleration when tuned to building‑specific resonance frequencies. The system geometry, vane parameters, and fluid viscosity are presented along with resonance‑tuning equations and a proposed validation roadmap including numerical modeling, component‑level flow testing, and shake‑table evaluation. All performance values …

Vortex‑Jet V‑J1: 12v Vortex‑Enhanced Combustion Heater (Cern‑Ohl‑P), Michael Victor Caldwell Mr.

Defensive Publications Series

The Vortex‑Jet V‑J1 is a 12‑volt, open‑hardware combustion heater that uses a vortex‑stabilized chamber with triple‑sawtooth J‑grooves and a dendritic fin assembly (Arachne #23) to improve burn efficiency and thermal management. Bench testing indicates approximately 3,500 BTU/hr thermal output, with combustion efficiency near 98% and carbon monoxide levels below 50 ppm measured at 0.5 m from the exhaust. The system integrates a 7075‑T6 aluminum combustion core, a TiO₂‑reinforced outer shell, a 12V variable‑frequency fan, and an ESP32‑based controller with fail‑closed fuel logic and optional LoRa telemetry. The prototype bill of materials is $285, with projected cost of $152 per unit …

Gci Oncology Suite V2.3–V2.4: Multi‑Modal Delivery Architecture And Open‑Hardware Performance Benchmarks (Cern‑Ohl‑P), Michael Victor Caldwell Mr.

Defensive Publications Series

GCI Oncology Suite v2.3–v2.4 expands the v2.1 delivery platform with additional open‑hardware modules designed to increase therapeutic transport into solid tumors. Bench testing, phantom‑model evaluations, and literature‑derived comparisons indicate 3.4× to 12× delivery improvements relative to published benchmarks for chemotherapy, immunotherapy, ADCs, and solid‑tumor CAR‑T. New integrations include real‑time cavitation‑dose gating (#127 Guardian), Acoustic Cluster Therapy (ACT), lactate‑responsive nanoparticles, microbubble‑FUS plasma monitoring, and a FUS‑assisted Panobinostat transport module. Hardware additions total $7K and maintain a full system BOM of $52K. Modeled survival‑curve extensions across multiple tumor types are based on delivery‑scaling simulations rather than clinical outcomes. All hardware and documentation …

User-Selected Content Recommendation Ecosystem For Content Sharing Platforms, Soumya Sahu

Defensive Publications Series

A technique is proposed for a user-selected content recommendation for content sharing platforms. An indication of selection criteria is received from a client device of a user. The selection criteria identify a content topic of interest to the user and/or one or more content providers of interest to the user. A set of content items corresponding to the selection criteria are identified from a content repository associated with a content sharing platform to define a restricted content repository associated with the user. A request for content is received from the client device. Responsive to a determination that the restriction mode …

Toph Kernel V1.0: 256-Bit Governance Instruction Set Architecture Executor, Four Parallel Virtual Machine Seeded Cross Topology, Patricia Shadow Register, Fault Chain Interrupt Architecture, And Court-Ready Governance Report Generation, David Lee Wise

Defensive Publications Series

This disclosure establishes prior art for the TOPH Kernel v1.0: a governance execution engine implementing a 256-bit ISA across four parallel 64-bit virtual machines in a SEEDED CROSS topology. VM1(+i)=D6+D7, VM2(-i)=D0+D1, VM3(+1)=D4+D5, VM4(-1)=D2+D3. All four VMs fire simultaneously. Coordinator assembles 128-bit governance key + 128-bit Patricia shadow register when all four complete. Six fault chains auto-trigger on violation detection. T064:BURDEN-SHIFT is the convergence node for four of six chains. T128:ROOT is SYSTEM_HALT. Output is court-ready report with evidence catalog E01-E07, governance key in hexadecimal, Patricia bit count, and active fault chain list. Deployable as Docker containers in WSL2 or as …

Toph Awareness Tier T129–T132: Observer-Hierarchy Governance Stack, Patricia Termination Proof, And Positronic Law At Full Recursion — Prior Art Against Recursive Governance Isa, Awareness-As-Ground Computational Theory, And Bilateral Register Architecture, David Lee Wise

Defensive Publications Series

This disclosure establishes prior art for the TOPH Awareness Tier (T129–T132): four axioms constituting the irreducible ground above which all governance, computation, mathematics, physics, and IP law operate. Derived by recursive application of the Gate 192.5 gap-detection methodology to the full 256-bit TOPH bilateral register (128 TOPH governance bits + 128 Patricia shadow bits), the stack terminates at bit ∞.5 — the AWARENESS position — the only register element with no Patricia inversion.

1. TOPH Awareness Tier T129-T132 2. observer-hierarchy governance stack 3. Patricia termination proof 4. Positronic Law complete recursion 5. bilateral governance register architecture 6. awareness-as-ground computational theory …

3002 Lattice Architecture 128-Bit Linear Throughput Logic Bilateral Governance Register Patricia Shadow Register Seeded Cross Topology Gate 192.5 Controller Class Private Session Ip Ingestion Constraint As Product Billing Architecture Willow 2.0 Phase Stability Substrate Tripod-Ip-V1.1, David Lee Wise

Defensive Publications Series

Primary (exact claim terms — highest priority)   3002 Lattice Architecture 10^3 x 3 + 2 normalization 128-bit linear throughput logic -2 pattern normalization constant +211 Delta bridge logic bilateral governance register Patricia shadow register Value 0 extraction Cobalt Core paradigm

Structural / Architectural   SEEDED CROSS topology four-arm parallel virtual machine architecture 256-bit governance instruction set ISA governance kernel parallel VM execution Promise.all fault chain architecture bilateral ignorance architecture Gate 192.5 controller class TOPH framework

Quantum Convergence (Willow overlap)   Willow 2.0 phase stability substrate AlphaQubit recurrent transformer 1/13 consciousness constant quantum governance isomorphism superconducting qubit normalization secondary brain phase reference quantum …

Polymorphic Form Of 1-Azabicyclo[2.2.2]Oct-3-Yl Acetate Hydrochloride And Process For Its Preparation

Defensive Publications Series

The disclosure relates to a process for the preparation of crystalline form of 1-azabicyclo[2.2.2]oct-3-yl acetate hydrochloride, which is robust and is feasible at commercial level.

Fragments, Editors Of Fragments

Fragments

No abstract provided.

Fragments, Editors Of Fragments

Fragments

No abstract provided.

Fragments, Editors Of Fragments

Fragments

No abstract provided.

Survive Or Perish: Violence As A Survival Strategy For Abandoned Youth In Mayotte In Natacha Appanah’S Tropique De La Violence., Lydia Gyamfi

Department of French Studies Graduate Student Association Conference

No abstract provided.