Digital Commons Network^™

Evaluation Of Machine Learning Algorithm On Drinking Water Quality For Better Sustainability, Sanaa Kaddoura

All Works

Water has become intricately linked to the United Nations' sixteen sustainable development goals. Access to clean drinking water is crucial for health, a fundamental human right, and a component of successful health protection policies. Clean water is a significant health and development issue on a national, regional, and local level. Investments in water supply and sanitation have been shown to produce a net economic advantage in some areas because they reduce adverse health effects and medical expenses more than they cost to implement. However, numerous pollutants are affecting the quality of drinking water. This study evaluates the efficiency of using …

Uab Mhrc Celebrates 20 Years With Name Change To Uab Minority Health And Health Equity Research Center, Staff

Browse All News

No abstract provided.

Information Needs And Seeking Behaviour Of Illegal Oil Bunkers In Imiringi Town Of Bayelsa State, Nigeria, Tangkat Yusuf Dushu Mr.

Library Philosophy and Practice (e-journal)

This study focused on the information needs and seeking behavior of Illegal oil bunkers in Imiringi Town of Bayelsa state. Three research questions were formulated to guide the study. and was carried out using 150 questionnaires in order to ascertain the information needs and information seeking behavior of Illegal oil bunkers. The study adopted a descriptive survey design. Frequencies and percentages were used to analyze the data. The result showed that the Illegal oil bunkers do not have access to adequate information because the libraries as well as the local government, who this responsibility rests on, have been inefficient. Recommendations …

Owsley And Mcgwin Receive $2 Million One-Year Grant From Nih's Bridge2ai Program, Adam Pope

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No abstract provided.

Staying Cyber-Aware: New Social Media Scams To Watch Out For, Brianna Hoge

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No abstract provided.

Uab Aims To Boost Use Of Artificial Intelligence In Biomedical Research, Ryan Mccain

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No abstract provided.

Taking A Break: How Rest Breaks Can Reduce Acute Fatigue During The Covid-19 Pandemic, Knar Sagherian

Sigma Foundation for Nursing Research Grant Reports

The overall purpose was to evaluate the effect of rest breaks during work hours on reducing COVID-19 work strain among hospital nurses.

The project was conducted using a cross-sectional design among hospital nurses via online survey across the United States. Our specific aims were to:

1) Identify for the first time in a large sample the characteristics (e.g., type, duration, content, and context) of rest breaks taken by nurses during 12-hour shifts.

2) Determine the characteristics of rest breaks that best reduce acute fatigue and how these differ between nurses who care for patients with COVID-19 and those who do …

Americans For Indian Opportunity, Ladonna Harris

LaDonna Harris Native American Collection

This is a synthesized statement of philosophy and purpose of AIO, a non-profit organization headquartered in Washington, D.C. that works to improve relationships among Indians and non-Indians to strike down stereotypes and to build upon the strong, positive self-image and powerful motivating force of pride in Indianness.

Bet Inhibition Induces Vulnerability To Mcl1 Targeting Through Upregulation Of Fatty Acid Synthesis Pathway In Breast Cancer, Gonghong Yan, Augustin Luna, Heping Wang, Behnaz Bozorgui, Xubin Li, Zeynep Dereli, Goknur Kara, Xiaohua Chen, Caishang Zheng, Daniel Mcgrail, Nidhi Sahni, Yiling Lu, Ozgun Babur, Murat Cokol, Bora Lim, Bulent Ozpolat, Chris Sander, Gordon B Mills, Anil Korkut

Faculty, Staff and Student Publications

Therapeutic options for treatment of basal-like breast cancers remain limited. Here, we demonstrate that bromodomain and extra-terminal (BET) inhibition induces an adaptive response leading to MCL1 protein-driven evasion of apoptosis in breast cancer cells. Consequently, co-targeting MCL1 and BET is highly synergistic in breast cancer models. The mechanism of adaptive response to BET inhibition involves the upregulation of lipid synthesis enzymes including the rate-limiting stearoyl-coenzyme A (CoA) desaturase. Changes in lipid synthesis pathway are associated with increases in cell motility and membrane fluidity as well as re-localization and activation of HER2/EGFR. In turn, the HER2/EGFR signaling results in the accumulation …

Delineating Covid-19 Immunological Features Using Single-Cell Rna Sequencing, Guangsheng Pei, Qiheng Yan, Zhongming Zhao

Faculty, Staff and Student Publications

Understanding the molecular mechanisms of coronavirus disease 2019 (COVID-19) pathogenesis and immune response is vital for developing therapies. Single-cell RNA sequencing has been applied to delineate the cellular heterogeneity of the host response toward COVID-19 in multiple tissues and organs. Here, we review the applications and findings from over 80 original COVID-19 single-cell RNA sequencing studies as well as many secondary analysis studies. We describe that single-cell RNA sequencing reveals multiple features of COVID-19 patients with different severity, including cell populations with proportional alteration, COVID-19-induced genes and pathways, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in single cells, and adaptation …

Curating A Knowledge Base For Individuals With Coinfection Of Hiv And Sars-Cov-2: A Study Protocol Of Ehr-Based Data Mining And Clinical Implementation, Chen Liang, Sharon Weissman, Bankole Olatosi, Eric G. Poon, Michael E. Yarrington, Xiaoming Li Ph.D.

Faculty Publications

Introduction Despite a higher risk of severe COVID-19 disease in individuals with HIV, the interactions between SARS-CoV-2 and HIV infections remain unclear. To delineate these interactions, multicentre Electronic Health Records (EHR) hold existing promise to provide fullspectrum and longitudinal clinical data, demographics and sociobehavioural data at individual level. Presently, a comprehensive EHR-based cohort for the HIV/SARS-CoV-2 coinfection has not been established; EHR integration and data mining methods tailored for studying the coinfection are urgently needed yet remain underdeveloped. Methods and analysis The overarching goal of this exploratory/developmental study is to establish an EHR-based cohort for individuals with HIV/SARS-CoV-2 coinfection and …

System Archetypes Underlying Formal-Informal Urban Water Supply Dynamics, Rakhshinda Bano, Mehdi Khiadani, Yong Saebastian Nyam

Research outputs 2022 to 2026

Contrary to developed countries, developing countries have been observed to have an increased reliance on a diversity of water supply options to meet their daily demands, where formal supply systems are incapable of fulfilling the daily needs of consumers. In filling a demand-supply gap, informal supply systems are increasingly being associated with issues of long-term sustainability, higher consumer cost, and inequity. Emerging formal-informal dynamics in developing countries require a thorough understanding of complex human-water interactions for policy direction, in order to best support the advancement of urban water sustainability. Accordingly, system archetypes offer a platform to explain the behaviors of …

Innexin Function Dictates The Spatial Relationship Between Distal Somatic Cells In The Caenorhabditis Elegans Gonad Without Impacting The Germline Stem Cell Pool, Theadora Tolkin, Ariz Mohammad, Todd A Starich, Ken C Q Nguyen, David H Hall, Tim Schedl, E Jane Albert Hubbard, David Greenstein

2020-Current year OA Pubs

Gap-junctional signaling mediates myriad cellular interactions in metazoans. Yet, how gap junctions control the positioning of cells in organs is not well understood. Innexins compose gap junctions in invertebrates and affect organ architecture. Here, we investigate the roles of gap-junctions in controlling distal somatic gonad architecture and its relationship to underlying germline stem cells in

American Society Of Hematology Living Guidelines On The Use Of Anticoagulation For Thromboprophylaxis In Patients With Covid-19: January 2022 Update On The Use Of Therapeutic-Intensity Anticoagulation In Acutely Ill Patients, Adam Cuker, Kristen M Sanfilippo, Et Al

2020-Current year OA Pubs

BACKGROUND: COVID-19-related acute illness is associated with an increased risk of venous thromboembolism (VTE).

OBJECTIVE: These evidence-based guidelines from the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in making decisions about the use of anticoagulation in patients with COVID-19.

METHODS: ASH formed a multidisciplinary guideline panel that included patient representatives and applied strategies to minimize potential bias from conflicts of interest. The McMaster University GRADE Centre supported the guideline development process and performed systematic evidence reviews (through November 2021). The panel prioritized clinical questions and outcomes according to their importance for …

American Society Of Hematology Living Guidelines On The Use Of Anticoagulation For Thromboprophylaxis For Patients With Covid-19: March 2022 Update On The Use Of Anticoagulation In Critically Ill Patients, Adam Cuker, Kristen M Sanfilippo, Et Al

2020-Current year OA Pubs

BACKGROUND: COVID-19-related critical illness is associated with an increased risk of venous thromboembolism (VTE).

OBJECTIVE: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in decisions about the use of anticoagulation for patients with COVID-19.

METHODS: ASH formed a multidisciplinary guideline panel, including 3 patient representatives, and applied strategies to minimize potential bias from conflicts of interest. The McMaster University Grading of Recommendations Assessment, Development and Evaluation (GRADE) Centre supported the guideline development process, including performing systematic evidence reviews (up to January 2022). The panel prioritized clinical questions …

The First Reported Case Of A Patient With Pancreatic Cancer Treated With Cone Beam Computed Tomography-Guided Stereotactic Adaptive Radiotherapy (Ct-Star), Minsol Kim, Joshua P Schiff, Alex Price, Eric Laugeman, Pamela P Samson, Hyun Kim, Shahed N Badiyan, Lauren E Henke

2020-Current year OA Pubs

BACKGROUND: Online adaptive stereotactic radiotherapy allows for improved target and organ at risk (OAR) delineation and inter-fraction motion management via daily adaptive planning. The use of adaptive SBRT for the treatment of pancreatic cancer (performed until now using only MRI or CT on rails-guided adaptive radiotherapy), has yielded promising outcomes. Herein we describe the first reported case of cone beam CT-guided stereotactic adaptive radiotherapy (CT-STAR) for the treatment of pancreatic cancer.

CASE PRESENTATION: A 61-year-old female with metastatic pancreatic cancer presented for durable palliation of a symptomatic primary pancreatic mass. She was prescribed 35 Gy/5 fractions utilizing CT-STAR. The patient …

Full-Length Transcriptomic Sequencing And Temporal Transcriptome Expression Profiling Analyses Offer Insights Into Terpenoid Biosynthesis In Artemisia Argyi, Ran Xu, Yue Ming, Yongchang Li, Shaoting Li, Wenjun Zhu, Hongxun Wang, Jie Guo, Shaohua Shu, Chao Xiong, Xiang Cheng, Limei Wang, Jingmao You, Dingrong Wan

Student Publications

Artemisiae argyi Folium is a traditional herbal medicine used for moxibustion heat therapy in China. The volatile oils in A.argyi leaves are closely related to its medicinal value. Records suggest that the levels of these terpenoids components within the leaves vary as a function of harvest time, with June being the optimal time for A. argyi harvesting, owing to the high levels of active ingredients during this month. However, the molecular mechanisms governing terpenoid biosynthesis and the time-dependent changes in this activity remain unclear. In this study, GC-MS analysis revealed that volatile oil levels varied across four different harvest …

Transplant Outcomes After Cpx-351 Vs 7 + 3 In Older Adults With Newly Diagnosed High-Risk And/Or Secondary Aml, Geoffrey L Uy, Laura F Newell, Tara L Lin, Stuart L Goldberg, Matthew J Wieduwilt, Robert J Ryan, Stefan Faderl, Jeffrey E Lancet

2020-Current year OA Pubs

No abstract provided.

Gracefully Recover Wifi, Luca Scalia, Rishabh Bhardwaj

Defensive Publications Series

During transportation, personal area network (PAN) host devices may often interface with PAN client devices via potentially complex PAN protocols. In the instance of a disconnection, the system may attempt to determine whether the user has intended to disable the connection, or whether the PAN host device experiences a non-intentional disruption of service (sometimes referred to as an “interference drop”) due to, for example, interference jammers or other devices that produce signals that interfere with the PAN session. In these instances, the PAN host device should try to recover the connection only if it is an interference drop so as …

Reduction Of Protein Levels In Broiler Feed For Commercial Application – A German Case, Andreas Lemme, Kilian Fenske, Heiner Westendarp, Mathias Guhe, Elmar Rother

Proceedings of the Arkansas Nutrition Conference

A project was initiated to apply dietary CP reduction under commercial conditions. The main objective was to demonstrate and validate that dietary CP can be reduced without compromising broiler performance in a production system which is already rather efficient. In addition, we wanted to demonstrate the potential of dietary CP reduction on reducing N-excretions especially in the context of German revised regulations and monitoring attempts. Finally, as previous research suggested, few further aspects such as impact of dietary CP reduction on litter quality and quantity, footpad health, change of ingredient inclusion levels and related impact on sustainability impact factors were …

Application Of Simulation Modelling In Broiler Integration: Is It A Necessary Nutritional Tool?, Peter Chrystal

Proceedings of the Arkansas Nutrition Conference

Modelling techniques have been used in many industries globally to illustrate to others an understanding of the way processes work. Also, engineers and scientists employ models to predict the consequences of various courses of action. Simple pictorial models, such as the diagram of the chicken digestive system, are useful in education and may be more suitable than a photograph for the purposes of explaining how the animal converts ingested feed into components that can be assimilated, leaving residue that is excreted. Complex, predictive models seek to quantify a specified outcome based on defined inputs. Many attempts have been made over …

State Of The Art Pullet And Breeder Nutrition, Rick Van Emous

Proceedings of the Arkansas Nutrition Conference

During the last six to seven decades, broilers have been successfully selected for maximum growth and feed efficiency (Zuidhof et al., 2014). Modern fast-growing broilers reach a body weight of 2.0 to 2.5 kg in 35 to 45 days with an average daily growth of 55 or more gram a day (Augère-Granier, 2019). In a study with different broiler strains representative of broilers in 1957 or 1978 were compared with a broiler strain from 2005 (Zuidhof et al., 2014). The 2005 strain showed, over a 56-day growth period, a 4.6 times higher growth rate and a 50% lower feed conversion …

Broiler Breeder Males: Feed And Nutrition Discussion, Benton Hudson

Proceedings of the Arkansas Nutrition Conference

The methods for feeding broiler breeder males have evolved over recent decades, and further revisions will likely be needed as males become more challenging to manage. Since the introduction of separate male feeding systems in the early 1980’s, breeder males’ nutrient needs have been better managed via daily feed restriction. If a breeder operation can effectively produce, haul, and store a separate male diet, then it provides more options to use different nutrient levels or feed additives that are designed to enhance fertility. This article will outline the history of male-separate feeding and revisit nutritional research on fertility of broiler …

Amino Acids Were Not All Created Equal, Peter H. Selle, Shemil P. Macelline, Peter V. Chrystal, Sonia Y. Liu

Proceedings of the Arkansas Nutrition Conference

The contention that amino acids were not all created equal is based on the simple premise that intestinal uptakes of non-bound (synthetic, crystalline, feed-grade) amino acids are more rapid than their protein-bound counterparts. The post-enteral ramifications of this difference in bioequivalence are amplified in broiler chickens given their express growth rates and just one complication is the post-prandial oxidation of amino acids. The lack of bioequivalence between non-bound and protein-bound amino acids is a real obstacle to the development and adoption of reduced-crude protein diets that have the potential to promote sustainable chicken-meat production Thus, the purpose of this paper …

Recent Advancements On Calcium And Phosphorus Recommendations In Broilers, Justina Caldas, Marcelo Silva

Proceedings of the Arkansas Nutrition Conference

Calcium and phosphorus have been recognized essential nutrients in chickens since 1950’s (Lesson & Summers, 2001) playing important roles in bone development, among other functions. Calcium is assumed an inexpensive nutrient in animal least cost formulation while phosphorus is considered expensive and scant. The actual economic impact comes from the influence of calcium on phosphorus requirements, changes in phosphorus digestibility, buffer capacity, gut health, trace mineral absorption, fat digestibility, welfare traits, etc. Both minerals have important interactions to be considered during formulation. Few changes have been made over the past 20 years to calcium and phosphorus recommendations because these values …

Decoding The Gut Microbiome; Providing Solutions For Poultry Production, Nichoals Evans, Peter Karnezos, Curtis Novak, Diana Ayala, Emily Kimminau, Kay Russo

Proceedings of the Arkansas Nutrition Conference

The term “microbiome” refers to all the micro-organisms within a particular environment. In poultry, the microbiome is influenced by the barn, diet, and age of the birds and is believed to modulate immunity and inflammation. In the past, culture methods were primarily used to evaluate the presence of the various micro-organisms present in the microbiome; however, recent technological advances in genomic sequencing have revolutionized sample analysis. This technology has opened new avenues of research in poultry production and our understanding of the associated health challenges. Turkey cellulitis has been a major economic and health concern for many years. Traditional bacterial …

Application Of Nutritional Immunology In The Mitigation Of Economic And Production Losses In The Poultry Industry Associated With Food-Borne Pathogens, Coccidiosis, And Necrotic Enteritis., Shahna Fathima, Ramesh K. Selvaraj

Proceedings of the Arkansas Nutrition Conference

Sub-therapeutic doses of antibiotics were used in poultry production since the 1950s for improved production, prophylaxis, and animal welfare. Extensive and indiscriminatory use of antibiotics led to the emergence of antibiotic resistance in food-borne pathogens of public health significance (Jones & Ricke, 2003). As per the United States Centre for Disease Control, more than 2.8 million infections in 2019 were caused by multidrug resistant bacteria. Due to public health concerns, the use of antibiotic growth promoters in livestock production was prohibited by Sweden and Denmark in 1986 and 1998 respectively (Hammerum et al., 2007). The European Union banned the use …

A Dynamic Approach To Feed Formulation, Rob Gous

Proceedings of the Arkansas Nutrition Conference

The objective of this paper is to demonstrate that the opportunity cost of using fixed tables of nutrient requirements when formulating feeds for broilers can be considerable, and that nutritionists should consider a more dynamic approach to defining the lower bounds of amino acids in particular, in line with the objective of the business, which is to maximise profit. In order to do this, it is necessary to consider the potential growth rate of the broiler, the cost of feed and amount of feed consumed, and the income generated from the sale of product.

Transitioning To Net Energy: A Swine Story, John F. Patience

Proceedings of the Arkansas Nutrition Conference

Net energy (NE) is one member of the sequence of energy systems which also includes gross energy (GE), digestible energy (DE), and metabolizable energy (ME). It is perhaps the most sophisticated because it attempts to consider more components of the ingredient or diet which normally cannot be used by the pig for maintenance and/or productive purposes. Gross energy makes no such adjustment and therefore has little direct value in diet formulation. Digestible energy corrects for energy which is lost in the feces, and metabolizable energy also adjusts for energy lost in the urine. The data in Table …

Where Can We Go With Net Energy In Poultry?, Katie Hilton

Proceedings of the Arkansas Nutrition Conference

Metabolizable energy (ME) is the main system used globally in poultry industry for feed formulation and for evaluating feed ingredients and mixed feeds (de Boer and Bickel, 1988). ME is considered a reliable index of what is available to the bird for maintenance and production but is not a predictor of how efficiently the bird uses the available energy (MacLeod, 2000). The ME system developed by Hill and Anderson (1958) was reported to provide less variation in energy values for feed and ingredients than the Fraps PE system, but MacLeod (1994, 1997, 1999) suggest that the low variation …