Digital Commons Network^™

Targeting Of The Hedgehog Signaling Pathway In Cancer Treatment, Andrew J. Hawes

The Cardinal Edge

The Hedgehog (Hh) signaling pathway is a developmental pathway that is highly conserved evolutionarily. While typically only displaying high activity during embryogenesis, overactivation of the Hh pathway in adults has been linked to multiple forms of cancer including acute myeloid leukemia, myelofibrosis, basal-cell carcinoma, pancreatic ductal adrenal carcinoma, and triple negative breast cancer. The prevalence of Hh activation in many different cancers has made it a prime target for inhibition of these cancers through novel therapies. This literature review sought to assess the current state of cancer treatment through inhibition of Hh signaling. Most current clinical trials involving the pathway …

Worker Ownership And The Public-Private Dichotomy: Disparity In Cudd’S Capitalism: For And Against, Zane R. Phelps

The Cardinal Edge

Ideological traditions, movements, and their associated developments are riddled with interpretation and disparity: human affairs are too complex and too riddled with contradiction to be narrowed down, to be sure. To maximize clarity, as well as its benefits in dialectics and discourse, critical analysis of these disparities in authored research can be a step towards maximizing the utility of debate, wherein both sides reach a conclusion or synthesis, ending up better off than before. This is the formula to be applied in the case of Cudd and Holmstrom. I take Cudd’s reading and interpretation of concepts such as worker ownership …

Revitalizing The Puerto Rican Economy After Hurricane Maria, Aditya Mehta

The Cardinal Edge

Puerto Rico is an island in the Caribbean that is an unincorporated territory of the U.S. It is naturally beautiful and caters heavily to tourists. However, it is currently in the midst of an economic crisis that has been building for years and is struggling to rebuild in the aftermath of Hurricane Maria. Additionally, popular culture and statistics have demonstrated that many Puerto Ricans are emigrating from the island. Puerto Rico must address these issues to ensure that its citizens can continue to have a good quality of life on the island. To do this, the U.S. government must work …

Inducing Cognitive Reflection And Its Impact On Contradictory Beliefs, Margaret Powers, Meg Powers

The Cardinal Edge

Currently, there is extensive research within psychology about two distinct processing models where one is fast, automatic, and relatively effortless and the other is slow, systematic, and effortful. One mechanism of effortful processing is cognitive reflection which is one’s ability to reflect on their intuition. While there is research on explicit instructions of certain cognitive mechanisms and implicit induction of cognitive reflection, there is a lack of research on the explicit induction of cognitive reflection specifically. In this study, two techniques were investigated to see if cognitive reflection could be explicitly induced. Participants either read a prompt before beginning the …

Evaluation Of Respiratory Function Using Blood Gas Parameters In Yucatan Minipigs Following Spinal Cord Injury, Jackson Gallagher, Monique Morgan, Chase Knibbe, Destiny Gibson, Maxwell Boakye

The Cardinal Edge

There are approximately 17,810 new spinal cord injuries (SCI) in the U.S. each year [1]. Physical damage to the spinal cord has the potential to interfere with normal motor, sensory, and/or autonomic function, such as impairment of the respiratory system. In fact, respiratory insufficiency is the number one cause of mortality and morbidity after SCI. The more rostral the injury, the more likely there will be disruption to normal ventilation (generally rostral to T6) [2]. To conduct relevant preclinical research, it has been shown that large animal models, such as the Yucatan minipig, have a better success rate of translating …

Characterization Of The Function Of Pprgtb2 From Mutant Phenotypes, Briana L. Seibert, Hyun Jin Jung, Mark P Running

The Cardinal Edge

Protein prenylation, a common lipid post-translational modification, is required for growth and development in eukaryotes. One type, , but its biological function is not well known. The moss Physcomitrella patens (P. patens) was used as a model organism due to its simple structure, limited cell types, sequenced genome, and its high gene targeting efficiency. P. patens has one copy of Rab-GGT α subunit (PpRGTA1) and two copies of β subunit (PpRGTB1 and PpRGTB2). It has been found that the knockout of either PpRGTB1 or PpRGTB2 results in no visible phenotype, which indicates that these …

Research Opportunities For Undergraduate Students, Aamira Shah, Jaley F Adkins

The Cardinal Edge

No abstract provided.

An Interdisciplinary Discussion On Climate Change, Aamira Shah, Jaley F. Adkins, Kelsey Littrell, Priyadarshini Chandrashekhar

The Cardinal Edge

No abstract provided.

Women In Stem, Priyadarshini Chandrashekhar, Kelsey Littrell, Aamira Shah

The Cardinal Edge

No abstract provided.

The Failure Of Uncertainty Within United States' Immigration Law In The Competition For Critical Chinese-Born Stem Grads, Neil Rutledge

Nebraska Law Bulletin (Selected Issues)

It is difficult to overstate the information technology sector’s role in the United States economy. According to the Brookings Institute, “(i)n 2017 alone, the IT industry’s contribution to real economic output in the United States exceeded that of the professional and business services, finance and insurance, and manufacturing sectors.” The Covid-19 pandemic further accelerated this growth–49 members of the Fortune 500 are now tech companies.

In the battle for economic and national-security supremacy, Chinese-born students and scientists studying and working at United States’ universities have emerged as a singular vital component in each nation's strategic ambitions. In the United States, …

People Lining Up To Get On The Train, Tina To

Kizuna: Bonds Beyond Incarceration (Summer 2022)

Grayce and her family board a barely furnished train. The wooden benches inside each hot musty car seat 70 passengers. There will be no stops to stretch and no beds for sleeping.

For many passengers this is the first trip east, and new landscapes offer pleasant diversion. Their final scenery, however, will be barbed wire and guard towers at Rohwer.

Pencegahan Tindak Pidana Terorisme Di Indonesia Melalui Kebijakan Migrasi: Dampak Dan Tantangan, Ikram A. Taha, Wilman Jayawardhana, Parida Johanna Siregar, Adhista Cahya Mustika

Jurnal Kajian Stratejik Ketahanan Nasional

International migration is carried out by people from various parts of the world with specific aims and objectives. Some people do international migration deliberately to leave their country of origin due to conflicts, natural disasters, repressive governments, economic factors, etc. This study aims to determine the relationship between international migration and acts of terrorism in Indonesia. The research method is a qualitative descriptive analytical method. Acts of terrorism and migration become instruments in understanding and formulating explanations about the relationship between the two. Literature and document searches are used to collect data and information. The results of the study show …

Two Causal Relationships Between The Planes Of Fact-Finding And Substantive Law, Henrique Carneiro

Nebraska Law Bulletin (Selected Issues)

This essay depicts two causal processes that demonstrate how, in the American legal system, the fact-finding plane is more fundamental than the substantive law (or substantive rights) plane. In the first process, a priori policy judgments about what facts should be available, and a priori epistemological claims about what facts can be available, drive expansions, contractions, and intentional reaffirmations of legal rights’ substantive scope. In the second process, factual wrinkles in individual cases are seized upon by judges and/or litigators and exercise an outsized influence on the development of substantive law. Although these processes are present across different areas of …

Unh Women’S Soccer: Guarente’S Hat Trick Boosts ‘Cats Over Terriers, Joey Rizzi

Digital Edition

An independent student produced newspaper from the University of New Hampshire.

What Are Neighboring Colleges Doing To Fight Food Insecurity?, Rhianwen Watkins

Digital Edition

An independent student produced newspaper from the University of New Hampshire.

Weekly Pop-Up Class: Understanding The Lgbtq+ Civil Rights Movement And Why It Matters, Benjamin N. Cardozo School Of Law

Cardozo News 2022

Cardozo launches a weekly pop-up class exploring LGBTQ+ law, policy, history,and civil rights challenges past, present and future with prominent scholars, researchers and movement leaders.

Racial Disparities In Diabetes Mellitus Prevalence In Prostate Cancer Patients On Androgen Deprivation Therapy, Sameh Gomaa, William Kelly, Do, Grace Lu-Yao, Phd, Edith Mitchell, Md, Tingting Zhan, Phd, Kuang-Yi Wen, Phd

Department of Medical Oncology Posters

Intro/Background

• Androgen deprivation therapy (ADT) is successfully used in patients with advanced prostate cancer.
• ADT has show to prolong survival.
• The use of ADT is associated with many side effects, most notably an increase in diabetes incidence for patients on ADT.
• African American men have higher prevalence and mortality rates from prostate cancer than White men.
• It is unclear how prostate cancer treatment such as ADT affects these disparities.
• This study examines racial differences in the prevalence of diabetes mellitus in prostate cancer patients based on their ADT status in the US.

Mgrre_Thinsections_05_A_24, Mgrre

Thin Sections

No abstract provided.

A Bucket Case, Beth Broderick

Erma Bombeck Writers' Workshop Blog

I love flying into Oakland, California. On approach, the plane glides over San Francisco Bay, slowly getting lower and lower until it seems it will surely dip a wheel into the water, and as it lands, it appears to touch the earth. It is enchanting. I never tire of watching the drama unfold from my tiny window, though I admit a small knot of worry forms every time.

The Social Value Of Intellectual Property, Alina Ng

Journal Articles

The focus of this paper is not on how intellectual property owners can misuse intellectual property rights in harmful ways in society. Much has already been written about that topic. Instead, this paper is about how to encourage intellectual property owners, especially corporate owners, to make decisions and implement strategies about their intellectual property rights that are socially valuable and positively impactful. This paper argues that if corporate and business owners of intellectual property understand the role that their intellectual property rights can have in creating a positive social impact, the influence that they can have in the market as …

Application Of Enzyme And Enzyme Technology In Deep Processing Of Tea, Fei Fan, Liu Chang-Wei, Niu Li, Liu Zhong-Hua

Food and Machinery

Enzymes can efficiently and specifically accelerate biochemical reactions in biological processes. In the field of tea deep processing, the application of exogenous enzymes can be greener and more efficient in the extraction, separation, preparation, or biosynthesis of tea functional components to realize the high value utilization of tea resources. In the present review, the application of enzymes and enzyme engineering technology in tea deep processing were discussed from the following four aspects, i.e., enzyme-assisted extraction, enzyme-assisted synthesis, bioenzyme-modified tea extracts and immobilized enzyme technology. Moreover, the problems and outlooks the research directions of enzymes and the technology in the field …

Saint Jude's, September 18, 2022

Saint Jude's

A newsletter published for Deaf Catholics in Waltham, MA

Saint Jude's Finding Aid

2022-2023 Baroque In Boca: From The Studio Of Lisa Leonard With Special Guest Artists, Lisa Leonard, Marina Machado, Silvia Valdivia Villasante, Sergei Skobin, Lauren Washburn, Benjamin Shaposhnikov, Benjamin Kremer, Niloufar Mirzanabi Khani, Sungkyun Lee, Kari Jenks, Frederic Renaud, Rosa Zoraida Ortega Iannelli, Dina Bikzhanova, Jonathan Dills, Dylan Fafard

Studio Recitals

No abstract provided.

Warranty Calls Are An Auto Motive, Jerry Zezima

Erma Bombeck Writers' Workshop Blog

The main difference between me and my car — aside from the alarming fact that my fluids need to be changed twice a night — is that I don’t come with an extended warranty.

Dawn Of New Era In The Arts At The University, Staff Report

University of Mississippi News

No abstract provided.

Joanne Kong Lecture-Recital. Johann Sebastian Bach: The Well-Tempered Clavier, Book I, Department Of Music, University Of Richmond

Music Department Concert Programs

No abstract provided.

The Guardian The Week Of September 18, 2022, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of September 18, 2022. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

A Two-Phase Approach To Re-Calibrating Expensive Computer Simulation For Sex-Specific Colorectal Neoplasia Development Modeling, Carolina Vivas-Valencia, You Zhou, Aditya Sai, Thomas F. Imperiale, Nan Kong

Purdue University Libraries Open Access Publishing Fund

Medical evidence from more recent observational studies may significantly alter our understanding of disease incidence and progression, and would require recalibration of existing computational and predictive disease models. However, it is often challenging to perform recalibration when there are a large number of model parameters to be estimated. Moreover, comparing the fitting performances of candidate parameter designs can be difficult due to significant variation in simulated outcomes under limited computational budget and long runtime, even for one simulation replication.

Newsletter, September 2022, Cedar Oaks Guild

Cedar Oaks Guild Newsletter

No abstract provided.

Radiometric Effects Of Centimeter Scale Roughness Of Bare Soils, Dylan J. Shiltz

Theses

The roughness of a bare soil surface has important implications in both the reflective and microwave domains of remote sensing. In a natural environment, roughness is present at a wide range of length scales, from the roughness of individual particles to meter or kilometer scale geological features. This thesis will focus on centimeter scale roughness,i.e. surface features whose length scale is much greater than individual soil particles, but which are still small enough that they are unresolved in remote sensing applications. Wind driven and hydrologically driven features, such as the ripples found on a beach or on the surfaces of …