Digital Commons Network^™

Early Preclinical Experience Of A Mixed Reality Ultrasound System With Active Guidance For Needle-Based Interventions: The Guide Study, David Bloom, Jamie N Colombo, Nathan Miller, Michael K Southworth, Christopher Andrews, Alexander Henry, William B Orr, Jonathan R Silva, Jennifer N Avari Silva

2020-Current year OA Pubs

BACKGROUND: Use of ultrasound (US) to facilitate vascular access has increased compared to landmark-based procedures despite ergonomic challenges and need for extrapolation of 2-dimensional images to understand needle position. The MantUS™ system (Sentiar, Inc.,) uses a mixed reality (MxR) interface to display US images and integrate real-time needle tracking.

OBJECTIVE: The purpose of this prospective preclinical study was to evaluate the feasibility and usability of MantUS in a simulated environment.

METHODS: Participants were recruited from pediatric cardiology and critical care. Access was obtained in 2 vascular access training models: a femoral access model and a head and neck model for …

Spirality: A Novel Way To Measure Spiral Arm Pitch Angle, Deanna Shields, Benjamin Boe, Casey Pfountz, Benjamin L. Davis, Matthew Hartley, Ryan Miller, Zac Slade, M. Shameer Abdeen, Daniel Kennefick, Julia Kennefick

Physics Faculty Publications and Presentations

We present the MATLAB code Spirality, a novel method for measuring spiral arm pitch angles by fitting galaxy images to spiral templates of known pitch. Computation time is typically on the order of 2 min per galaxy, assuming 8 GB of working memory. We tested the code using 117 synthetic spiral images with known pitches, varying both the spiral properties and the input parameters. The code yielded correct results for all synthetic spirals with galaxy-like properties. We also compared the code’s results to two-dimensional Fast Fourier Transform (2DFFT) measurements for the sample of nearby galaxies defined by DMS PPak. Spirality’s …

Emergence Of Ferrimagnetism In Li-Intercalated Nips3, Rabindra Basnet, Dawn Ford, Kaylee Tenbarge, Joshua Lochala, Jin Hu

Physics Faculty Publications and Presentations

Intercalation has become a powerful approach to tune the intrinsic properties and introduce novel phenomena in layered materials. Intercalating van der Waals (vdW) magnetic materials is a promising route to engineer the low-dimensional magnetism. Recently, metal thiophosphates, MPX₃, has been widely studied because their magnetic orders are highly tunable and persist down to the two-dimensional limit. In this work, we used electrochemical technique to intercalate Li into NiPS₃ single crystals and found the emergence of ferrimagnetism at low temperature in Li-intercalated NiPS₃. Such tuning of magnetic properties highlights the effectiveness of intercalation, providing …

Comprehensive Characterization Of The Multiple Myeloma Immune Microenvironment Using Integrated Scrna-Seq, Cytof, And Cite-Seq Analysis, Lijun Yao, Reyka G Jayasinghe, Mark A Fiala, Michael C Wendl, Stephen T Oh, John F Dipersio, Ravi Vij, Li Ding

2020-Current year OA Pubs

UNLABELLED: As part of the Multiple Myeloma Research Foundation (MMRF) immune atlas pilot project, we compared immune cells of multiple myeloma bone marrow samples from 18 patients assessed by single-cell RNA sequencing (scRNA-seq), mass cytometry (CyTOF), and cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) to understand the concordance of measurements among single-cell techniques. Cell type abundances are relatively consistent across the three approaches, while variations are observed in T cells, macrophages, and monocytes. Concordance and correlation analysis of cell type marker gene expression across different modalities highlighted the importance of choosing cell type marker genes best suited to …

Incentivizing Innovation: Promoting Technical Competency To Win Future Wars., James E. Bevins

Faculty Publications

Despite numerous studies and initiatives, most current Air Force efforts to add science and technology talent have been insufficient. This begs the question: How does the Air Force incentivize and promote the necessary technical competence required to win future competition, conflicts, and wars? Several key initiatives, grounded in behavioral economics, can incentivize innovation and pursue science and technology expertise. Developed in the context of peer adversaries’ actions; global trends in technology, competition, and conflict; and the global competition for science and technology talent, these recommendations have the potential to reform institutional culture and unleash the creativity and talent of the …

Monocular Camera Viewpoint-Invariant Vehicular Traffic Segmentation And Classification Utilizing Small Datasets, Amr Yousef, Jeff Flora, Khan Iftekharuddin

Electrical & Computer Engineering Faculty Publications

The work presented here develops a computer vision framework that is view angle independent for vehicle segmentation and classification from roadway traffic systems installed by the Virginia Department of Transportation (VDOT). An automated technique for extracting a region of interest is discussed to speed up the processing. The VDOT traffic videos are analyzed for vehicle segmentation using an improved robust low-rank matrix decomposition technique. It presents a new and effective thresholding method that improves segmentation accuracy and simultaneously speeds up the segmentation processing. Size and shape physical descriptors from morphological properties and textural features from the Histogram of Oriented Gradients …

A Mesh-Free Method Using Piecewise Deep Neural Network For Elliptic Interface Problems, Cuiyu He, Xiaozhe Hu, Lin Mu

School of Mathematical & Statistical Sciences Faculty Publications

In this paper, we propose a novel mesh-free numerical method for solving the elliptic interface problems based on deep learning. We approximate the solution by the neural networks and, since the solution may change dramatically across the interface, we employ different neural networks for each sub-domain. By reformulating the interface problem as a least-squares problem, we discretize the objective function using mean squared error via sampling and solve the proposed deep least-squares method by standard training algorithms such as stochastic gradient descent. The discretized objective function utilizes only the point-wise information on the sampling points and thus no underlying mesh …

Author-Meets-Critic: The Humor Hack, Sophia A. Stone

Faculty and Staff Publications & Presentations

No abstract provided.

A Mixed Methodological Examination Of Older Adults’ Psychological Reactance Toward Caregiving Messages From Their Adult Children, Hannah Ball, Keith Weber, Alan K. Goodboy, Christine E. Kunkle, Christa L. Lilly, Scott A. Myers

Communication Faculty Articles and Research

This study extends psychological reactance theory (PRT) to family caregiving by exploring autonomy-threatening messages adult child caregivers use to gain compliance from older adult parents. Results of focus groups and interviews with older adult care recipients (Study One) and caregivers (Study Two) corroborated three types of autonomy-threatening messages, which were used to test PRT (Study Three). Older adults (N = 281) were randomly assigned a caregiving message and answered reactance-related survey questions. Results supported serial mediation: relative to an autonomy-supporting message, two types of autonomy-threatening messages (i.e., offering directives, expressing doubt) triggered greater freedom threat, which amplified reactance. In …

Sticky Me: Self-Relevance Slows Reinforcement Learning, M Golubickis, Cn Macrae

School of Psychology

A prominent facet of social-cognitive functioning is that self-relevant information is prioritized in perception, attention, and memory. What is not yet understood, however, is whether similar effects arise during learning. In particular, compared to other people (e.g., best friend) is information about the self acquired more rapidly? To explore this matter, here we used a probabilistic selection task in combination with computational modeling (i.e., Reinforcement Learning Drift Diffusion Model analysis) to establish how self-relevance influences learning under conditions of uncertainty (i.e., choices are based on the perceived likelihood of positive and negative outcomes). Across two experiments, a consistent pattern of …

Applying Biotechnology In Agriculture, Sulaiya Piemchaiwat

Halal Insight

No abstract provided.

The Hsc Attended The 29th Imt-Gt Senior Offcials’ Meeting, The 19th Chief Ministers And Governors’ Forum (Cmgf) Meeting And The 28th Imt-Gt Ministerial Meeting (Mm) Meeting, Staff -

Halal Insight

No abstract provided.

The Halal Science Center, Chulalongkorn University Joined As A Speaker To Present The Application Of Halal Science And Innovation At The International Halal Conference In The United States, Staff -

Halal Insight

No abstract provided.

Analyze Financial Market And Financial Institutions After Covid-19, Rada Nima

Halal Insight

No abstract provided.

Neom, The New Future Of Halal Science City, Sunainee Mahama

Halal Insight

No abstract provided.

Dairy Products Can Get Rid Of Insomnia, Nureesun Mahamud

Halal Insight

No abstract provided.

Developing Southern Andaman Provinces To Become Center Of Medical And Health Services, Arseeyoh Lateh

Halal Insight

No abstract provided.

Product Development & Innovation, Malarin Srimoonkum

Halal Insight

No abstract provided.

Tdcs Induced Gaba Change Is Associated With The Simulated Electric Field In M1, An Effect Mediated By Grey Matter Volume In The Mrs Voxel, Tulika Nandi, Oula Puonti, William T. Clarke, Caroline Nettekoven, Helen C. Barron, James Kolasinski, Taylor Hanayik, Emily L. Hinson, Adam Berrington, Anderson M. Winkler

School of Medicine Publications

Background and objective

Transcranial direct current stimulation (tDCS) has wide ranging applications in neuro-behavioural and physiological research, and in neurological rehabilitation. However, it is currently limited by substantial inter-subject variability in responses, which may be explained, at least in part, by anatomical differences that lead to variability in the electric field (E-field) induced in the cortex. Here, we tested whether the variability in the E-field in the stimulated cortex during anodal tDCS, estimated using computational simulations, explains the variability in tDCS induced changes in GABA, a neurophysiological marker of stimulation effect.

Methods

Data from five previously conducted MRS …

Predictive Performance And Clinical Application Of Cov50, A Urinary Proteomic Biomarker In Early Covid-19 Infection: A Prospective Multicentre Cohort Study, Jan A. Staessen, Ralph Wendt, Yu-Ling Yu, Sven Kalbitz, Lutgarde Thijs, Justyna Siwy, Julia Raad, Jochen Metzger, Barbara Neuhaus, Gladys E. Maestre

School of Medicine Publications

Background: The SARS-CoV-2 pandemic is a worldwide challenge. The CRIT-CoV-U pilot study generated a urinary proteomic biomarker consisting of 50 peptides (COV50), which predicted death and disease progression from SARS-CoV-2. After the interim analysis presented for the German Government, here, we aimed to analyse the full dataset to consolidate the findings and propose potential clinical applications of this biomarker.

Methods: CRIT-CoV-U was a prospective multicentre cohort study. In eight European countries (Austria, France, Germany, Greece, North Macedonia, Poland, Spain, and Sweden), 1012 adults with PCR-confirmed COVID-19 were followed up for death and progression along the 8-point WHO scale. Capillary electrophoresis …

Residence In A Latinx Enclave And End-Induction Minimal Residual Disease Positivity Among Children With Acute Lymphoblastic Leukemia, Joshua P Muñiz, John P Woodhouse, Amy E Hughes, Sandi L Pruitt, Karen R Rabin, Michael E Scheurer, Philip J Lupo, Jeremy M Schraw

Center for Medical Ethics and Health Policy Staff Publications

Racial and ethnic inequities in survival persist for children with acute lymphoblastic leukemia (ALL). In the US, there are strong associations between SES, race/ethnicity, and place of residence. This is evidenced by ethnic enclaves: neighborhoods with high concentrations of ethnic residents, immigrants, and language isolation. The Latinx enclave index (LEI) can be used to investigate how residence in a Latinx enclave is associated with health outcomes. We studied the association between LEI score and minimal residual disease (MRD) in 142 pediatric ALL patients treated at Texas Children's Hospital. LEI score was associated with end-induction MRD positivity (OR per unit increase …

Characteristics Of Graft-Versus-Host Disease (Gvhd) After Post-Transplantation Cyclophosphamide Versus Conventional Gvhd Prophylaxis, Rima M Saliba, Amin M Alousi, Joseph Pidala, Mukta Arora, Stephen R Spellman, Michael T Hemmer, Tao Wang, Camille Abboud, Sairah Ahmed, Joseph H Antin, Amer Beitinjaneh, David Buchbinder, Michael Byrne, Jean-Yves Cahn, Hannah Choe, Rabi Hanna, Peiman Hematti, Rammurti T Kamble, Carrie L Kitko, Mary Laughlin, Lazaros Lekakis, Margaret L Macmillan, Rodrigo Martino, Parinda A Mehta, Taiga Nishihori, Sagar S Patel, Miguel-Angel Perales, Hemalatha G Rangarajan, Olov Ringdén, Joseph Rosenthal, Bipin N Savani, Kirk R Schultz, Sachiko Seo, Takanori Teshima, Marjolein Van Der Poel, Leo F Verdonck, Daniel Weisdorf, Baldeep Wirk, Jean A Yared, Jeffrey Schriber, Richard E Champlin, Stefan O Ciurea

Center for Medical Ethics and Health Policy Staff Publications

Post-transplantation cyclophosphamide (PTCy) has been shown to effectively control graft-versus-host disease (GvHD) in haploidentical (Haplo) transplantations. In this retrospective registry study, we compared GvHD organ distribution, severity, and outcomes in patients with GvHD occurring after Haplo transplantation with PTCy GvHD prophylaxis (Haplo/PTCy) versus HLA-matched unrelated donor transplantation with conventional prophylaxis (MUD/conventional). We evaluated 2 cohorts: patients with grade 2 to 4 acute GvHD (aGvHD) including 264 and 1163 recipients of Haplo and MUD transplants; and patients with any chronic GvHD (cGvHD) including 206 and 1018 recipients of Haplo and MUD transplants, respectively. In comparison with MUD/conventional transplantation ± antithymocyte globulin …

Men's Rights, Gun Ownership, Racism, And The Assault On Women's Reproductive Health Rights: Hidden Connections, Walter S. Dekeseredy

Dignity: A Journal of Analysis of Exploitation and Violence

In this current era characterized by much fear of, and anxiety about, the political influence and actions of the U.S. alternative right (alt-right), only a small number of men’s rights organizations receive attention from the media, the Democratic Party, or a large cadre of progressives. This article demonstrates that ignoring all-male anti-feminist organizations is a flawed strategy for challenging the recent rise of the alt-right because these misogynistic groups are heavily involved in the gun rights movement, major contributors to racist practices and discourses, and active participants in efforts to criminalize and curtail women’s access to abortion. Another, but equally …

Table Of Contents (V. 31, No. 1)

William & Mary Bill of Rights Journal

No abstract provided.

Liberalism Triumphant? Ideology And The En Banc Process In The Ninth Circuit Court Of Appeals, Arthur D. Hellman

William & Mary Bill of Rights Journal

More than 40 years ago, President Jimmy Carter, a Democrat, appointed 15 of the then-23 judges of the Ninth Circuit Court of Appeals. Those judges were predominantly liberal, and some were extremely liberal. Ever since then, the Ninth Circuit has been widely regarded as “a reliably liberal appeals court” that predictably issues “rulings favorable to liberal causes.” But some knowledgeable commentators, including Professor (now Dean) Erwin Chemerinsky, have disputed the characterization, calling it a “myth.”

Until now, no one has empirically tested whether the Ninth Circuit is indeed the liberal bastion that it is reputed to be. That is the …

The Right To Train: A Pillar Of The Second Amendment, Joseph G.S. Greenlee

William & Mary Bill of Rights Journal

Since the Supreme Court confirmed that the Second Amendment protects “the individual right to possess and carry weapons” in District of Columbia v. Heller, lower courts have been grappling with whether there is also a right to train with those weapons. Courts have considered whether training is a protected activity, whether it is a “core” right, and whether its protection is limited to gaining the minimum competency needed for self-defense.

[...]

No court yet has explored the legal history of the right to train, nor has any article. This Article presents the first in-depth historical exploration of the right. …

Thinking Outside The Box: Preimplantation Genetic Diagnosis, In Vitro Fertilization, And Disability Screening In The Wake Of Box V. Planned Parenthood, Christian J. Sorensen

William & Mary Bill of Rights Journal

A circuit split has recently emerged regarding the constitutionality of state laws banning trait-selective abortions, i.e., abortions based on fetal characteristics like disability. Much of the dialogue surrounding trait selection has revolved around whether such abortions are eugenic in nature and whether they could be regulated differently than other forms of abortion—under either Roe and Casey or the post- Roe regime ushered in by Dobbs. However, the same concerns underlying this debate over eugenic abortions apply with equal force to preimplantation genetic diagnosis (PGD) coupled with in vitro fertilization. Because PGD seems certain to be the next battlefield in …

Making Hazelwood Age-Appropriate: How Viewpoint Neutrality And Recontextualizing The Age-Appropriate Standard Might Save School-Sponsored Lgbt Speech, Rebecca Girardin

William & Mary Bill of Rights Journal

Younger people are identifying as lesbian, gay, bisexual, or transgender (henceforth “LGBT”) more than any previous generation. Likewise, there has been a proliferation of free-speech litigation involving student speech that discusses LGBT issues. Beyond just LGBT speech in school, there has been a recent resurgence in the discussion around the relationship between parents, students, school administrators, and school boards when it comes to regulating school-sponsored speech.

Besides the growing number of students identifying as LGBT, protecting LGBT speech in school is of particular importance because the manner in which a school deals with LGBT speech directly influences the mental health …

Balancing Liberty And Security: A Proposal For Amplified Procedural Due Process Protections In The U.S. Sanctions Regime, Allison Lofgren

William & Mary Bill of Rights Journal

This Note will concentrate on procedural due process concerns stemming from the imposition of terrorist financing sanctions, and it will primarily discuss designated U.S. persons. This is a narrow focus, but it can be viewed as a microcosm for due process issues present throughout the broader IEEPA [International Emergency Economic Powers Act] regime. Ultimately, this Note will conclude that OFAC [Office of Foreign Assets Control]'s terrorist financing designation process inadequately protects the procedural due process rights of targets, and it will advocate for the implementation of additional procedural protections that balance undeniable constitutional requirements with the critical concern of national …

Ducking The System: Examining The Efficacy Of Bounty Hunting Statutes That Stifle The Free Exercise Of Constitutional Rights, Allie Zunski

William & Mary Bill of Rights Journal

[...] This Note examines the legal hurdles surrounding the novel “citizen deputy” statute—including its structure, the attendant legal doctrines, and its broader implications—using SB 8 as a test case for the analysis. While SB 8’s prohibition is no longer unconstitutional, the divisive history of the abortion debate that gave rise to the structure sheds light on the reasons why states may be motivated to infringe on constitutional rights and whether such efforts can succeed in practice. SB 8 is thus a useful test case to examine the structure and its potential for reuse. For purposes of this analysis, this Note …