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Transdisciplinarity In Transformative Ocean Governance Research - Reflections Of Early Career Researchers, Mia Strand, Kelly Ortega-Cisneros, Holly J. Niner, Michel Wahome, James Bell, Jock C. Currie, Hashali Hamukuaya, Giulia La Bianca, Alana M.S.N. Lancaster, Ntemesha Maseka, Lisa Mcdonald, Kirsty Mcquaid, Marly M. Samuel, Alexander Winkler Oct 2022

Transdisciplinarity In Transformative Ocean Governance Research - Reflections Of Early Career Researchers, Mia Strand, Kelly Ortega-Cisneros, Holly J. Niner, Michel Wahome, James Bell, Jock C. Currie, Hashali Hamukuaya, Giulia La Bianca, Alana M.S.N. Lancaster, Ntemesha Maseka, Lisa Mcdonald, Kirsty Mcquaid, Marly M. Samuel, Alexander Winkler

School of Biological and Marine Sciences

This paper interrogates the concept of transdisciplinarity, both theoretically and practically, from a perspective of early career researchers (ECRs) in transformative ocean governance research. Aiming to advance research methodologies for future complex sustainability challenges, the paper seeks to illuminate some common uncertainties and challenges surrounding transdisciplinarity from a marine science perspective. Following a literature review on transdisciplinary research, workshops, and a series of surveys, we determine that transdisciplinarity appears to be a concept in search of definition, and that there is a need to explore transdisciplinarity specifically from an ocean research perspective. The paper discusses a number of challenges experienced …


Coalition For Prisoner's Rights Newsletter, Vol. 47-D, No. 10, Coalition For Prisoners' Rights Oct 2022

Coalition For Prisoner's Rights Newsletter, Vol. 47-D, No. 10, Coalition For Prisoners' Rights

Coalition for Prisoners' Rights Newsletters

Developments in conditions

Migrantes fueron victimas de un delito

The Least Read Part of the Newsletter

Send Us Holiday/Calendar Card Designs

More On Levels of Abuse


Diffraction-Free Beam Propagation At The Exceptional Point Of Non-Hermitian Glauber Fock Lattices, Cem Yuce, Hamidreza Ramezani Oct 2022

Diffraction-Free Beam Propagation At The Exceptional Point Of Non-Hermitian Glauber Fock Lattices, Cem Yuce, Hamidreza Ramezani

Physics & Astronomy Faculty Publications

We construct localized beams in a non-Hermitian Glauber Fock (NGF) lattice of coupled waveguides and show that they can propagate for a long distance without almost no diffraction. We specifically obtain the diffraction-free beams in a finite NGF lattice at the exceptional point (EP) by using the exact eigenstates of the semi-infinite unidirectional NGF lattice. We provide a numerical approach to finding other lattices that are capable of supporting non-diffracting beams at EPs.


Genome-Wide Identification Of The A20/An1 Zinc Finger Proteon Family Genes In Ipomoea Batatas And Its Two Relatives And Function Analysis Of Ibsap16 In Salinity Tolerance, Hao Xie, Qiangqiang Yang, Xiaoxiao Wang, Michael Schläppi, Hui Yan, Meng Kou, Wei Tang, Xin Wang, Yungang Zhang, Qiang Li, Shaojun Dai, Yaju Liu Oct 2022

Genome-Wide Identification Of The A20/An1 Zinc Finger Proteon Family Genes In Ipomoea Batatas And Its Two Relatives And Function Analysis Of Ibsap16 In Salinity Tolerance, Hao Xie, Qiangqiang Yang, Xiaoxiao Wang, Michael Schläppi, Hui Yan, Meng Kou, Wei Tang, Xin Wang, Yungang Zhang, Qiang Li, Shaojun Dai, Yaju Liu

Biological Sciences Faculty Research and Publications

Stress-associated protein (SAP) genes—encoding A20/AN1 zinc-finger domain-containing proteins—play pivotal roles in regulating stress responses, growth, and development in plants. They are considered suitable candidates to improve abiotic stress tolerance in plants. However, the SAP gene family in sweet potato (Ipomoea batatas) and its relatives is yet to be investigated. In this study, 20 SAPs in sweet potato, and 23 and 26 SAPs in its wild diploid relatives Ipomoea triloba and Ipomoea trifida were identified. The chromosome locations, gene structures, protein physiological properties, conserved domains, and phylogenetic relationships of these SAPs were analyzed systematically. Binding motif analysis of IbSAPs indicated that …


Countermovement Jump And Squat Jump Force-Time Curve Analysis In Control And Fatigue Conditions, Steven Hughes, John Warmenhoven, G. Gregory Haff, Dale W. Chapman, Sophia Nimphius Oct 2022

Countermovement Jump And Squat Jump Force-Time Curve Analysis In Control And Fatigue Conditions, Steven Hughes, John Warmenhoven, G. Gregory Haff, Dale W. Chapman, Sophia Nimphius

Research outputs 2014 to 2021

This study aimed to reanalyze previously published discrete force data from countermovement jumps (CMJs) and squat jumps (SJs) using statistical parametric mapping (SPM), a statistical method that enables analysis of data in its native, complete state. Statistical parametric mapping analysis of 1-dimensional (1D) force-time curves was compared with previous zero-dimensional (0D) analysis of peak force to assess sensitivity of 1D analysis. Thirty-two subjects completed CMJs and SJs at baseline, 15 minutes, 1, 24, and 48 hours following fatigue and control conditions in a pseudo random cross-over design. Absolute (CMJABS/SJABS) and time-normalized (CMJNORM/SJNORM) …


The Diagnostic Role Of Cytokeratin 8/18 Immunohistochemical Marker For Lean Non-Alcoholic Fatty Liver Disease, P Telli, M Buyuk, Nazli Begum Ozturk, Z Istemihan, K Nuriyev, A Atasoy, B Cavus, A Cifcibasi Ormeci, U Akyuz, K Demir Oct 2022

The Diagnostic Role Of Cytokeratin 8/18 Immunohistochemical Marker For Lean Non-Alcoholic Fatty Liver Disease, P Telli, M Buyuk, Nazli Begum Ozturk, Z Istemihan, K Nuriyev, A Atasoy, B Cavus, A Cifcibasi Ormeci, U Akyuz, K Demir

Conference Presentation Abstracts

Introduction

Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases. NAFLD spectrum begins from simple steatosis to non-alcoholic steatohepatitis (NASH), progressive fibrosis, cirrhosis, and even hepatocellular carcinoma. Although most NAFLD patients are overweight and obese, 30% are lean. We analyzed lean and non-lean NAFLD patients’ liver biopsies for cytokeratin 8/18 immunohistochemical staining differences.

Aims & Methods

Thirty biopsy-proven NAFLD patients (15 patients with BMI ≤ 25 kg/m2, 15 patients with BMI > 25 kg/m2) were included in the study. Demographic, biochemical, and histologic features of the patients were recorded. Biopsy specimens from our archive were …


Bet Protein Complexes With Ets1 And Mediates The Senescence-Associated Secretory And Apoptotic Resistant Phenotypes Of Senescent Cholangiocytes, Jeong-Han Kang, Patrick Splinter, Christy Trussoni, Nicholas E. Pirius, Maria Eugenia Guicciardi, Anuradha Krishnan, Nazli Begum Ozturk, Gregory J. Gores, Nicholas F. Larusso, Steven P. O'Hara Oct 2022

Bet Protein Complexes With Ets1 And Mediates The Senescence-Associated Secretory And Apoptotic Resistant Phenotypes Of Senescent Cholangiocytes, Jeong-Han Kang, Patrick Splinter, Christy Trussoni, Nicholas E. Pirius, Maria Eugenia Guicciardi, Anuradha Krishnan, Nazli Begum Ozturk, Gregory J. Gores, Nicholas F. Larusso, Steven P. O'Hara

Conference Presentation Abstracts

Background: We reported that cholangiocyte senescence is a pathogenic feature of Primary Sclerosing Cholangitis (PSC) and is regulated by the transcription factor, ETS1. We also showed that Histone 3 Lysine 27 is acetylated at senescence-associated loci. The bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that bind acetylated histones, recruit transcription factors, and drive gene expression. Thus, we tested the hypothesis that BET proteins interact with ETS1 to drive gene expression and promote cholangiocyte senescence. Methods: We performed immunofluorescence to assess cholangiocyte expression of two BET proteins, BRD2 and BRD4, in tissue from PSC patients and PSC mouse models …


Standing The Ground: The Crises Of The 1790s And The Philosophies Of The Federalist Papers, Maria Vostrizansky Oct 2022

Standing The Ground: The Crises Of The 1790s And The Philosophies Of The Federalist Papers, Maria Vostrizansky

Armstrong Undergraduate Journal of History

The paper provides a unique outlook on the Federalist Papers, a series of eighty- five essays published in 1788, written by John Jay, Alexander Hamilton, and James Madison, as it examines the consistency of the philosophies and opinions presented in the Federalist Papers in light of the numerous crises the nation experienced in the 1790s. The paper compares the political belief presented in the Federalist Papers with the actions undertaken by authors during the Whiskey Tax’s enactment in 1791, the Genet Affair’s crisis of 1793, and the implementation of the Alien and Sedition Acts in 1798. Looking at these testing …


The Downfall Of A President: The Media Coverage Of Richard Nixon’S Resignation, Ning Xi Oct 2022

The Downfall Of A President: The Media Coverage Of Richard Nixon’S Resignation, Ning Xi

Armstrong Undergraduate Journal of History

The Watergate Scandal stands out as being the first, and so-far only, event that was catastrophic and damming enough to force a sitting President of the United States to resign from office. The exceptional circumstances of Richard Nixon’s departure from presidency invites many questions regarding how Nixon deciding to resign was initially covered by the new media. An analysis of excerpts from newspaper editorials from a variety of places around the United States demonstrates that there was a strong consensus that resigning was the best and only thing Nixon could have done. Yet, wide support for Nixon’s resignation co-existed with …


The Museum As Object Of Display: Experiencing The Ashmolean, Jack Z. Chen Oct 2022

The Museum As Object Of Display: Experiencing The Ashmolean, Jack Z. Chen

Armstrong Undergraduate Journal of History

Conventionally, museums are most often considered as a series of objects displayed, but I argue that the museum itself should be seen, first and foremost, as the object on display. The Ashmolean Museum in Oxford, built at the high tide of British Imperialism, is a very interesting case study. Interested in its engagement with its own past, I do not seek to investigate the actions it takes as an institution, for instance, as regards to the politics of repatriation. Instead, I want to explore the whole experience it facilitates as an object in its own right.

This experience begins with …


Conflict Dynamics In Scale-Free Networks With Degree Correlations And Hierarchical Structure, Eduardo Jacobo-Villegas, Bibiana Obregón-Quintana, Lev Guzmán-Vargas, Larry S. Liebovitch Oct 2022

Conflict Dynamics In Scale-Free Networks With Degree Correlations And Hierarchical Structure, Eduardo Jacobo-Villegas, Bibiana Obregón-Quintana, Lev Guzmán-Vargas, Larry S. Liebovitch

Publications and Research

We present a study of the dynamic interactions between actors located on complex networks with scale-free and hierarchical scale-free topologies with assortative mixing, that is, correlations between the degree distributions of the actors. The actor’s state evolves according to a model that considers its previous state, the inertia to change, and the influence of its neighborhood. We show that the time evolution of the system depends on the percentage of cooperative or competitive
interactions. For scale-free networks, we find that the dispersion between actors is higher when all interactions are either cooperative or competitive, while a balanced presence of interactions …


The Importance Of Low Iq To Early Diagnosis Of Autism, Kristina Denisova, Zhichun Lin Oct 2022

The Importance Of Low Iq To Early Diagnosis Of Autism, Kristina Denisova, Zhichun Lin

Publications and Research

Abstract
Some individuals can flexibly adapt to life’s changing demands while others, in particular those with Autism Spectrum Disorder (ASD), find it challenging. The origin of early individual differences in cognitive abilities, the putative tools with which to navigate novel information in life, including in infants later diagnosed with ASD remains unexplored. Moreover, the role of intelligence quotient (IQ) vis-à-vis core features of autism remains debated. We systematically investigate the contribution of early IQ in future autism outcomes in an extremely large, population-based study of 8000 newborns, infants, and toddlers from the US between 2 and 68 months with over …


A Comprehensive Characterization Of Hollow Conductor Additively Manufactured Coils And Thermal Management System For A 250 Kw Spm Machine, Sina Vahid, Salar Koushan, Towhid Islam Chowdhury, Ayman El-Refaie Oct 2022

A Comprehensive Characterization Of Hollow Conductor Additively Manufactured Coils And Thermal Management System For A 250 Kw Spm Machine, Sina Vahid, Salar Koushan, Towhid Islam Chowdhury, Ayman El-Refaie

Electrical and Computer Engineering Faculty Research and Publications

This paper provides an extensive and comprehensive analysis on characterization of additively manufactured coils and heat pipe based liquid cooling thermal management system, for a 250 kW and 5,000 rpm machine. AC and DC electrical tests at 140 Arms and 70 ADC are conducted on AlSi10Mg additively manufactured coils to extract their thermal and electrical characteristics. Heat pipes and liquid cooling test setups are described and discussed. The thermal discussion is concluded by experimental results showing the effectiveness of the thermal management system proposed in this paper. FEA are performed on the coils using ANSYS Maxwell to accurately predict the …


Health Literacy And Its Association With Human Papilloma Virus Vaccination Among Adults: Findings From The Behavioral Risk Factor Surveillance System, Vinodh Bhoopathi, Bhagavatula Pradeep, Maharaj Singh Oct 2022

Health Literacy And Its Association With Human Papilloma Virus Vaccination Among Adults: Findings From The Behavioral Risk Factor Surveillance System, Vinodh Bhoopathi, Bhagavatula Pradeep, Maharaj Singh

College of Nursing Faculty Research and Publications

Health literacy is associated with the utilization of preventive health services. We examined the association between health literacy (HL) levels and receipt of at least one dose of the human papilloma virus (HPV) vaccination. We analyzed the data from the 2016 Behavioral Risk Factor Surveillance System (BRFSS) among adults aged 18 to 32. The primary outcome variable was the ‘yes/no’ response to the question that assessed whether the participant received at least the first dose of HPV vaccination. The primary independent variable was a summative HL score (range 3 through 12) we created for each respondent by adding the scores …


The Association Of Preoperative Frailty And Neighborhood-Level Disadvantage With Outcome In Patients With Newly Diagnosed High Grade Glioma, Pranav Mirpuri, Maharaj Singh, Richard Rovin Oct 2022

The Association Of Preoperative Frailty And Neighborhood-Level Disadvantage With Outcome In Patients With Newly Diagnosed High Grade Glioma, Pranav Mirpuri, Maharaj Singh, Richard Rovin

College of Nursing Faculty Research and Publications

Objective

Individual patient and socioeconomic factors are underexplored prognostic factors for glioblastoma (GBM). Frailty, a measure of physiological vulnerability, and area deprivation, a measure of socioeconomic status, are easily obtained during the preoperative evaluation. These metrics are predictors of outcome and access to treatments for other cancers. Therefore, we sought to determine the association of frailty and neighborhood disadvantage with outcomes of patients with newly diagnosed GBM.

Methods

This was a retrospective review of newly diagnosed patients with GBM undergoing surgery from 2015 through 2020. The 5-factor modified frailty index and national area deprivation index were determined for each patient. …


Defining Foundational Competence For Prelicensure And Graduate Nursing Students: A Concept Analysis And Conceptual Model, Katie L. Mcdermott, Kristina Dreifuerst Oct 2022

Defining Foundational Competence For Prelicensure And Graduate Nursing Students: A Concept Analysis And Conceptual Model, Katie L. Mcdermott, Kristina Dreifuerst

College of Nursing Faculty Research and Publications

Aim

To define the concept of foundational competence as it pertains to prelicensure and graduate nursing students during their educational program, thereby informing pedagogical and assessment practices.

Background

Competence has many definitions and uses, however a lack of consensus of a clear and useful definition in nursing persists. Without shared language, competence remains open for interpretation across and among groups and impedes the ability to teach and assess it in a competency-based education framework.

Method

Using the Walker & Avant method of concept analysis, literature was reviewed and synthesized to define and explain the concept of foundational competence in nursing …


Causal Evidence For A Role Of Cerebellar Lobulus Simplex In Prefrontal-Hippocampal Interaction In Spatial Working Memory Decision-Making, Yu Liu, Samuel S Mcafee, Meike E Van Der Heijden, Mukesh Dhamala, Roy V Sillitoe, Detlef H Heck Oct 2022

Causal Evidence For A Role Of Cerebellar Lobulus Simplex In Prefrontal-Hippocampal Interaction In Spatial Working Memory Decision-Making, Yu Liu, Samuel S Mcafee, Meike E Van Der Heijden, Mukesh Dhamala, Roy V Sillitoe, Detlef H Heck

Duncan NRI Faculty and Staff Publications

Spatial working memory (SWM) is a cerebrocerebellar cognitive skill supporting survival-relevant behaviors, such as optimizing foraging behavior by remembering recent routes and visited sites. It is known that SWM decision-making in rodents requires the medial prefrontal cortex (mPFC) and dorsal hippocampus. The decision process in SWM tasks carries a specific electrophysiological signature of a brief, decision-related increase in neuronal communication in the form of an increase in the coherence of neuronal theta oscillations (4-12 Hz) between the mPFC and dorsal hippocampus, a finding we replicated here during spontaneous exploration of a plus maze in freely moving mice. We further evaluated …


Semiautomated Analysis Of An Optical Atp Indicator In Neurons, Taher Dehkharghanian, Arsalan Hashemiaghdam, Ghazaleh Ashrafi Oct 2022

Semiautomated Analysis Of An Optical Atp Indicator In Neurons, Taher Dehkharghanian, Arsalan Hashemiaghdam, Ghazaleh Ashrafi

2020-Current year OA Pubs

No abstract provided.


Barbara Lynette Thomas Oct 2022

Barbara Lynette Thomas

African American Funeral Programs

Barbara_-Lynette-_Thomas.pdf - Funeral program for Barbara Lynette Thomas


Response To Brentuximab Vedotin By Cd30 Expression In Non-Hodgkin Lymphoma, Deepa Jagadeesh, Steve Horwitz, Nancy L Bartlett, Youn Kim, Eric Jacobsen, Madeleine Duvic, Meredith Little, William Trepicchio, Keenan Fenton, Matthew Onsum, Julie Lisano, Ranjana Advani Oct 2022

Response To Brentuximab Vedotin By Cd30 Expression In Non-Hodgkin Lymphoma, Deepa Jagadeesh, Steve Horwitz, Nancy L Bartlett, Youn Kim, Eric Jacobsen, Madeleine Duvic, Meredith Little, William Trepicchio, Keenan Fenton, Matthew Onsum, Julie Lisano, Ranjana Advani

2020-Current year OA Pubs

BACKGROUND: The safety and efficacy of brentuximab vedotin (BV), an antibody-drug conjugate directed to the CD30 antigen, has been assessed in several trials in patients with peripheral T-cell lymphoma (PTCL), cutaneous T-cell lymphoma (CTCL), or B-cell non-Hodgkin lymphoma (NHL). The objective of this research was to examine the relationship between CD30 expression level and clinical response to BV.

PATIENTS AND METHODS: We analyzed response in patients treated with BV monotherapy in 5 prospective clinical studies in relapsed or refractory PTCL, CTCL, or B-cell NHL. CD30 expression was assessed by immunohistochemistry (IHC) using the Ber H2 antibody for 275 patients.

RESULTS: …


Khirbat Safra (2020-2021), Paul Z. Gregor, Paul Ray, Robert D. Bates, Trisha Broy, Talmadge Gerald Oct 2022

Khirbat Safra (2020-2021), Paul Z. Gregor, Paul Ray, Robert D. Bates, Trisha Broy, Talmadge Gerald

Faculty Publications

No abstract provided.


A Proposed Sec Cyber Data Disclosure Advisory Commission, Lawrence J. Trautman, Neal Newman Oct 2022

A Proposed Sec Cyber Data Disclosure Advisory Commission, Lawrence J. Trautman, Neal Newman

Faculty Scholarship

Constant cyber threats result in: intellectual property loss; data disruption; ransomware attacks; theft of valuable company intellectual property and sensitive customer information. During March 2022, The Securities and Exchange Commission (SEC) issued a proposed rule addressing Cybersecurity Risk Management, Strategy, Governance, and Incident Disclosure, which requires: 1. Current reporting about material cybersecurity incidents; 2. Periodic disclosures about a registrant’s policies and procedures to identify and manage cybersecurity risks; 3. Management’s role in implementing cybersecurity policies and procedures; 4. Board of directors’ cybersecurity expertise, if any, and its oversight of cybersecurity risk; 5. Registrants to provide updates about previously reported cybersecurity …


Content Moderation As Surveillance, Hannah Bloch-Wehba Oct 2022

Content Moderation As Surveillance, Hannah Bloch-Wehba

Faculty Scholarship

Technology platforms are the new governments, and content moderation is the new law, or so goes a common refrain. As platforms increasingly turn toward new, automated mechanisms of enforcing their rules, the apparent power of the private sector seems only to grow. Yet beneath the surface lies a web of complex relationships between public and private authorities that call into question whether platforms truly possess such unilateral power. Law enforcement and police are exerting influence over platform content rules, giving governments a louder voice in supposedly “private” decisions. At the same time, law enforcement avails itself of the affordances of …


The Relationship Between Performance, Body Composition, And Processing Yield In Broilers: A Systematic Review And Meta-Regression, Diego A. Martinez, Jordan T. Weil, Nawin Suesuttajit, Cole Alan Umberson, Abdullah Scott, Craig N. Coon Oct 2022

The Relationship Between Performance, Body Composition, And Processing Yield In Broilers: A Systematic Review And Meta-Regression, Diego A. Martinez, Jordan T. Weil, Nawin Suesuttajit, Cole Alan Umberson, Abdullah Scott, Craig N. Coon

Poultry Science Faculty Publications and Presentations

This study aims to model the relationship among performance, whole body composition, and processing yield through meta-regression. Scientific papers found in Scopus and Google Scholar were included if they reported results and variability values of an actual experiment in the three mentioned groups of variables using a single broiler genetic line. Weighted mean effect sizes were determined with a random model, the risk of bias was determined, and heterogeneity was considered an indicator of usefulness. Meta-regressions considered the effect sizes of the response variable and the percent change in one or more variables as predictors. A 78-row database was built …


Interaction Between The Hypothalamo-Pituitary-Adrenal And Thyroid Axes During Immobilization Stress, Hakeem J. Kadhim, Wayne J. Kuenzel Oct 2022

Interaction Between The Hypothalamo-Pituitary-Adrenal And Thyroid Axes During Immobilization Stress, Hakeem J. Kadhim, Wayne J. Kuenzel

Poultry Science Faculty Publications and Presentations

The location of corticotropin-releasing hormone receptor 2 (CRH-R2) on thyrotropes within the avian anterior pituitary (APit) and its activation by different stressors indicate a possible communication between hypothalamo-pituitary-adrenal (HPA) and thyroid (HPT) axes. Therefore, an experiment was designed to 1) compare the timing of major components of the HPT axis to those of the HPA axis; 2) address whether stressors activating the HPA axis may simultaneously upregulate components of the HPT axis. Blood, brain, and APit were sampled from chicks prior to stress (control) and 15, 30, 60, 90, and 120 min following immobilization (IM) stress. The nucleus of the …


The Administrative Agon: A Democratic Theory For A Conflictual Regulatory State, Daniel E. Walters Oct 2022

The Administrative Agon: A Democratic Theory For A Conflictual Regulatory State, Daniel E. Walters

Faculty Scholarship

A perennial challenge for the administrative state is to answer the “democracy question”: how can the bureaucracy be squared with the idea of self-government of, by, and for a sovereign people with few direct means of holding agencies accountable? Scholars have long argued that this challenge can be met by bringing sophisticated thinking about democracy to bear on the operation of the administrative state. These scholars have invoked various theories of democracy—in particular, pluralist, civic republican, deliberative, and minimalist theories—to explain how allowing agencies to make policy decisions is consistent with core ideas about what democracy is.

There is a …


The Uniform Commercial Code Survey: Introduction, Jennifer S. Martin, Colin P. Marks, Wayne Barnes Oct 2022

The Uniform Commercial Code Survey: Introduction, Jennifer S. Martin, Colin P. Marks, Wayne Barnes

Faculty Scholarship

The survey that follows highlights the most important developments of 2021 dealing with domestic and international sales of goods, personal property leases, payments, letters of credit, documents of title, investment securities, and secured transactions.


Beyond Bristol-Myers : Personal Jurisdiction Over Class Actions, Adam N. Steinman Oct 2022

Beyond Bristol-Myers : Personal Jurisdiction Over Class Actions, Adam N. Steinman

Faculty Scholarship

The Supreme Court's 2017 decision in Bristol-Myers Squibb Co. v. Superior Court threatens a sea change in the relationship between personal jurisdiction and aggregate litigation. The most crucial concern has been what the decision means for class actions. Must a court subject the claims of every unnamed class member to separate jurisdictional scrutiny? If so, it could be impossible for a plaintiff who sues in her home state to represent class members outside that state; instead, the Constitution would permit multi-state or nationwide class actions only in states where the defendant is subject to general jurisdiction. For claims against a …


The Trouble With Court-Packing, Neil S. Siegel Oct 2022

The Trouble With Court-Packing, Neil S. Siegel

Faculty Scholarship

Wide-ranging public discussion of U.S. Supreme Court reform implicates fundamental questions of constitutional policy, norms, and law. This Article focuses on the reform proposal that poses the greatest threat to judicial legitimacy and independence: Court-packing. This Article contends that there has likely been a constitutional convention against Court-packing for a long time now, although it is uncertain whether the convention continues to exist given Senate conduct since 2016. This Article also maintains that Court-packing is not as free from constitutional difficulty as the conventional wisdom holds, even if the arguments for its constitutionality are stronger on balance. Most importantly, this …


High Polygenic Risk Scores Are Associated With Early Age Of Onset Of Alcohol Use Disorder In Adolescents And Young Adults At Risk, John I Nurnberger Jr, Kathleen Bucholz, Laura Bierut, Vivia Mccutcheon, Andrey P Anokhin, Et Al. Oct 2022

High Polygenic Risk Scores Are Associated With Early Age Of Onset Of Alcohol Use Disorder In Adolescents And Young Adults At Risk, John I Nurnberger Jr, Kathleen Bucholz, Laura Bierut, Vivia Mccutcheon, Andrey P Anokhin, Et Al.

2020-Current year OA Pubs

BACKGROUND: Genome-wide association studies have been conducted in alcohol use disorder (AUD), and they permit the use of polygenic risk scores (PRSs), in combination with clinical variables, to predict the onset of AUD in vulnerable populations.

METHODS: A total of 2794 adolescent/young adult subjects from the Collaborative Study on the Genetics of Alcoholism were followed, with clinical assessments every 2 years. Subjects were genotyped using a genome-wide chip. Separate PRS analyses were performed for subjects of European ancestry and African ancestry. Age of onset of DSM-5 AUD was evaluated using the Cox proportional hazard model. Predictive power was assessed using …