Digital Commons Network^™

10-Minute Ebd: Should Chipped Or Worn Dental Sealants Be Observed, Touched Up, Or Restored?, Elliot Abt Dds, Ms, Msc

The Journal of the Michigan Dental Association

This column discusses the management of chipped or worn dental sealants in a 22-year-old patient seeking a second opinion. The author explores the need for occlusal restorations, sealant repair, or no treatment for such cases. A literature search, guided by a PICO question, reveals strong evidence supporting sealant effectiveness in preventing caries. The Cochrane review found an 88% reduction in caries odds with sealants. Clinical guidelines and systematic reviews from organizations like the American Dental Association (ADA) further endorse sealant use. The column emphasizes the importance of universal sealant application and highlights challenges in their adoption, such as concerns over …

Eye Safety In Dentistry, Marie T. Fluent Dds, Cdipc

The Journal of the Michigan Dental Association

In this article, Dr. Fluent underscores the importance of eye safety from vision loss that ended her clinical dental career. The article emphasizes the prevalence of ocular injuries in occupational settings, with about 2,000 U.S. workers suffering job-related eye injuries daily. Dental professionals face multiple eye hazards, including flying debris, chemicals, and infectious materials. Protective eyewear is crucial, with the CDC and OSHA recommending its use.

A significant concern is the "bottom gap" in protective eyewear, which exposes dental personnel to risks. The article introduces a new ANSI standard, ANSI/ISEA Z87.62-2021, to standardize eye and face protection against bloodborne pathogens …

Dentistry And The Law: Dealing With Patients Who Have Been Using Marijuana, Dan Schulte Jd

The Journal of the Michigan Dental Association

When dealing with patients who emit a strong marijuana odor, it's crucial to focus on their capacity to provide informed consent and the ability to deliver treatment up to the standard of care. Judging their level of intoxication solely by appearance and smell can be unreliable, so it's best to avoid making such judgments. Instead, inform patients that you may refuse treatment if their odor or other factors hinder your ability to provide care. To prevent last-minute issues, communicate this policy in advance, particularly to patients with a history of marijuana odor. Dismissing such patients from your practice may also …

Protect Yourself From Occupational Risks, Christopher J. Smiley Dds

The Journal of the Michigan Dental Association

This month’s editorial underscores the importance of safeguarding against occupational risks in dentistry. Dr. Smiley shares personal experiences, highlighting potential hazards to oral health care workers' eyes and hearing, including intense lights, noisy equipment, and exposure to infectious pathogens. He emphasizes the need for protective eyewear, light shields, and equipment calibration to reduce eye-related risks and the use of custom musician earplugs to reduce the risk of job-related hearing damage. The overall message stresses that taking steps to protect oneself from occupational risks can preserve the quality of life and a professional career.

Mda At Your Service: What Is The Recommendation Regarding Prescribing Clindamycin?, Eric Tye Dds, Angela Kanazeh Ms, Cmp

The Journal of the Michigan Dental Association

The MDA at Your Service Column addresses member resources available from the MDA. This month presents guidance in prescribing practices, particularly regarding clindamycin. Clindamycin’s association with an increased risk of antibiotic-associated diarrhea, including Clostridioides difficile (C. diff) infection, has increased. The report highlights how to access an ADA clinical guideline, its preference for azithromycin over clindamycin, and the warning associated with prescribing clindamycin. Further reference is available in the August 2020 MDA Journal article "Antibiotic Guidelines for Dentistry: Who, When, What, Why and How to Prescribe,” by Elaine Bailey, PharmD, and Marie Fluent, DDS. Additional member resources discussed in this …

Staff Matters: Do You Have Quiet Quitters In Your Practice?, Jodi Schafer Sphr, Shrm-Scp

The Journal of the Michigan Dental Association

In the post-COVID workplace, "quiet quitting" has become a concerning issue where employees meet basic job requirements but lack motivation. This behavior includes a reluctance to take on extra tasks or provide input. To address it, communicate with the affected employees, inquire about their well-being, and assess whether the cause is work-related or personal. Fostering appreciation, connection to the practice's goals, and open feedback can help re-engage employees. Regular one-on-one meetings promote relationships and demonstrate care for their success, improving morale and engagement.

Association Of Prior Periodontal Disease With Cancer – Exploring Epidemiologic Evidence Of Periodontal Exudate-Exposed Site Cancer Risk Versus Remote Gastrointestinal Sites, Asma Alzahrani

Theses and Dissertations

Background: Periodontal disease, a chronic bacterial infection of the gums, if untreated, causes chronic inflammation over years and eventual tooth loss. The associations between periodontal disease (measured by missing teeth) and certain sites of cancer have been established, in epidemiological studies, and attributed to systemic inflammatory impacts causing carcinogenic change over decades. Because periodontal exudates are toxic, containing locally bioactive bacteria and toxins, this study hypothesized and studied the potential higher cancer risk of anatomic sites exposed to oral exudates (exudate-exposed site cancers (EEC); head and neck, oral, pharynx, larynx, esophagus, stomach). The study studied the risk of exudate exposed …

Speculative Pasts: American Historical Fiction In An Age Of Empire, Gregory William Deinert

Theses and Dissertations

This study identifies a new generic form termed here the “Speculative Historical Novel” within contemporary American fiction. The works that Speculative Pasts collect all agonize over the erasure of the past, and question how we can incorporate history into the present while accepting that full recuperation may be impossible. In their emphasis on the erasure of the past, these novels trace the manifold silences created by the imperial conquest of the New World and articulate how this past continues to structure the lived experiences of everyone on this continent.

This speculation is, on the one hand, necessarily suppositional. When faced …

Deciphering The Molecular Circuitry That Controls Iron Regulation In Non-Pathogenic Yeast, Debolina Hati

Theses and Dissertations

The trace metal iron is essential for the survival of almost all living organisms. It is a co-factor for many proteins involved in a variety of vital functions such as respiration, nitrogen fixation, and DNA biosynthesis, to name a few. Iron homeostasis in non-pathogenic fungi such as Schizosaccharomyces pombe has been extensively studied over the past few decades to better understand how intracellular iron is regulated under different environmental conditions. Iron regulation in S. pombe is controlled by two Fe-responsive transcriptional repressors known as Php4 and Fep1. Both rely on iron-sulfur (Fe-S) clusters as signals to balance iron acquisition, storage, …

Coastal Stormwater Pond Pollutants And The Potential For Development Of Antimicrobial Resistance In Vibrio And Enterococcus Bacteria, Cassandra L. Horton

Theses and Dissertations

The Southeastern coastal plain is the most rapidly urbanizing region in the United States. Associated landscape changes which increase imperviousness lead to hydrological cycle alterations, increasing runoff of nonpoint source (NPS) pollution. Urban and agricultural NPS runoff is generally discharged into stormwater ponds, which sequester chemical contaminants, nutrients, and microbes to reduce loading into coastal ecosystems. Studies of these ponds have indicated elevated levels of trace metals, antimicrobial compounds, and bacterial contamination (SCSGC 2018).

Interactions of aquatic pathogens Vibrio vulnificus and Enterococcus faecium with trace metals (arsenic, copper, zinc) and clinically relevant antimicrobials (triclosan, ciprofloxacin, oxytetracycline) commonly found in coastal …

Extensions Of Discrete Choice Experiment Theory For Public Health, Farahnaz Islam

Theses and Dissertations

A discrete choice experiment (DCE) allows researchers to understand how individuals value characteristics of a product or service in hypothetical scenarios and the trade-offs these individuals are willing to make between these characteristics. DCEs quickly gained traction in public health but as more researchers utilized DCEs in broader contexts, several methodological questions have arisen. This dissertation addresses some of these gaps in the literature.

One critique of DCEs is whether individuals would make the same choice in reality as they claimed they would have made in the hypothetical scenario. Perhaps the most efficient way to evaluate the predictive value of …

Assessment Of The Quality Of Emergency Obstetric Care In Public Hospitals In Bangladesh: Evidence From The National Health Facility Assessment Survey, Kaji Korotki

Theses and Dissertations

INTRODUCTION: The quality of obstetric care is low in Bangladesh, especially at the sub-district level, and below sub-district level facilities such as union health centers and community clinics. Using nationally representative health facility assessment survey data, this study assessed the change in the quality of basic and comprehensive obstetric care in terms of human resources, equipment, and service availability at sub-district public health facilities in 2014 and 2017.

METHODS: Based on Donabedian’s model of quality of care (QoC), the quality of comprehensive delivery care was measured using an index of 9 indicators known as Signal Functions (SF), while basic obstetric …

Novel Dietary Index For Gut Microbiota And Associations With Colorectal Cancer And Breast Cancer Risk, Bezawit Eyob Kase

Theses and Dissertations

Introduction: Diet serves as a driving force for shaping the gut microbiome. Understanding how diet may modify gut microbiota and subsequently may be associated with chronic disease is critical to public health prevention efforts. Aims: We aimed to develop a novel dietary index that captures the quality of diet with respect to attaining beneficial composition and function of gut microbiota. We then examined the relationship between the dietary index and two gut microbiota-related cancers, i.e., colorectal and breast cancers.

Methods: We conducted a systematic review of studies that examined the effect of foods on gut microbiota in adult populations. Dietary …

Mechanistic Insights Into An Iron-Responsive Repressor, Fep1, From Schizosaccharomyces Pombe, Allison Nicole Kimsey

Theses and Dissertations

Iron is an essential metal cofactor required for a variety of biochemical pathways in most living organisms. In recent years, the nonpathogenic fungi Schizosaccharomyces pombe has been used to study iron regulation and uncover the molecular mechanisms for controlling intracellular iron levels. Some of these regulation pathways are conserved with those of pathogenic fungi, making these studies applicable for the future development of antifungals that target iron homeostasis. In S. pombe, the GATA-type transcriptional repressor Fep1 is responsible for repressing iron uptake genes during times of iron abundance. Previous reports have proposed that the binding of an iron-sulfur (Fe-S) …

Spatial And Age Disparities In Covid-19 Outcomes, Qian Huang

Theses and Dissertations

COVID-19 has caused significant social, economic, environmental, and political impacts globally and affected communities unequally in the U.S. The pandemic has also sparked interest in age-specific manifestations of infection, for example, studies confirmed the risk of increasing age with COVID-19 severity. However, the nonstationarity effects of health determinants among age groups have not been well examined. This study aims to explore the nonstationarity effects of social, behavioral, environmental, health care access, and political contexts on COVID-19 outcomes. This study poses three broad questions: 1) how did COVID-19 vaccinations align with COVID-19 daily cases and deaths in the United States; 2) …

The Night’S Last Howl, Victoria Genevieve Mullis

Theses and Dissertations

The following collection of poems works through memory, peeling back the speaker’s relationship to the self, nature, and the mother. With each poem, time is relative; the speaker exists both then and now. There are, as the speaker discovers, multiple selfs of which they identify: the dreamer, the daughter, the therapy patient, the stranger. Consider each poem a self.

Liquid Phase Modeling In Metal Catalysis And In Zeolites, Subrata Kumar Kundu

Theses and Dissertations

Liquid phase processing is often desired for selective product formation, such as during catalytic conversion of biomass, and for purification of waste-water streams. Since the liquid phase environment influences the adsorption properties and reactivity of solid catalysts and porous materials, significant performance changes have been observed as a function of solvent properties for various industrial catalytic and separation processes. There is a need to better understand these solvation effects on processes at solid-liquid interfaces and to develop novel multiscale models that permit one to explore solvation effects on surface catalyzed reactions and during adsorption in porous media such as zeolites. …

Uncovering The Diverse Roles Of The Human Cst (Ctc1-Stn1-Ten1) Complex In Resolving Genomic Stress, Percy Logan Schuck

Theses and Dissertations

The CST (CTC1-STN1-TEN1) complex is a heterotrimeric single-stranded DNA binding protein known to stimulate polymerase α-primase (Pol α) and promote telomere length regulation, genome-wide DNA replication and double strand break repair. However, much of its cellular function remains unknown. The focus of my dissertation work was to uncover novel roles of CST in DNA stress response pathways. In particular, my work relates to understanding the function of CST in sister chromatid cohesion (SCC) and base excision repair (BER) as well as characterizing CST protein interactions. SCC is established following DNA replication by loading of the cohesion complex, which encircles replicated …

Development Of Peptidomimetic Inhibitors Targeting The Polo Box Domain Of Plk1 As Potential Cancer Therapeutics, Jessy Mariam Stafford

Theses and Dissertations

PLK1 overexpression has shown to be associated with tumor progression and an unfavorable prognosis in a wide variety of cancer types. Interfering with PLK1 genetically and chemically induces apoptotic cell death in cancer cells thus confirming PLK1 as a validated anticancer target. From a drug discovery perspective, PLK1 offers two functionally distinct, essential, and interconnected target sites in one molecule. These are the ATP binding kinase domain (KD) and the unique Polo Box Domain (PBD), where the interplay between these results in dynamic structural regulation of catalytic activity and sub cellular localization. Since the KD is conserved among kinases and …

Changes In The Regulation Of The Unfolded Protein Response During Aging In Peromyscus, Elham Soltanmohammadi

Theses and Dissertations

Endoplasmic reticulum (ER) stress has been linked to various metabolic pathologies, neurodegeneration, and aging. Although various mechanistic aspects of the resulting unfolded protein response (UPR) have been elucidated, its regulation in genetically diverse populations remains elusive. In the present study we evaluated the expression of chaperones BiP/GRP78, GRP94 and calnexin (CANX) in the lungs, liver, and brain of 7 months old and 2–3 years old outbred deer mice P. maniculatus and P. leucopus. Chaperones’ _expression was highly variable between species, tissues and ages suggesting that levels of expression of individual chaperones do not change consistently during aging. Despite this variation, …

Topics In Multilevel Mediation Analysis, Chung Li Wu

Theses and Dissertations

A proper study design assures adequate power to detect statistically significant differences. Existing power calculations for multilevel mediation analysis make a strong distributional assumption of normality. However, binary outcomes are commonly seen in real-world study. Motivated by this fact, we conduct a simulation-based power study for a multilevel mediation analysis with binary outcomes. The numbers of participants needed to achieve 80% power are summarized in tables for future reference.

Mixed-effect regression is commonly used in multilevel analysis for panel data. Yet, the estimated coefficients from the random-intercept model could represent either purely between-cluster, purely within-cluster, or weighted-average effects. Therefore, we …

Characterization Of The Interaction Between Grx4-Bol2 And The Iron-Responsive Transcription Factor Aft1 In Candida Glabrata, Evan A. Talib

Theses and Dissertations

Iron is an indispensable protein cofactor that plays a critical role in biological functions such as cellular respiration. However, excess iron causes cellular damage via the generation of reactive oxygen species. To obtain optimal intracellular iron levels, eukaryotic cells have developed mechanisms to tightly regulate iron levels. The molecular mechanism for iron regulation in the pathogenic yeast Candida glabrata has not yet been explored, although this yeast bears iron regulation pathways that are very similar to the model yeast Saccharomyces cerevisiae. Understanding how C. glabrata regulates iron levels is critical for the treatment of infections caused by this opportunistic …

Identifying Racial Differences In Colorectal Polyp Profile At Screening Colonoscopy Using Traditional Regression And Machine Learning Approaches, Yuqi Wu

Theses and Dissertations

Background

Colorectal cancer (CRC), the second leading cause of cancer and cancer deaths in the United States, can largely be prevented by screening the age-appropriate adult population with colonoscopy to remove precancerous lesions. However, despite the encouraging annual, population-wide decline in CRC incidence and mortality in recent decades, and widespread adoption of screening colonoscopy since 2000 (~60% population coverage rate), the Black population has consistently suffered higher CRC incidence and mortality than Whites, currently 20% and 40% respectively, little changed from the 2000 rats of 26% and 52%.

The reason for this is thought to be that the Black population …

Sleep Challenges And Temperament Among Infants At Elevated Likelihood Of Autism Spectrum Disorder, Miranda Hope Foster

Theses and Dissertations

The current study used parent report in a prospective longitudinal design to examine the relationship between early sleep difficulties and temperament among infants with an older sibling diagnosed with ASD (EL-ASIB, n = 32), those born pre-term (EL-PT, n = 24) and those with no familial history of ASD (LL, n = 28) across the first year of life. At 3, 4, 6 and 12 months, caregivers completed the Short Form of the Infant Behavior Questionnaire-Revised (IBQ-R) (Putnam et al., 2014). To understand how sleep difficulties are related to temperament, a new scale of Sleep Challenges was created with items …

Motivation And Interest In Participation In Stem Beyond The Classroom Experiences: Effects Of Blended Learning Systems On High School Students, Michael Owdij

Theses and Dissertations

Beyond the classroom experiences are useful learning endeavors designed to help students connect classroom learning to the real world (Kilgo et al., 2015). The purpose of this action research was to evaluate the effect of a technology-based blended learning system on student motivation and interest in participation in beyond the classroom experiences. The blended learning system was offered to STEM-focused junior and senior students who attended a New Jersey high school. The focus of the study was centered around the following questions: How does interest in participation in beyond the classroom experiences change after STEM-focused high school students participate in …

Experimental Investigations Of Yarn Pull-Out Behavior In Kevlar®: Influence Of Applied Metallic Coatings And Effect Of Dynamic Loading, Julie Ann Roark

Theses and Dissertations

Flexible woven Kevlar® textile fabrics are widely used in protective armor applications. Yarn pull-out, comprised of yarn uncrimping (i.e., straightening) and yarn translation, is a major energy absorption mechanism during ballistic impact onto these fabrics, especially for impact velocities below the ballistic limit. Yarn pull-out is influenced by various parameters including inter-yarn friction, pull-out distance, pull-out velocity, transverse pre-tension, fiber diameter, fabric architecture, fabric waviness, fabric count and yarn modulus.

The first part of this thesis investigates yarn pull-out behavior of commercially available Kevlar® KM2+ individual yarns coated with metallic layers (copper, aluminum, aluminum nitride, silver) via a directed vapor …

The Optimization Of Anion Exchange Membrane Fuel Cells And Water Electrolyzers By Varying Catalyst Design And Changing Gas Inlet Composition, Jasmine D. Bohannon

Theses and Dissertations

Researchers around the globe are looking to avoid the consequences of climate change by shifting away from the burning of fossil fuels as a source of energy. While using fossil fuels have negatively affected the earth’s climate for at least the last hundred and fifty years, the introduction of renewables looks to use abundant and naturally occurring resources. Sources of renewable energy include solar power, wind power, hydropower, geothermal energy, and biomass2 . These sources work by converting the abundant source into mechanical, electrical, or chemical energy that can be used to power industrial plants or residential areas and they …

Implementing A Technology-Based Instructional Module In An Introduction To Engineering Course: The Impact On Student’S Vocabulary Retention And Attitudes Towards Learning, Robin T. Amick

Theses and Dissertations

The purpose of this study was to evaluate the academic impact of a technology-based instructional module for content vocabulary instruction in the Project Lead the Way (PLTW) Introduction to Engineering course. The goal of the study was to answer two key questions: 1) How does implementing a technology-based instructional module impact Engineering vocabulary academic gains for students taking the Introduction to Engineering course? and 2) What is the effect of implementing a technology-based instructional model on attitudes towards learning Engineering vocabulary for students taking the Introduction to Engineering course? This study was conducted with Introduction to Engineering students (N …

Memristive Ising Circuits, Vincent James Dowling

Theses and Dissertations

Resistance random access memory (ReRAM) cells are emerging passive components showing great promise for applications in non-volatile storage, in-memory computing, and neuromorphic circuits, to name a few. Various experimental ReRAM cells have demonstrated excellent characteristics. This includes nanoscale size, short read and write times, and small energy requirements needed to manipulate the information. The main obstacles preventing the widespread adoption of ReRAM technology are significant device-to-device and cycle-to-cycle variability.

In essence, ReRAM cells are resistors with memory whose state (resistance) can be changed by an applied signal such as voltage. Many models were developed for describing their response. These range …

Natural Variation Of Fructose-1,6-Bisphosphatase In Colias Butterflies, Andrea Blair Stokes

Theses and Dissertations

In a process known as the evolutionary recursion, it is possible to follow how adaptation affects natural selection at successive stages of a species’ life cycle. Through studying allele and genotype frequencies of enzymes in glycolysis, a central metabolic pathway, it is possible to document how polymorphisms can shift the evolving functionality of enzymes within or among species. Fructose-1,6-bisphosphatase (FBPase) is an enzyme in gluconeogenesis that converts fructose-1,6-bisphosphate to fructose 6- phosphate. It is also known to convert the unused amino acid carbon skeletons of glycolysis into glycogen storage. Appearing to play a vital role in the acquisition, storage, and …