Digital Commons Network^™

Characterization Of The Long Non-Coding Rna Proins In Human Pancreatic Β-Cell, Shareena Saeed Lootah

Dissertations

It is well established that the genome is pervasively transcribed. Only 2% of those transcripts are translated into proteins, and the remaining 98% are non-translated, generating the non-coding RNAs (ncRNAs) species. A close observation of these transcripts directed the scientific community to their increasing potential functional roles in the cells. Indeed, the literature exponentially unveils this notion, with many ncRNAs showing substantial and variable biological functions. The field is in its infancy; however, efforts are accelerating to discover and define this ocean of new species.

Long non-coding RNAs (lncRNAs) are sub-species of ncRNAs with an arbitrary size of more than …

Distance Based Image Classification: A Solution To Generative Classification’S Conundrum?, Wen-Yan Lin, Siying Liu, Bing Tian Dai, Hongdong Li

Research Collection School Of Computing and Information Systems

Most classifiers rely on discriminative boundaries that separate instances of each class from everything else. We argue that discriminative boundaries are counter-intuitive as they define semantics by what-they-are-not; and should be replaced by generative classifiers which define semantics by what-they-are. Unfortunately, generative classifiers are significantly less accurate. This may be caused by the tendency of generative models to focus on easy to model semantic generative factors and ignore non-semantic factors that are important but difficult to model. We propose a new generative model in which semantic factors are accommodated by shell theory’s [25] hierarchical generative process and non-semantic factors by …

Singapore Public Sector Ai Applications Emphasizing Public Engagement: Six Examples, Steven M. Miller

Research Collection School Of Computing and Information Systems

This article provides an overview of six examples of public sector AI applications in Singapore that illustrate different ways of enhancing engagement with the public. These applications demonstrate ways of enhancing engagement with the public by providing greater accessibility to government services (access anywhere, anytime) and speedier responses to public processes and feedback. Some applications make it substantially easier for members of the public to do things or make choices, while others reduce waiting time, either across an entire public infrastructure, or for an individual transaction. Some provide highly individualized coaching to guide a person through the process of doing …

Secure Hierarchical Deterministic Wallet Supporting Stealth Address, Xin Yin, Zhen Liu, Guomin Yang, Guoxing Chen, Haojin Zhu

Research Collection School Of Computing and Information Systems

Over the past decade, cryptocurrency has been undergoing a rapid development. Digital wallet, as the tool to store and manage the cryptographic keys, is the primary entrance for the public to access cryptocurrency assets. Hierarchical Deterministic Wallet (HDW), proposed in Bitcoin Improvement Proposal 32 (BIP32), has attracted much attention and been widely used in the community, due to its virtues such as easy backup/recovery, convenient cold-address management, and supporting trust-less audits and applications in hierarchical organizations. While HDW allows the wallet owner to generate and manage his keys conveniently, Stealth Address (SA) allows a payer to generate fresh address (i.e., …

Towards An Optimal Bus Frequency Scheduling: When The Waiting Time Matters, Songsong Mo, Zhifeng Bao, Baihua Zheng, Zhiyong Peng

Research Collection School Of Computing and Information Systems

Reorganizing bus frequencies to cater for actual travel demands can significantly save the cost of the public transport system. This paper studies the bus frequency optimization problem considering the user satisfaction. Specifically, for the first time to our best knowledge, we study how to schedule the buses such that the total number of passengers who could receive their bus services within the waiting time threshold can be maximized. We propose two variants of the problem, FAST and FASTCO, to cater for different application needs and prove that both are NP-hard. To solve FAST effectively and efficiently, we first present an …

Efficacy And Safety Of Acupuncture And Or Moxibustion For Managing Primary Dysmenorrhea: A Systematic Review And Meta-Analysis, Weiting Liu, Carol Chunfeng Wang, Khui Hung Lee, Xiaopeng Ma, Timothy Leen Kang

Research outputs 2022 to 2026

Acupuncture and moxibustion have been accepted as add-on options for primary dysmenorrhea (PD); however, the clinical evidence is still inadequate. We searched AMED, CENTRAL, EMBASE, PubMed, Web of Science, CBM, CNKI, VIP, Wangfang database, ANZCTR, ClinicalTrials.gov, and the WHO ICTRP, from their inception to February 2021. The pooled analysis of 13 RCTs with 675 participants for VAS showed that acupuncture and moxibustion were more effective in managing PD than the control group with the MD of −1.93 (95% CI [−2.80, −1.06] and −2.67 (95% CI [−4.96, −0.38]). With the CMSS, seven studies with 487 participants showed that these modalities were …

Systemic Perturbations Of The Kynurenine Pathway Precede Progression To Dementia Independently Of Amyloid-Β, Marcela Cespedes, Kelly R. Jacobs, Paul Maruff, Alan Rembach, Christopher J. Fowler, Brett Trounson, Kelly K. Pertile, Rebecca L. Rumble, Stephanie R. Rainey-Smith, Christopher C. Rowe, Victor L. Villemagne, Pierrick Bourgeat, Chai K. Lim, Pratishtha Chatterjee, Ralph N. Martins, Arne Ittner, Colin L. Masters, James D. Doecke, Gilles J. Guillemin, David B. Lovejoy

Research outputs 2022 to 2026

Increasing evidence suggests that kynurenine pathway (KP) dyshomeostasis may promote disease progression in dementia. Studies in Alzheimer's disease (AD) patients confirm KP dyshomeostasis in plasma and cerebrospinal fluid (CSF) which correlates with amyloid-β and tau pathology. Herein, we performed the first comprehensive study assessing baseline levels of KP metabolites in participants enrolling in the Australian Imaging Biomarkers Flagship Study of Aging. Our purpose was to test the hypothesis that changes in KP metabolites may be biomarkers of dementia processes that are largely silent. We used a cross-sectional analytical approach to assess non-progressors (N = 73); cognitively normal (CN) or mild …

Abdominal Aortic Calcification On Lateral Spine Images Captured During Bone Density Testing And Late-Life Dementia Risk In Older Women: A Prospective Cohort Study, Tenielle Porter, Marc Sim, Richard L. Prince, John T. Schousboe, Catherine Bondonno, Wai H. Lim, Kun Zhu, Douglas P. Kiel, Jonathan M. Hodgson, Simon M. Laws, Joshua R. Lewis

Research outputs 2022 to 2026

Background: Dementia after the age of 80 years (late-life) is increasingly common due to vascular and non-vascular risk factors. Identifying individuals at higher risk of late-life dementia remains a global priority. Methods: In prospective study of 958 ambulant community-dwelling older women ( ≥ 70 years), lateral spine images (LSI) captured in 1998 (baseline) from a bone density machine were used to assess abdominal aortic calcification (AAC). AAC was classified into established categories (low, moderate and extensive). Cardiovascular risk factors and apolipoprotein E (APOE) genotyping were evaluated. Incident 14.5-year late-life dementia was identified from linked hospital and mortality records. Findings: At …

Feasibility, Psychosocial Effects, Influence, And Perception Of Elastic Band Resistance Balance Training In Older Adults, Nichola M. Davis, Andy Pringle, Anthony D. Kay, Anthony J. Blazevich, Danielle Teskey, Mark A. Faghy, Minas A. Mina

Research outputs 2022 to 2026

This study utilised feedback from older adults during balance-challenging, elastic band resistance exercises to design a physical activity (PA) intervention. Methods: Twenty-three active participants, aged 51 – 81 years, volunteered to perform a mini balance evaluation test and falls efficacy scale, and completed a daily living questionnaire. Following a 10 min warm-up, participants performed eight pre-selected exercises (1 × set, 8 – 12 repetitions) using elastic bands placed over the hip or chest regions in a randomised, counterbalanced order with 15 min seated rests between interventions. Heart rate (HR) and rate of perceived exertion (RPE) were measured throughout. Participant interview …

Renewable And Recyclable Polymeric Materials For Food Packaging: A New Open Special Issue In Materials, Shima Jafarzadeh, Masoumeh Zargar, Mehrdad Forough

Research outputs 2022 to 2026

“Renewable and Recyclable Polymeric Materials for Food Packaging” is a new open Special Issue of Materials that will publish original and review papers on new scientific and applied research, and the articles it contains will make a contribution to the discovery and understanding of biodegradable and recyclable materials, their functional properties, characterization and applications.

The Molecular Basis Of Diabetic Cardiomyopath, Ahmed Salaheldin Mustafa Ali Sultan

Dissertations

Diabetes mellitus (DM) is a major and worsening global health problem. Type 2 diabetes mellitus (T2DM) accounts for more than 90% of DM and the global epidemic of obesity largely explains the dramatic increase in the incidence and prevalence of T2DM over the past 20 years. Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. The electrocardiogram (ECG) of diabetic and obese patients is frequently disturbed. The aim of this project was to characterize and clarify the molecular basis of electro-mechanical dysfunction in the hearts of type 2 diabetic and type 2 diabetic/obese rats. Experiments were …

The Equity Theory: A Quantitative Perspective Using Data Envelopment Analysis, Parto Ahmadpour-Samani, Hosein Arman, Amirali Foukerdi, Abdollah Hadi-Vencheh, Reza Kiani Mavi

Research outputs 2022 to 2026

Equity theory (ET) is an organizational theory investigating how fairly people feel they have been treated. The literature on ET does not address two essential questions: what is the magnitude of the equity that one may perceive compared to other members in an organization?, and how much should be the resources (outcomes) of an underpaid member reduced (increased) to feel equal? The group members may respond to these questions emotionally, and their answers could be biased based on their personalities. This paper proposes a novel method using data envelopment analysis (DEA) to quantify the ET and answer these questions more …

Whole-Genome Sequencing Links Clostridium (Clostridioides) Difficile In A Single Hospital To Diverse Environmental Sources In The Community, Su-Chen Lim, Deirdre Collins, Korakrit Imwattana, Daniel R. Knight, Sicilia Perumalsamy, Natasza M.R. Hain-Saunders, Papanin Putsathit, David Speers, Thomas Riley

Research outputs 2022 to 2026

To investigate if Clostridium (Clostridioides) difficile infection (CDI), traditionally thought of as hospital-acquired, can be genomically linked to hospital or community environmental sources, and to define possible importation routes from the community to the hospital.

In 2019, C. difficile was isolated from 89/300 (29.7%) floor and 96/300 (32.0%) shoe sole samples at a tertiary hospital in Western Australia. Non-toxigenic C. difficile ribotype (RT) 010 predominated among floor (96.6%) and shoe sole (73.2%) isolates, while toxigenic RT 014/020 was most prevalent among contemporaneous clinical cases (33.0%) at the hospital. Whole-genome sequencing and high-resolution core genome single nucleotide polymorphism (cgSNP) …

A Heuristic Approach To Predict The Tensile Strength Of A Non-Persistent Jointed Brazilian Disc Under Diametral Loading, Mostafa Asadizadeh, Nima Babanouri, Taghi Sherizadeh

Mining Engineering Faculty Research & Creative Works

The mechanical response of rock bridges plays a key role in the stability of concrete and rock structures. In particular, the tensile failure of non-persistent discontinuities can result in their coalescence and the failure of rock or concrete engineering structures. The effect of non-persistent joint parameters on rock structures' failure under tensile mode has not been investigated by many researchers yet. Many non-persistent jointed Brazilian concrete discs are tested under diametral loading in this work, to study the influence of joint spacing, joint continuity factor, loading direction with regard to joint angle, and bridge angle on their tensile behavior. Heuristic …

Wettability Alteration Process At Pore-Scale During Engineered Waterflooding Using Computational Fluid Dynamics, Yongqiang Chen, Ping Chang, Guang Xu, Quan Xie

Mining Engineering Faculty Research & Creative Works

Engineered waterflooding modifies chemistry of injected brine to efficiently and environmentally friendly enhance oil recovery. The common practice of engineered waterflooding includes low salinity waterflooding (LSW) and carbonated waterflooding. Among these oil recovery methods, wettability alteration has been perceived as a critical physicochemical process for additional oil recovery. While extensive work has been conducted to characterize the wettability alteration, the existing theory cannot explain the conflict oil recovery between secondary mode (injecting engineered water at the very beginning of flooding) and tertiary mode (injecting engineered water after conventional waterflooding), where secondary engineered waterflooding always gives a greater incremental oil recovery …

Products Pricing And Return Strategies For The Dual Channel Retailers, Jian Liu, Xinyue Sun, Yanyan Liu

Electrical and Computer Engineering Faculty Research & Creative Works

This paper analyzed how different return strategies and return rates affect dual-channel retailers' profits and channel pricings. Return can stimulate sales; however, the return has presented significant challenges to retailers. The return has long been studied to maximize profit and pricing; however, the different return strategies for dual-channel retailers affect channel both. This paper aimed to study whether or not dual-channel retailers should allow customers to return items in two channels and whether or not the retailer should contract with the manufacturers and pay extra fees to return products. This study indicated when the retailer should allow customers' returns to …

Effects Of Drying Temperature On Preparation Of Pectin Polysaccharide Thin Film For Resistive Switching Memory, Poh Liang Yap, Kuan Yew Cheong, Hooi Ling Lee, Feng Zhao

Electrical and Computer Engineering Faculty Research & Creative Works

Commercially purchased pectin powder was formulated and processed into a thin film with different drying temperatures (60 °C–180 °C) and subsequently, sandwiched between Ag and ITO as top and bottom electrodes, respectively, for resistive switching memory study. Chemical functional groups, surface roughness, elemental chemical composition, and cross-sectional morphology of the dried pectin thin film were investigated via Fourier transform infrared spectroscopy, atomic force microscopy, and high-resolution transmission electron microscopy-energy dispersive X-ray spectroscopy. The higher the drying temperature, the rougher the surface with less residual moisture and more defect sites within the thin film was observed. Current–voltage measurements together with the …

Estimating Flashpoints Of Fuels And Chemical Compounds Using Hybrid Machine-Learning Techniques, Farid Amirkhani, Amir Dashti, Hossein Abedsoltan, Amir H. Mohammadi, Abdoulmohammad Gholamzadeh Chofreh, Feybi Ariani Goni, Jiří Jaromír Klemeš

Chemical and Biochemical Engineering Faculty Research & Creative Works

Flashpoint of organic materials is a crucial physical property in industrial applications and laboratory experiments, which provides information on safety standards and needed precautions in handling various organic materials. Proposed methods to determine the flashpoint of an organic material suffer from dependency on other physical properties of the chemical or demand complicated calculations which are time-consuming. In this work, a direct system model is proposed to anticipate the flashpoints of organic materials for a wide range of chemical compounds. The following models of genetic algorithm-adaptive neuro-fuzzy inference system, the least-squares version of the support vector machine, particle swarm optimization-adaptive neuro-fuzzy …

The Depth Of Depravity And The Remedy Of An All-Embracing Life System, Joya S. Schreurs

Pro Rege

No abstract provided.

Christian Education: Can We Afford It?, Calvin Vandermeyden

Pro Rege

No abstract provided.

Wonderfully Made: A Protestant Theology Of The Body (Book Review), Alida Sewell

Pro Rege

Reviewed Title: Wonderfully Made: A Protestant Theology of the Body by John W. Kleinig. Bellingham, WA: Lexham Press, 2021. 235 pp. ISBN: 9781683594680.

Love Your Neighbor: The Church's Response To Individualism's Impact On Interpersonal Engagement, Anna Herman

Pro Rege

No abstract provided.

Constraints On The Very High Energy Gamma-Ray Emission From Short Grbs With Hawc, A. Albert, R. Alfaro, C. Alvarez, J. C. Arteaga-Velázquez, K. P. Arunbabu, D. Avila Rojas, H. A.Ayala Solares, R. Babu, E. Belmont-Moreno, C. Brisbois, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, O. Chaparro-Amaro, U. Cotti, J. Cotzomi, S. Coutiño De León, C. De Leon, E. De La Fuente, R. Diaz Hernandez, S. Dichiara, B. L. Dingus, M. A. Duvernois, M. Durocher, J. C. Diaz-Velez, K. Engel, C. Espinoza, K. L. Fan, N. Fraija, A. Galvan-Gamez, J. A. Garcia-Gonzalez, F. Garfias, M. M. Gonzalez, J. A. Goodman, J. P. Harding, S. Hernandez, B. Hona, D. Huang, F. Hueyotl-Zahuantitla, T. B. Humensky, P. Huntemeyer, A. Iriarte, V. Joshi, S. Kaufmann, A. Lara, W. H. Lee, H. Leon Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, S. S. Marinelli, O. Martinez, J. Martinez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Morales-Soto, E. Moreno, M. Mostafa, A. Nayerhoda, L. Nellen, M. Newbold, R. Noriega-Papaqui, A. Peisker, Y. Perez Araujo, E. G. Perez-Perez, Z. Ren, C. D. Rho, D. Rosa-Gonzalez, M. Rosenberg, J. R. Sacahui, H. Salazar, F. Salesa Greus, A. Sandoval, J. Serna-Franco, A. J. Smith, R. W. Springer, P. Surajbali, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, L. Villasenor, Xiaojie Wang, E. Willox, A. Zepeda, H. Zhou

Physics Faculty Research & Creative Works

Many gamma-ray bursts (GRBs) have been observed from radio wavelengths, and a few at very high energies (VHEs, >100 GeV). The High-Altitude Water Cherenkov (HAWC) gamma-ray observatory is well suited to study transient phenomena at VHEs owing to its large field of view and duty cycle. These features allow for searches of VHE emission and can probe different model assumptions of duration and spectra. In this paper, we use data collected by HAWC between 2014 December and 2020 May to search for emission in the energy range from 80 to 800 GeV coming from a sample of 47 short GRBs …

Enhancement Of 2d Topological Semimetal Transport Properties By Current Annealing, A. Fereidouni, M. H. Doha, K. Pandey, R. Basnet, J. Hu, H. O. H. Churchill

Physics Faculty Publications and Presentations

Observation of intrinsic quantum transport properties of two-dimensional (2D) topological semimetals can be challenging due to suppression of high mobility caused by extrinsic factors introduced during fabrication. We demonstrate current annealing as a method to substantially improve electronic transport properties of 2D topological semimetal flakes. Contact resistance and resistivity were improved by factors up to 2×10⁶ and 2×10⁴⁠, respectively, in devices based on exfoliated flakes of two topological semimetals, ZrSiSe and BaMnSb₂. Using this method, carrier mobility in ZrSiSe was improved by a factor of 3800, resulting in observation of record-high mobility for exfoliated ZrSiSe. …

Metallization Of Polymers And Composites: State-Of-The-Art Approaches, Ruslan Melentiev, Arief Yudhanto, Ran Tao, Todor Vuchkov, Gilles Lubineau

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Polymers and their composites are widely used for designing structures in aerospace, automotive, electronic, sport industries due to their lightweight, cost, and processing advantages. However, the surface of polymeric materials typically exhibits intrinsic deficiencies, limiting their durability and functionalities, e.g., low wear resistance, low thermal and electrical conductivity, low adhesion, low bioactivity, low reflectiveness, and weak photochemical resistance. Polymer metallization is an emerging concept that addresses these deficiencies by forming a metallic skin on polymeric surfaces. Herein, the working principles, recent advances, challenges, functional capabilities, and applications of the state-of-the-art polymer metallization methods in the fields of additive manufacturing, coating …

Improved Additive Manufacturing Of Silicon Carbide Parts Via Pressureless Electric Field-Assisted Sintering, Adam Bratten, Ruoyu Chen, Joshua Rittenhouse, Ming-Chuan Leu, Haiming Wen

Mechanical and Aerospace Engineering Faculty Research & Creative Works

High solids loading silicon carbide (SiC)-based aqueous slurries containing only.5 wt. % organic additives were utilized to create specimens of various geometries via an extrusion-based additive manufacturing (AM) technique. Pressure less electric field-assisted sintering was performed to densify each specimen without deformation. The combination of these techniques produced parts with >98% relative density despite containing only 5 wt.% oxide sintering additives. After sintering, specimens contained only the α-SiC and yttrium aluminum perovskite phases. This suggests the evolution of a nonequilibrium yttrium aluminate phase, as well as transformation from β-SiC to α-SiC. The fabrication method presented in this work has advantages …

Globalisation And City-Zenship In A Not-So-Networked Society: Looking For Narratives Of Empowerment In The Process Of Seepage Of Techno-Cultural Practices, Atreyee Majumder

Articles

The article seeks to answer questions crucial to the marginalisation debate like - Is commercial globalisation bringing in more than consumer goods into the developing countries? And if so, then what is the consequent impact on the relationship between the state and its citizens. While the city in the developed world acts as a node of contact with the forces of globalisation, sending out the messages of the global ‘fantasy’, the city in the developing world acts as the receptor of such signals from which the 'fantasy’ can be accessed by the rest of the developed world. Persons living in …

Love With Abandon, Walker R. Cosgrove

Pro Rege

No abstract provided.

We The Fallen People: The Founders And The Future Of American Democracy (Book Review), Jack R. Van Der Slik

Pro Rege

Reviewed Title: We the Fallen People: The Founders and the Future of American Democracy by Robert Tracy McKenzie. Downers Grove, IL: InterVarsity Press, 2021. 304 pp. ISBN: 9780830852963.

Moonshine Promises (Book Review), Shaun Stiemsma

Pro Rege

Reviewed Title: Moonshine Promises by John Van Rys. Eugene, Oregon: Resource Publications, An Imprint of Wipf and Stock Publishers, 2021. 228 pp. Hardcover ISBN: 97816667112629.