Digital Commons Network^™

Diallyl Disulfide Inhibits Proliferation, Epithelial—Mesenchymal Transition, And Invasion Through Rorα-Mediated Downregulation Of Wnt1/Β-Catenin Pathway In Gastric Cancer Cells, Jian Su, Hui He, Yu-Kun Li, Hong Xia, Fang Liu, Ying Zeng, Xi Zeng, Hui Ling, Bo Su, Qi Su

Journal of Food and Drug Analysis

Overactivation of Wnt/β-catenin pathway due to dysfunction of retinoid-related orphan receptor α (RORα) is related to cancer development and progression. Diallyl disulfide (DADS), an active component of garlic, has been reported in our previous study for upregulation of RORα expression in gastric cancer (GC) cells. It remains to be elucidated the role and mechanism of RORα in DADS against GC. This study revealed that DADS treatment resulted in reduced expression levels of Wnt1, β-catenin, TCF-4, intranuclear β-catenin and p-β-catenin in GC cells, concomitant with the compromised expression of β-catenin target genes (Axin, c-Jun, and c-Myc). RORα overexpression augmented DADS-induced downregulation …

Melatonin Exerts Anti-Fibrinolytic Effects By Regulating Il-1Β-Induced Changes In Upa, Upar, And Pai-1 Expression/Production In Human Dental Pulp Cells, Mei-Chi Chang, Bor-Hao Zhong, Hui-Na Lee, Fu-Hsiung Chuang, Ming-Shu Lee, Hsiao-Hua Chang, Yu-Hwa Pan, Jiiang-Huei Jeng

Journal of Food and Drug Analysis

Interleukin-1b (IL-1β) is a pro-inflammatory cytokine and its expression is increased in inflamed dental pulp. IL-1β affects plasminogen activation system molecules, which are crucial for tissue inflammation, fibrinolysis, matrix turnover, and cell adhesion and migration. Melatonin, which provides circadian and seasonal signals, is a physiological endocrine generated by the pineal gland. It has anti-oxidant and anti-inflammatory properties. Studies are warranted to determine whether melatonin prevents IL-1β-induced expression/production of plasminogen system molecules. Human dental pulp cells (HDPCs) were exposed to IL-1β or melatonin alone or to IL-1β with/without pretreatment with melatonin or other inhibitors. The mRNA expression of uPA, uPAR, and …

Stress Amelioration And Anti-Inflammatory Potential Of Shiikuwasha (Citrus Depressa Hayata) Essential Oil, Limonene, And Γ-Terpinene, Yonathan Asikin, Kuniyoshi Shimizu, Hironori Iwasaki, Hirosuke Oku, Koji Wada

Journal of Food and Drug Analysis

Shiikuwasha (Citrus depressa Hayata) essential oil (SEO) extracted from Shiikuwasha fruit pulp contains two major volatile components, limonene and γ-terpinene (56.56–57.31 and 24.41–24.98%, respectively). In this study, we showed that the aroma streams of SEO, limonene, and γ-terpinene exhibited significant physiological stress amelioration effects in nine healthy female panelists tested in a 30-min visual display task. While SEO administration significantly reduced work errors by 15 min compared to the odorless control condition, the limonene stream reduced work errors only at the first and fourth 5-min intervals, and the γ-terpinene effect lasted only for the initial 5-min. However, γ-terpinene inhalation …

Composition Decipherment Of Ficus Pumila Var. Awkeotsang And Its Potential On Covid-19 Symptom Amelioration And In Silico Prediction Of Sars-Cov-2 Interference., Hao-Chun Hu, Szu-Yin Yu, Xiao-Shan Hung, Chun-Han Su, Yu-Liang Yang, Chien-Kei Wei, Yuan-Bin Cheng, Yang-Chang Wu, Chia-Hung Yen, Tsong-Long Hwang, Shu-Li Chen, István Szatmári, Attila Hunyadi, Yi-Hong Tsai, Fang-Rong Chang

Journal of Food and Drug Analysis

The jelly from achenes of Ficus pumila var. awkeotsang (FPAA) is a famous beverage ingredient in Taiwan. In this work, ficumarin (1), a new compound was obtained from its twigs (FPAT) and elucidated with comprehensive spectroscopic data. The biosynthetic origin was proposed from the p‐coumaroyl‐CoA pathway. Alloxanthoxyletin, betulinic acid, and catechin were identified as the major and active constituents responsible for relieving neutrophilic inflammation by FPAT. Among them, the most potent alloxanthoxyletin was found to interact with PRO350 and GLU377 of human INOSOX. Further, Nrf2 activating capacity of the FPAT fraction and its coumarins was confirmed. With …

Phytochemical Characterization, Antioxidant Potential, And Health Risk Assessment Of Radix Oryzae Glutinosae, Hai-Ping Liu, Jian-Feng Tang, Kai Ren, Tong-Jun Chen, Ping-Ping Zhu, Dong-Dong Sun, Wei-Yun Wang

Journal of Food and Drug Analysis

Radix Oryzae Glutinosae (ROG) has been used as a traditional anhidrotic agent in China. Ten samples were systematically assessed based on four aspects of their chemical profiles and antioxidant activity. The former was achieved using ultraviolet-visible spectra (UV), infrared absorption spectra (IR), proton nuclear magnetic resonance spectroscopy (¹H NMR), and inductively coupled plasma-mass spectrometry (ICP-MS) fingerprints, and antioxidant activity was assessed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, the 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) assay, and the ferric reducing antioxidant power (FRAP) assay. The presence of amino acids, flavonoids, organic acids, and sugars was indicated in all samples. A hierarchical …

Systems Pharmacology Dissection Of The Mechanisms And Therapeutic Potential Of Cassiae Semen For Hepatoprotection And Brightening Eyes, Jing-Xiao Zhang, Zi-Yi Chen, Xue-Zhen Huang, Lin-Yue Qi, Wei Zhou

Journal of Food and Drug Analysis

Cassiae semen has been shown to play significant roles in reversing “liver fire” to improve vision. The systems mechanism of Cassiae semen for hepatoprotection and brightening eyes has not been fully explored. The systems pharmacology approach is proposed to dissect the potential pharmacological mechanism of Cassiae semen for hepatoprotection and brightening eyes. The results showed that 26 active components of Cassiae semen that connected with 230 targets were obtained. Gene ontology enrichment, network and pathway analysis explored that Cassiae semen is responsible for hepatoprotection and brightening eyes. The current study will contribute to the research and development of functional foods.

Exploring The Relationship Between Metabolite Composition And The Cold/Hot Properties Ascribed In Traditional Chinese Medicine By Mass Spectral Molecular Networking–A Pilot Study, Chun-Han Su, Yu-Chieh Cheng, Kuei-Hung Lai, Yu-Chia Chang, Chi-Hui Sun, Po-Wen Tu, Ching-Chih Lin, Tsong-Long Hwang, Yu-Liang Yang

Journal of Food and Drug Analysis

Traditional Chinese medicine (TCM) has been applied to improve human health for millennia. In the TCM system, “medicinal property” (yao xing; hot and cold properties) is a core concept used to describe the influences of medicinal materials on human physiological conditions, and metabolites are believed to be one of the major ingredients of TCMs that affect their medicinal property. However, due to a lack of comprehensive analyses of TCM metabolomes, information about the relationships between TCM metabolite composition and medicinal property remains limited. In this pilot study, a mass spectral molecular networking-based platform was established and applied to …

Quantification Of Anthocyanosides In Grapes By Quechers And Biphenyl-Uhplc Tandem Mass Spectrometry, Lun-Chi Yang, Sung-Fang Chen

Journal of Food and Drug Analysis

In this study, the QuEChERS and UHPLC-MS/MS method using a biphenyl stationary phase was developed and applied for the rapid separation of 12 anthocyanosides in grapes. Efficient separation was achieved for a wide range of mono- and un-glycosylated anthocyanosides. The linear ranges of the target anthocyanosides were 0.5 to 500 ng mL⁻¹. The intra- and inter-day precisions were both below 11.8%. Anthocyanosides in grapes from different sources were successfully quantified. Thus, the developed QuEChERS and UHPLC-MS/MS method provide an attractive alternative for the quantification of anthocyanosides in grapes.

Fluorescence Detection Of Malachite Green In Fish Based On Aptamer And Sybr Green I, Jia Wang, Chengyi Hong, Zhengzhong Lin, Zhi-Yong Huang

Journal of Food and Drug Analysis

A simple fluorescence method to quantitatively monitor malachite green (MG) was introduced based on the conformation switch effect of MG-aptamer (Apt) and the fluorochrome of SYBR Green I (SGI). SGI can embed in the stem–loop structure of Apt to produce fluorescence. However, the fluorescence will be quenched when MG is introduced because of the specific binding of Apt to MG. Under the optimal conditions, the fluorescence method displayed excellent linear relationship between the fluorescence quenching efficiencies and the MG concentrations ranging from 0.02 μmol L⁻¹ to 1.0 μmol L⁻¹. The detection limit of the method was 0.67 …

Bromelain Activates The Amp-Activated Protein Kinase-Autophagy Pathway To Alleviate Hepatic Lipid Accumulation, Po-An Hu, Man-Chen Hsu, Szu-Han Chen, Chia-Hui Chen, Yu Ru Kou, Jenq-Wen Huang, Tzong-Shyuan Lee

Journal of Food and Drug Analysis

Bromelain, a cysteine protease found in pineapple, is known to exert protective effects against non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanism is unclear. In this study, we aimed to investigate the molecular mechanisms underlying the beneficial effects of bromelain using in vivo and in vitro models. C57BL/6 mice were fed a high-fat diet (HFD) with or without bromelain (20 mg/kg/day) for 12 weeks. We found that treatment with bromelain alleviated hepatic lipid accumulation accompanied by the activation of AMP-activated protein kinase (AMPK) and autophagy flux, as evidenced by the elevated levels of phosphorylated AMPK, ATG5, ATG7, LC3-II, and …

Metabolism-Involved Drug Interactions With Traditional Chinese Medicines In Cardiovascular Diseases, Ren-Jong Liang, Shu-Hao Hsu, Tien-Yu Chang, Tzu-Yi Chiang, Hong-Jaan Wang, Yune-Fang Ueng

Journal of Food and Drug Analysis

Herbal medicines have been widely used for the past millennia. Traditional Chinese medicine (TCM) is a major modality in Chinese medical care and has garnered global attention owing to its pharmacological effects and multi-targeted actions. The increased incidence of sequential or concurrent use of herbs and drugs in patients forces us to consider herb-drug interactions (HDIs) in this modern era. One of the main causes of HDIs is modulation of drug metabolism, in which cytochrome P450 (CYP), UDP-glucuronosyltransferase (UGT), and transporters play primary roles. In this review, we focus on in vivo studies of HDIs, particularly in the treatment of …

Real-World Evidence Of The Herb-Drug Interactions, Hsueh-Yi Pan, Li-Wei Wu, Pin-Chun Wang, Ping-Hung Chiu, Meng-Ting Wang

Journal of Food and Drug Analysis

Herbal medicine (HM) is a type of medicine that uses active ingredients made from plants to treat diseases and maintain health and wellbeing. Due to its increasing worldwide usage, the possibility of HMs and conventional drugs being concurrently used is high, potentially leading to adverse events resulting from herb-drug interactions. Despite the safety concerns regarding such interactions, few studies have been conducted for assessing clinical consequences of using HMs with conventional drugs in real-world settings. As clinical trials are not forthcoming rapidly enough to provide the evidence for herb-drug interactions, observational studies are considered as an alternative approach. The present …

Providing A Meeting Reminder To An Invitee Not In Attendance At A Meeting, John Costello, Ollie Fagan, Robert Headon, Owen Friel

Defensive Publications Series

How often, in this busy world in which we work, has a meeting invitee forgotten to join a meeting (in time or at all)? Let's be honest—it happens all the time and sometimes it's important that a particular invitee is present, particularly for meetings in which other attendees are relying on the invitee's input during a meeting. Techniques presented herein provide for the ability for an absent invitee for a meeting to receive a reminder to join the potentially forgotten and, more importantly, potentially vital meeting when the absent invitee's name is mentioned during the meeting.

Pemberdayaan Perempuan Melalui Lembaga Keuangan Mikro, Ali Aljihad, Arif Wibowo

Jurnal Pembangunan Manusia

The existence of disparities between the human development index of women and men and the mandate of the RPJMN regarding gender equality needs to be considered. Empowerment of women through microfinance has long been implemented and is indeed the main target for microfinance institutions that run it. With so many studies on women's empowerment, there needs to be an analysis of how the forms of empowerment are carried out by microfinance institutions. This writing uses a literature review method which discusses five microfinance institutions from existing research, then analyzes how the forms of women's empowerment are carried out by these …

Pendayagunaan Kelembagaan Lokal Dalam Meningkatkan Ketahanan Pangan Masyarakat Pada Masa Pandemi Covid-19, Novita Sari, Isbandi Rukminto Adi

Jurnal Pembangunan Manusia

The Covid-19 pandemic is a disease outbreak that has hit Indonesia since 2020. The impact of this epidemic changed the order and habits of society in general. This pandemic not only destroyed the health and economic structure, but also triggered a world food crisis, including Indonesia. Regions in Indonesia are experiencing various problems and crises, one of which is Kampar Regency. The fulfillment of food needs in Kampar Regency is mostly imported from West Sumatra via the West Sumatra-Riau national road. The dependence of Kampar Regency on West Sumatra can be seen when landslides occur, so there is a spike …

Proses Pembentukan Kampung Tematik Di Kampung Budaya Tehyan, Kelurahan Mekarsari, Kecamatan Neglasari, Kota Tangerang, Rossiana Jasmine, Indra Lestari Fawzi

Jurnal Pembangunan Manusia

Poverty is a problem that continues to exist in urban and rural areas. With the ‘1 RW 1 Kampung Tematik’ movement, Tangerang city government makes the thematic village an effort to improve environmental conditions while at the same time elevating the socio-economic potential of the community and ultimately alleviating poverty. Kampung Budaya Tehyan is one of the thematic villages located in RW 04, Mekarsari Village, Neglasari District, Tangerang City and it focuses on the cultural theme and potential of the minority Benteng Chinese ethnic community. This article discusses the establishment process of Kampung Budaya Tehyan together with its supporting and …

Program Kartu Prakerja Sebagai Program Pemberdayaan Di Bidang Ketenagakerjaan Di Tengah Pandemi, Mochamad Rangga Septiyadi, Ety Rahayu

Jurnal Pembangunan Manusia

As predicted, Indonesia will experience a demographic bonus, starting in 2020 as indicated by the population of productive citizens group (15-64 years) which is larger than other population groups. In response to the situation, fundamental efforts need to be made to ensure that the demographic surplus can be an economic driver. In early 2020, the government launched the Pre-employment Card program. This program was launched in the midst of the Covid-19 pandemic which disrupted many aspects of society, especially the economy and health. This research examines the Pre-employment Card program from the point of view of the empowerment concept. Research …

Mary Yamashita, Tina To

Kizuna: Bonds Beyond Incarceration (Summer 2022)

Mary, a Stockton Junior College student, reports and edits for the Pacific Weekly newspaper too. She and Jimmie met in study hall at Stockton High and use the club meetings to catch up. Mary plans to pursue an English degree and Jimmie will go to Berkeley for his PhD.

Company

Theatre and Performance Studies Programs

TPS pays tribute to the titan of American Musical Theatre with a concert staging of this musical that features many of Sondheim’s beloved songs. How are your life decisions affected by the company you keep? Company takes us on Bobby's journey as the couples around him ponder his singlehood and encourage him to find a mate. We question whether his friends are living their own advice. Company is a delightful look at how society molds our ideals and how those ideals are translated into our relationships.

2022-09-14_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

Contains the tables Statewide Hospital Capacity Report for COVID-19, COVID-19 Metrics, Statewide Hospital Available PPE Tracking for COVID-19, as well as the tables PPE Days On Hand and Patient Census.

2022-2023 Master Class - Webb Wiggins (Harpsichord), Webb Wiggins, Dina Bikzhanova, Jonathan Dills, Sergei Skobin, Sungkyun Lee, Rosa Ortega, Frederic Renaud, Silvia Valdivia Villasante, Marina Machado

Master Classes

No abstract provided.

We Are ... Marshall, September 14, 2022, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Committee On Academic Standing Minutes September 14, 2022, Bronx Community College Committee On Academic Standing

BCC Governance Archives

Minutes for the meeting of the Committee on Academic Standing on September 14, 2022.

Spartan Daily, September 14, 2022, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2022

Volume 159, Issue 10

Analysis Of Air And Soil Quality Around Thermal Power Plants And Coal Mines Of Singrauli Region, India, Harsimranjit Kaur Romana, Ramesh P. Singh, Chandra S. Dubey, Dericks P. Shukla

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Singrauli region is known as the energy capital of India, as it generates nearly 21 GW of electricity, supplied to various parts of the northern India. Many coal-based Thermal Power Plants (TPPs) using coal from several nearby coal mines, and numerous industries are set up in this region which has made it as one of the highly polluted regions of India. In the present study, detailed temporal analysis and forecast of carbon dioxide (CO₂), nitrogen dioxide (NO₂), sulfur dioxide (SO₂), and methane (CH₄) concentrations retrieved from satellite data have been carried out …

Honoring Military And First Responders – 9/11, Office Of Marketing And Communications

Newsroom

Governors State University (GSU) commemorates the September 11th attacks by remembering the heroic acts of the first responders who risked and gave their lives on that tragic day.

Emergency Response Team's Guide To Stay Connected, Office Of Marketing And Communications

Newsroom

Welcome Back, Jaguars! We are fortunate to begin this school year in-person, and have updated the university’s COVID-19 masking requirements.

Living Blues Features Mr. Sipp, Rebecca Lauck Cleary

Blog Posts

Living Blues #280 features the Mississippi Blues Child, Mr. Sipp. In 2013 Mr. Sipp seemed to come out of nowhere and reached the IBC finals in Memphis. But Castro Coleman was already a well-established name in the gospel scene in Mississippi; he was just rebranding himself as a blues artist.

Congress Must End The ‘One China’ Policy, Matthew Becker

Faculty and Student Publications

No abstract provided.

2022-09-14_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/resources/covid-19-vaccine/covid-19-dashboard.

First-dose tracker above is for entire Michigan Population. Coverage maps below are for age 5+.

Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Primary Series Doses Administered, Primary Series Doses by Vaccine, …