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Locker V. State Of Nevada, 138 Nev. Adv. Op. 62 (Sep. 1, 2022), Michael Pappas Sep 2022

Locker V. State Of Nevada, 138 Nev. Adv. Op. 62 (Sep. 1, 2022), Michael Pappas

Nevada Supreme Court Summaries

A first or second conviction for a category E felony possession of a schedule I or schedule II narcotic under fourteen grams requires the district court to defer conviction when the defendant consents to a drug treatment plan under NRS 176.211(3)(a)(1). When that statute applies, the courts have no discretion; it must defer to a drug rehabilitation program if the defendant consents.


Elk Point Country Club Hoa V. K. H. Brown, Llc, 138 Nev. Adv. Op. 60 (Aug. 18, 2022), Alexander Provan Sep 2022

Elk Point Country Club Hoa V. K. H. Brown, Llc, 138 Nev. Adv. Op. 60 (Aug. 18, 2022), Alexander Provan

Nevada Supreme Court Summaries

When a planned communities’ governing documents restrict real property use to residential use only, NRS 116.340(1)(a) permits a real property owner to use real property for transient commercial use so long as the governing documents of the community do not prohibit such use. Transient commercial use is the use of property, for remuneration, as transient lodging, if the term of occupancy is thirty days or less—i.e., short-term rentals. It is a reversable error to interpret bylaws and governing documents as prohibiting rentals when they use the terms “tenants” and


Matkulak V. Davis, 138 Nev. Adv. Op. 61 (Sept. 01, 2022), Sam Pope Sep 2022

Matkulak V. Davis, 138 Nev. Adv. Op. 61 (Sept. 01, 2022), Sam Pope

Nevada Supreme Court Summaries

Deviations from the Nevada Administration Code’s framework for calculating a parent’s base child support obligations may not exceed the party’s total obligation. Furthermore, a district court’s decision to award reasonable attorney fees and costs will stand absent an abuse of discretion. Here, the district court deviated from NAC 425.150(1)’s framework and increased the appellant’s child support obligation by nearly $2,000 per month over NAC 425.140’s base child support obligation. This deviation exceeded the appellant’s monthly total obligation which the district court calculated to $823.04. Therefore, the Supreme Court of Nevada reversed the district court’s decision and remanded with instructions to …


Las Vegas Police Protective Association, Inc. V. The Eighth Judicial District Court, 138 Nev. Adv. Op. 59 (Aug. 18, 2022), Benjamin Reber Sep 2022

Las Vegas Police Protective Association, Inc. V. The Eighth Judicial District Court, 138 Nev. Adv. Op. 59 (Aug. 18, 2022), Benjamin Reber

Nevada Supreme Court Summaries

In order to intervene as a necessary third party, the motion to intervene must be filed before a final judgement has been entered that resolves the case. Additionally, even though the Las Vegas Police Protective Association attempted to intervene too late, the Court considered whether they were a necessary party at all. The Court concluded that they were not a necessary party because their absence would not impair or impede any of their interests.


Weather Information And Decision-Support Tool Needs Assessment, Lily Calderwood, Glen Koehler, Sean Birkel, Erin H. Roche Sep 2022

Weather Information And Decision-Support Tool Needs Assessment, Lily Calderwood, Glen Koehler, Sean Birkel, Erin H. Roche

Journal of Extension

University of Maine researchers developed three commodity-specific grower focus groups (lowbush blueberry, apple, mixed vegetable) to discuss and survey 1) current access to weather information, and 2) interest in weather-based decision support tools. NOAA National Weather Service (30%) (n=47) was most commonly cited as a weather information source. Growers ranked greater forecast accuracy (31%) and localization (19%) (n=48) as highest priorities. Only 34% of growers reported current use of weather-based decision support tools, but 86% expressed interest in future use (n=134). The project team is using grower input to improve weather data access and decision-support tools for Maine farmers.


Contributing Or Clocking In: A Study Of Work Engagement, Stacey Ellison, Amy Harder Sep 2022

Contributing Or Clocking In: A Study Of Work Engagement, Stacey Ellison, Amy Harder

Journal of Extension

While organizations benefit from lower operating costs resulting from higher quality and quantity of work when employees are engaged in their work, (Risher, 2018). This study used the Utrecht Work Engagement Scale (Schuafeli & Bakker, 2004) to uncover the work engagement levels of county extension agents at one University. Findings suggest Extension agents report Florida Extension agents reported possessing high levels of self-perceived work engagement. These findings were consistent with other previous research (Abbott, 2017; Weyrauch, 2010) which likewise found Extension agents often or very often report dedication.


Engaging Farmers, Culinary Schools, And Communities In Value-Added Production To Strengthen Local Food Systems, Lauren B. Errickson, Ethan D. Schoolman, Virginia Quick, Sarah Davis, Anthony Capece Sep 2022

Engaging Farmers, Culinary Schools, And Communities In Value-Added Production To Strengthen Local Food Systems, Lauren B. Errickson, Ethan D. Schoolman, Virginia Quick, Sarah Davis, Anthony Capece

Journal of Extension

Value-added products can generate farm income and improve community food access, yet lack of available kitchen infrastructure and labor can limit farm production capacity. This project explored how community-based culinary schools might fill the gap. A unique “product share” model was identified and piloted, meeting the collective needs of farmers, a culinary school, and urban consumers. By researching farmer crop availability and business model preferences, and aligning value-added production with community food preferences, we demonstrate a successful pilot indicative that similar initiatives can be replicated in other metropolitan areas, with potential to engage cross-disciplinary extension professionals.


Covid-19 Prevention Behaviors In A Cooperative Extension Audience: Findings From A Nutrition Education Study, Matthew Greene, Catherine Ruth Losavio, Denise Holston Sep 2022

Covid-19 Prevention Behaviors In A Cooperative Extension Audience: Findings From A Nutrition Education Study, Matthew Greene, Catherine Ruth Losavio, Denise Holston

Journal of Extension

The COVID-19 pandemic has dramatically impacted the delivery of nutrition education through Cooperative Extension. This study aimed to identify a Cooperative Extension audience’s attitudes towards virus prevention behaviors, preferred sources of information regarding COVID-19, and nutrition education preferences during the pandemic. We distributed an online survey to 477 potential nutrition education participants including questions about behaviors like mask wearing, preferences for virtual nutrition lesson delivery, and attitudes towards sources of information about COVID-19. Attitudes towards mask wearing and preferred sources of information differed significantly by race, income, and age. These differences have serious implications for future outreach and program delivery.


Oneoppf: A Personal Finance Professional Development Resource, Barbara M. O'Neill, Martie Gillen, Selena Garrison, Molly C. Herndon Sep 2022

Oneoppf: A Personal Finance Professional Development Resource, Barbara M. O'Neill, Martie Gillen, Selena Garrison, Molly C. Herndon

Journal of Extension

This article describes personal finance programming available through the OneOp Personal Finance team (OneOpPF) for the professional development of Extension educators and military Personal Financial Managers for outreach to their clientele. Included is a brief description of six OneOpPF deliverables (webinars, blog posts, Question of the Day tweets, podcasts, social media, and newsletters) and a discussion of impact indicators such as online outreach statistics and continuing education units awarded to program participants. The article concludes with four best practices for working with military stakeholders and a description of how OneOpPF program materials can be accessed by Extension professionals.


Identifying Opportunities And Priorities For Energy Extension, Drew F. Schiavone Sep 2022

Identifying Opportunities And Priorities For Energy Extension, Drew F. Schiavone

Journal of Extension

An online survey was administered to all educators and specialists within the University of Maryland Extension to assess client-driven opportunities and priorities for energy-related programming, while in-service training evaluations were used to further assess programmatic needs. Results indicate the need for information related to energy conservation and clean energy technology for agricultural and residential clientele. Primary barriers were perceived as the insufficient understanding and high costs associated with clean energy, while experiential participation and firsthand observation were reported as preferred learning methods. These results provide an understanding of how energy-related programming can expand the role and relevancy of Extension.


Tiktok, Tomatoes, And Teenagers: Using New Social Media Apps To Connect Extension Education With Younger Audiences, Coleman K. Simpson, Joseph L. Donaldson Sep 2022

Tiktok, Tomatoes, And Teenagers: Using New Social Media Apps To Connect Extension Education With Younger Audiences, Coleman K. Simpson, Joseph L. Donaldson

Journal of Extension

Social media usage has precipitated changes in Cooperative Extension’s delivery of programs to amplify involvement with selected audiences and it is important that we craft relevant content for a variety of audiences. Current research tells us that social media and related content can enrich education and can create broader audiences for programming. Resources like blogs, podcasts, and geofilters have shown to be received positively by a wide range of audiences and have created greater rates of engagement.

Yet, one platform that has received limited attention is TikTok, perhaps due to TikTok’s mixed reviews in educational systems. With current trends showing …


Making Virtual Meetings Engaging: Creating Community In Virtual Settings Beyond The Pandemic, Matthew Newman, Alayne Torretta Sep 2022

Making Virtual Meetings Engaging: Creating Community In Virtual Settings Beyond The Pandemic, Matthew Newman, Alayne Torretta

Journal of Extension

When in-person programs were suspended during the pandemic, Extension professionals quickly embraced virtual learning platforms to conduct programs. One of the more popular platforms was Zoom. In addition to the standard features that come equipped with Zoom, there are several other free or low-cost online resources that can be used to enhance virtual programs and create a greater sense of community virtually.


Minnesota Cottage Food Industry: Insights From Extension Food Safety Education, Morrine Omolo, Regina Mcgoff, Suzanne Driessen, Katherine Brandt, Joanne Slavin, Michael Schmitt Sep 2022

Minnesota Cottage Food Industry: Insights From Extension Food Safety Education, Morrine Omolo, Regina Mcgoff, Suzanne Driessen, Katherine Brandt, Joanne Slavin, Michael Schmitt

Journal of Extension

The cottage food industry has become a significant part of the food supply in Minnesota, most likely as a result of the growing consumer demand for locally produced, minimally processed and value-added foods. Using post-training evaluations, we characterized the cottage food producers in Minnesota and assessed the impact of our food safety course. The results showed that the producers are mostly white women (71%), producing and selling a variety of products. The learners gained knowledge to safely produce and handle homemade food products for direct sale to consumers. Majority (80%) of the learners were satisfied with the course.


The Intersection Between Toxicology And Aging Research: A Toxic Aging Coin Perspective., John P. Wise Jr. Sep 2022

The Intersection Between Toxicology And Aging Research: A Toxic Aging Coin Perspective., John P. Wise Jr.

Faculty and Staff Scholarship

We are imminently faced with the challenges of an increasingly aging population and longer lifespans due to improved health care. Concomitantly, we are faced with ubiquitous environmental pollution linked with various health effects and age-related diseases which contribute to increased morbidity with age. Geriatric populations are rarely considered in the development of environmental regulations or in toxicology research. Today, life expectancy is often into one’s 80s or beyond, which means multiple decades living as a geriatric individual. Hence, adverse health effects and late-onset diseases might be due to environmental exposures as a geriatric, and we currently have no way of …


Fireside Chat With James Weddle, James Tricarico Jr. Institute For The Business Of Law And In-House Counsel Sep 2022

Fireside Chat With James Weddle, James Tricarico Jr. Institute For The Business Of Law And In-House Counsel

James Tricarico Jr Institute for the Business of Law and In-House Counsel

September 21, 2022


Mechanistic Insight Into Functionally Different Human Islet Polypeptide (Hiapp) Amyloid: The Intrinsic Role Of The C-Terminal Structural Motifs, Dibakar Sarkar, Narayan Chandra Maity, Gourav Shome, Kyriakos Gabriel Varnava, Vijayalekshmi Sarojini, Subramanian Vivekanandan, Nirakar Sahoo, Sourav Kumar, Atin Kumar Mandal, Ranjit Biswas, Anirban Bhunia Sep 2022

Mechanistic Insight Into Functionally Different Human Islet Polypeptide (Hiapp) Amyloid: The Intrinsic Role Of The C-Terminal Structural Motifs, Dibakar Sarkar, Narayan Chandra Maity, Gourav Shome, Kyriakos Gabriel Varnava, Vijayalekshmi Sarojini, Subramanian Vivekanandan, Nirakar Sahoo, Sourav Kumar, Atin Kumar Mandal, Ranjit Biswas, Anirban Bhunia

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Targeting amyloidosis requires high-resolution insight into the underlying mechanisms of amyloid aggregation. The sequence-specific intrinsic properties of a peptide or protein largely govern the amyloidogenic propensity. Thus, it is essential to delineate the structural motifs that define the subsequent downstream amyloidogenic cascade of events. Additionally, it is important to understand the role played by extrinsic factors, such as temperature or sample agitation, in modulating the overall energy barrier that prompts divergent nucleation events. Consequently, these changes can affect the fibrillation kinetics, resulting in structurally and functionally distinct amyloidogenic conformers associated with disease pathogenesis. Here, we have focused on human Islet …


Electrospun Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate)/Olive Leaf Extract Fiber Mesh As Prospective Bio-Based Scaffold For Wound Healing, Jose Gustavo De La Ossa, Serena Danti, Jasmine Esposito Salsano, Bahareh Azimi, Veronika Tempesti, Niccoletta Barbani, Maria Digiacomo, Marco Macchia, Mohammed Jasim Uddin, Caterina Cristallini Sep 2022

Electrospun Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate)/Olive Leaf Extract Fiber Mesh As Prospective Bio-Based Scaffold For Wound Healing, Jose Gustavo De La Ossa, Serena Danti, Jasmine Esposito Salsano, Bahareh Azimi, Veronika Tempesti, Niccoletta Barbani, Maria Digiacomo, Marco Macchia, Mohammed Jasim Uddin, Caterina Cristallini

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Polyhydroxyalkanoates (PHAs) are a family of biopolyesters synthesized by various microorganisms. Due to their biocompatibility and biodegradation, PHAs have been proposed for biomedical applications, including tissue engineering scaffolds. Olive leaf extract (OLE) can be obtained from agri-food biowaste and is a source of polyphenols with remarkable antioxidant properties. This study aimed at incorporating OLE inside poly(hydroxybutyrate-co-hydroxyvalerate) (PHBHV) fibers via electrospinning to obtain bioactive bio-based blends that are useful in wound healing. PHBHV/OLE electrospun fibers with a size of 1.29 ± 0.34 µm were obtained. Fourier transform infrared chemical analysis showed a uniform surface distribution of hydrophilic -OH groups, confirming the …


Corporate Social Responsibility And Operating Performance In Life And Health Insurance Market : Evidence From China, Ji Zhang Sep 2022

Corporate Social Responsibility And Operating Performance In Life And Health Insurance Market : Evidence From China, Ji Zhang

Lingnan Theses (MPhil & PhD)

Extant literature is equivocal on whether and how corporate social responsivity (CSR) activities affect corporates’ performance. To the best of our knowledge, a very limited number of research investigates CSR-performance relationship in insurance and even no research examines this relationship in China’s life and health (LH) insurance market. China LH insurance market has been the world’s second biggest LH insurance market albeit receiving limited attention in academia. We innovatively use two measurements of philanthropic activities as proxy for positive CSR performance. Alternatively, we use administrative penalties received from the provincial regulators as a proxy for the negative shock on the …


Are U.S. Consumers Willing To Pay More By The Lake? An Analysis Of Preferences For Great Lakes Region Fish, April Athnos, Simone Valle De Souza, Kwamena Quagrainie, Chinonso Etumnu, William Knudson, Ronald E. Kinnunen, Paul Hitchens Sep 2022

Are U.S. Consumers Willing To Pay More By The Lake? An Analysis Of Preferences For Great Lakes Region Fish, April Athnos, Simone Valle De Souza, Kwamena Quagrainie, Chinonso Etumnu, William Knudson, Ronald E. Kinnunen, Paul Hitchens

Department of Agricultural Economics Faculty Publications

U.S. per capita seafood consumption is historically high due to population and income growth and consumer preference shifts toward healthy protein options. Despite this expansion, U.S. fisheries, especially those in the Great Lakes region, no longer fulfill domestic demand due to pressure on fish stocks and regulatory constraints. Instead, aquaculture and imports fill the gap. Rainbow trout, yellow perch, and walleye—three species historically produced in the North Central Region (NCR)—exemplify such trends. To expand marketing opportunities for NCR aquaculture producers, this study estimates willingness to pay (WTP) for these species and several search and credence fish attributes. We designed and …


Cannabis Securities Litigation, Gideon Mark Sep 2022

Cannabis Securities Litigation, Gideon Mark

Seton Hall Journal of Legislation and Public Policy

No abstract provided.


Convergence And Divergence Of Alcohol And Marijuana Regulation In A Federalist System, H. Justin Pace Sep 2022

Convergence And Divergence Of Alcohol And Marijuana Regulation In A Federalist System, H. Justin Pace

Seton Hall Journal of Legislation and Public Policy

No abstract provided.


Evaluating Large Delay Estimation Techniques For Assisted Living Environments, Swarnadeep Bagchi, Ruairí De Fréin Sep 2022

Evaluating Large Delay Estimation Techniques For Assisted Living Environments, Swarnadeep Bagchi, Ruairí De Fréin

Articles

Abstract Phase wraparound due to large inter-sensor spacings in multi-channel demixing limits the range of relative delays that many time–frequency relative delay estimators can estimate. The performance of a large relative delay estimation method, called the elevatogram, is evaluated in the presence of significant phase wraparound. This paper compares the elevatogram with the popular relative delay estimator used in DUET and the brute-force approach in D-AdRess and analyses its computational efficiency. The elevatogram can accurately estimate relative delays of speech signals of up to 800 samples, whereas DUET and D-AdRess were limited to delays of 7 and 35 samples, given …


Audience Segmentation In Extension Horticultural Programs, Katie M. Wagner, Lendel K. Narine, Rebecca Hales Sep 2022

Audience Segmentation In Extension Horticultural Programs, Katie M. Wagner, Lendel K. Narine, Rebecca Hales

Journal of Extension

Cluster analysis was used to segment horticulture clientele using data from a needs assessment. Gardeners were segmented into two groups based on their horticulture practices. These groups were described using several factors including age and time spent maintaining different garden areas. Results from this study indicate the importance of considering the target audience prior to design and implementation of a gardening certificate program.


The Go Wild With Whole Grains! School-Based Program: Positive Impacts Among Children, Joshua Bailey, Sara Van Offelen, Hyunjun Kim, Marla Reicks Sep 2022

The Go Wild With Whole Grains! School-Based Program: Positive Impacts Among Children, Joshua Bailey, Sara Van Offelen, Hyunjun Kim, Marla Reicks

Journal of Extension

Whole grain foods have been associated with health benefits, yet are underconsumed by youth compared to recommendations. This study evaluated impacts of a school-based curriculum among children in grades 3-5 to address barriers to intake (2018-2019) (n = 1,748). Surveys before and after the program indicated youth were more willing to try and better able to identify whole grain foods. Open-ended responses confirmed findings regarding increased ability to identify whole grain foods, increased preferences and perceptions of availability. Together, these impacts could increase the likelihood that youth can meet whole grain intake recommendations to improve diet quality and health.


Evaluating Utah's Rural Online Initiative: Empowering Organizational Leaders Through Remote Work, Paul A. Hill, Amanda D. Ali, Lendel K. Narine, Andrea T. Schmutz, Tyson M. Riskas, Debra M. Spielmaker Sep 2022

Evaluating Utah's Rural Online Initiative: Empowering Organizational Leaders Through Remote Work, Paul A. Hill, Amanda D. Ali, Lendel K. Narine, Andrea T. Schmutz, Tyson M. Riskas, Debra M. Spielmaker

Journal of Extension

Compared to urban counties, Utah's rural counties experienced high levels of unemployment. Informed by a statewide needs assessment, Utah State University Extension developed a remote work leadership course to equip business leaders with knowledge and skills to create remote jobs as a solution to rural unemployment. This descriptive evaluation study collected data from course participants (N = 62). Findings showed short-term outcomes were achieved; participants experienced increases in knowledge and skills and had more positive intentions toward creating remote jobs and hiring employees from rural counties. Extension professionals can design and evaluate their programs using the framework in this study.


Protecting Cattle Feedyard Workers In The Central States Region: Exploring State, Regional, And National Data On Fatal And Nonfatal Injuries In Agriculture And The Beef Production Sector, Athena K. Ramos, Suraj Adhikari, Risto Rautiainen, Aaron Yoder Sep 2022

Protecting Cattle Feedyard Workers In The Central States Region: Exploring State, Regional, And National Data On Fatal And Nonfatal Injuries In Agriculture And The Beef Production Sector, Athena K. Ramos, Suraj Adhikari, Risto Rautiainen, Aaron Yoder

Journal of Extension

Working in agriculture can be dangerous. Despite ongoing efforts of Extension, animal production worker safety has not been adequately addressed. We present state, regional, and national counts and rates on fatal and nonfatal injuries in agriculture and animal production using publicly available data from the Bureau of Labor Statistics. We found that animal production had a high number of fatal injuries and a higher rate of nonfatal injuries than the average within agriculture. More needs to be done to protect livestock workers from injury. Extension professionals can play a key role in increasing safety knowledge and changing behaviors.


Participatory Evaluation And Needs Assessment Tools For Cooperative Extension In A Virtual Environment, Karen A. Vines Sep 2022

Participatory Evaluation And Needs Assessment Tools For Cooperative Extension In A Virtual Environment, Karen A. Vines

Journal of Extension

The Cooperative Extension organization could be categorized as a participatory organization because of our focus on local needs in driving our work. The pandemic moved a lot of our work to online platforms. This article reflects on use of online tools for program evaluation and needs assessment. Online focus groups were successful in gathering high quality data from a diverse and geographically dispersed population for program evaluation and as part of a needs assessment process. Coupling the focus groups with a modified World Café approach allowed us to go beyond identification of needs to prioritization and development of potential solutions.


Cooperative Extension’S Capacity To Address Food Insecurity By Supporting Food Recovery Organizations, H. Lester Schonberger, Lily L. Yang, Melissa Chase, Tiffany Drape, Sarah Misyak, Renee Boyer Sep 2022

Cooperative Extension’S Capacity To Address Food Insecurity By Supporting Food Recovery Organizations, H. Lester Schonberger, Lily L. Yang, Melissa Chase, Tiffany Drape, Sarah Misyak, Renee Boyer

Journal of Extension

Virginia Cooperative Extension (VCE) educators are uniquely positioned to support the food recovery organizations (FROs) which address hunger-related needs resulting from food insecurity. Based on an online survey to measure how VCE educators have engaged with FROs and their experiences, respondents who previously supported FROs did so across multiple programming areas, and those who had not indicated an interest while also experiencing barriers. Respondents also reported the need for context- and audience-specific resources particular to the spectrum of food recovery. Addressing barriers and resource needs through a transdisciplinary eXtension Food Recovery Community of Practice may support educators in doing this …


Teaching Educators Basic Fruit Tree Grafting Methods, Jeffrey C. Wilson, Wayne Porter, Casey Barickman Sep 2022

Teaching Educators Basic Fruit Tree Grafting Methods, Jeffrey C. Wilson, Wayne Porter, Casey Barickman

Journal of Extension

Hands-on education has proven to be successful in teaching basic grafting methods. MSU Extension developed and conducted eleven statewide workshops teaching Extension Agents and Master Gardeners preferred fruit tree grafting methods. The hands-on workshops provided specialists, agents, and Master Gardeners training on teaching fruit tree grafting classes for clientele. Each workshop consisted of a pre-test, a PowerPoint presentation, a post-test, and a grafting demonstration. Post-test scores showed a significant gain in knowledge over pre-test scores. This training can be replicated/adapted by other organizations to conduct educational outreach.


Gastrointestinal Microbiome Disruption And Antibiotic-Associated Diarrhea In Children Receiving Antibiotic Therapy For Community-Acquired Pneumonia, Jiye Kwon, Yong Kong, Martina Wade, Derek J Williams, Clarence Buddy Creech, Scott Evans, Emmanuel B Walter, Judy M Martin, Jeffrey S Gerber, Jason G Newland, Meghan E Hofto, Mary Allen Staat, Henry F Chambers, Vance G Fowler, W Charles Huskins, Melinda M Pettigrew Sep 2022

Gastrointestinal Microbiome Disruption And Antibiotic-Associated Diarrhea In Children Receiving Antibiotic Therapy For Community-Acquired Pneumonia, Jiye Kwon, Yong Kong, Martina Wade, Derek J Williams, Clarence Buddy Creech, Scott Evans, Emmanuel B Walter, Judy M Martin, Jeffrey S Gerber, Jason G Newland, Meghan E Hofto, Mary Allen Staat, Henry F Chambers, Vance G Fowler, W Charles Huskins, Melinda M Pettigrew

Faculty, Staff and Student Publications

Antibiotic-associated diarrhea (AAD) is a common side effect of antibiotics. We examined the gastrointestinal microbiota in children treated with β-lactams for community-acquired pneumonia. Data were from 66 children (n = 198 samples), aged 6-71 months, enrolled in the SCOUT-CAP trial (NCT02891915). AAD was defined as ≥1 day of diarrhea. Stool samples were collected on study days 1, 6-10, and 19-25. Samples were analyzed using 16S ribosomal RNA gene sequencing to identify associations between patient characteristics, microbiota characteristics, and AAD (yes/no). Nineteen (29%) children developed AAD. Microbiota compositional profiles differed between AAD groups (permutational multivariate analysis of variance, P < .03) and across visits (P < .001). Children with higher baseline relative abundances of 2 Bacteroides species were less likely to experience AAD. Higher baseline abundance of Lachnospiraceae and amino acid biosynthesis pathways were associated with AAD. Children in the AAD group experienced prolonged dysbiosis (P < .05). Specific gastrointestinal microbiota profiles are associated with AAD in children.