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Systematically Higher Ki67 Scores On Core Biopsy Samples Compared To Corresponding Resection Specimen In Breast Cancer: A Multi-Operator And Multi-Institutional Study, Balazs Acs, Samuel C Y Leung, Kelley M Kidwell, Indu Arun, Renaldas Augulis, Sunil S Badve, Yalai Bai, Anita L Bane, John M S Bartlett, Jane Bayani, Gilbert Bigras, Annika Blank, Henk Buikema, Martin C Chang, Robin L Dietz, Andrew Dodson, Susan Fineberg, Cornelia M Focke, Dongxia Gao, Allen M Gown, Carolina Gutierrez, Johan Hartman, Zuzana Kos, Anne-Vibeke Lænkholm, Arvydas Laurinavicius, Richard M Levenson, Rustin Mahboubi-Ardakani, Mauro G Mastropasqua, Sharon Nofech-Mozes, C Kent Osborne, Frédérique M Penault-Llorca, Tammy Piper, Mary Anne Quintayo, Tilman T Rau, Stefan Reinhard, Stephanie Robertson, Roberto Salgado, Tomoharu Sugie, Bert Van Der Vegt, Giuseppe Viale, Lila A Zabaglo, Daniel F Hayes, Mitch Dowsett, Torsten O Nielsen, David L Rimm, International Ki67 In Breast Cancer Working Group Of The Breast International Group And North American Breast Cancer Group (Big-Nabcg)

Faculty, Staff and Students Publications

Ki67 has potential clinical importance in breast cancer but has yet to see broad acceptance due to inter-laboratory variability. Here we tested an open source and calibrated automated digital image analysis (DIA) platform to: (i) investigate the comparability of Ki67 measurement across corresponding core biopsy and resection specimen cases, and (ii) assess section to section differences in Ki67 scoring. Two sets of 60 previously stained slides containing 30 core-cut biopsy and 30 corresponding resection specimens from 30 estrogen receptor-positive breast cancer patients were sent to 17 participating labs for automated assessment of average Ki67 expression. The blocks were centrally cut …

Post-Rift Geomorphological Evolution Of A Passive Continental Margin (Paraíba Region, Northeastern Brazil): Insights From River Profile And Drainage Divide Analysis, Fabio Corrêa Alves, Martin Stokes, Sarah J. Boulton, Fátima Rossetti D De, Morisson Valeriano M De

School of Geography, Earth and Environmental Sciences

The post-rift erosional history of elevated passive continental margins (EPCMs) has been considered of low-rate tectonics across many regions worldwide. However, research in the northeastern Brazilian passive continental margin suggests variations in the post-rift tectonic styles, timing and rates. This is especially the case of the Paraíba region, where there are reports of uplift affecting Quaternary strata. However, transient fluvial features potentially developed during this event remain to be investigated. In this study, we document transient responses of a fluvial landscape promoted by variations in Quaternary tectonic uplift in the Paraíba region, where outcrops are scarce. The aim was to …

Constraining A Model Of Punctuated River Incision For Quaternary Strath Terrace Formation, Jesse R. Zondervan, Martin Stokes, Matt W. Telfer, Sarah J. Boulton, Anne E. Mather, Jan Pieter Buylaert, Mayank Jain, Andrew S. Murray, Mhamed A. Belfoul

School of Geography, Earth and Environmental Sciences

In the small fraction of Earth's surface with the highest erosion rates such as the Alps and Himalayas quantifying rates of incision, rock uplift and inferring climatic controls on the landscape can be relatively straightforward once the ages of river terraces cut in bedrock (strath terraces) are constrained. However, in many mid to lower relief settings that are more typical of mountain belts worldwide, periods of net river incision and riverbed lowering are relatively short (punctuated), interrupted by long periods of sediment aggradation or stasis. We define a conceptual model of punctuated river incision and strath terrace formation for the …

Effect Of Supplementation With Leucine Alone, With Other Nutrients Or With Physical Exercise In Older People With Sarcopenia: A Systematic Review, Enrique Conde Maldonado, Diego Marqués-Jiménez, Patricia Casas-Agustench, Anna Bach-Faig

School of Health Professions

Background: Older adults are at a greater risk of developing sarcopenia as a result of reduced mobility, malnutrition, dietary changes and certain diseases. There are no systematic reviews in the literature analysing the effects of supplementation with leucine alone or as part of a supplement, and with or without physical exercise in older people with sarcopenia. We aimed to systematically review the evidence in intervention studies on the effects of supplementation with leucine, either alone, combined with other supplements, or combined with other supplements and physical exercise in older people with sarcopenia. Materials and methods: Literature searches related to the …

Dietary Inorganic Nitrate As An Ergogenic Aid: An Expert Consensus Derived Via The Modified Delphi Technique, Oliver M. Shannon, Jason D. Allen, Raul Bescos, Louise Burke, Tom Clifford, Chris Easton, Javier T. Gonzalez, Andrew M. Jones, Kristin L. Jonvik, Filip J. Larsen, Peter Peeling, Barbora Piknova, Mario Siervo, Anni Vanhatalo, Kerry Mcgawley, Simone Porcelli

School of Health Professions

Abstract Introduction Dietary inorganic nitrate is a popular nutritional supplement, which increases nitric oxide bioavailability and may improve exercise performance. Despite over a decade of research into the effects of dietary nitrate supplementation during exercise there is currently no expert consensus on how, when and for whom this compound could be recommended as an ergogenic aid. Moreover, there is no consensus on the safe administration of dietary nitrate as an ergogenic aid. This study aimed to address these research gaps. Methods The modified Delphi technique was used to establish the views of 12 expert panel members on the use of …

Eating In Theory, Hannah Drayson

School of Art, Design and Architecture

No abstract provided.

Riding Off Into The Sunset: Dual-Class Structure In The Age Of Unicorns Going Public, Hao Liang, Junho Park, Wei Zhang

Research Collection Lee Kong Chian School Of Business

The increasing adoption of dual-class shares (DCS)—an ownership structure that gives corporate insiders greater voting power than other shareholders—among newly listed companies has raisedsignificant governance concerns. We investigate the decision to adopt the DCS structure and itsvalue implications in the recent U.S. IPOs. Using founder cultural traits and Silicon Valley lawfirms as instrumental variables, we find significant post-IPO outperformance by firms adopting DCSwith a sunset clause, especially incapacity-based sunset which stipulates that the DCS will ceaseafter founders’ death, incapacitation or departure, compared to non-DCS firms and DCS firms without sunsets. This outperformance is more pronounced for high-tech firms, after Google’s …

The Alphabet Soup In Reporting And Measuring Esg, Hao Liang, Kam Chee Chan

Research Collection Lee Kong Chian School Of Business

Harmonising frameworks with the Impact-Weighted Accounts Framework.

Ethical Branding In A Divided World: How Political Orientation Motivates Reactions To Marketplace Transgressions, Thomas Allard, Brent Mcferran

Research Collection Lee Kong Chian School Of Business

In today's marketplace, users (e.g., purchasers, influencers) are increasingly the “face” of brands to potential consumers, increasing the risk for brands should these users act poorly. Across seven studies, we document that political orientation moderates the desire for punishment toward users of ethical (vs. conventional) brands who commit moral transgressions. In response to identical marketplace transgressions, we observe that liberals punish ethical brand users less than conventional brand users. In contrast, conservatives punish the same users of ethical brands more than conventional brand users. We document that this bias stems from how people interpret the inconsistency between the ethical branding …

Price Dynamics Of Swedish Pharmaceuticals, Aljoscha Janssen

Research Collection School Of Economics

This paper investigates price patterns of off-patent pharmaceuticals in Sweden. I show that price dynamics are dependent on the number of competitors in the market. The price patterns follow predictions from a model of dynamic price competition in which the demand for pharmaceuticals incorporates the known biases of consumers: habit persistence and brand preferences. Using the regulated market of Swedish pharmaceuticals, I show that price dynamics may help in identifying possible tacit collusion by manufacturers in markets where consumers experience behavioral frictions.

Using Machine Learning To Extract Insights From Consumer Data, Hannah H. Chang, Anirban Mukherjee

Research Collection Lee Kong Chian School Of Business

Advances in digital technology have led to the digitization of everyday activities of billions of people around the world, generating vast amounts of data on human behavior. From what people buy, to what information they search for, to how they navigate the social, digital, and physical world, human behavior can now be measured at a scale and level of precision that human history has not witnessed before. These developments have created unprecedented opportunities for those interested in understanding observable human behavior–social scientists, businesses, and policymakers—to (re)examine theoretical and substantive questions regarding people’s behavior. Moreover, technology has led to the emergence …

Good Names Beget Favors: The Impact Of Country Image On Trade Flows And Welfare, Pao-Li Chang, Tomoki Fujii, Wei Jin

Research Collection School Of Economics

This paper estimates the effects of time-varying consumer preference bias on trade flows and welfare. We use a unique data set from the BBC World Service Poll, which surveys (annually during 2005–2017 with some gaps) the populations of a wide array of countries on their views of whether an evaluated country is having a mainly positive or negative influence in the world. We identify the effects on consumer preference parameters due to shifts in these country image perceptions and quantify their general equilibrium effects on bilateral exports and welfare (each time for an evaluated exporting country, holding the exporting country’s …

A Consumer Perspective On Managing The Consequences Of Chain Liability, Julia Hartmann, Sebastian Forkmann, Sabine Benoit, Stephan C. Henneberg

Research Collection Lee Kong Chian School Of Business

Consumers tend to hold a focal firm responsible for its suppliers' unsustainable practices (chain liability), suggesting that firms need effective responses that can mitigate negative consumer reactions. In applying psychological contract theory to investigate recovery efforts related to such chain liability, the current study addresses three broad focal firm responses: Do nothing, choose a nonsubstantive response that verbally clarifies its own and the supplier's roles in the incident, or substantively rectify the supplier's wrongdoing with sustainability-focused responses, such as termination, monitoring or development. With a vignette-based experiment, we examine consumer perceptions and behaviors in three stages: before the unsustainable supplier …

Portrait Of The Artist’S Wife: Dorothea Webster Mitchell, 1894-1985, Molly Mcclain

History: Faculty Scholarship

Dorothea Webster Mitchell participated in the career of her husband, a well-known plein air artist Alfred R. Mitchell working in San Diego, California. The article reconstructs Dorothea's subjectivity, or changing conceptions of herself as a creative and artistic woman who found herself enmeshed in her husband's life and work.

Disentangling The Effects Of Gatt/Wto On Variable And Fixed Trade Costs: Trade Status, Trade Margins, And Export Sales Distribution, Pao-Li Chang, Renjing Chen, Wei Jin

Research Collection School Of Economics

In this paper, we develop an estimation procedure to identify the partial (direct) effects of the GATT/WTO membership on the variable and the fixed trade cost, re-spectively. This extends the techniques of Anderson and Van Wincoop (2003) on the structural relationship of multilateral resistance terms and of Helpman, Melitz and Rubinstein (2008) on the structural modelling of trade incidence. We then develop a general equilibrium framework (that allows the presence of zero trade) to simulate the impact of variable, fixed, and total trade cost changes on the firm-level trade structure (including bilateral export productivity cutoff, weighted/unweighted extensive margin of export, …

Robust Testing For Explosive Behavior With Strongly Dependent Errors, Yiu Lim Lui, Peter C. B. Phillips, Jun Yu

Research Collection School Of Economics

A heteroskedasticity-autocorrelation robust (HAR) test statistic is proposed to test for the presence of explosive roots in financial or real asset prices when the equation errors are strongly dependent. Limit theory for the test statistic is developed and extended to heteroskedastic models. The new test has stable size properties unlike conventional test statistics that typically lead to size distortion and inconsistency in the presence of strongly dependent equation errors. The new procedure can be used to consistently time-stamp the origination and termination of an explosive episode under similar conditions of long memory errors. Simulations are conducted to assess the finite …

On The Optimal Forecast With The Fractional Brownian Motion, Xiaohu Wang, Chen Zhang, Jun Yu

Research Collection School Of Economics

This paper examines the performance of alternative forecasting formulae with the fractional Brownian motion based on a discrete and finite sample. One formula gives the optimal forecast when a continuous record over the infinite past is available. Another formula gives the optimal forecast when a continuous record over the finite past is available. Alternative discretiza-tion schemes are proposed to approximate these formulae. These alternative discretization schemes are then compared with the conditional expectation of the target variable on the vector of the discrete and finite sample. It is shown that the conditional expectation delivers more accurate forecasts than the discretization-based …

Low-Rank Panel Quantile Regression: Estimation And Inference, Yiren Wang, Yichong Zhang, Yichong Zhang

Research Collection School Of Economics

In this paper, we propose a class of low-rank panel quantile regression models which allow for unobserved slope heterogeneity over both individuals and time. We estimate the heterogeneous intercept and slope matrices via nuclear norm regularization followed by sample splitting, row- and column-wise quantile regressions and debiasing. We show that the estimators of the factors and factor loadings associated with the intercept and slope matrices are asymptotically normally distributed. In addition, we develop two specification tests: one for the null hypothesis that the slope coefficient is a constant over time and/or individuals under the case that true rank of slope …

The Relationship Between Performance, Body Composition, And Processing Yield In Broilers: A Systematic Review And Meta-Regression, Diego A. Martinez, Jordan T. Weil, Nawin Suesuttajit, Cole Alan Umberson, Abdullah Scott, Craig N. Coon

Poultry Science Faculty Publications and Presentations

This study aims to model the relationship among performance, whole body composition, and processing yield through meta-regression. Scientific papers found in Scopus and Google Scholar were included if they reported results and variability values of an actual experiment in the three mentioned groups of variables using a single broiler genetic line. Weighted mean effect sizes were determined with a random model, the risk of bias was determined, and heterogeneity was considered an indicator of usefulness. Meta-regressions considered the effect sizes of the response variable and the percent change in one or more variables as predictors. A 78-row database was built …

Symptom Severity Mixity In Older-Age Bipolar Disorder: Analyses From The Global Aging And Geriatric Experiments In Bipolar Disorder Database (Gage-Bd), Farren B.S. Briggs, Martha Sajatovic

Faculty Scholarship

Objective: Some individuals with bipolar disorder (BD) experience manic and depressive symptoms concurrently, but data are limited on symptom mixity in older age bipolar disorder (OABD). Using the Global Aging & Geriatric Experiments in Bipolar Disorder Database, we characterized mixity in OABD and associations with everyday function. Methods: The sample (n = 805), from 12 international studies, included cases with both mania and depression severity ratings at a single timepoint. Four mixity groups were created: asymptomatic (A), mixed (Mix), depressed only (Dep), and manic only (Man). Generalized linear mixed models used mixity group as the predictor variable; cohort was included …

Organic Leadership—Implicit Followership Interaction: Relations Among Trust In Supervisor, Active Followership And Ocb, Sheng-Wen Liu, Ming-Tsang Hsieh, Ralph Norcio, Harika Rao

Faculty and Staff Publications & Presentations

Due to the impact of COVID-19, a large number of employees of organizations around the world have been forced to work remotely from home starting in 2020. As a result, leaders and followers face new communication and interaction challenges. If an enterprise is to be successful in the new wave of economic development, it must embrace the role of employee followers. However, there is currently no relevant research. Therefore, the purpose of this study is to analyze the interaction between organic leadership and implicit followers from the perspective of followers who are working remotely and further analyze their relationship with …

Fooled By The Cycle: Permanent Versus Cyclical Improvements In Social Indicators, Jose A. Camarena, Luciana Galeano, Luis Morano, Jorge Puig, Daniel Riera-Crichton, Carlos Vegh, Lucila Venturi, Guillermo Vuletin

All Faculty Scholarship

This paper studies the time series behavior of a set of widely-used social indicators and uncovers two important stylized facts. First, not all social indicators are created equal in terms of the importance of cyclical fluctuations. While some social indicators such as the unemployment rate and monetary poverty show large cyclical fluctuations, other social measures such as the Human Development Index are, by construction, dominated by long-run trends. Second, interestingly, yet not surprisingly, a large part of the cyclical fluctuations in social indicators can be explained by cyclical changes in income (proxied by real GDP per capita). For this reason, …

Reducing Time To Antibiotics In Patients With Neutropenic Fever On A Bone Marrow Transplant Unit, Regina Mcguire, Christopher Anand Gardner, Jordan Villars, William O'Hara, Jessica Radicke, Felicia Rivera, Jill Cristiano, Joanne E. Filicko-O'Hara, Usama Gergis, Adam F. Binder

Student Papers, Posters & Projects

Background/Methods: Timely administration of antibiotics in patients with neutropenic fever (NF) is essential for reducing morbidity and mortality among oncology patients. The optimal time to antibiotics (TTA) for patients with NF is unclear, but IDSA/ASCO guidelines recommend a median TTA within one hour of documented fever. This study focused on identifying barriers at a single academic institution to timely antibiotic administration for patients admitted to the inpatient Bone Marrow Transplant (BMT) unit, and implemented new processes to reduce median TTA to less than 60 minutes.

Methods: Chart reviews were performed to identify causes for delays in antibiotics (abx). Based on …

The Space Density Of Intermediate-Redshift, Extremely Compact, Massive Starburst Galaxies, Kelly E. Whalen, Ryan C. Hickox, Alison L. Coil, Aleksandar M. Diamond-Stanic, James E. Geach, John Moustakas, Gregory H. Rudnick, David S.N. Rupke, Paul H. Sell, Christy A. Tremonti, Julie D. Davis, Serena Perrotta, Grayson C. Petter

All Faculty Scholarship

We present a measurement of the intrinsic space density of intermediate-redshift (z ∼ 0.5), massive (M * ∼ 1011 M ⊙), compact (R e ∼ 100 pc) starburst (ΣSFR ∼ 1000 M ⊙ yr−1 kpc−1) galaxies with tidal features indicative of them having undergone recent major mergers. A subset of them host kiloparsec-scale, > 1000 km s−1 outflows and have little indication of AGN activity, suggesting that extreme star formation can be a primary driver of large-scale feedback. The aim for this paper is to calculate their space density so we can place them in a better cosmological context. We do …

Recommendations For Establishing A Market For Invasive Green Crabs In New England, Eve Fischer, Jesse Minor, Marissa Mcmahan

All Faculty Scholarship

Green crabs are one of the most invasive marine species in the world. Their populations in New England have grown significantly due to climate change, increasing their environmental and socioeconomic impacts. Green crabs are voracious predators of soft shell clams, and have had a detrimental impact on the region’s valuable clam fisheries. They also prey on juvenile lobsters and other shellfish and compete with native crab species for resources. Green crabs burrow into and damage eelgrass beds, which are a vital habitat for many marine species and an important “blue carbon” sink. Due to their rapid rate of reproduction as …

Redefining The Catalytic Hect Domain Boundaries For The Hect E3 Ubiquitin Ligase Family, Emma I. Kane, Steven A. Beasley, Johanna M. Schafer, Justine E. Bohl, Young Sun Lee, Kayla J. Rich, Elizabeth F. Bosia, Donald E. Spratt

Chemistry

There are 28 unique human members of the homologous to E6AP C-terminus (HECT) E3 ubiquitin ligase family. Each member of the HECT E3 ubiquitin ligases contains a conserved bilobal HECT domain of approximately 350 residues found near their C-termini that is responsible for their respective ubiquitylation activities. Recent studies have begun to elucidate specific roles that each HECT E3 ubiquitin ligase has in various cancers, age-induced neurodegeneration, and neurological disorders. New structural models have been recently released for some of the HECT E3 ubiquitin ligases, but many HECT domain structures have yet to be examined due to chronic insolubility and/or …

The Trichloroethylene Metabolite S-(1,2-Dichlorovinyl)-L-Cysteine Inhibits Lipopolysaccharide-Induced Inflammation Transcriptomic Pathways And Cytokine Secretion In A Macrophage Cell Model, Sean M. Harris, Kelly M. Bakulski, John Dou, Ethan Houskamp, Eleanor Scheeres, Emily Schellenboom, Olivia Harlow, Rita Loch-Caruso, Erica Boldenow

University Faculty Publications and Creative Works

Studies have shown that the trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine (DCVC) inhibits cytokine secretion in pathogen stimulated fetal membrane tissue but little is known about the mechanism for these effects, including which cell types or transcriptomic pathways are impacted. Macrophages play a critical role in fetal membrane immune responses during infection. We tested the hypothesis that DCVC inhibits lipopolysaccharide (LPS) stimulated inflammation pathways in macrophage-like THP-1 cells. We treated THP-1 cells for 24 h then treated with 1, 5, or 10 μM DCVC for 24 h. After a 4 h incubation with lipopolysaccharide (LPS), we collected RNA and cell media. We performed …

Examining The Continued Impact Of The Pandemic On Student Achievement In Gvsu Charter Schools - Year 2 Report, Kiel Mcqueen, Grand Valley State University

Charter School Research Reports

In December 2021, Basis Policy Research (Basis) released a report examining the continued impact of the COVID-19 pandemic on student achievement in Grand Valley State University (GVSU) charter schools. Findings revealed students made achievement gains in math and reading in 2021 but at a lower rate as compared to prior years. Furthermore, Basis researchers found that students’ achievement in spring 2021 was lower compared to the pre-pandemic period; achievement in spring 2021 was between 8 to 18 percentile points lower than spring 2019, with larger declines in math as compared to reading.

This report continues examining the impact of the …

A Century Of Drought In HawaiʻI: Geospatial Analysis And Synthesis Across Hydrological, Ecological, And Socioeconomic Scales, Abby G. Frazier, Christian P. Giardina, Thomas W. Giambelluca, Laura Brewington, Yi Leng Chen, Pao Shin Chu, Lucas Berio Fortini, Danielle Hall, David A. Helweg, Victoria W. Keener, Ryan J. Longman, Matthew P. Lucas, Alan Mair, Delwyn S. Oki, Julian J. Reyes, Stephanie G. Yelenik, Clay Trauernicht

Geography

Drought is a prominent feature of Hawaiʻi’s climate. However, it has been over 30 years since the last comprehensive meteorological drought analysis, and recent drying trends have emphasized the need to better understand drought dynamics and multi-sector effects in Hawaiʻi. Here, we provide a comprehensive synthesis of past drought effects in Hawaiʻi that we integrate with geospatial analysis of drought characteristics using a newly developed 100-year (1920–2019) gridded Standardized Precipitation Index (SPI) dataset. The synthesis examines past droughts classified into five categories: Meteorological, agricultural, hydrological, ecological, and socioeconomic drought. Results show that drought duration and magnitude have increased significantly, consistent …

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