Digital Commons Network^™

Changes In The Regulation Of The Unfolded Protein Response During Aging In Peromyscus, Elham Soltanmohammadi

Theses and Dissertations

Endoplasmic reticulum (ER) stress has been linked to various metabolic pathologies, neurodegeneration, and aging. Although various mechanistic aspects of the resulting unfolded protein response (UPR) have been elucidated, its regulation in genetically diverse populations remains elusive. In the present study we evaluated the expression of chaperones BiP/GRP78, GRP94 and calnexin (CANX) in the lungs, liver, and brain of 7 months old and 2–3 years old outbred deer mice P. maniculatus and P. leucopus. Chaperones’ _expression was highly variable between species, tissues and ages suggesting that levels of expression of individual chaperones do not change consistently during aging. Despite this variation, …

Topics In Multilevel Mediation Analysis, Chung Li Wu

Theses and Dissertations

A proper study design assures adequate power to detect statistically significant differences. Existing power calculations for multilevel mediation analysis make a strong distributional assumption of normality. However, binary outcomes are commonly seen in real-world study. Motivated by this fact, we conduct a simulation-based power study for a multilevel mediation analysis with binary outcomes. The numbers of participants needed to achieve 80% power are summarized in tables for future reference.

Mixed-effect regression is commonly used in multilevel analysis for panel data. Yet, the estimated coefficients from the random-intercept model could represent either purely between-cluster, purely within-cluster, or weighted-average effects. Therefore, we …

Motivation And Interest In Participation In Stem Beyond The Classroom Experiences: Effects Of Blended Learning Systems On High School Students, Michael Owdij

Theses and Dissertations

Beyond the classroom experiences are useful learning endeavors designed to help students connect classroom learning to the real world (Kilgo et al., 2015). The purpose of this action research was to evaluate the effect of a technology-based blended learning system on student motivation and interest in participation in beyond the classroom experiences. The blended learning system was offered to STEM-focused junior and senior students who attended a New Jersey high school. The focus of the study was centered around the following questions: How does interest in participation in beyond the classroom experiences change after STEM-focused high school students participate in …

Experimental Investigations Of Yarn Pull-Out Behavior In Kevlar®: Influence Of Applied Metallic Coatings And Effect Of Dynamic Loading, Julie Ann Roark

Theses and Dissertations

Flexible woven Kevlar® textile fabrics are widely used in protective armor applications. Yarn pull-out, comprised of yarn uncrimping (i.e., straightening) and yarn translation, is a major energy absorption mechanism during ballistic impact onto these fabrics, especially for impact velocities below the ballistic limit. Yarn pull-out is influenced by various parameters including inter-yarn friction, pull-out distance, pull-out velocity, transverse pre-tension, fiber diameter, fabric architecture, fabric waviness, fabric count and yarn modulus.

The first part of this thesis investigates yarn pull-out behavior of commercially available Kevlar® KM2+ individual yarns coated with metallic layers (copper, aluminum, aluminum nitride, silver) via a directed vapor …

Connecting Writing To Life: The Effects Of Place-Conscious Education On Writing In A First Grade Classroom, Tara P. Dietrich

Theses and Dissertations

This study describes a problem of practice encountered in a first-grade class in the southeast. Students exhibited negative attitudes during the writing process. Because of this, the quality of their writing suffered. The purpose of this study was to explore the relationship between attitudes and writing achievement in a first-grade class using place-conscious education. Additionally, this study was also built upon the social constructivism learning theory. To address the problem of practice, the researcher conducted a mixed-methods action research case study to analyze the effects of place-conscious education on students’ attitudes and proficiencies on writing. The study was guided by …

The Effects Of Project-Based Game Development On Student Learning And Attitudes: Action Research In An 8Th Grade Introductory Computer Science Course, Theodore G. Jenks

Theses and Dissertations

The purpose of this action research was to implement a digital game development project and describe its effects on the performance and attitudes of eighth-grade students in a required computer science course at South Carolina School District Alpha. The following research questions were explored: (1) How does the game development project impact participants’ ability to analyze and develop algorithms? (2) What is the effect of the game development project on participants’ attitudes toward computer science? and (3) What is the relationship between participants’ attitudes toward computer science and their performance?

There were 28 participants composed of students in a science, …

Hydrodynamic Response Of A Floating Offshore Wind Turbine (1st Fowt Comparative Study Dataset), Edward Ransley, Scott Brown, Emma Edwards, Tom Tosdevin, Kieran Monk, A. Reynolds, Deborah Greaves, Martyn Hann

Faculty of Science and Engineering Datasets

The 1st FOWT Comparative Study was run in conjunction with the ISOPE 2023 conference, in Ottawa, Canada, 19-23 June 2023 as part of the EPSRC funded project entitled ‘Extreme Loading on Floating Offshore Wind Turbines (FOWT) under Complex Environmental Conditions.‘ The study considers the hydrostatic and hydrodynamic response of a 1:70 scale model of the IEA 15MW reference wind turbine (IEA-15-240-RWT) and UMaine VolturnUS-S semi-submersible platform. The test cases consist of static equilibrium load cases, free decay tests (in heave, surge and pitch) and a pair of focused wave cases (one 'operational' and one 'extreme'). This dataset includes the physical …

An Intersectional Lens To Covid-19: Promoting Youth Well-Being In The Midst Of Social-Political Stressors, Magdalena S. Moskal

Theses and Dissertations

Guided by interpretative phenomenological methodology and intersectionality theory, this thesis aims to uncover the mental health experiences of youth surrounding the COVID-19 pandemic. This study also seeks to situate these experiences with the subsequent stressors that young people face in the current social-political context (e.g., witnessing trauma in the media, uprisings to address racism and the resulting backlash, rhetoric of the 2020 presidential election). Furthermore, this thesis aims to give insight and voice how intersectionality shapes the COVID-19-related experiences of youth in South Carolina. Data was collected through semi-structured interviews with 23 participants aged 16-21 years old in South Carolina. …

Identifying And Understanding Factors Which Affect Persistence In Academically At-Risk Minority Prelicensure Nursing Students: An Action Research Study, Christina L.K. Eaton

Theses and Dissertations

Increased representation of minority groups is imperative for professions like nursing and education. With the growing rate of minority racial and ethnic groups within the United States, there should be corresponding changes within these professions, however there is not. This action research study seeks to explore the factors that affect persistence in academically at-risk minority nursing students at a small Midwestern Christian University. The main research question for this study asks, “What factors do at-risk minority nursing students identify as affecting their ability to persist in our nursing program?” The use of Urie Bronfenbrenner’s Social Ecological Model and Critical Theory …

Timeless Light: A Singer’S Compendium Of Art Songs For Tenor By Black Composers, Johnnie J. Felder

Theses and Dissertations

This compendium of Black art songs is intended to serve as both a resource and reference for teachers of singing and performers who desire to assign or program reputable, contemporary art song literature by lesser-known, marginalized composers of the African Diaspora. The American academic structure needs a compendium of African American Art Songs, specifically for the tenor fach, that will provide biographical information, composers’ names, publishing details, and exact locations as to where to retrieve these worthy gems that are still too often excluded from the academic and classical canon. Comprised of more than 331 songs, this document is sure …

The Underrepresentation Of Black Males In Advanced Courses, Jacquelyn Ortner

Theses and Dissertations

The purpose of this phenomenological case study was to examine the forces that impact Black male enrollment in advanced courses at an urban public high school in the southeast. In two rounds of one-on-one interviews and two focus group sessions, qualitative data was collected from students who were currently enrolled in advanced courses as well as from students who had been identified as gifted but were not currently enrolled in advanced courses. Data was coded inductively using constant comparative analysis. Emergent themes included problems with the marketing and incentivizing of advanced coursework; irregularities in the notification and advisement process; participants’ …

Fostering The Development Of Instructor Cultural Competence: A Mixed Methods Action Research Study, Jennifer Lilly Engle

Theses and Dissertations

The purpose of this action research study was to understand the impact purposeful professional development has on the levels of higher education instructors’ cultural competence. The training developed as an intervention for this study included two 75-minute sessions and an independent book study over a five-week period. Fourteen faculty members participated in this mixed methods study. Quantitative data was collected via pretest and posttest scores on the Cultural Intelligence Scale (CQS) and analysis of the statistical significance was performed to gauge the effectiveness of the intervention and its impact on instructors’ cultural competence. Open-ended responses from participants on a three-item …

Genomic Analysis Workflows To Identify Mutational Signatures And Structural Variations In Ovcar8 Cells And Rad51d-Deficient Mouse Embryonic Fibroblasts, Manli Yang

Theses and Dissertations

Specific genomic profiles associated with exposure to DNA damaging agents have been identified in cancer related genes, revealing that mutational patterns can be carcinogen- specific. However, there have been limited efforts to demonstrate similar clear relationships for endogenous mutational processes. One endogenous source of mutations is contamination of the deoxynucleotide pool with damaged bases that, if incorporated into DNA, cause mutations.

The Catalog of Somatic Mutations In Cancer (COSMIC) represents an international effort to characterize mutations in cancer. A mutational signature is the pattern of mutations generated by a mutational process. Each mutational process contains two parts: DNA damage and …

Improving Undergraduate Psychology Students’ Academic Advising Experiences, Kelsey Grant

Theses and Dissertations

This action research study evaluated how to prepare undergraduate Psychology students for the transition from a developmental style of advising to the prescriptive advising style of departmental advisors. As an Undergraduate Academic Advisor, I drew upon a theoretical framework of appreciative advising, positive psychology, and the theory of transition to examine how to improve my practice in terms of this transition. Survey data from students who had not yet made this transition and interview data from students who had already made the transition enabled me to evaluate their perceptions of the advisor–advisee relationship and overall advising model in Psychology, as …

Uncrewed Aircraft Systems For Autonomous Infrastructure Inspection, Michail Kalaitzakis

Theses and Dissertations

Uncrewed Aircraft Systems (UAS) are becoming increasingly popular for infrastructure inspections since they offer increased safety, decreased costs and consistent results, compared to traditional methods. However, there are still many open challenges before fully autonomous, reliable, and repeatable UAS inspections. While a UAS platform has increased mobility and can easily approach hard to reach areas, it has limited range and payload capacity and is susceptible to environmental disturbances. Therefore, current operations are limited to Visual Line of Sight (VLOS) manual inspections that usually result in just a qualitative (visual) assessment of the structure.

The objective of this work is to …

Monitoring Titanium Dioxide Engineered Particles In Rural And Urban Surface Waters, Md Mahmudun Nabi

Theses and Dissertations

Quantifying and characterizing engineered particles in environmental systems is key for assessing their risk but remains challenging and requires the distinction between natural and engineered particles. The Ph.D. dissertation research described in this thesis contributes to the current attempts to improve environmental nanoparticle analysis and better understand nanoparticle behavior in natural systems, with the focus being on natural streams, and the application of single particle inductively coupled plasma-time of flight-mass spectrometry (SP-ICP-TOF-MS) for distinguishing and tracing the origins of environmental nanoparticles. The objective of this dissertation is to characterize and quantify the concentrations of titanium dioxide engineered particles in urban …

Fabrication Of Asymmetrical Hollow Fiber-Supported Thin Film Membranes, Stack Assembly, And Accelerated Long-Term Stability Test For Oxygen Production From Air, Myongjin Lee

Theses and Dissertations

Air separation is a widely used process for oxygen production. Several separation technologies have been developed for air separation, including cryogenic distillation, swing adsorption, redox process of metal oxides, and electrochemical process. Among these technologies, electrochemical permeation process stands out as a cost-effective and simple process for pure oxygen production from air. The electrochemical permeation process employs a gas-tight membrane to permeate and separate oxygen from air directly, where the membrane conducts both ions and electrons simultaneously. Different membrane designs have been studied to obtain the improved performance for oxygen permeation, typically planar and tubular designs. Among these membrane configurations, …

Gis Analysis Of Housing Delinquency After Repeated Flooding In Horry County, South Carolina, Andrew White

Theses and Dissertations

How communities react and change after disaster has been well-studied in recent decades. Knowledge around time scales, spatial scales, and specific facets of the built environment, such as housing recovery, have all developed largely around the opportunities that disasters have provided in understanding societal functions. This research has given policy makers and institutions insights into shortcomings of disaster specific recoveries, but these shortcomings are generalized beyond the scope of the originally studied areas. This thesis adapts this body of knowledge to a GIS methodology to help localize understanding to the coastal South Carolina context of Horry County. This low-lying area …

Shear Localization In The Metallic Nanolayered Composites, Shujing Dong

Theses and Dissertations

In this dissertation, the influences of layer thickness (h), interface orientation relationship (OR) and dislocation slip activities on shear band (SB) formation mechanisms was investigated by means of molecular dynamics (MD) simulations.

The effect of h and dislocation slip systems on the shear localization in Cu-FCC/Nb-BCC MNCs was studied. The strain softening observed in those samples was triggered by the SB formation. The microstructure evolutions and dislocation slips revealed that the unsymmetrical dislocation transmission across the interface induces the shear localization and promotes the SB formation. The quantitative analysis of the change in the separation distance of initially …

Tropical Cyclone And Ocean-Atmosphere Interactions In The Gulf Of Mexico, Emily Nichole Eley

Theses and Dissertations

The Gulf of Mexico (GoM) is historically a favorable region for the formation, maintenance and intensification of tropical cyclones that frequently evolve into powerful hurricanes. These natural disasters threaten the basin’s innate habitat and wildlife diversity, and the expansive coastal economies and communities. The dominant ocean circulation feature in the GoM is the Loop Current System (LCS) which includes the Loop Current (LC) and its associated mesoscale eddy field. The LC originates at the Yucatán Channel, loops anticyclonically into the basin, and ends at the Florida Straits; further it produces both anticyclonic and cyclonic eddies. The existence of the LCS …

Behavioral And Neurophysiological Measures Of Speech Auditory Feedback Processing Impairment In Left Hemisphere Stroke, Stacey Sangtian

Theses and Dissertations

The purpose of this study was to identify behavioral and neural correlates of impaired speech auditory feedback processing in people with a history of left-hemisphere stroke (LHS). To do this, we used the altered auditory feedback (AAF) paradigm to externally induce speech errors by randomly shifting the pitch frequency of the online auditory feedback up or down at ±100 cents in 38 LHS and 27 neurologically intact control participants under two experimental conditions: 1) active vocalizations of a steady speech vowel sound “ah,” and 2) passive listening to the playback of the same self-produced vocalizations. Randomized control trials were included …

Cnn-Based Dendrite Core Detection From Microscopic Images Of Directionally Solidified Ni-Base Alloys, Xiaoguang Li

Theses and Dissertations

Dendrite core is the center point of the dendrite. The information of dendrite core is very helpful for material scientists to analyze the properties of materials. Therefore, detecting the dendrite core is a very important task in the material science field. Meanwhile, because of some special properties of the dendrites, this task is also very challenging. Different from the typical detection problems in the computer vision field, detecting the dendrite core aims to detect a single point location instead of the bounding-box. As a result, the existing regressing bounding-box based detection methods can not work well on this task because …

Literature As A Monument: Uncle Tom’S Cabin Reflecting The Morality Of A Nation, Shalane Parcenue Conrads

Theses and Dissertations

This essay studies the critical response to Harriet Beecher Stowe’s novel Uncle Tom’s Cabin by studying the novel’s critical reception from publication and into contemporary America to understand how the novel remains an institution of Civil War remembrance. In accepting the polemical status of Uncle Tom’s Cabin, as both a literary and historical document, I argue that the novel is a monument in American culture. In studying the wide spectrum of critical response to the novel since its publication, Uncle Tom’s Cabin becomes a social barometer that reflects the controversial race relations in the United States from the Civil …

The Binge Viewing Index: Creating And Testing A New Measure, Larry J. Webster Jr.

Theses and Dissertations

Television Binge Viewing is a media consumption behavior that is in its research infancy. To date, researches have used a dichotomous variable to measure binge viewing. That measure is based on operationalizing binge viewing as having watched two to six episodes of the same television program in one sitting. This research project created and applied a continuous measure by creating the Binge Viewing Index (BVI), which is based on the duration (number of episodes) and the frequency (weekly average) of binge viewing sessions. These dimensions are structured similarly to measures for binge drinking. A national survey demonstrated the intensity of …

Cocreating A Strength-Based Behavioral Intervention Plan With Twice-Exceptional Students: A Youth Participatory Action Research Approach, Kristy L. Garrett

Theses and Dissertations

Twice-exceptional students are dually identified as academically gifted and talented and learning or medically disabled. These students face greater challenges to success in school and often have social and emotional issues that require accommodations and supports beyond those available in the general classroom. These students may not be receiving social and emotional supports through IEP or 504 Plans, or these supports may use a deficit rather than a strength-based approach. This study used a youth participatory action research method to empower twice-exceptional students to cocreate a strength-based, behavioral intervention plan to help them self-modulate strong emotional responses that hindered their …

Vox Populi Or News From Spain, Translated According To The Spanish Copy Which May Serve To Forewarn Both England And The United Provinces How Far To Trust To Spanish Pretenses, Imprinted In The Year 1620, Thomas Scott

English 144 Class Projects

No abstract provided.

Empirical Studies Of Esg Scores With Corporate Credit Spreads (Insights From Popularity-Based Pricing), Eugene Okyere-Yeboah

Doctoral Dissertations (DBA)

This study examines various factors or characteristics (risk and non-risk) that determine a firm’s credit risk premium, as measured by its credit default swap (CDS) spread, with a particular focus on the impact of environment, social, and governance (ESG) scores. The framework employed is a general equilibrium asset pricing model which integrates classical and behavioral finance elements, known as popularity-based asset pricing. It treats all attributes or characteristics of an asset as ”factors” to which investors assign a degree of popularity, which changes over time. Non-risk characteristics are classified as ”tastes” or ”disagreements”, Fama French (2007). Firms’ degree of adherence …

Teaching Presence In Online Discussions: Relationship-Based Learning By Design, Mary Quest

Dissertations

Activity Theory, Community of Inquiry Model, Interaction Analysis Model, Online learning, Social Construction of Knowledge, Teaching Presence

The Political Economy Of Capitalism In The Digital Age, Economic Democracy, And The Case For The Digital Commons, Alec Stubbs

Dissertations

Autonomist Marxism, capitalism, digital commons, digital economy, economic democracy, social factory

Structural And Transient Kinetic Analysis On Mechanism-Based Inactivators Of Human Ornithine Aminotransferase, Arseniy Butrin

Dissertations

HCC, Hepatocellular carcinoma, MBI, Mechanism-based inactivator, OAT, Ornithine Aminotransferase