Digital Commons Network^™

Machine Learning Modeling Of Protein-Intrinsic Features Predicts Tractability Of Targeted Protein Degradation, Wubing Zhang, Shourya S Roy Burman, Jiaye Chen, Katherine A Donovan, Yang Cao, Chelsea Shu, Boning Zhang, Zexian Zeng, Shengqing Gu, Yi Zhang, Dian Li, Eric S Fischer, Collin Tokheim, X Shirley Liu

Faculty, Staff and Student Publications

Targeted protein degradation (TPD) has rapidly emerged as a therapeutic modality to eliminate previously undruggable proteins by repurposing the cell’s endogenous protein degradation machinery. However, the susceptibility of proteins for targeting by TPD approaches, termed “degradability”, is largely unknown. Here, we developed a machine learning model, model-free analysis of protein degradability (MAPD), to predict degradability from features intrinsic to protein targets. MAPD shows accurate performance in predicting kinases that are degradable by TPD compounds [with an area under the precision–recall curve (AUPRC) of 0.759 and an area under the receiver operating characteristic curve (AUROC) of 0.775] and is …

Dosimetric Analysis Of Mr-Linac Treatment Plans For Salvage Spine Sbrt Re-Irradiation, Eun Young Han, Debra N Yeboa, Tina M Briere, Jinzhong Yang, He Wang

Faculty, Staff and Student Publications

PURPOSE: We investigated the feasibility of thoracic spine stereotactic body radiotherapy (SBRT) using the Elekta Unity magnetic resonance-guided linear accelerator (MRL) in patients who received prior radiotherapy. We hypothesized that Monaco treatment plans can improve the gross tumor volume minimum dose (GTVmin) with spinal cord preservation and maintain consistent plan quality during daily adaptation.

METHODS: Pinnacle clinical plans for 10 patients who underwent thoracic spine SBRT (after prior radiotherapy) were regenerated in the Monaco treatment planning system for the Elekta Unity MRL using 9 and 13 intensity-modulated radiotherapy (IMRT) beams. Monaco adapt-to-position (ATP) and adapt-to-shape (ATS) workflow plans were generated …

Efficacy And Safety Of A Single Dose Of Casirivimab And Imdevimab For The Prevention Of Covid-19 Over An 8-Month Period: A Randomised, Double-Blind, Placebo-Controlled Trial, Gary A Herman, Meagan P O'Brien, Eduardo Forleo-Neto, Neena Sarkar, Flonza Isa, Peijie Hou, Kuo-Chen Chan, Katharine J Bar, Ruanne V Barnabas, Dan H Barouch, Myron S Cohen, Christopher B Hurt, Dale R Burwen, Mary A Marovich, Bret J Musser, John D Davis, Kenneth C Turner, Adnan Mahmood, Andrea T Hooper, Jennifer D Hamilton, Janie Parrino, Danise Subramaniam, Alina Baum, Christos A Kyratsous, A Thomas Dicioccio, Neil Stahl, Ned Braunstein, George D Yancopoulos, David M Weinreich, Covid-19 Phase 3 Prevention Trial Team

Faculty, Staff and Student Publications

BACKGROUND: There is an unmet need for COVID-19 prevention in patient populations who have not mounted or are not expected to mount an adequate immune response to complete COVID-19 vaccination. We previously reported that a single subcutaneous 1200 mg dose of the monoclonal antibody combination casirivimab and imdevimab (CAS + IMD) prevented symptomatic SARS-CoV-2 infections by 81·4% in generally healthy household contacts of SARS-CoV-2-infected individuals over a 1-month efficacy assessment period. Here we present additional results, including the 7-month follow-up period (months 2-8), providing additional insights about the potential for efficacy in pre-exposure prophylaxis settings.

METHODS: This was a randomised, …

Lenvatinib Plus Pembrolizumab In Japanese Patients With Endometrial Cancer: Results From Study 309/Keynote-775, Kan Yonemori, Mayu Yunokawa, Kimio Ushijima, Jun Sakata, Ayumi Shikama, Shinichiro Minobe, Tomoka Usami, Takayuki Enomoto, Kazuhiro Takehara, Kosei Hasegawa, Wataru Yamagami, Keiko Yamamoto, Shirong Han, Lea Dutta, Robert Orlowski, Takuma Miura, Vicky Makker, Keiichi Fujiwara

Faculty, Staff and Student Publications

Study 309/KEYNOTE-775 is a phase 3 open-label, randomized trial of lenvatinib plus pembrolizumab versus treatment of physician's choice (TPC) in patients with advanced endometrial cancer with progression after platinum-based therapy. Primary endpoints of superiority for lenvatinib plus pembrolizumab were met for progression-free survival (PFS) and overall survival (OS) in all-comers (ie, regardless of mismatch repair [MMR] status) and patients with MMR proficiency (pMMR). We present results for the Japanese subset. Patients were randomized to oral lenvatinib 20 mg/day plus intravenous pembrolizumab 200 mg every 3 weeks (Q3W; up to 35 cycles of pembrolizumab) or TPC (intravenous doxorubicin 60 mg/m

A Randomized Controlled Trial Evaluating The Effects Of Social Networking On Chronic Disease Management In Rheumatoid Arthritis, Maria A Lopez-Olivo, Jessica T Foreman, Cheuk Leung, Heather Y Lin, Tiffany Westrich-Robertson, Catherine Hofstetter, Jude K A Des Bordes, Anne Lyddiatt, Amye Leong, Irmgard U Willcockson, Susan K Peterson, Maria E Suarez-Almazor

Faculty, Staff and Student Publications

OBJECTIVE: Social networking has been shown to improve health outcomes in certain patient populations. While patients with rheumatoid arthritis (RA) increasingly use social networking to communicate with peers, the effects of these interactions are largely unknown.

METHODS: In a randomized controlled trial, we compared RA patients who participated in a social networking group moderated by peer leaders and who had access to a static website offering RA materials with a control group, who only had access to the website. The primary outcomes were patients' RA knowledge, self-efficacy and empowerment. Secondary outcomes included participation in desired health behaviors, and satisfaction with …

Use Of Breast Surveillance Between Women With Pathogenic Variants And Variants Of Uncertain Significance In Breast Cancer Susceptibility Genes, Sukh Makhnoon, Minxing Chen, Brooke Levin, Megan Ensinger, Kristin D Mattie, Generosa Grana, Sanjay Shete, Banu K Arun, Susan K Peterson

Faculty, Staff and Student Publications

BACKGROUND: Use of surveillance mammography and magnetic resonance imaging (MRI) has been understudied among women with variant of uncertain significance (VUS) compared to pathogenic and likely pathogenic variants (P/LP).

METHODS: Using data from two cancer settings, we calculated use of risk-reducing mastectomy (RRM) and surveillance during each 13-month span after genetic testing up to 6 years afterwards for a cohort of genetically elevated risk women.

RESULTS: Of 889 women, VUS carriers were less likely to undergo RRM compared to those with P/LP (hazard ratio [HR], 0.17; p =

CONCLUSION: The authors found that VUS, whether in high or moderate penetrance …

Immunogenomic Profiling Of Lung Adenocarcinoma Reveals Poorly Differentiated Tumors Are Associated With An Immunogenic Tumor Microenvironment, Neal Akhave, Jiexin Zhang, Erin Bayley, Meredith Frank, Shin-Heng Chiou, Carmen Behrens, Runzhe Chen, Xin Hu, Edwin Roger Parra, Won-Chul Lee, Stephen Swisher, Luisa Solis, Annikka Weissferdt, Cesar Moran, Neda Kalhor, Jianhua Zhang, Paul Scheet, Ara A Vaporciyan, Boris Sepesi, Don L Gibbons, John V Heymach, Jack J Lee, Ignacio I Wistuba, P Andrew Futreal, Jianjun Zhang, Junya Fujimoto, Alexandre Reuben

Faculty, Staff and Student Publications

OBJECTIVES: Pathologists have routinely observed distinct histologic patterns of growth in early-stage lung adenocarcinoma (LUAD), which have been suggested to be associated with prognosis. Herein, we investigated the relationship between LUAD patterns of growth, as defined by the updated international association for the study of lung cancer (IASLC) grading criteria, and differences in the tumor immune microenvironment to identify predictors of response to immunotherapy.

METHODS: 174 resected stage I-III LUAD tumors were classified by histologic pattern of growth (i.e. solid, micropapillary, acinar, papillary, and lepidic) and then grouped as well differentiated, moderately differentiated, and poorly differentiated. Comprehensive multiplatform analysis including …

Backscattering Analysis Utilizing Relaxed Hierarchical Equivalent Source Algorithm (Rhesa) For Scatterers In Vegetation Medium, Syabeela Syahali, Hong Tat Ewe, Gobi Vetharatnam, Li (Lijun) Jun Jiang

Electrical and Computer Engineering Faculty Research & Creative Works

The backscattering cross section of cylindrical and elliptical disk-shaped scatterers was investigated in this study, utilising a new numerical solution method called the relaxed hierarchical equivalent source algorithm (RHESA). The results were compared with the backscattering cross section of similar cases, using analytical method validation from literature. The objective of this research was to look into the possibility of replacing analytical methods with the RHESA in volume scattering calculations, and integrating it into modelling the backscattering of layers of dense media for microwave remote sensing in vegetation; as RHESA provides the freedom to model any shape of scatterer, as opposed …

Predicting Defects In Laser Powder Bed Fusion Using In-Situ Thermal Imaging Data And Machine Learning, Sina Malakpour Estalaki, Cody S. Lough, Robert G. Landers, Edward C. Kinzel, Tengfei Luo

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Variation in the local thermal history during the Laser Powder Bed Fusion (LPBF) process in Additive Manufacturing (AM) can cause micropore defects, which add to the uncertainty of the mechanical properties (e.g., fatigue life, tensile strength) of the built materials. In-situ sensing has been proposed for monitoring the AM process to minimize defects, but successful minimization requires establishing a quantitative relationship between the sensing data and the porosity, which is particularly challenging with a large number of variables (e.g., laser speed, power, scan path, powder property). Physics-based modeling can simulate such an in-situ sensing-porosity relationship, but it is computationally costly. …

The Courier, Fall 2022, Tennessee. Historical Commission.

Tennessee Historical Commission

No abstract provided.

2022 Tennessee State Aging Profile, Tennessee. Commission On Aging & Disability.

Department of Disability & Aging

No abstract provided.

Recasting The Second Fiddle: The Need For A Clear Line Of Lieutenant Gubernatorial Succession, T. Quinn Yeargain

South Carolina Law Review

No abstract provided.

Quasi-Property No More: "Human Heritage" As A New Legal Status For The Dead, Alida B. Soileau

South Carolina Law Review

No abstract provided.

Black And Barred: The Bar Examination's History Of Exclusivity And The Threat Of Further Exclusion Posed By Aba Standard 316, Nicola A. Boothe

South Carolina Law Review

No abstract provided.

Juvenile Report, October 2022, Tennessee. Department Of Correction.

Juvenile Reports

No abstract provided.

Coordinated School Health 2021-22 Annual Report, Tennessee. Department Of Education.

Coordinated School Health

No abstract provided.

Coordinated School Health, 2021-22 Physical Education/Physical Activity (Pe/Pa) Annual Report, Tennessee. Department Of Education.

Coordinated School Health

No abstract provided.

Coordinated School Health, Tennessee Public Schools, A Summary Of Weight Status Data 2021-22, Tennessee. Department Of Education.

Coordinated School Health

No abstract provided.

2022 Annual Report, Tennessee. Department Of Treasury.

Treasurer’s Report

No abstract provided.

Tennessee Felon Population Update, October 2022, Tennessee. Department Of Correction.

Felon Population Reports

No abstract provided.

Tennessee Labor Market Report, October 2022, Alternative Measures Of Labor Underutilization, Tennessee. Department Of Labor & Workforce Development.

Labor Market Reports

No abstract provided.

Tolerance Of Peppermint To Tiafenacil Applied Postharvest, Stephen L. Meyers, Jeanine Arana, Brandi C. Woolam

Department of Horticulture & Landscape Architecture Faculty Publications

Trials were conducted in two experimental runs at the Purdue University Horticulture Greenhouses, West Lafayette, IN, to determine ‘Redefined Murray Mitcham’ peppermint tolerance to tiafenacil. Established peppermint in 20-cm-diameter polyethylene pots was subjected to a simulated harvest by removing aboveground biomass at the substrate surface; then, tiafenacil was applied at 0, 25, 50, 100, and 200 g ai ha−1. Visible crop injury, height, and aboveground dry biomass data were subjected to regression analysis to generate predictive models. At 2 wk after treatment (WAT), peppermint injury increased from 63% to 86% and from 25% to 76% in Experimental Run 1 and …

상형글자로 전해오는 동북아 역사 연구 방법, Don S. Lee

KAUPA Letters

No abstract provided.

Cure Process Modeling And Characterization Of Composites Using In-Situ Dielectric And Fiber Otpic Sensor Monitoring, Muthu Elenchezhian, Ryan Enos, Noah Martin, Suruchi Sen, Dianyun Zhang, Nikos Pantelelis

School of Aeronautics and Astronautics Faculty Publications

Liquid Composite Molding (LCM) techniques including the Resin Transfer Molding (RTM) and Vacuum Assisted Resin Transfer Molding (VARTM) are gaining significant importance for fabricating aerospace and automotive composite parts, owing to the low investment costs. During the curing process, the resin undergoes a property change due to cross-linking of polymers, where it transitions from the liquid state to the solid state. Further, during the cooling process, there is a change in the glass transition temperature, resulting in residual stress and strains. The residual strain and deformations accumulated during the curing of the resin at high temperatures result in significant challenges …

A Book Review: Cannery Row, Young B. Choi

KAUPA Letters

No abstract provided.

Conflict Dynamics In Scale-Free Networks With Degree Correlations And Hierarchical Structure, Eduardo Jacobo-Villegas, Bibiana Obregón-Quintana, Lev Guzmán-Vargas, Larry S. Liebovitch

Publications and Research

We present a study of the dynamic interactions between actors located on complex networks with scale-free and hierarchical scale-free topologies with assortative mixing, that is, correlations between the degree distributions of the actors. The actor’s state evolves according to a model that considers its previous state, the inertia to change, and the influence of its neighborhood. We show that the time evolution of the system depends on the percentage of cooperative or competitive
interactions. For scale-free networks, we find that the dispersion between actors is higher when all interactions are either cooperative or competitive, while a balanced presence of interactions …

The Importance Of Low Iq To Early Diagnosis Of Autism, Kristina Denisova, Zhichun Lin

Publications and Research

Abstract
Some individuals can flexibly adapt to life’s changing demands while others, in particular those with Autism Spectrum Disorder (ASD), find it challenging. The origin of early individual differences in cognitive abilities, the putative tools with which to navigate novel information in life, including in infants later diagnosed with ASD remains unexplored. Moreover, the role of intelligence quotient (IQ) vis-à-vis core features of autism remains debated. We systematically investigate the contribution of early IQ in future autism outcomes in an extremely large, population-based study of 8000 newborns, infants, and toddlers from the US between 2 and 68 months with over …

Sustainability Matters: Advocating For The Establishment And Continuation Of Peer-Led Team Learning, A.E. Dreyfuss

Publications and Research

The successful dissemination of the Peer-Led Team Learning (PLTL) model at multiple institutions of higher education, in the United States and other countries, is reflected in the number of publications (see www.pltlis.org). However, many PLTL campus programs are no longer active or exist. This may be due, more recently, to the COVID pandemic and its disruptions. Historically, programs no longer exist because grant funding that supported the initiative ended; other reasons include the promotion, retirement, or even death of the practitioners whose work championing their PLTL program ended. What can sustain a campus PLTL program so that its benefits …

The Link Between Democratic Institutions And Population Health In The American States, Julianna Pacheco, Scott Lacombe

Government: Faculty Publications

Context: This project investigates the role of state-level institutions in explaining variation in population health in the American states. Although cross-national research has established the positive effects of democracy on population health, little attention has been given to subnational units. The authors leverage a new data set to understand how political accountability and a system of checks and balances are associated with state population health. Methods: The authors estimate error correction models and two-way fixed effects models to estimate how the strength of state-level democratic institutions is associated with infant mortality rates, life expectancy, and midlife mortality. Findings: The authors …

Barriers When Implementing A Multi-Tiered System Of Supports, Chelsea R. Norton

All NMU Master's Theses

This mixed-methods study investigated the perceptions educators have during the initial stages of implementing the Multi-Tiered System of Support (MTSS) model. A survey and semi-structured interviews were collected to identify if the perceived barriers found in a rural context were consistent with prior research. Quantitative survey data indicated that participants felt confident about their practicing foundational skills of MTSS, and felt MTSS will benefit both staff and students. However, quantitative survey results also indicated a discrete difference in the data between the answers regarding participant confidence, knowledge, and the answers regarding attitude regarding time, resources, and leadership. Qualitative analysis from …