Digital Commons Network^™

Isolation And Functional Analysis Of A Pancreatic Enzyme In An Introductory Student Lab, Peter J. Lyons

Faculty Publications

Structure and function are correlated at all levels of biology. This topic is typically addressed early in an undergraduate class in general or molecular biology before students have gained much skill or knowledge in molecular biology. However, an understanding of the chemical bonds involved in forming and maintaining the structure of proteins is critical to understanding how enzymes function and how their activity can be regulated. Here, a laboratory activity is described that is suitable for undergraduate biology students. This activity examines the activity of carboxypeptidase A (CPA), an abundant pancreatic enzyme with a rich history in enzymology and structural …

A Non-Canonical Retina-Iprgcs-Scn-Pvt Visual Pathway For Mediating Contagious Itch Behavior, Fang Gao, Jun Ma, Yao-Qing Yu, Xiao-Fei Gao, Yang Bai, Yi Sun, Juan Liu, Xianyu Liu, Devin M Barry, Steven Wilhelm, Tyler Piccinni-Ash, Na Wang, Dongyang Liu, Yan Hao, Jin-Jing Jia, Qianyi Yang, Johan Van Nispen, Zhou-Feng Chen, Et Al.

2020-Current year OA Pubs

Contagious itch behavior informs conspecifics of adverse environment and is crucial for the survival of social animals. Gastrin-releasing peptide (GRP) and its receptor (GRPR) in the suprachiasmatic nucleus (SCN) of the hypothalamus mediates contagious itch behavior in mice. Here, we show that intrinsically photosensitive retina ganglion cells (ipRGCs) convey visual itch information, independently of melanopsin, from the retina to GRP neurons via PACAP-PAC1R signaling. Moreover, GRPR neurons relay itch information to the paraventricular nucleus of the thalamus (PVT). Surprisingly, neither the visual cortex nor superior colliculus is involved in contagious itch. In vivo calcium imaging and extracellular recordings reveal contagious …

Association Between Mnsod Activity And Cognitive Impairment In Unmedicated First-Episode Schizophrenia: Regulated By Mnsod Ala-9val Gene Polymorphism, Dong Mei Wang, Rong Rong Zhu, Yang Tian, Kadir Uludag, Jia Jing Chen, Hui Xia Zhou, Li Wang, Thomas R Kosten, Xiang Yang Zhang

Faculty, Staff and Students Publications

The imbalance between pro-oxidants and antioxidants is thought to be responsible for aging and cognitive impairment in many degenerative diseases, including schizophrenia (SZ). As the first antioxidant enzyme to detoxify superoxide radicals in mitochondria, manganese superoxide dismutase (MnSOD) activity and its functional polymorphism of Ala-9Val have been found to be associated with SZ. In this study, we explored the association between MnSOD activity, MnSOD Ala-9Val polymorphism and cognitive dysfunction in unmedicated first-episode (UMFE) SZ patients, which has not been examined. We recruited 234 UMFE SZ patients and 232 healthy controls (HC) and evaluated them with Repeated Battery for the Assessment …

Proportionality: Reconsidering The Application Of An Established Principle In International Law, Rüdiger Wolfrum

International Law Studies

Traditionally, the principle of proportionality is defined as limiting State action to rational and reasonable means with the view to achieve a goal permissible under international law without unduly encroaching on the protected rights of another State, States, or individuals. The principle applies to the planning, as well as the implementation, of State activities. The application of the principle of proportionality is common in national constitutional and administrative law. A vast national jurisprudence exists in this regard. However, due to the plurality of approaches in the various national legal systems, it is hardly possible to draw any general legal conclusions …

Location Verification For Future Wireless Vehicular Networks: Research Directions And Challenges, Shihao Yan, Ullah Ihsan, Robert Malaney, Linlin Sun, Stefano Tomasin

Research outputs 2022 to 2026

Vehicle location information obtained through the global navigation satellite system (GNSS) will play a pivotal role in emerging vehicular networks. This vital information is, however, susceptible to a host of unwanted manipulations, especially if a malicious entity is involved. The most obvious example of such manipulations is the forwarding by a malicious vehicle of false GNSS locations to other members of the network. Such events can lead to poor operational outcomes for the vehicular network, and in extreme cases even lead to catastrophic safety violations. Here, we highlight research efforts pursued in the past few years that have attempted to …

Examining Physical Education Teaching Practices During The Covid-19 Pandemic, Ken Murfay, Aaron Beighle, Heather E. Erwin, Erin Aiello, Sarah Pyszczynski

International Journal of Physical Activity and Health

Purpose/Method: This qualitative case study examined through an interpretive worldview how current high school (HS) physical education (PE) teachers (n=14) implemented online experiences that could have influenced students’ interpretations of their vicarious experiences during the Covid-19 pandemic (spring/fall of 2020). The study sought to better understand teachers’ perceptions of how social modeling of PA was implemented online, how online PA experiences impacted opportunities for social comparison among the students, and what teachers’ opinions of these practices were in relation to supporting students’ PA self-efficacy. Results: The results found that the study participants differed in their opinions on the most effective …

Mosaic Clinical Trial Statistical Analysis Plan Primary Analysis V1.2, Gareth Lingham, Emmanuel Kobia-Acquah, James Loughman, Daniel Ian Flitcroft

Other Resources

The Myopia Outcome Study of Atropine Treatment in Children (MOSAIC) is an investigator-led, double-masked randomised controlled trial of nightly atropine 0.01% eye drops compared to nightly placebo eye drops. A previously published protocol paper outlines the rationale, objective and sample size calculation for the study.¹ A total of 250 participants were enrolled in the study and were randomised 2:1 to active treatment and placebo, respectively. This document outlines the plan for analysis of the 24-month outcomes of the MOSAIC.

A Tem Study Of Fe3+X Co3-XTi2 (X = 0, 1, 2, 3) Intermetallic Alloys, Xingzhong Li, Anandakumar Sarella, B. Balasubramanian, Shah R. Valloppilly

David Sellmyer Publications

A TEM study has been carried out on crystal structures in the rare-earth-free intermetallic alloys, Fe_3+xCo_3-xTi₂ (x = 0, 1, 2, 3). These alloys have been demonstrated to have potentially high magnetic anisotropy. In these alloys, the main intermetallic compound was recently reported as a new hexagonal phase with a space group of P-6 m2. The present study reveals that the main compound belongs to Laves C14 variant surrounded by α-Fe type crystal as secondary phase in the Fe_3+xCo_3-xTi₂ (x = 0, 1, 2, 3) alloys, in agreement with the …

Morphometric And Molecular Characterization Of An Unpigmented Haemosporidian Parasite In The Neotropical Turnip-Tailed Gecko (Thecadactylus Rapicauda), Nubia E. Matta, Leydy P. González, Mario Vargas-Ramírez, Gediminas Valkiūnas, Ananias A. Escalante, M. Andreína Pacheco

Harold W. Manter Laboratory of Parasitology: Library Materials

Morphological traits from blood stages have been the gold standard for determining haemosporidian parasite species. However, the status of some taxa and the value of such traits in parasites from reptiles remain contentious. The scarce sampling of these species worsens the situation, and several taxa lack molecular data. A survey was performed in the Magdalena Department in Colombia, where 16 species of reptiles were captured. A peculiar haemosporidian parasite was found in the Turnip-tailed gecko Thecadactylus rapicauda. This haemosporidian does not show malarial pigment in blood stages under light microscopy; thus, it fits the Garnia genus’s characters belonging to …

National Lab Honors, Beth Potier

UNH Today Archive

No abstract provided.

Seeking To Stem The Tide, David Vogt

UNH Today Archive

No abstract provided.

Second Service: 28 U.S.C. § 1448 And State Court Service Of Process After Removal, Leigh Forsyth

Fordham Law Review

28 U.S.C. § 1448 governs the requirements of process after removal, providing that when defendants are not completely or perfectly served prior to removal, plaintiffs may complete such process or service, or new process may be issued in the same manner as in cases originally filed in the district court. There remains an open question as to whether state court service issued prior to removal, but served after removal, retains its efficacy in federal court under § 1448. This open question has led to divergent interpretations among district courts, with differing consequences. As of this Note’s publication, at least twenty-seven …

Large Variability And Complexity Of Isothermal Solubility For A Series Of Redox-Active Phenothiazines†, Anton S. Perera, Thilini Malsha Suduwella, Nuwan Harsha Attanayake, Rahul Kant Jha, William L. Eubanks, Ilya A. Shkrob, Chad Risko, Aman Preet Kaur, Susan A. Odom

Chemistry Faculty Publications

The development of redox-active organic molecules (ROM) with large solubilities in all states of charge in organic electrolytes is imperative to the continued development of non-aqueous redox flow batteries. The capability to a priori predict ROM solubility would be a game changer, allowing for a move away from time and resource consuming trial-and-error approaches to materials design and deployment. However, it is not presently clear that such predictions are generally possible, even for chemically related ROM, given the large number of physicochemical factors in play. Here we use quantitative structure–property relationships (QSPR) to examine solubility trends for a set of …

Tennessee Board Of Regents - System Office For The Year Ended June 30, 2021, Tennessee. Comptroller Of The Treasury.

Financial and Compliance Audit Reports

No abstract provided.

Faculty Recital Series: Mark Babbitt, Trombone; Katherine Lewis, Viola; Lu Witzig, Piano; October 4, 2022, Mark Babbitt, Katherine Lewis, Lu Witzig

School of Music Programs

Kemp Recital Hall
October 4, 2022
Tuesday Evening
7:30 p.m.

Case Growth Analysis To Inform Local Response To Covid-19 Epidemic In A Diverse Us Community, Marcia C De Oliveira Otto, Frances A Brito, Ji Yun Tark, Eric Bakota, Jose-Miguel Yamal, Dritana Marko, Shreela V Sharma, Michael R Brown, Savitri N Appana, Alison M Rector, Stephen H Linder, Jennifer Kiger, Karen C Tseng, Alanna C Morrison, Eric Boerwinkle

Faculty, Staff and Student Publications

Early detection of new outbreak waves is critical for effective and sustained response to the COVID-19 pandemic. We conducted a growth rate analysis using local community and inpatient records from seven hospital systems to characterize distinct phases in SARS-CoV-2 outbreak waves in the Greater Houston area. We determined the transition times from rapid spread of infection in the community to surge in the number of inpatients in local hospitals. We identified 193,237 residents who tested positive for SARS-CoV-2 via molecular testing from April 8, 2020 to June 30, 2021, and 30,031 residents admitted within local healthcare institutions with a positive …

The Prospector, October 4, 2022, Utep Student Publications

The Prospector

Headline: Head to Head: Future Texas Governor

Department Of History News, Georgia Southern University

History: News & Publications

• Dr. Allison Delivers Gary R. Hess Lecture at Bowling Green State University

Mechanical Engineering News, Georgia Southern University

Mechanical Engineering: News & Publications (2013-2023)

• Research Symposium

Good Newsletter October 4, 2022, Seattle University School Of Law Dean

GOOD NEWSletter

No abstract provided.

Student Life E-Newsletter October 04, 2022, Seattle University School Of Law Student Life

Student Life E-Newsletters

No abstract provided.

Case Growth Analysis To Inform Local Response To Covid-19 Epidemic In A Diverse Us Community, Marcia C De Oliveira Otto, Frances A Brito, Ji Yun Tark, Eric Bakota, Jose-Miguel Yamal, Dritana Marko, Shreela V Sharma, Michael R Brown, Savitri N Appana, Alison M Rector, Stephen H Linder, Jennifer Kiger, Karen C Tseng, Alanna C Morrison, Eric Boerwinkle

Faculty, Staff and Student Publications

Early detection of new outbreak waves is critical for effective and sustained response to the COVID-19 pandemic. We conducted a growth rate analysis using local community and inpatient records from seven hospital systems to characterize distinct phases in SARS-CoV-2 outbreak waves in the Greater Houston area. We determined the transition times from rapid spread of infection in the community to surge in the number of inpatients in local hospitals. We identified 193,237 residents who tested positive for SARS-CoV-2 via molecular testing from April 8, 2020 to June 30, 2021, and 30,031 residents admitted within local healthcare institutions with a positive …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern University Police Arrest Three in Aftermath of Weekend Armed Robbery

Do “You Have To Be Better? ”: A Narrative Inquiry Exploration Of Black Female Former Ncaa Division I Student-Athletes’ Experiences In Athletic Departments, Jessica Jeanne Brown

Theses and Dissertations

The purpose of this study was to explore how former National Collegiate Athletic Association (NCAA) Division I (DI) Black female student-athletes experienced their mid-major athletic departments and to better understand how they navigated these anti-Black spaces. BlackCrit theory (Dumas & Ross, 2019; Johnson, 2019), Black Feminist Thought (BFT) (Collins, 2000), and Intersectionality (Crenshaw, 1989; Collins & Bilge, 2016) comprised the theoretical framework used to examine Black female former NCAA DI student-athletes’ lived experiences with athletic departments that lead, cultivate experiences, develop policies, and monitor the safety of student-athletes. Seven Black female former NCAA DI student-athletes who played at mid-major colleges …

Titans Hiring Titans: Searles '95 Finds Alumni Ready For Multifaceted Careers, Julia Perez

News and Events (Discontinued Series)

No abstract provided.

Protecting Ocean Carbon Through Biodiversity And Climate Governance, Laura G. Elsler, Maartje Oostdijk, Lisa A. Levin, Erin V. Satterthwaite, Malin L. Pinsky, Guillermo Ortuño Crespo, Mary S. Wisz

Articles

Global policy goals for halting biodiversity loss and climate change depend on each other to be successful. Marine biodiversity and climate change are intertwined through foodwebs that cycle and transport carbon and contribute to carbon sequestration. Yet, biodiversity conservation and fisheries management seldom explicitly include ocean carbon transport and sequestration. In order to effectively manage and govern human activities that affect carbon cycling and sequestration, international biodiversity and climate agreements need to address both biodiversity and climate issues. International agreements that address issues for climate and biodiversity are best poised to facilitate the protection of ocean carbon with existing policies. …

Distinct Immune Signature Predicts Progression Of Vestibular Schwannoma And Unveils A Possible Viral Etiology, Moran Amit, Tongxin Xie, Frederico O Gleber-Netto, Patrick J Hunt, Gautam U Mehta, Diana Bell, Deborah A Silverman, Ismail Yaman, Yi Ye, Jared K Burks, Gregory N Fuller, Paul W Gidley, Marc-Elie Nader, Shaan M Raza, Franco Demonte

Faculty, Staff and Student Publications

BACKGROUND: The management of sub-totally resected sporadic vestibular schwannoma (VS) may include observation, re-resection or irradiation. Identifying the optimal choice can be difficult due to the disease's variable progression rate. We aimed to define an immune signature and associated transcriptomic fingerprint characteristic of rapidly-progressing VS to elucidate the underpinnings of rapidly progressing VS and identify a prognostic model for determining rate of progression.

METHODS: We used multiplex immunofluorescence to characterize the immune microenvironment in 17 patients with sporadic VS treated with subtotal surgical resection alone. Transcriptomic analysis revealed differentially-expressed genes and dysregulated pathways when comparing rapidly-progressing VS to slowly or …

Biophysics Of Cancer, Alemayehu A Gorfe

Faculty, Staff and Student Publications

No abstract provided.

2022-10-04 Minutes, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress meeting minutes from October 4, 2022.

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.