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Analisis Terhadap Kesepakatan Lisan Untuk Menjalankan Waralaba Sesuai Dengan Perjanjian Waralaba Yang Telah Berakhir (Studi Kasus Putusan Nomor 52/Pdt.G/2019 Jo. Putusan Nomor 396/Pdt/2021/Pt Dki, Fahira Zahara Ghassani Oct 2022

Analisis Terhadap Kesepakatan Lisan Untuk Menjalankan Waralaba Sesuai Dengan Perjanjian Waralaba Yang Telah Berakhir (Studi Kasus Putusan Nomor 52/Pdt.G/2019 Jo. Putusan Nomor 396/Pdt/2021/Pt Dki, Fahira Zahara Ghassani

Lex Patrimonium

Franchising is a business system that makes it easy for entrepreneurs to expand their marketing. Therefore, before running a franchise business, the parties must make a franchise agreement that aims to protect the interests of the parties properly. A franchise agreement made in written form can be the basis or evidence if one of the parties defaults. However, there are still franchise businesses that make agreements in the form of unwritten or verbal actors, even though PP 42/2007 and Permendag 71/2019 require written agreements. This is what becomes between the franchisor and the franchisees involved in the franchise business as …


"Pemanfaatan Barang Milik Daerah Kabupaten Penajam Paser Utara (Studi Kasus Penyerahan Pengelolaan Sisi Darat Pelabuhan Buluminung)", Melindya Santoso Putri Oct 2022

"Pemanfaatan Barang Milik Daerah Kabupaten Penajam Paser Utara (Studi Kasus Penyerahan Pengelolaan Sisi Darat Pelabuhan Buluminung)", Melindya Santoso Putri

Lex Patrimonium

The Regent as the Regional Head in the North Penajam Paser Regency should carry out Regional Property Management (BMD). With the existence of five forms of utilization in the form of rental, borrowing, utilization cooperation, building to handover or building handover, and cooperation in providing infrastructure based on PP 27/2014, PP 28/2020, Permendagri 19/2016, Pemda Penajam Paser North 11/2018. A port is a place consisting of land and or waters with certain boundaries as a place for government and company activities. There is a legal problem, namely in the transition of the Management of the Land Side of the Buluminung …


Perbandingan Hukum Pemutusan Surat Kuasa Secara Sepihak Antara Indonesia Dan Belanda Sebagai Bentuk Wanprestasi (Studi Putusan Nomor 704/Pdt.G2017/Pn.Mdn), Karsten Maruli Rogate Hutauruk Oct 2022

Perbandingan Hukum Pemutusan Surat Kuasa Secara Sepihak Antara Indonesia Dan Belanda Sebagai Bentuk Wanprestasi (Studi Putusan Nomor 704/Pdt.G2017/Pn.Mdn), Karsten Maruli Rogate Hutauruk

Lex Patrimonium

The power of attorney agreement is commonly found in dealing with a legal problem that carried out by the community, both in Indonesia and the Netherlands. In Indonesia the Power of Attorney Agreement, is regulated in Articles 1823 and 1814 of the Book of Civil Law which states that the Principal could revoke power of attorney at any time, but turns out that in practice there is Power of Attorney that can not be revoked called Irrevocable Power of Attorney. Regulated in the Instruction of the Internal Affairs Minister No. 14/1982 and Government Regulation No. 24 of 1997 that regulate …


Analisis Pencantuman Klausul Kompensasi Dalam Perjanjian Perkawinan Sebagai Implementasi Asas Kebebasan Berkontrak, Dinda Ramadhani Oct 2022

Analisis Pencantuman Klausul Kompensasi Dalam Perjanjian Perkawinan Sebagai Implementasi Asas Kebebasan Berkontrak, Dinda Ramadhani

Lex Patrimonium

Marriage agreement is commonly recognized by the society nowadays. Article 29 Subsection (2) of Indonesian Marriage Act only regulate a limitation that the content of marriage agreement can not violate the law, religion, and ethics. There are different kind of opinions regarding whether marriage agreement can only regulate regarding matrimonial assets in accordance with Indonesian civil code or it can regulate in every aspect as long as it does not cross the limitation set by Article 29 Subsection (2). This research analyses about the inclusion of compensation clause in marriage agreement as an implementation of freedom of contract principle. Method …


Pewarisan Akun Digital, Nicolas Mario Gunawan Oct 2022

Pewarisan Akun Digital, Nicolas Mario Gunawan

Lex Patrimonium

The rise of digital growth in this era of globalization has shown the need for adjustments in existing law in society, in relation to problems that may arise from said digital growth. One growth that can be said to have happened rampantly can be seen in the law of property, which has to face a lot of new additions that came due to digital growth, for example in bitcoins, MP3 Files, among many other things. Within said property, there is an item that are of interests due to the uniqueness of it, which is an account. Such uniqueness comes from …


Analisis Perbandingan Hukum Mengenai Tunjangan Pasca Perceraian Di Indonesia, Richard Daniel Oct 2022

Analisis Perbandingan Hukum Mengenai Tunjangan Pasca Perceraian Di Indonesia, Richard Daniel

Lex Patrimonium

Divorce, one of the many causes of the end of a marital relationship, brings an impact towards the parties bound in the marital relationship, specifically in the economic conditions.Of the many divorce cases present, the wife in the relationship more often experiences economic hardships, due to the fact that their livelihood during the marriage was provided by the husband. Hence, to prevent condition whereas one of the former spouses being burdened because of divorce, it is necesarry to have defined law regarding spousal maintance after divorce. This thesis discusses the law of spousal maintance in Indonesia and compares it with …


Personality And Psychopathology Correlates Of Institutional Misconduct Among Juvenile Offenders, Paula Floyd Oct 2022

Personality And Psychopathology Correlates Of Institutional Misconduct Among Juvenile Offenders, Paula Floyd

Dissertations

Juvenile delinquency is a national concern, as delinquent behavior is associated with a host of poor psychosocial outcomes during later adolescence and adulthood. To address delinquency, it is important to understand psychological adjustment among adolescents who have already made contact with the juvenile justice system. One way to explore adjustment within this population involves examining personality and psychopathology correlates of institutional misconduct (i.e., behavioral infractions while incarcerated). While there is a robust body of literature regarding personality and psychopathology correlates of misconduct in adult inmate samples, there has been far less work devoted to these relationships among justice-involved youth. Furthermore, …


Zeid Ra'ad Al Hussein To Present Norman And Louis Miller Lecture At St. Norbert College, St. Norbert College Oct 2022

Zeid Ra'ad Al Hussein To Present Norman And Louis Miller Lecture At St. Norbert College, St. Norbert College

Press Releases 2022

No abstract provided.


Observations On Late Cretaceous Micrampulla (Corethrales, Bacillariophyceae) From The Campbell Plateau (Zealandia), Southwest Pacific Ocean, Kenta Abe, David M. Harwood, Richard W. Jordan Oct 2022

Observations On Late Cretaceous Micrampulla (Corethrales, Bacillariophyceae) From The Campbell Plateau (Zealandia), Southwest Pacific Ocean, Kenta Abe, David M. Harwood, Richard W. Jordan

Department of Earth and Atmospheric Sciences: Faculty Publications

Late Cretaceous (late Campanian) diatom assemblages from the Campbell Plateau (Zealandia), southwest Pacific Ocean, obtained from Deep Sea Drilling Project (DSDP) Leg 29 Site 275, contain well-preserved specimens of two enigmatic diatom species currently assigned to the genus Ktenodiscus; Micrampulla parvula originally described from the Maastrichtian-age Moreno Shale, California, and Pterotheca cretacea from DSDP Site 275. In general, the two species share a number of common features with modern Corethron (domed valves, probable heterovalvate frustules, T-shaped serrated articulated spines, marginal sockets), but differ in the location of the sockets (i.e. vertically at the base of the valve dome and …


Grounding Systemic Functional Linguistics And Critical Theory In Deepening Ell's Discipline Knowledge And Exploring The Praxis Of Teaching And Researching Disciplinary Literacy Development: A Book Review, Elih Sutisna Yanto, Junjun Muhamad Ramdani Oct 2022

Grounding Systemic Functional Linguistics And Critical Theory In Deepening Ell's Discipline Knowledge And Exploring The Praxis Of Teaching And Researching Disciplinary Literacy Development: A Book Review, Elih Sutisna Yanto, Junjun Muhamad Ramdani

The Qualitative Report

In the book, Teaching and Researching ELLs’ Disciplinary Literacies: SFL in Action in the Context of US School Reform (2019), Meg Gebhard, professor of Applied Linguistics and co-director of the Secondary English Education Program at the University of Massachusetts, Amherst, USA, provides a comprehensive description to second language researchers, multilingual learners, language teachers, and teacher educators of how Halliday's Systemic Functional Linguistics (SFL) can be applied to give ELLs access to the language and literacies they need to succeed across the curriculum. Throughout the chapters, Gebhard provides convincing evidence that mastering their various grammars and genres (text types) is equally …


Alfalfa Water Productivity And Yield Gaps In The U.S. Central Great Plains, Kaylin P. Fink, Patricio Grassini, Alexandre Rocateli, Leonardo M. Bastos, Jude Kastens, Luke P. Ryan, Xiaomao Lin, Andres Patrignani, Romulo P. Lollato Oct 2022

Alfalfa Water Productivity And Yield Gaps In The U.S. Central Great Plains, Kaylin P. Fink, Patricio Grassini, Alexandre Rocateli, Leonardo M. Bastos, Jude Kastens, Luke P. Ryan, Xiaomao Lin, Andres Patrignani, Romulo P. Lollato

Department of Agronomy and Horticulture: Faculty Publications

Context: Yield gap (Yg) analyses using farmer-reported yield and management data have been performed for a number of annual grain crops, but it lacks for perennial forages. The U.S. accounts for 21 % of the global alfalfa production with a large rainfed area located in the central Great Plains, serving as an interesting case-study for Yg in perennial forages. Most existing alfalfa Yg analyses quantified the magnitude of the Yg but failed to identify associated management practices to reduce it. Challenging this analysis, a systematic benchmark for alfalfa water productivity [WP, kg dry matter per mm evapotranspiration (ETc)] that …


Effect Of Water Stress On Weed Germination, Growth Characteristics, And Seed Production: A Global Meta-Analysis, Mandeep Singh, Resham Thapa, Meetpal Singh Kukal, Suat Irmak, Steven Mirsky, Amit J. Jhala Oct 2022

Effect Of Water Stress On Weed Germination, Growth Characteristics, And Seed Production: A Global Meta-Analysis, Mandeep Singh, Resham Thapa, Meetpal Singh Kukal, Suat Irmak, Steven Mirsky, Amit J. Jhala

Department of Agronomy and Horticulture: Faculty Publications

Weeds compete with crops for soil moisture, along with other resources, which can impact the germination, growth, and seed production of weeds; however, this impact has not been systematically recorded and synthesized across diverse studies. To address this knowledge gap, a global meta-analysis was conducted using 1,196 paired observations from 86 published articles assessing the effect of water stress on weed germination, growth characteristics, and seed production. These studies were conducted and published during 1970 through 2020 across four continents (Asia, Australia, Europe, and North America). Imposed water stress was expressed as solution osmotic potential (ψsolution), soil water potential (ψsoil), …


Soho Lofts Nyc, Llc V. Ferrer Oct 2022

Soho Lofts Nyc, Llc V. Ferrer

All Decisions

No abstract provided.


Ouattara V. State Of N.Y. Div. Of Hous. & Community Renewal Oct 2022

Ouattara V. State Of N.Y. Div. Of Hous. & Community Renewal

All Decisions

No abstract provided.


Munday V. 224 Lafayette St. Corp Oct 2022

Munday V. 224 Lafayette St. Corp

All Decisions

No abstract provided.


Metabolome-Wide Associations Of Gestational Weight Gain In Pregnant Women With Overweight And Obesity, Jin Dai, Nansi S. Boghossian, Mark Sarzynski Ph.D., Faha, Facsm, Feng Luo, Xiaoqian Sun, Jian Li, Oliver Fiehn, Jihong Liu Sc.D., Liwei Chen Oct 2022

Metabolome-Wide Associations Of Gestational Weight Gain In Pregnant Women With Overweight And Obesity, Jin Dai, Nansi S. Boghossian, Mark Sarzynski Ph.D., Faha, Facsm, Feng Luo, Xiaoqian Sun, Jian Li, Oliver Fiehn, Jihong Liu Sc.D., Liwei Chen

Faculty Publications

Excessive gestational weight gain (GWG) is associated with adverse pregnancy outcomes. This metabolome-wide association study aimed to identify metabolomic markers for GWG. This longitudinal study included 39 Black and White pregnant women with a prepregnancy body mass index (BMI) of ≥ 25 kg/m2. Untargeted metabolomic profiling was performed using fasting plasma samples collected at baseline (mean: 12.1 weeks) and 32 weeks of gestation. The associations of metabolites at each time point and changes between the two time points with GWG were examined by linear and least absolute shrinkage and selection operator (LASSO) regression analyses. Pearson correlations between the …


Gata Now!, Georgia Southern University Oct 2022

Gata Now!, Georgia Southern University

Athletics: News & Publications

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Interfacial Oxidative Oligomerization Of Catechol, Marcelo I. Guzman, Elizabeth A. Pillar-Little, Alexis J. Eugene Oct 2022

Interfacial Oxidative Oligomerization Of Catechol, Marcelo I. Guzman, Elizabeth A. Pillar-Little, Alexis J. Eugene

Chemistry Faculty Publications

The heterogeneous reaction between thin films of catechol exposed to O3(g) creates hydroxyl radicals (HO•) in situ, which in turn generate semiquinone radical intermediates in the path to form heavier polyhydroxylated biphenyl, terphenyl, and triphenylene products. Herein, the alteration of catechol aromatic surfaces and their chemical composition are studied during the heterogeneous oxidation of catechol films by O3(g) molar ratios ≥ 230 ppbv at variable relative humidity levels (0% ≤ RH ≤ 90%). Fourier transform infrared micro-spectroscopy, atomic force microscopy, electrospray ionization mass spectrometry, and reverse-phase liquid chromatography with UV−visible and mass spectrometry detection …


Executive Committee - Agenda 10/11/2022, Academic Senate Oct 2022

Executive Committee - Agenda 10/11/2022, Academic Senate

Academic Senate Agendas

No abstract provided.


Wcax October 2022 Election Survey Results, Unh Survey Center Oct 2022

Wcax October 2022 Election Survey Results, Unh Survey Center

All UNH Survey Center Polls

No abstract provided.


Department Of Human Resources News, Georgia Southern University Oct 2022

Department Of Human Resources News, Georgia Southern University

Human Resources (2010-2023)

  • Making a Difference In Georgia


Role Of Stem Cell Transplant In Cd30+ Ptcl Following Frontline Brentuximab Vedotin Plus Chp Or Chop In Echelon-2., Kerry J Savage, Steven M Horwitz, Ranjana Advani, Jacob Haaber Christensen, Eva Domingo-Domenech, Giuseppe Rossi, Franck Morschhauser, Onder Alpdogan, Cheolwon Suh, Kensei Tobinai, Andrei Shustov, Marek Trneny, Sam Yuen, Pier Luigi Zinzani, Lorenz Trümper, Tim Ilidge, Owen A O'Connor, Barbara Pro, Harry Miao, Veronica Bunn, Keenan Fenton, Michelle Fanale, Markus Puhlmann, Swaminathan Iyer Oct 2022

Role Of Stem Cell Transplant In Cd30+ Ptcl Following Frontline Brentuximab Vedotin Plus Chp Or Chop In Echelon-2., Kerry J Savage, Steven M Horwitz, Ranjana Advani, Jacob Haaber Christensen, Eva Domingo-Domenech, Giuseppe Rossi, Franck Morschhauser, Onder Alpdogan, Cheolwon Suh, Kensei Tobinai, Andrei Shustov, Marek Trneny, Sam Yuen, Pier Luigi Zinzani, Lorenz Trümper, Tim Ilidge, Owen A O'Connor, Barbara Pro, Harry Miao, Veronica Bunn, Keenan Fenton, Michelle Fanale, Markus Puhlmann, Swaminathan Iyer

Department of Medical Oncology Faculty Papers

Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of aggressive non-Hodgkin lymphomas, the majority of which have high relapse rates following standard therapy. Despite use of consolidative stem cell transplant (SCT) following frontline therapy, there remains no consensus on its utility. The double-blind randomized phase 3 ECHELON-2 study (#NCT01777152; clinicaltrials.gov) demonstrated improved progression-free survival (PFS) and overall survival with frontline brentuximab vedotin plus cyclophosphamide, doxorubicin, and prednisone (A+CHP). Herein, we conducted an exploratory subgroups analysis of the impact of consolidative SCT on PFS in patients with previously untreated CD30+ PTCL (ALK- anaplastic large cell lymphoma [ALCL] and non-ALCL) …


A Dynamic New Dean: Anthony E. Varona Looks To Take Seattle U Law To New Heights Of Achievement, Seattle University School Of Law Oct 2022

A Dynamic New Dean: Anthony E. Varona Looks To Take Seattle U Law To New Heights Of Achievement, Seattle University School Of Law

News Center Articles

No abstract provided.


Whole Genome Sequence Analysis Of Blood Lipid Levels In >66,000 Individuals, Margaret Sunitha Selvaraj, Xihao Li, Zilin Li, Akhil Pampana, David Y Zhang, Joseph Park, Stella Aslibekyan, Joshua C Bis, Jennifer A Brody, Brian E Cade, Lee-Ming Chuang, Ren-Hua Chung, Joanne E Curran, Lisa De Las Fuentes, Paul S De Vries, Ravindranath Duggirala, Barry I Freedman, Mariaelisa Graff, Xiuqing Guo, Nancy Heard-Costa, Bertha Hidalgo, Chii-Min Hwu, Marguerite R Irvin, Tanika N Kelly, Brian G Kral, Leslie Lange, Xiaohui Li, Martin Lisa, Steven A Lubitz, Ani W Manichaikul, Preuss Michael, May E Montasser, Alanna C Morrison, Take Naseri, Jeffrey R O'Connell, Nicholette D Palmer, Patricia A Peyser, Muagututia S Reupena, Jennifer A Smith, Xiao Sun, Kent D Taylor, Russell P Tracy, Michael Y Tsai, Zhe Wang, Yuxuan Wang, Wei Bao, John T Wilkins, Lisa R Yanek, Wei Zhao, Donna K Arnett, John Blangero, Eric Boerwinkle, Donald W Bowden, Yii-Der Ida Chen, Adolfo Correa, L Adrienne Cupples, Susan K Dutcher, Patrick T Ellinor, Myriam Fornage, Stacey Gabriel, Soren Germer, Richard Gibbs, Jiang He, Robert C Kaplan, Sharon L R Kardia, Ryan Kim, Charles Kooperberg, Ruth J F Loos, Karine A Viaud-Martinez, Rasika A Mathias, Stephen T Mcgarvey, Braxton D Mitchell, Deborah Nickerson, Kari E North, Bruce M Psaty, Susan Redline, Alexander P Reiner, Ramachandran S Vasan, Stephen S Rich, Cristen Willer, Jerome I Rotter, Daniel J Rader, Xihong Lin, Gina M Peloso, Pradeep Natarajan Oct 2022

Whole Genome Sequence Analysis Of Blood Lipid Levels In >66,000 Individuals, Margaret Sunitha Selvaraj, Xihao Li, Zilin Li, Akhil Pampana, David Y Zhang, Joseph Park, Stella Aslibekyan, Joshua C Bis, Jennifer A Brody, Brian E Cade, Lee-Ming Chuang, Ren-Hua Chung, Joanne E Curran, Lisa De Las Fuentes, Paul S De Vries, Ravindranath Duggirala, Barry I Freedman, Mariaelisa Graff, Xiuqing Guo, Nancy Heard-Costa, Bertha Hidalgo, Chii-Min Hwu, Marguerite R Irvin, Tanika N Kelly, Brian G Kral, Leslie Lange, Xiaohui Li, Martin Lisa, Steven A Lubitz, Ani W Manichaikul, Preuss Michael, May E Montasser, Alanna C Morrison, Take Naseri, Jeffrey R O'Connell, Nicholette D Palmer, Patricia A Peyser, Muagututia S Reupena, Jennifer A Smith, Xiao Sun, Kent D Taylor, Russell P Tracy, Michael Y Tsai, Zhe Wang, Yuxuan Wang, Wei Bao, John T Wilkins, Lisa R Yanek, Wei Zhao, Donna K Arnett, John Blangero, Eric Boerwinkle, Donald W Bowden, Yii-Der Ida Chen, Adolfo Correa, L Adrienne Cupples, Susan K Dutcher, Patrick T Ellinor, Myriam Fornage, Stacey Gabriel, Soren Germer, Richard Gibbs, Jiang He, Robert C Kaplan, Sharon L R Kardia, Ryan Kim, Charles Kooperberg, Ruth J F Loos, Karine A Viaud-Martinez, Rasika A Mathias, Stephen T Mcgarvey, Braxton D Mitchell, Deborah Nickerson, Kari E North, Bruce M Psaty, Susan Redline, Alexander P Reiner, Ramachandran S Vasan, Stephen S Rich, Cristen Willer, Jerome I Rotter, Daniel J Rader, Xihong Lin, Gina M Peloso, Pradeep Natarajan

Faculty, Staff and Student Publications

Blood lipids are heritable modifiable causal factors for coronary artery disease. Despite well-described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery of lipid-associated alleles using whole genome sequencing (WGS), partly due to limited sample sizes, ancestral diversity, and interpretation of clinical significance. Among 66,329 ancestrally diverse (56% non-European) participants, we associate 428M variants from deep-coverage WGS with lipid levels; ~400M variants were not assessed in prior lipids genetic analyses. We find multiple lipid-related genes strongly associated with blood lipids through analysis of common and rare coding variants. We discover several associated rare non-coding variants, largely at Mendelian lipid …


The Relationship Between Spirituality And Greed: Sex Matters, Alan G. Walker, Ian S. Mercer Oct 2022

The Relationship Between Spirituality And Greed: Sex Matters, Alan G. Walker, Ian S. Mercer

Journal of Religion and Business Ethics

Abstract

Organizational malfeasance is oftentimes attributed to greed (Hansen & Movahedi, 2010). Such attributions appear appropriate given recent research demonstrating relationships between greed and shareholder return (Hayes et al., 2017). However, research exploring antecedents of greed is scant. We explored one such antecedent by examining the relationship between participants’ spirituality and a trait measure of greed. Results indicated that individuals’ spirituality explained unique variance in greed above that variance explained by sex (being a male) and college major (being a business major) - which have well-established relationships with unethical outcomes. This finding suggests that (a) spirituality was a precursor to …


Analysis Of Hybrid Learning For Students With Learning Disabilities In Primary Schools Providing Inclusive Education, Nugraheni Rachmawati, Asep Supena, Yufiarti Yufiarti, Gusti Yarmi, Asep Rudi Casmana Oct 2022

Analysis Of Hybrid Learning For Students With Learning Disabilities In Primary Schools Providing Inclusive Education, Nugraheni Rachmawati, Asep Supena, Yufiarti Yufiarti, Gusti Yarmi, Asep Rudi Casmana

The Qualitative Report

Many special-needs children, including students with learning disabilities, are enrolled in public schools. The current state of education is transitioning from online to face-to-face learning due to the improving situation after the COVID-19 pandemic. Hybrid learning is one of the alternative methods applied during the transition period. Therefore, this study aims to explore the experiences of teachers in implementing hybrid learning in students with disabilities in Indonesia using a qualitative description. Data was collected through interviews with one class teacher, two students with learning disabilities and their parents, and one school principal. Furthermore, observations were made on the learning process …


A Snapshot Of Science Education During Covid-19 In The Spring Of 2021, Lily Bentley Oct 2022

A Snapshot Of Science Education During Covid-19 In The Spring Of 2021, Lily Bentley

The Qualitative Report

The COVID-19 pandemic has placed many unique challenges on our education system. Unpacking the many issues that educators faced will allow researchers to understand some of the impacts that resulted from this unique phenomenon. This exploratory qualitative research study sought to understand how science educators and administrators made sense of science instruction during the spring of 2021. Data was collected through semi-structured interviews and online observations with ten K-12 science teachers and four administrators across two different counties within Virginia. Thematic coding was employed to analyze the findings, and results were validated through member checking with participants. Participants shared that …


Nationwide Public Perceptions Regarding The Acceptance Of Using Wastewater For Community Health Monitoring In The United States., A. Scott Lajoie, Asli Aslan, Rochelle H. Holm, Lauren B. Anderson, Heather D. Ness, Ted Smith Oct 2022

Nationwide Public Perceptions Regarding The Acceptance Of Using Wastewater For Community Health Monitoring In The United States., A. Scott Lajoie, Asli Aslan, Rochelle H. Holm, Lauren B. Anderson, Heather D. Ness, Ted Smith

Faculty and Staff Scholarship

To assess the levels of infection across communities during the coronavirus disease 2019 pandemic, researchers have measured severe acute respiratory syndrome coronavirus 2 RNA in feces dissolved in sewer water. This activity is colloquially known as sewer monitoring and is referred to as wastewater-based epidemiology in academic settings. Although global ethical principles have been described, sewer monitoring is unregulated for health privacy protection when used for public health surveillance in the United States. This study used Qualtrics XM, a national research panel provider, to recruit participants to answer an online survey. Respondents (N = 3,083) answered questions about their knowledge, …


New York Tech Week: A Taste Of Web3: Building Workshop, Innovation Center For Law And Technology Oct 2022

New York Tech Week: A Taste Of Web3: Building Workshop, Innovation Center For Law And Technology

Innovation Center for Law and Technology

October 11, 2022


Mesoscale Structure-Function Relationships In Mitochondrial Transcriptional Condensates, Marina Feric, Azadeh Sarfallah, Furqan Dar, Dmitry Temiakov, Rohit V. Pappu, Tom Misteli Oct 2022

Mesoscale Structure-Function Relationships In Mitochondrial Transcriptional Condensates, Marina Feric, Azadeh Sarfallah, Furqan Dar, Dmitry Temiakov, Rohit V. Pappu, Tom Misteli

Department of Biochemistry and Molecular Biology Faculty Papers

In live cells, phase separation is thought to organize macromolecules into membraneless structures known as biomolecular condensates. Here, we reconstituted transcription in condensates from purified mitochondrial components using optimized in vitro reaction conditions to probe the structure-function relationships of biomolecular condensates. We find that the core components of the mt-transcription machinery form multiphasic, viscoelastic condensates in vitro. Strikingly, the rates of condensate-mediated transcription are substantially lower than in solution. The condensate-mediated decrease in transcriptional rates is associated with the formation of vesicle-like structures that are driven by the production and accumulation of RNA during transcription. The generation of RNA alters …