Digital Commons Network^™

Dnaja1- And Conformational Mutant P53-Dependent Inhibition Of Cancer Cell Migration By A Novel Compound Identified Through A Virtual Screen., Shigeto Nishikawa, Atsushi Kaida, Alejandro Parrales, Atul Ranjan, Mohamed A.A. Alalem, Hongyi Ren, Frank J. Schoenen, David K. Johnson, Tomoo Iwakuma

Manuscripts, Articles, Book Chapters and Other Papers

Cancers are frequently addicted to oncogenic missense mutant p53 (mutp53). DNAJA1, a member of heat shock protein 40 (HSP40), also known as J-domain proteins (JDPs), plays a crucial role in the stabilization and oncogenic activity of misfolded or conformational mutp53 by binding to and preventing mutp53 from proteasomal degradation. However, strategies to deplete mutp53 are not well-established, and no HSP40/JDPs inhibitors are clinically available. To identify compounds that bind to DNAJA1 and induce mutp53 degradation, we performed an in silico docking study of ~10 million of compounds from the ZINC database for the J-domain of DNAJA1. A compound 7-3 was …

Examining The Link Between Professional Learning Communities And Teacher Burnout, Sabrina Caminero

Seton Hall University Dissertations and Theses (ETDs)

Public school teachers daily face high job stress, which puts them at an increased risk of experiencing burnout. Given the negative implications associated with burnout and the lack of research examining burnout and professional learning communities, this study explores the relationship between teacher participation in professional learning communities and burnout. I examine the relationship between professional learning communities and burnout and whether this relationship is sensitive to demographic controls. I used Quantitative methods to measure the relationship between professional learning communities and burnout using dimension reduction, simple regression analysis, multiple regression analysis, and pairwise correlations. I collected survey data from …

Indonesian Political Exiles In The Netherlands After 1965; Postcolonial Nationalists In An Era Of Transnationalism, David T. Hill

Wacana, Journal of the Humanities of Indonesia

This article presents brief life stories of select Indonesians who were forced into exile by the Suharto regime after the 1965 National Tragedy in Indonesia. It focuses on staunch nationalist exiles who were rendered stateless by the self-proclaimed “New Order“ for refusing to accept the overthrow of President Sukarno and declare loyalty to the military regime. Faced with a life in exile, they sought refuge in the former colonial nation of the Netherlands. After exploring a brief history of exile in the bilateral relationship, it explores the choices made by select individuals who moved to the Netherlands from a variety …

Transnational Connections; Diasporic (Re)Turns To Indonesia, Jorien Van Beukering

Wacana, Journal of the Humanities of Indonesia

In the twentieth century, decolonization sparked mass migration movements across the globe as former settlers left newly independent colonies for the former imperial metropole or a new country altogether. In the following decades, postcolonial migrants made new homes and created communities in their hostlands. Eventually, some travelled back to their country of origin, the former colony. Indisch Dutch returns to Indonesia are not uncommon and, although some members of the first generation visited Indonesia as tourists, accounts of (re)turns by the second and third generation are rare. To form a clearer picture of the transnational connections between Indonesia and the …

Objects Of Belonging And Displacement; Artefacts And European Migrants From Colonial Indonesia In Colonial And Post-Colonial Times, Caroline Drieënhuizen

Wacana, Journal of the Humanities of Indonesia

As colonial Indonesia never was intended to be a “settler colony”, many Dutch citizens spent only a certain period of their lives there before returning to the Netherlands. However, there were also Europeans, many with Asian-European roots, who had called the colony home for generations and were forced to leave that home after 1945.

All these different types of colonial migrants were displaced and maintained, built and reinforced their relations with the country (whether it was the colony or the “motherland”) they had left. This transnationalism (or, as I argue here, imperial orientation) took shape not only legally or relationally …

Three Generations Later; Examining Transnationalism, Cultural Preservation, And Transgenerational Trauma In United States Indo Population, Jamie D. Stern

Wacana, Journal of the Humanities of Indonesia

This paper examines the relationship between transnationalism, cultural preservation, and transgenerational trauma in the United States (US) Indo population. The information being analysed was compiled by the author from two separate surveys which took place between 2012 and 2021. This data was initially intended to act as a census for the scattered US Indo community however the salient information necessitated that the census be ongoing and that another survey be developed to measure effects of lingering trauma which has been passed down generationally. The two surveys invited Indos from around the globe to participate in data collection, which led to …

Anton Stolwijk (2021), "Aceh; Kisah Datang Dan Terusirnya Belanda Dan Jejak Yang Ditinggalkan", Moch Nur Ichwan

Wacana, Journal of the Humanities of Indonesia

No abstract provided.

Ronit Ricci (2019), "Banishment And Belonging; Exile And Diaspora In Sarandib, Lanka, And Ceylon", Achmad Sunjayadi

Wacana, Journal of the Humanities of Indonesia

No abstract provided.

Preface, Susi Moeimam

Wacana, Journal of the Humanities of Indonesia

No abstract provided.

Walang Panitikang Rehiyonal: Pinag-Isang Maraming Bayan Sa Tatlong Kritikal Na Akda Ni Bienvenido Lumbera (There Is No Such Thing As Regional Literature In The Philippines: Uniting The Archipelago In Bienvenido Lumbera’S Three Critical Works), Raniela E. Barbaza

Akda: The Asian Journal of Literature, Culture, Performance

Panahon na para tanggapin nating hindi na nakatutulong ang katawagang “panitikang rehiyonal” o “mga panitikan mula sa rehiyon” o “rehiyonal na panitikan” sa pag-aaral ng panitikang Pilipino. Nakatulong ang mga katawagang ito sa paghiraya natin ng mas makatarungan at makatwiran na imahen ng ating bayan. Sa kabila ng pagpapaalala ng pambansang alagad ng panitikan na si Bienvenido Lumbera na ang panitikang rehiyonal ay tumutukoy sa mga panitikan sa iba’t ibang rehiyon sa Pilipinas kabilang na ang rehiyon na Tagalog ang wika, nananatili ang pag-unawa sa panitikang rehiyonal na panitikan ng mga wika sa Pilipinas maliban sa Tagalog. Sa madaling salita, …

Coarse-Grained Modeling Studies Of Entangled Semiflexible Polymers: Melts, Glasses, And Granular Media, Joseph Fox D. Dietz

USF Tampa Graduate Theses and Dissertations

This dissertation is devoted to the computational study of model semiflexible polymers using a coarse-grained bead-spring approach and molecular dynamics (MD) simulations. Much of the work presented here is motivated by the need to derive predictive models for describing polymeric materials’ macroscopic mechanical response from the underlying local structure or local chain parameters. This dissertation describes polymeric materials in the context of granular media, melts, and glasses with a focus on relating characteristics such as chain stiffness and local structure to systems’ solidification, rheology, and fracture mechanisms.

Chain stiffness κ and structural properties like chains’ characteristic bond angle θ0 are …

Unintended Consequences Of A Transition To Synchronous, Virtual Simulations For Interprofessional Learners, Tiffany Champagne-Langabeer, Samuel E Neher, Marylou Cardenas-Turanzas, Jennifer L Swails

Faculty, Staff and Student Publications

The coronavirus pandemic shifted in-person environments to virtual environments. Little is known about the effectiveness of fully synchronous, virtual interprofessional education (IPE). This study aims to compare two IPE cases that occurred in-person pre-pandemic and virtual during-pandemic. Two cases are analyzed: a medical error care and a charity care case. Participants were students from various health science disciplines. Assessments were captured through The Interprofessional Collaborative Competency Attainment Survey (ICCAS). Effect sizes were calculated for the pre-and post-surveys and analyzed using Cohen's d for independent samples. From the in-person collection period, a total of 479 students participated in the medical error …

Naphthoquinones Oxidize H2s To Polysulfides And Thiosulfate, Implications For Therapeutic Applications, Kenneth R Olson, Kasey J Clear, Paul J Derry, Yan Gao, Zhilin Ma, Nathaniel M Cieplik, Alyssa Fiume, Dominic J Gaziano, Stephen M Kasko, Kathleen Narloch, Cecilia L Velander, Ifeyinwa Nwebube, Collin J Pallissery, Ella Pfaff, Brian P Villa, Thomas A Kent, Gang Wu, Karl D Straub

Faculty, Staff and Student Publications

1,4-Napththoquinones (NQs) are clinically relevant therapeutics that affect cell function through production of reactive oxygen species (ROS) and formation of adducts with regulatory protein thiols. Reactive sulfur species (RSS) are chemically and biologically similar to ROS and here we examine RSS production by NQ oxidation of hydrogen sulfide (H2S) using RSS-specific fluorophores, liquid chromatography-mass spectrometry, UV-Vis absorption spectrometry, oxygen-sensitive optodes, thiosulfate-specific nanoparticles, HPLC-monobromobimane derivatization, and ion chromatographic assays. We show that NQs, catalytically oxidize H2S to per- and polysulfides (H2Sn, n = 2−6), thiosulfate, sulfite and sulfate in reactions that consume oxygen and are accelerated by superoxide dismutase (SOD) and …

Are Safe Haven Laws An Adequate Replacement For Abortion Rights?, Sophia Foster

Cardozo International & Comparative Law Review (CICLR) Blog

The United States Supreme Court’s decision in Dobbs v. Jackson Women’s Health Organization had a devastating impact on an individual’s right to choose. By holding that there is no constitutional right to abortion, the Court overturned decades of precedent that had protected a person’s bodily autonomy, resulting in negative effects on a pregnant person’s rights. But there were other, less obvious, effects of the decision as well. One of these results is a renewed attention on a minimally discussed law – a law that all fifty states have some version of. This law, commonly known as a safe haven law, …

The Effects Of Teaching Undergraduate Freshmen Biology Courses In Spanish And English, Angela M. Chapman, Amy A. Weimer, Mirayda Torres-Avila, Cristina Trejo, Alexis Racelis

Teaching and Learning Faculty Publications

This study examines the attitudes and experiences of bilingual learners across two instructional types, identifying how the language of instruction affects the context of learning, and how the experience of the learners differs. Participants included 269 predominantly Hispanic undergraduate students in a general biology course attending a Hispanic Serving Institution in a bilingual community along the US-Mexico border. A bilingual faculty member, who recognizes the sociocultural and contextual factors that affect student learning and adopts a teaching philosophy founded in Culturally Responsive Practices (CRP) and valuing students’ Funds of Knowledge taught the class. This study utilized a mixed method design …

Chemotherapy-Induced Toxicities And Their Associations With Clinical And Non-Clinical Factors Among Breast Cancer Patients In Vietnam, Sang M Nguyen, Anh T Pham, Lan M Nguyen, Hui Cai, Thuan V Tran, Xiao-Ou Shu, Huong T T Tran

Faculty, Staff and Student Publications

Understanding the burden and factors related to chemotherapy-induced toxicity is important in treatment planning for breast cancer patients. We conducted a prospective study among 396 newly diagnosed and chemotherapy-treated breast cancer patients recruited in two major cancer hospitals in northern Vietnam. Toxicities were captured through medical chart reviews and patient self-reports and graded using NCI CTCAE classification. Associations for sociodemographic and clinical factors with chemotherapy-induced toxicities during first-line chemotherapy were evaluated via multivariable logistic regression. Severe (i.e., grade ≥ 3) hematological (38.6%), and gastrointestinal (12.9%) toxicities were common. A pre-existing nephrological condition was significantly associated with the risk of severe …

Which Countries Are Leading High-Impact Science In Astronomy?, Juan P. Madrid, Julie Steen

Physics & Astronomy Faculty Publications

Recent news reports claim that China is overtaking the United States and all other countries in scientific productivity and scientific impact. A straightforward analysis of high-impact papers in astronomy reveals that this is not true in our field. In fact, the United States continues to host, by a large margin, the authors that lead high-impact papers. Moreover, this analysis shows that 90% of all high-impact papers in astronomy are led by authors based in North America and Europe. That is, only about 10% of countries in the world host astronomers that publish “astronomy’s greatest hits".

#Golead Newsletter, Georgia Southern University

#GoLead Newsletter (2016-2023)

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Cost-Aware Generalized Α-Investing For Multiple Hypothesis Testing, Thomas Cook, Harsh Vardhan Dubey, Ji Ah Lee, Guangyu Zhu, Tingting Zhao, Patrick Flaherty

Information Systems and Analytics Department Faculty Journal Articles

We consider the problem of sequential multiple hypothesis testing with nontrivial data collection cost. This problem appears, for example, when conducting biological experiments to identify differentially expressed genes in a disease process. This work builds on the generalized α-investing framework that enables control of the false discovery rate in a sequential testing setting. We make a theoretical analysis of the long term asymptotic behavior of α-wealth which motivates a consideration of sample size in the α-investing decision rule. Using the game theoretic principle of indifference, we construct a decision rule that optimizes the expected return (ERO) of α-wealth and provides …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

The George-Anne Reflector Magazine Newsletter, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Making The Path To A Law Degree More Accessible For Everyone, A. Benjamin Spencer

Popular Media

US Supreme Court Justice Neil Gorsuch recently asked if a law degree should require seven years of college and mountains of debt. William & Mary Law School Dean A. Benjamin Spencer answers that question and provides solutions for knocking down the barriers to a legal education.

Search History Of A Medical Student, Brian R. Smith

Journal of Wellness

No abstract provided.

A Machine Learning-Based Method For Automatically Identifying Novel Cells In Annotating Single-Cell Rna-Seq Data, Ziyi Li, Yizhuo Wang, Irene Ganan-Gomez, Simona Colla, Kim-Anh Do

Faculty, Staff and Student Publications

MOTIVATION: Single-cell RNA sequencing (scRNA-seq) has been widely used to decompose complex tissues into functionally distinct cell types. The first and usually the most important step of scRNA-seq data analysis is to accurately annotate the cell labels. In recent years, many supervised annotation methods have been developed and shown to be more convenient and accurate than unsupervised cell clustering. One challenge faced by all the supervised annotation methods is the identification of the novel cell type, which is defined as the cell type that is not present in the training data, only exists in the testing data. Existing methods usually …

Standards In Semen Examination: Publishing Reproducible And Reliable Data Based On High-Quality Methodology, Lars Björndahl, Christopher L R Barratt, David Mortimer, Ashok Agarwal, Robert J Aitken, Juan G Alvarez, Natalie Aneck-Hahn, Stefan Arver, Elisabetta Baldi, Lluís Bassas, Florence Boitrelle, Riana Bornman, Douglas T Carrell, José A Castilla, Gerardo Cerezo Parra, Jerome H Check, Patricia S Cuasnicu, Sally Perreault Darney, Christiaan De Jager, Christopher J De Jonge, Joël R Drevet, Erma Z Drobnis, Stefan S Du Plessis, Michael L Eisenberg, Sandro C Esteves, Evangelini A Evgeni, Alberto Ferlin, Nicolas Garrido, Aleksander Giwercman, Ilse G F Goovaerts, Trine B Haugen, Ralf Henkel, Lars Henningsohn, Marie-Claude Hofmann, James M Hotaling, Piotr Jedrzejczak, Pierre Jouannet, Niels Jørgensen, Jackson C Kirkman Brown, Csilla Krausz, Maciej Kurpisz, Ulrik Kvist, Dolores J Lamb, Hagai Levine, Kate L Loveland, Robert I Mclachlan, Ali Mahran, Liana Maree, Sarah Martins Da Silva, Michael T Mbizvo, Andreas Meinhardt, Roelof Menkveld, Sharon T Mortimer, Sergey Moskovtsev, Charles H Muller, Maria José Munuce, Monica Muratori, Craig Niederberger, Cristian O'Flaherty, Rafael Oliva, Willem Ombelet, Allan A Pacey, Michael A Palladino, Ranjith Ramasamy, Liliana Ramos, Nathalie Rives, Eduardo Rs Roldan, Susan Rothmann, Denny Sakkas, Andrea Salonia, Maria Cristina Sánchez-Pozo, Rosanna Sapiro, Stefan Schlatt, Peter N Schlegel, Hans-Christian Schuppe, Rupin Shah, Niels E Skakkebæk, Katja Teerds, Igor Toskin, Herman Tournaye, Paul J Turek, Gerhard Van Der Horst, Monica Vazquez-Levin, Christina Wang, Alex Wetzels, Theodosia Zeginiadou, Armand Zini

Faculty, Staff and Student Publications

Biomedical science is rapidly developing in terms of more transparency, openness and reproducibility of scientific publications. This is even more important for all studies that are based on results from basic semen examination. Recently two concordant documents have been published: the 6th edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen, and the International Standard ISO 23162:2021. With these tools, we propose that authors should be instructed to follow these laboratory methods in order to publish studies in peer-reviewed journals, preferable by using a checklist as suggested in an Appendix to this article.

Graduate Joint Recital: Daniel G. Castillon Iii, Horn; Zhiyuan Gao, Horn; Grace Eom, Piano; Valen Pao, Piano; October 31, 2022, Daniel G. Castillon Iii, Zhiyuan Gao, Grace Eom, Valen Pao

School of Music Programs

Kemp Recital Hall
October 31, 2022
Monday Evening
6:30 p.m.

Harmonizing Open Licenses Among Online Databases Of Enthusiast Communities: Challenges For The Legal Integration Of Databases In The Japanese Visual Media Graph Project, S Schroff, M Pfeffer, Z Kacsuk, M Roth

School of Law, Humanities and Social Sciences

The Japanese Visual Media Graph project has created a knowledge graph for researchers working on popular Japanese visual media by combining data compiled by various enthusiast online communities. In order to open up the knowledge graph to researchers around the globe, the databases needed to be integrated legally. This article discusses the hurdles we encountered in this integration process and the solution we settled on to overcome these problems. We provide a brief look at the complexity of the legal protection afforded to databases, which we found to be an important source of problems even for communities that attempted to …

Increased Nitrate Intake From Beetroot Juice Does Not Alter Soluble Cellular Adhesion Molecules And Circulating Inflammatory Cytokines In Individuals With Treated Hypertension: A Randomised, Controlled Trial, Kyle Raubenheimer, Alex H. Liu, Henrietta Koch, Erika Bosio, Nicola P. Bondonno, Vance Matthews, Marc Sim, Lauren Blekkenhorst, Richard J. Woodman, Kevin Murray, Kevin Croft, Oliver Neubauer, Jonathan M. Hodgson, Catherine P. Bondonno

Research outputs 2022 to 2026

Dietary nitrate, found predominantly in green leafy vegetables and other vegetables such as radish, celery, and beetroot, has been shown to beneficially modulate inflammatory processes and immune cell function in animals and healthy individuals. The impact of increased nitrate intake on soluble inflammatory mediators in individuals with hypertension is unclear. We assessed whether the daily consumption of dietary nitrate via beetroot juice for 1-week lowered levels of circulating inflammatory markers in men and women with treated hypertension. Twenty-seven male and female participants were recruited to a randomized, placebo-controlled, double-blind crossover trial. The effects of 1-week intake of nitrate-rich beetroot juice …

Silkes V. B-U Realty Corp.

All Decisions

No abstract provided.

Sedgecliff Llc V. Oduro

All Decisions

No abstract provided.