Digital Commons Network^™

Tracking The Evolution Of Esophageal Squamous Cell Carcinoma Under Dynamic Immune Selection By Multi-Omics Sequencing, Sijia Cui, Nicholas Mcgranahan, Jing Gao, Peng Chen, Wei Jiang, Lingrong Yang, Li Ma, Junfang Liao, Tian Xie, Congying Xie, Tariq Enver, Shixiu Wu

Children’s Nutrition Research Center Staff Publications

Intratumoral heterogeneity (ITH) has been linked to decreased efficacy of clinical treatments. However, although genomic ITH has been characterized in genetic, transcriptomic and epigenetic alterations are hallmarks of esophageal squamous cell carcinoma (ESCC), the extent to which these are heterogeneous in ESCC has not been explored in a unified framework. Further, the extent to which tumor-infiltrated T lymphocytes are directed against cancer cells, but how the immune infiltration acts as a selective force to shape the clonal evolution of ESCC is unclear. In this study, we perform multi-omic sequencing on 186 samples from 36 primary ESCC patients. Through multi-omics analyses, …

Fort Hays State University Tiger Weekly, February 17, 2023, University Relations

Tiger Weekly Newsletters

No abstract provided.

What’S Effective Altruism? A Philosopher Explains, Jacob Bauer

Materials from the University of Dayton Magazine Website

Effective altruism, a term coined in 2011, refers to people who seek to use their money and time to make as much progress as possible toward solving the world’s most pressing problems. Jacob Bauer, University of Dayton lecturer of philosophy, explains.

How Far Must Employers Go To Accommodate Workers' Time Off For Worship? The Supreme Court Will Weigh In, Charles J. Russo

Materials from the University of Dayton Magazine Website

Employers navigating employees' requests for religious accommodations face some confusing guidance. A new Supreme Court case could clarify – and shift the norm, writes University of Dayton professor Charles J. Russo.

Staff Council Minutes, Georgia Southern University

Staff Council Meeting Minutes & Agendas

No abstract provided.

Staff Council Agenda

Staff Council Meeting Minutes & Agendas

No abstract provided.

The Use Of Neuraxial Dexmedetomidine In The Caesarean Patient, Garrett Franklin

Group: Samford University Moffett & Sanders School of Nursing

In obstetric patients undergoing a cesarean section, does a spinal block combining dexmedetomidine and local anesthetic compared with just local anesthetic result in a change in the incidence of side effects, density, onset, or duration of the block during the first 120 minutes from insertion of the medication?

The use of dexmedetomidine in spinal anesthesia has been well researched. Dexmedetomidine in the increments of 3,5, and 10 mcg has been shown to consistently reduce the onset time of the sensory and motor block of spinal anesthesia while also prolonging the duration of the sensory block significantly. Evidence shows that adding …

Methods Of Intra-Operative Airway Exchange, Catherine Kinney, Lauren Barnes

Group: Samford University Moffett & Sanders School of Nursing

In patients requiring an intra-operative airway exchange, does the use of a CAEC allow for safer, more effective airway exchange compared to a GEB?

One of the biggest benefits of the CAEC is its ability to provide oxygenation to the patient throughout the ETT exchange via jet ventilation. However, this oxygen and pressure can create a one-way valve, resulting in a pneumothorax and potentially leading to cardiovascular collapse. The rate of pneumothorax with a CAEC is up to 11%. In order to prevent this, CAECs with jet ventilation should not be used with patients who are at an increased risk …

A P53-Tlr3 Axis Ameliorates Pulmonary Hypertension By Inducing Bmpr2 Via Irf3, Aneel R. Bhagwani, Mehboob Ali, Bryce Piper, Mingjun Liu, Jaylen Hudson, Neil Kelly, Srimathi Bogamuwa, Hu Yang, James D. Londino, Joseph S. Bednash, Daniela Farkas, Rama K. Mallampalli, Mark R. Nicolls, John J. Ryan

Chemical and Biochemical Engineering Faculty Research & Creative Works

Pulmonary arterial hypertension (PAH) features pathogenic and abnormal endothelial cells (ECs), and one potential origin is clonal selection. We studied the role of p53 and toll-like receptor 3 (TLR3) in clonal expansion and pulmonary hypertension (PH) via regulation of bone morphogenetic protein (BMPR2) signaling. ECs of PAH patients had reduced p53 expression. EC-specific p53 knockout exaggerated PH, and clonal expansion reduced p53 and TLR3 expression in rat lung CD117+ ECs. Reduced p53 degradation (Nutlin 3a) abolished clonal EC expansion, induced TLR3 and BMPR2, and ameliorated PH. Polyinosinic/polycytidylic acid [Poly(I:C)] increased BMPR2 signaling in ECs via enhanced binding of interferon regulatory …

Leveraging The Resources At Sustainability Institute For More Effective Teaching Of A Sustainability Course, Shuili Du

Sustainability Institute Blog

No abstract provided.

Solda V. Kjl Ventures Llc

All Decisions

No abstract provided.

Implementation Of Superficial Radiation Therapy (Srt) Using Srt-100 Vision™ For Non-Melanoma Skin Cancer In A Radiation Oncology Clinic, Cecilia Lee, Stephan Davis, William Romaguera, Vibha Chaswal, Ranjini Tolakanahalli, Alonso Gutierrez, Noah Kalman

All Publications

No abstract provided.

West 107 Partners L.P. V. Alduey

All Decisions

No abstract provided.

Developing Methods For Measuring In Vivo Lipid Metabolism, Russell L. Denton

Theses and Dissertations

Lipid metabolism is critically important to the normal function of individual cells and for signaling between tissues of the human body. There is a great need to quantify changes in lipid metabolism because of its implications in both normal healthy conditions and during disease development. In our first study, we developed a liquid chromatography mass spectrometry based workflow to assess in vivo metabolism of murine brain lipids. This involved sample preparation, data acquisition, and analysis software development and improvements. Regarding sample preparation, we maintained the mice at 5% body water for the duration of the experiment. As mouse metabolism proceeds, …

Sakurabonsai: Protocol Design Of A Novel, Prospective Study To Explore Clinical, Imaging, And Biomarker Outcomes In Patients With Aqp4-Igg-Seropositive Neuromyelitis Optica Spectrum Disorder Receiving Open-Label Satralizumab, Jeffrey L Bennett, Kazuo Fujihara, Ho Jin Kim, Romain Marignier, Kevin C O'Connor, Robert C Sergott, Anthony Traboulsee, Heinz Wiendl, Jens Wuerfel, Scott S Zamvil, Veronica G Anania, Regine Buffels, Thomas Künzel, Annemarie N Lekkerkerker, Siân Lennon-Chrimes, Sean J Pittock

Wills Eye Hospital Papers

Background: Neuromyelitis optica spectrum disorder (NMOSD) is a rare, autoimmune disease of the central nervous system that produces acute, unpredictable relapses causing cumulative neurological disability. Satralizumab, a humanized, monoclonal recycling antibody that targets the interleukin-6 receptor, reduced NMOSD relapse risk vs. placebo in two Phase 3 trials: SAkuraSky (satralizumab ± immunosuppressive therapy; NCT02028884) and SAkuraStar (satralizumab monotherapy; NCT02073279). Satralizumab is approved to treat aquaporin-4 IgG-seropositive (AQP4-IgG+) NMOSD. SAkuraBONSAI (NCT05269667) will explore fluid and imaging biomarkers to better understand the mechanism of action of satralizumab and the neuronal and immunological changes following treatment in AQP4-IgG+ NMOSD.

Objectives: …

Racially Restrictive Covenants: A Story Of Segregation, Disinvestment, And Lingering Implications, Fadya Al Hammam, Janeka Haden, Livi Logan-Wood, Joseph Roeder

Center for Social Development Research

Racially restrictive covenants are agreements, typically embedded in property deeds, that limit the transfer of property to non-white people. The covenants remain common features of property deeds in the St. Louis region, though enforcement of them was outlawed by the U.S. Supreme Court’s Shelley v. Kraemer decision in 1948. This brief discusses the covenants and identifies strategies for communities to deploy in addressing them.

The contents of this brief evolved from a presentation given in the Colloquium on Inclusive Housing Policy for the St. Louis Region. Held in the Brown School at Washington University on December 15, 2022, the event …

Zoning: Issues And Reform, Olivia Borland, Casey Kohlstruk, Lindsay Owens

Center for Social Development Research

What steps can communities take to broaden equitable access to housing and prevent residential displacement? This brief identifies strategies for reforming zoning policy to advance those goals.

The contents of this brief evolved from a presentation given in the Colloquium on Inclusive Housing Policy for the St. Louis Region. Held in the Brown School at Washington University on December 15, 2022, the event was organized by the Center for Social Development in partnership with Women’s Voices Raised for Social Justice and the Alliance for Interracial Dignity. The contents may also be found in Welcome Home: A Policy Briefing Book for …

Several, Ruth, Sophia Maier Garcia

Bronx Jewish History Project

Ruth Several was born in 1951 and grew up living on the Grand Concourse, where her parents were living at the time. Her father worked at the Concourse Center of Israel, an orthodox synagogue on the Grand Concourse. They lived in a large apartment in an art deco style building. She remembers 95% of the building as Jewish, not including the non-Jewish superintendent. The neighborhood had many mom and pop stores, no chain stores, and many synagogues. Several attend a Jewish Day School in the Upper West Side of Manhattan, so her mother was a bookkeeper nearby who would take …

Black Faculty And Staff Association Newsletter. Issue 1 (2023), Brittany Champion

Black Faculty and Staff Association

Table of Contents

• President's Address - Geoffrey Habron
• BFSA Reads - Dr. Nashieli Marcano
• BFSA Members in Action
• Applications are now open for Master of Arts in Advocacy and Equity Studies at Furman University
• Community Read of The Bluest Eye - Dr. Kaniqua Robinson

'Connecting And Compassion Matters In Dental Care', A Nelder, R Potterton, E Mccoll

Peninsula Dental School

No abstract provided.

Alternative Polyadenylation Alters Protein Dosage By Switching Between Intronic And 3’Utr Sites, Winston Lee, Lauren C Tang, Kai-Lieh Huang, Ai Lin, Ping Ji, Venkata S Jonnakuti, Lia Boyle, Maximilian Cabaj, Salvatore Botta, Katrin Õunap, Karit Reinson, Monica H Wojcik, Jill A Rosenfeld, Weimin Bi, Kristian Tveten, Trine Prescott, Thorsten Gerstner, Audrey Schroeder, Chin-To Fong, Jaya K George-Abraham, Catherine A Buchanan, Andrea Hanson-Khan, Jonathan A Bernstein, Aikaterini A Nella, Wendy K Chung, Vicky Brandt, Marko Jovanovic, Kimara L Targoff, Hari Krishna Yalamanchili, Eric J Wagner, Vincenzo A Gennarino

Faculty, Staff and Students Publications

Alternative polyadenylation (APA) creates distinct transcripts from the same gene by cleaving the pre-mRNA at poly(A) sites that can lie within the 3' untranslated region (3'UTR), introns, or exons. Most studies focus on APA within the 3'UTR; however, here, we show that CPSF6 insufficiency alters protein levels and causes a developmental syndrome by deregulating APA throughout the transcript. In neonatal humans and zebrafish larvae, CPSF6 insufficiency shifts poly(A) site usage between the 3'UTR and internal sites in a pathway-specific manner. Genes associated with neuronal function undergo mostly intronic APA, reducing their expression, while genes associated with heart and skeletal function …

Students Invited To Attend Spring Internship, Job Fair, Maria Harmon

News and Events (Discontinued Series)

No abstract provided.

Policies For Digital Banking : Part - I, Ishrat Husain Dr.

Faculty Research - Newspaper and Magazine Articles

The State Bank of Pakistan has recently granted five licences for Starting digital banks that would provide the whole range of banking services through digital platforms or electronic channels from the comfort of homes and offices without making trips to brick-and-mortar branches of the banks. Two types of banks – digital retail banks and digital full banks – have been allowed both in the conventional as well as Islamic variants. The minimum capital requirement for digital banks is much lower than those for banks that are operating branches. A diverse range of applicants including domestic commercial banks, microfinance banks, electronic …

A Collection Of Calculus Lesson Plans: Deriving The 'Why' Behind Derivatives, Kasey Brabec

Honors Program: Senior Projects (Public)

The traditional mathematics classroom is led with a focus on procedural understanding, with deep conceptual understanding considered to be unimportant or too difficult to teach within the allotted time. Both levels of understanding are important mathematical competencies, as it is rare for either of them to function well without accessibility to the other. The disparity between conceptual understanding and procedural understanding in the mathematics classroom is no larger than in courses like Calculus. This project is a collection of fifteen lesson plans constructed with an emphasis on conceptual understanding and the connectivity of Calculus. Each lesson plan’s overview contains the …

Uab's New Als Clinic Offers Eight To One Advantage, Alicia Rohan

Browse All News

No abstract provided.

Board Of Trustees Agenda, Feb. 17 2023, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

Board Of Trustees Agenda, Feb. 17 2023 - Finance Committee, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

Cognitive Software Defined Networking And Network Function Virtualization And Applications, Sachin Sharma, Avishek Nag

Articles

The emergence of Software-Defined Networking (SDN) and Network Function Virtualization (NFV) has revolutionized the Internet. Using SDN, network devices can be controlled from a centralized, programmable control plane that is decoupled from their data plane, whereas with NFV, network functions (such as network address translation, firewall, and intrusion detection) can be virtualized instead of being implemented on proprietary hardware. In addition, Artificial Intelligence (AI) and Machine Learning (ML) techniques will be key to automating network operations and enhancing customer service. Many of the challenges behind SDN and NFV are currently being investigated in several projects all over the world using …

College Of Business News, Georgia Southern University

College of Business: News & Publications

• EVE Director of Marketing & Communications Speaks to Marketing Students

Windy Roberts Recipient Of Horace T. Morse Award, Communications And Marketing

Campus News Archive

No abstract provided.