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Nyls Students Weigh In With Their Advice For 1ls, Julia Sonenshein Feb 2023

Nyls Students Weigh In With Their Advice For 1ls, Julia Sonenshein

NYLS Community News

No abstract provided.


Trade And Transportation Talent Pipeline Blueprints: Building Universityindustry Talent Pipelines In Colleges Of Continuing And Professional Education, Tyler D. Reeb, Stacey Park Feb 2023

Trade And Transportation Talent Pipeline Blueprints: Building Universityindustry Talent Pipelines In Colleges Of Continuing And Professional Education, Tyler D. Reeb, Stacey Park

Mineta Transportation Institute

The rapid adoption of transformational technologies along with other economic and cultural shifts, have created a gap between workers and the skills and knowledge necessary for in-demand occupations. Trade and Transportation Talent Pipeline Blueprints: Building University-Industry Talent Pipelines in Colleges of Continuing and Professional Education identifies the steps required to build talent pipelines that target in-demand trade and transportation occupations requiring specific degrees, certificates, and non-credit professional development. This report provides a literature review and labor market data analysis. It also includes documentation of methodology in planning a pilot program for Colleges of Professional and Continuing Education housed within each …


Analysis Of Freight Movements In The San Joaquin Valley, Aly Tawfik, Utsav Shah Feb 2023

Analysis Of Freight Movements In The San Joaquin Valley, Aly Tawfik, Utsav Shah

Mineta Transportation Institute

Freight transportation plays a primary role in supply chains, costs, and availability of goods and is a major part of the economy. This study identifies, assesses, and utilizes different data sources to uncover and understand the patterns and movements of different types of freight in the San Joaquin Valley’s (SJV's) different counties. The San Joaquin Valley region consists of eight counties: San Joaquin, Stanislaus, Merced, Madera, Fresno, Kings, and Tulare. This research explored some major datasets with freight information, such as Global Trade Atlas (GTA), Port Imports and Exports Reporting Systems (PIERS), and Streetlight data insights for the year 2019 …


Evaluation, Comparison, And Improvement Recommendations For Caltrans Financial Programming Processes And Tools, Wenbin Wei, Nigel Blampied, Raajmaathangi Sreevijay Feb 2023

Evaluation, Comparison, And Improvement Recommendations For Caltrans Financial Programming Processes And Tools, Wenbin Wei, Nigel Blampied, Raajmaathangi Sreevijay

Mineta Transportation Institute

The California Transportation Improvement Program System (CTIPS) is the main tool used by Caltrans’ Division of Financial Programming to support the business of transportation programming. It is a multi-agency joint-use project programming database system applied to develop and manage various state and federal transportation programming documents. The goal of this project is to evaluate CTIPS and explore various new options that will maintain the current functionality of CTIPS, meet legislative guidelines for ADA compliance, ensure security of the system, and have sufficient scalability and capabilities for integration with other systems in the future. The research is based on the review …


Brainwave: A Flexible Method For Noninvasive Stimulation Of Brain Rhythms Across Species, Matthew K. Attokaren, Nuri Jeong, Lou Blanpain, Abigail L. Paulson, Kristie M. Garza, Ben Borron, Michael Walelign, Jon Willie, Annabelle C. Singer Feb 2023

Brainwave: A Flexible Method For Noninvasive Stimulation Of Brain Rhythms Across Species, Matthew K. Attokaren, Nuri Jeong, Lou Blanpain, Abigail L. Paulson, Kristie M. Garza, Ben Borron, Michael Walelign, Jon Willie, Annabelle C. Singer

2020-Current year OA Pubs

Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple brain functions, is impaired in many diseases. Despite the therapeutic potential of driving brain rhythms, methods to noninvasively target deep brain regions are limited. Accordingly, we recently introduced a noninvasive stimulation approach using flickering lights and sounds ("flicker"). Flicker drives rhythmic activity in deep and superficial brain regions. Gamma flicker spurs immune function, clears pathogens, and rescues memory performance in mice with amyloid pathology. Here, we present substantial improvements to this approach that is flexible, user-friendly, and generalizable across multiple experimental settings and species. We present novel open-source …


A Systematic Review And Meta-Analysis Of The Association Between Sars-Cov-2 Vaccination And Myocarditis Or Pericarditis, Juan Gao, Linya Feng, Yaru Li, Scott Lowe, Zhichun Guo, Rachel Bentley, Chuman Xie, Birong Wu, Peng Xie, Weihang Xia, Shaodi Ma, Haixia Liu, Xianwei Guo, John Patrick Nanola Uy, Qin Zhou, Hina Wazir, Chenyu Sun Feb 2023

A Systematic Review And Meta-Analysis Of The Association Between Sars-Cov-2 Vaccination And Myocarditis Or Pericarditis, Juan Gao, Linya Feng, Yaru Li, Scott Lowe, Zhichun Guo, Rachel Bentley, Chuman Xie, Birong Wu, Peng Xie, Weihang Xia, Shaodi Ma, Haixia Liu, Xianwei Guo, John Patrick Nanola Uy, Qin Zhou, Hina Wazir, Chenyu Sun

Student Publications

Introduction: There have been reports of potential negative cardiovascular effects from the COVID-19 vaccine, such as myocarditis or pericarditis. This study sought to ascertain the risk of myocarditis/pericarditis after COVID-19 vaccination by conducting an extensive meta-analysis of published cases.

Methods: A systematic literature search was conducted in 7 online databases by March 31, 2022. Heterogeneity was tested by I2 index. RR and 95% CI were pooled through either random-effect or fixed-effect models. Sensitivity analysis and publication bias were also conducted.

Results: A total of 11 studies with 58,620,611 subjects were included. COVID-19 vaccination correlated with an increased risk of myocarditis …


Sex-Specific Hypnotic Effects Of The Neuroactive Steroid (3Β,5Β,17Β)-3-Hydroxyandrostane-17-Carbonitrile Are Mediated By Peripheral Metabolism Into An Active Hypnotic Steroid, Francesca M Manzella, Omar H Cabrera, Davis Wilkey, Brier Fine-Raquet, Jelena Klawitter, Kathiresan Krishnan, Douglas F Covey, Vesna Jevtovic-Todorovic, Slobodan M Todorovic Feb 2023

Sex-Specific Hypnotic Effects Of The Neuroactive Steroid (3Β,5Β,17Β)-3-Hydroxyandrostane-17-Carbonitrile Are Mediated By Peripheral Metabolism Into An Active Hypnotic Steroid, Francesca M Manzella, Omar H Cabrera, Davis Wilkey, Brier Fine-Raquet, Jelena Klawitter, Kathiresan Krishnan, Douglas F Covey, Vesna Jevtovic-Todorovic, Slobodan M Todorovic

2020-Current year OA Pubs

BACKGROUND: The novel synthetic neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH) blocks T-type calcium channels but does not directly modulate neuronal γ-aminobutyric acid type A (GABA

METHODS: We used a combination of behavioural loss of righting reflex, neuroendocrine, pharmacokinetic, in vitro patch-clamp electrophysiology, and in vivo electrophysiological approaches in wild-type mice and in genetic knockouts of the Ca

RESULTS: Adult male mice were less sensitive to the hypnotic effects of 3β-OH compared with female mice, and these differences appeared during development. Adult males had higher 3β-OH brain concentrations despite being less sensitive to its hypnotic effects. Females metabolised 3β-OH into the active GABA …


Building Resilience In Graduate Nurses Through Online Virtual Simulation, Robert Grant Harmon Feb 2023

Building Resilience In Graduate Nurses Through Online Virtual Simulation, Robert Grant Harmon

Electronic Theses and Dissertations

Resilience has become a popular topic in nursing research. Nurses experience enormous stress throughout their training process that extends into their first employment as they transition into practice. Simulation training is a standard for training nurses and for continuing professional education within academia. Most simulation training for nurses is focused on building critical thinking skills. While critical thinking is an essential quality equipping nurses to meet professional demands, resilience is a crucial quality to overcome the stress of both training and practice. Resilience is believed to play an essential role in the retention of new graduate nurses and preventing burnout …


Pediatric Obesity In Primary Care, Lynne C. Liggins Feb 2023

Pediatric Obesity In Primary Care, Lynne C. Liggins

Electronic Theses and Dissertations

The purpose of this evidence-based quantitative quasi-experimental research was to compare if providing the parents with information on the health risk associated with childhood obesity would cause the parents to make healthier food choices and encourage their children to be involved in a full hour of physical activity a day. Participants included parents and pediatric and adolescent children 5 to 18 years of age at a solo practice primary care office in a large city in Southern, California, which specializes in treating pediatric and adolescent patients. A pre- and postquantitative intervention design were used and analyzed using the paired t …


Pathways To Success For Black Women Leaders In Online Higher Education: Intersectionality Of Gender, Race, And Personality Traits, Shanaya Kuykendahl Anderson Feb 2023

Pathways To Success For Black Women Leaders In Online Higher Education: Intersectionality Of Gender, Race, And Personality Traits, Shanaya Kuykendahl Anderson

Electronic Theses and Dissertations

Previous literature has been used by researchers to suggest that Black women face challenges and obstacles seeking leadership roles at higher education institutions (HEIs). Many of these Black women have consistently and pervasively faced prevailing stereotypes, biases, and barriers as they seek career advancements at online HEIs (Nigar, 2020; Tarbutton, 2019). This qualitative phenomenological study was undertaken in order to examine the intersectionality of gender, race, and personality traits of Black women leaders who hold positions of department chair level or higher in HEIs. Using the theoretical framework of Black feminist thought, this research was conducted to understand better the …


Female Ex-Offenders Transitioning Into Society, Stacey L. Forte Feb 2023

Female Ex-Offenders Transitioning Into Society, Stacey L. Forte

Electronic Theses and Dissertations

The purpose of this qualitative study was to examine female ex-offenders’ perceptions of their lived experience(s) while transitioning into society after incarceration. This study examined risk factors that female ex-offenders faced while transitioning into society asking the question, “What are the lived experiences of female ex-offenders who utilized transitional housing for reentry with regard to their perception of the benefits of certain services/offerings and staff support?” Nine participants were part of the study ranging from 25–64 years of age, with the majority being between the ages of 25 and 55 years old, residing originally in five different states. Sixty percent …


Leadership Style In A Faith-Based Athletic Department Setting, Adam P. Ybarra Feb 2023

Leadership Style In A Faith-Based Athletic Department Setting, Adam P. Ybarra

Electronic Theses and Dissertations

In this intrinsic case study, the researcher sought to explore athletic directors’ leadership styles with their coaches’ and administrators’ workplace satisfaction at a Christian-affiliated college in the Southwestern United States. The study explored which leadership style is likely to encourage motivation (i.e., achievement, recognition, growth) and hygiene factors (i.e., policies, supervision, work conditions), which could potentially increase or decrease job satisfaction. The data collection method was semistructured interviews conducted with athletic department personnel. The researcher transcribed and quality-checked the interviews against the audio recordings. The transcripts were member-checked by sharing them with each of the study participants. The researcher analyzed …


Mindfulness Based Stress Reduction Techniques In Chronic Illness, Anna Celia Gil Feb 2023

Mindfulness Based Stress Reduction Techniques In Chronic Illness, Anna Celia Gil

Electronic Theses and Dissertations

Abstract

Chronic stress and its effect on both physical and mental health have been a topic of increasing interest in the past several decades. There is mounting evidence that recurrent, persistent stress of both a physiologic and psychological nature leads to a dysfunction in the hypothalamic pituitary axis (HPA), the system which helps the body recover and adapt to short term stress. In long term stress, this HPA dysfunction leads to impairment of the immune and neuroendocrine systems resulting in chronic low-grade inflammation. This type of chronic inflammation acts as a precursor to several chronic illnesses such as diabetes, hypertension, …


Exploring A Cooperative Learning Model With A Mixed Methods Design, Zhidong Zhang, Liza Ramos Feb 2023

Exploring A Cooperative Learning Model With A Mixed Methods Design, Zhidong Zhang, Liza Ramos

Teaching and Learning Faculty Publications

The exploratory sequential design was used in this study. The mixed methods design consisted of two modules: a qualitative module and a quantitative module. The qualitative module was used to code the data into categories and further into the structure in terms of Saldana’s model. Based on the analysis of the interview transcripts, three themes were recognized to support the cooperative learning models. These three themes were Knowing by Undergone Events and Contexts (KUEC), Implementation and Action (I&A), and Opinions and Perceptions (OP). These three themes consisted of a Collaborative Learning Model describing and evaluating different topic patterns.


Fixed-Dose Combination Therapy-Based Protocol Compared With Free Pill Combination Protocol: Results Of A Cluster Randomized Trial, Olutobi A Sanuade, Mark D Huffman, Et Al. Feb 2023

Fixed-Dose Combination Therapy-Based Protocol Compared With Free Pill Combination Protocol: Results Of A Cluster Randomized Trial, Olutobi A Sanuade, Mark D Huffman, Et Al.

2020-Current year OA Pubs

Fixed-dose combination (FDC) therapy is recommended for hypertension management in Nigeria based on randomized trials at the individual level. This cluster-randomized trial evaluates effectiveness and safety of a treatment protocol that used two-drug FDC therapy as the second and third steps for hypertension control compared with a protocol that used free pill combinations. From January 2021 to June 2021, 60 primary healthcare centers in the Federal Capital Territory of Nigeria were randomized to a protocol using FDC therapy as second and third steps compared with a protocol that used the same medications in free pill combination therapy for these steps. …


Lgmdd1 Natural History And Phenotypic Spectrum: Implications For Clinical Trials, Andrew R Findlay, Sarah E Robinson, Stephanie Poelker, Michelle Seiffert, Rocio Bengoechea, Conrad C Weihl Feb 2023

Lgmdd1 Natural History And Phenotypic Spectrum: Implications For Clinical Trials, Andrew R Findlay, Sarah E Robinson, Stephanie Poelker, Michelle Seiffert, Rocio Bengoechea, Conrad C Weihl

2020-Current year OA Pubs

OBJECTIVE: To delineate the full phenotypic spectrum and characterize the natural history of limb girdle muscular dystrophy type D1 (LGMDD1).

METHODS: We extracted age at clinical events of interest contributing to LGMDD1 disease burden via a systematic literature and chart review. Manual muscle testing and quantitative dynamometry data were used to estimate annualized rates of change. We also conducted a cross-sectional observational study using previously validated patient-reported outcome assessments (ACTIVLIM, PROMIS-57) and a new LGMDD1 questionnaire. Some individuals underwent repeat ACTIVLIM and LGMDD1 questionnaire assessments at 1.5 and 2.5 years.

RESULTS: A total of 122 LGMDD1 patients were included from …


The Insurance Landscape For Implant- And Autologous-Based Breast Reconstruction In The United States, Louisa C. Boyd, Jason A. Greenfield, Sravya S. Ainapurapu, Rachel Skladman, Gary Skolnick, Durai Sundaramoorthi, Justin M. Sacks Feb 2023

The Insurance Landscape For Implant- And Autologous-Based Breast Reconstruction In The United States, Louisa C. Boyd, Jason A. Greenfield, Sravya S. Ainapurapu, Rachel Skladman, Gary Skolnick, Durai Sundaramoorthi, Justin M. Sacks

2020-Current year OA Pubs

UNLABELLED: Insurance coverage of postmastectomy breast reconstruction is mandated in America, regardless of reconstructive modality. Despite enhanced patient-reported outcomes, autologous reconstruction is utilized less than nonautologous reconstruction nationally. Lower reimbursement from Medicare and Medicaid may disincentivize autologous-based reconstruction. This study examines the impact of insurance and sociodemographic factors on breast reconstruction.

METHODS: A retrospective analysis of the Healthcare Cost and Utilization Project National Inpatient Sample Database from 2014 to 2017 was performed. International Classification of Diseases Clinical Modification and Procedure Coding System codes were used to identify patients for inclusion. De-identified sociodemographic and insurance data were analyzed using

RESULTS: In …


Autophagy Requirements For Eye Lens Differentiation And Transparency, Lisa Brennan, M Joseph Costello, J Fielding Hejtmancik, A Sue Menko, S Amer Riazuddin, Alan Shiels, Marc Kantorow Feb 2023

Autophagy Requirements For Eye Lens Differentiation And Transparency, Lisa Brennan, M Joseph Costello, J Fielding Hejtmancik, A Sue Menko, S Amer Riazuddin, Alan Shiels, Marc Kantorow

2020-Current year OA Pubs

Recent evidence points to autophagy as an essential cellular requirement for achieving the mature structure, homeostasis, and transparency of the lens. Collective evidence from multiple laboratories using chick, mouse, primate, and human model systems provides evidence that classic autophagy structures, ranging from double-membrane autophagosomes to single-membrane autolysosomes, are found throughout the lens in both undifferentiated lens epithelial cells and maturing lens fiber cells. Recently, key autophagy signaling pathways have been identified to initiate critical steps in the lens differentiation program, including the elimination of organelles to form the core lens organelle-free zone. Other recent studies using ex vivo lens culture …


Toxin Induced Parkinsonism And Hospitalization Related Adverse Outcome Mitigation For Parkinson’S Disease: A Comprehensive Review, Kenneth R. Dalton, Charles J. Kidd, Nawaz Hack Feb 2023

Toxin Induced Parkinsonism And Hospitalization Related Adverse Outcome Mitigation For Parkinson’S Disease: A Comprehensive Review, Kenneth R. Dalton, Charles J. Kidd, Nawaz Hack

School of Medicine Publications

Patients with Parkinson’s disease admitted to the hospital have unique presentations. This unique subset of patients requires a multidisciplinary approach with a knowledge-based care team that can demonstrate awareness of complications specific to Parkinson’s disease to reduce critical care admissions, morbidity, and mortality. Early recognition of toxic exposures, medication withdrawals, or medication-induced symptoms can reduce morbidity and mortality. This review can assist in the critical assessment of new or exacerbating Parkinson’s disease symptoms.


Ash Aerosol Particle Size Distribution, Composition, And Deposition Behavior While Co-Firing Coal And Steam-Exploded Biomass In A 1.5 Mwth Combustor, Rajarshi Roy, Brian Schooff, Xiaolong Li, Scott Montgomery, Jacob Tuttle, Jost O.L. Wendt, Kingsley Dickson, Brian Iverson, Andrew R. Fry Feb 2023

Ash Aerosol Particle Size Distribution, Composition, And Deposition Behavior While Co-Firing Coal And Steam-Exploded Biomass In A 1.5 Mwth Combustor, Rajarshi Roy, Brian Schooff, Xiaolong Li, Scott Montgomery, Jacob Tuttle, Jost O.L. Wendt, Kingsley Dickson, Brian Iverson, Andrew R. Fry

Faculty Publications

Five different blends of Utah bituminous coal and steam-exploded pine (100/0, 75/25, 50/50, 25/75, 0/100 by mass) were fired in a 1.5 MWth combustor. Primary objectives were to understand mineral matter behavior by analyzing aerosol size distribution, aerosol size-segregated composition, ash deposition mass, and ash composition. For particle size < 0.1 μm, pure coal had the lowest aerosol concentration and pure biomass showed the highest (higher nucleation of potassium salts), a trend which reversed for particles >0.1 μm. During pure biomass combustion, aerosol particles >15 μm contained higher mass fractions of potassium (+126%), calcium (+132%), and iron (+115%) and lower fractions of aluminum (−49%) and silicon (−29%) than pure coal. Ash deposition mass decreased with increasing biomass blends. …


Forgotten Brother Reuben Lewis: Missouri River Fur Trader And Indian Agent For The Arkansas Cherokees, Jay H. Buckley, Deveney Reber Feb 2023

Forgotten Brother Reuben Lewis: Missouri River Fur Trader And Indian Agent For The Arkansas Cherokees, Jay H. Buckley, Deveney Reber

Faculty Publications

Reuben Lewis was born in 1777, the fourth and youngest child of William Lewis and Lucy Meriwether. Their oldest child, Jane, married and lived out her days at Locust Hill, the family estate in Virginia. The Lewis’ second child, baby Lucinda, died in infancy. Their third child, Meriwether – the closest in age and friendship to Reuben – became the famous first half of the Lewis and Clark Expedition which explored the uncharted West before he met his tragic and mysterious death on the Natchez Trace in Tennessee. While Reuben’s life has been rightly overshadowed by his older brother Meriwether’s …


Examination Of Korean Feminism From The Intersections Of Colonialism, Modernity, And Nationalism In Colonial Korea (1910–1945), Yae Hee Choi Feb 2023

Examination Of Korean Feminism From The Intersections Of Colonialism, Modernity, And Nationalism In Colonial Korea (1910–1945), Yae Hee Choi

Dissertations, Theses, and Capstone Projects

This thesis aims to investigate the politics of Korean feminism during the time of Japanese colonization (1910-1945) from the perspectives of colonialism, modernity, and nationalism. The study illustrates how Korean women perceived themselves in terms of individuals, colonial subjects, and Korean nationals during a period of significant societal changes. It also intends to broaden the boundaries of gender inquiries in colonial Korea, which often focus on binary constructions of Japanese repression versus national resistance. This study argues that a nationalist paradigm oversimplifies the intricate dynamics and varied experiences of colonized subjects, specifically women. The logic of nationalism places all forms …


Police Academy Attrition Rates: A Long-Term Analysis Of Female Candidates In California, Texas, Wisconsin, Arizona, And New Jersey, Shamus W. Smith Feb 2023

Police Academy Attrition Rates: A Long-Term Analysis Of Female Candidates In California, Texas, Wisconsin, Arizona, And New Jersey, Shamus W. Smith

Dissertations, Theses, and Capstone Projects

Police agencies throughout the country still have an underrepresentation of women police officers. Research has shown that the benefits of hiring women police officers are many, as they have proven to be as competent as their male counterparts, less likely to use excessive force, can implement community-oriented policing, respond to calls for domestic violence effectively, bring about beneficial changes in policy for all agencies, and reduce the problems of sexual discrimination and harassment within an agency. Yet, the obstacles encountered for women are significantly different from their male counterparts. As such, this research uses secondary, non-identifiable data obtained from police …


Analysis Of Electrophysiological Markers And Correlated Components Of Neural Responses To Discourse Coherence, Kurt M. Masiello Feb 2023

Analysis Of Electrophysiological Markers And Correlated Components Of Neural Responses To Discourse Coherence, Kurt M. Masiello

Dissertations, Theses, and Capstone Projects

Constructing meaning from spoken language is invaluable for learning, social interaction, and communication. In clinical populations with developmental disorders of speech comprehension, the severity of disruption can persist and vary from limiting occupational opportunities to lower performance outcomes. Previous research has reported an event-related potential (ERP) neural positivity over right hemisphere lateral anterior sites in response to semantic and discourse processing. Although useful as a marker for clinical populations of autism spectrum disorder (ASD) and developmental language disorder (DLD), little is understood about the dynamics and neural sources of this biological marker. In addition to traditional methods of ERP analysis, …


Storytelling In Modernist Fiction: A “Method Of Presence”, Laura Malhotra Feb 2023

Storytelling In Modernist Fiction: A “Method Of Presence”, Laura Malhotra

Dissertations, Theses, and Capstone Projects

This dissertation explores the relationship between narrative modes in cinema and literature and adopts the lineage laid out by Lukács that connects the oral tradition and epic poetry to the novel. I attach art cinema to this lineage and seek to justify its position as an equally significant medium representative of the age in which it is produced. This study aims to correct one established view of film, put forth by the Frankfurt School, of its low value as an art form and as a site of meaning. I compare the birth of literary modernism in Britain to the emergence …


Indigenous Performances In Contemporary Indian Urban Public Theatres: Coloniality, Globalization, And The State, Mayurakshi Sen Feb 2023

Indigenous Performances In Contemporary Indian Urban Public Theatres: Coloniality, Globalization, And The State, Mayurakshi Sen

Dissertations, Theses, and Capstone Projects

Indigenous Performances in Contemporary Indian Urban Public Theatres: Coloniality, Globalization, and the State examines the aesthetic and political dimensions of contemporary public theatres in the major Indian cities of Kolkata, Mumbai, and Delhi, with a special focus on the utilization of India’s indigenous precolonial (or extra-colonial) classical, regional, and folk performance forms, elements, and repertoires in such urban practice. Through dramaturgical, ethnographic, and archival analyses, this dissertation studies significant contemporary productions from representative urban Indian theatre groups, including Nandikar, Rangakarmee, and Padatik in Kolkata; the Indian People’s Theatre Association, Mumbai, Ekjute, and Rangshila in Mumbai; and Circle Theatre Company and …


Origin And Evolution Of Marsupial-Specific Imprinting Clusters Through Lineage-Specific Gene Duplications And Acquisition Of Promoter Differential Methylation, Wenqi Cao, Kory C. Douglas, Paul B. Samollow, John Vandeberg, Xu Wang, Andrew G. Clark Feb 2023

Origin And Evolution Of Marsupial-Specific Imprinting Clusters Through Lineage-Specific Gene Duplications And Acquisition Of Promoter Differential Methylation, Wenqi Cao, Kory C. Douglas, Paul B. Samollow, John Vandeberg, Xu Wang, Andrew G. Clark

School of Medicine Publications

Genomic imprinting is a parent-of-origin-specific expression phenomenon that plays fundamental roles in many biological processes. In animals, imprinting is only observed in therian mammals, with ∼200 imprinted genes known in humans and mice. The imprinting pattern in marsupials has been minimally investigated by examining orthologs to known eutherian imprinted genes. To identify marsupial-specific imprinting in an unbiased way, we performed RNA-seq studies on samples of fetal brain and placenta from the reciprocal cross progeny of two laboratory opossum stocks. We inferred allele-specific expression for >3,000 expressed genes and discovered/validated 13 imprinted genes, including three previously known imprinted genes, Igf2r, Peg10, …


Multi-Ancestry Transcriptome-Wide Association Analyses Yield Insights Into Tobacco Use Biology And Drug Repurposing, Fang Cheng, Xingyan Wang, Seon-Kyeong Jang, Bryan C. Quach, J. Dylan Weissenkampen, Chachrit Khunsriraksakul, Lina Yang, John Blangero, Joanne E. Curran, Ravindranath Duggirala, Juan M. Peralta Feb 2023

Multi-Ancestry Transcriptome-Wide Association Analyses Yield Insights Into Tobacco Use Biology And Drug Repurposing, Fang Cheng, Xingyan Wang, Seon-Kyeong Jang, Bryan C. Quach, J. Dylan Weissenkampen, Chachrit Khunsriraksakul, Lina Yang, John Blangero, Joanne E. Curran, Ravindranath Duggirala, Juan M. Peralta

School of Medicine Publications

Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and lack diversity. To overcome this limitation, we aggregated genome-wide association study (GWAS) summary statistics, whole-genome sequences and expression quantitative trait locus (eQTL) data from diverse ancestries. We developed a new approach, TESLA (multi-ancestry integrative study using an optimal linear combination of association statistics), to integrate an eQTL dataset with a multi-ancestry GWAS. By exploiting shared phenotypic effects between ancestries and accommodating potential effect heterogeneities, TESLA improves power over other TWAS methods. When applied to tobacco use phenotypes, TESLA identified 273 new genes, up to 55% more compared with …


The Effect Of An American Heart Association–Approved Exercise Regimen On Burnout In Nurse Practitioners And Physician Assistants Working In Emergency Departments, Michelle Lee Johnson Feb 2023

The Effect Of An American Heart Association–Approved Exercise Regimen On Burnout In Nurse Practitioners And Physician Assistants Working In Emergency Departments, Michelle Lee Johnson

Electronic Theses and Dissertations

Burnout is a widely known state of physical and emotional fatigue previously noted to affect as many as 60% of healthcare providers, but one that is understudied in nurse practitioners and physician assistants working in emergency departments. It is imperative that the providers of healthcare recognize in themselves signs of burnout and have resources available to mitigate the condition. A pretest–posttest, quasi-experimental, nonequivalent control group, descriptive research design with descriptive statistics analysis was used to analyze answers to an email-based survey sent to nurse practitioners and physician assistants working for one large emergency medicine staffing company. The intent of this …


The Perceptions Of Faculty And Instructional Designers Regarding The Impact Of Professional Development To Teach Online Courses, Scott Mitchell January Feb 2023

The Perceptions Of Faculty And Instructional Designers Regarding The Impact Of Professional Development To Teach Online Courses, Scott Mitchell January

Electronic Theses and Dissertations

Leadership at a mid-sized 4-year university in the western region of Texas asserted a problem with the low amount of faculty training impacting online courses’ creation and quality. The purpose of this qualitative single case study was to investigate the elements needed to design quality online courses, determine how faculty and instructional designers perceived professional development provided by the university to develop online courses, and find out how faculty and instructional designers perceived professional development impacted faculty skills as an online instructor. Three research questions were created which generated two interview protocols. The following research questions were used and were …