Digital Commons Network^™

Implicit Bias Mask: Inside Out (The Life Of A Medical Student), Akarsh Lal, Shawn O'Malley, Elizabeth Choi, Emily Falkowski, Ramneet Chauhan, Damian Daryl Nucum

Patient Education Projects

No abstract provided.

Implicit Bias Mask: The Duality Of Self, Malik Al-Jamal, Laura Geneseo, Nolan Tews, Marla Adam, Kendall Brothers, Edward Abarado

Patient Education Projects

No abstract provided.

Implicit Bias Mask: "Undefining Ourselves"​, Ajay Pradhan, Nina Brahmbhatt, Aminah Fayyaz, Adam Chaban, Cyrus Amirfazli, Karina Haleblian

Patient Education Projects

No abstract provided.

Inhibition Of Colorectal Cancer Tumorigenesis By Ursolic Acid And Doxorubicin Is Mediated By Targeting The Akt Signaling Pathway And Activating The Hippo Signaling Pathway, Dan Hu, Ruo Yu Meng, Thi Van Nguyen, Ok Hee Chai, Byung Hyun Park, Ju-Seog Lee, Soo Mi Kim

Faculty, Staff and Student Publications

Colorectal cancer (CRC) is one of the deadliest malignant tumors worldwide and its prevalence is increasing in South Korea. The efficacy of combined treatment with natural product‑derived and chemotherapy agents including curcumin combined with 5‑fluorouracil, resveratrol combined with cisplatin and epigallocatechin‑3‑gallate (EGCG) combined with cisplatin in preventing cancer progression and killing cancer cells has emerged. The Akt and Hippo signaling pathways serve a key role in colorectal tumor growth; however, the exact role of the crosstalk between Akt and Hippo signaling pathways in CRC remains poorly elucidated. The combined effect of UA and DOX on the cell proliferation, apoptosis, migration …

The Impact Of Covid-19 Pandemic Upon Non-Elective Admissions And Surgery At A Safety-Net Hospital, Aurelien Amiot, Jean-Francois Rahier, Filip Baert, Stephane Nahon, Ailsa Hart, Nikos Viazis, Livia Biancone, Eugeni Domenech, Catherine Reenears, Laurent Peyrin-Biroulet, Laurent Beaugerie, Johan Burisch, I-Care Collaborator Group

Faculty, Staff and Student Publications

BACKGROUND AND AIMS: There are concerns regarding the potential impact of the COVID-19 outbreak on patients with inflammatory bowel disease [IBD]. We report on the impact of the COVID-19 outbreak in a European prospective cohort study of patients with IBD.

PATIENTS AND METHODS: We prospectively collected data from 5457 patients with IBD nested in the ongoing I-CARE project and still followed up in April 2020, with monthly online monitoring of clinical activity, treatment, imaging and endoscopy. Investigators were also contacted to report incidental cases.

RESULTS: In total, 233 [4.3%] reported COVID-19 and 12 [0.2%] severe COVID-19, with no COVID-19 deaths. …

Monitoring And Modulating Diet And Gut Microbes To Enhance Response And Reduce Toxicity To Cancer Treatment, Anne Knisely, Yongwoo David Seo, Jennifer A Wargo, Manoj Chelvanambi

Faculty, Staff and Student Publications

The gut microbiome comprises a diverse array of microbial species that have been shown to dynamically modulate host immunity both locally and systemically, as well as contribute to tumorigenesis. In this review, we discuss the scientific evidence on the role that gut microbes and diet play in response and toxicity to cancer treatment. We highlight studies across multiple cancer cohorts that have shown an association between particular gut microbiome signatures and an improved response to immune checkpoint blockade, chemotherapy, and adoptive cell therapies, as well as the role of particular microbes in driving treatment-related toxicity and how the microbiome can …

Is It Time To Re-Think Fast? A Systematic Review And Meta-Analysis Of Contrast-Enhanced Ultrasound (Ceus) And Conventional Ultrasound For Initial Assessment Of Abdominal Trauma, Bayu Sutarjono, Matthew Kessel, Dorian Alexander, Ekjot Grewal

Faculty, Staff and Student Publications

BACKGROUND: The Focused Assessment with Sonography for Trauma (FAST) examination using conventional ultrasound has limited utility for detecting solid organ injury. Therefore, this systematic review and meta-analysis compares the performance of contrast-enhanced ultrasound (CEUS) to conventional ultrasound when used as the initial assessment for abdominal trauma prior to computed tomography (CT) imaging.

METHODS: A systematic literature search of major databases was conducted of human studies investigating the diagnostic accuracy of conventional ultrasound and CEUS occurring prior to CT imaging for abdominal trauma. The study followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. The quality of studies …

A Survey With Interventional Components Delivered On Tablet Devices Versus Usual Care To Increase Pre-Exposure Prophylaxis Uptake Among Cisgender Black Women: A Pilot Randomized Controlled Trial, Mandy J Hill, Angela M Heads, Robert Suchting, Angela L Stotts

Faculty, Staff and Student Publications

BACKGROUND: Cisgender (cis) Black women in the USA are more likely to become HIV positive during their lifetime than other women. We developed and implemented a behavioral intervention, Increasing PrEP (iPrEP), the first pilot randomized controlled trial (RCT) aimed at motivating cis Black women to be willing to use PrEP for HIV prevention and attend an initial PrEP clinic visit following an emergency department visit.

METHODS: Eligible participants were Black cisgender women ages 18-55 years who acknowledged recent condomless sex and substance use. Participants were randomized to iPrEP or usual care (UC). iPrEP is a survey-based intervention designed to raise …

4d Lung Mri With High-Isotropic-Resolution Using Half-Spoke (Ute) And Full-Spoke 3d Radial Acquisition And Temporal Compressed Sensing Reconstruction, Can Wu, Guruprasad Krishnamoorthy, Victoria Yu, Ergys Subashi, Andreas Rimner, Ricardo Otazo

Faculty, Staff and Student Publications

Objective:

To develop a respiratory motion-resolved 4D MRI technique with high-isotropic-resolution (1.1 mm) using 3D radial sampling, camera-based respiratory motion sensing, and temporal compressed sensing reconstruction for lung cancer imaging.

Approach:

Free-breathing half- and full-spoke 3D golden-angle radial acquisitions were performed on eight healthy volunteers and eight patients with lung tumors of varying size. A back-and-forth k-space ordering between consecutive interleaves of the 3D radial acquisition was performed to minimize eddy current-related artifacts. Data were sorted into respiratory motion states using camera-based motion navigation and 4D images were reconstructed using temporal compressed sensing to reduce scan time. Normalized sharpness indices …

Mirna-205: A Future Therapeutic Molecule For Liver Diseases, Marco A. Cabrera, Meghana Kolli, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

School of Medicine Publications

miR-205 is consistently downregulated in liver fibrosis, liver cirrhosis, and liver cancer, which indicates it may be a potential therapeutic restoration molecule to tackle liver diseases.

The spectrum of liver diseases presents a major public health concern that is widespread across the globe, accounting for 2 million deaths per year [1]. Among all liver diseases, the most common, nonalcoholic fatty liver disease (NAFLD), has been globally estimated to account for a quarter of all cases, ranging regionally from 14 to 32% [2]. In addition, liver cancer is the 16th most common cause of mortality worldwide [ …

Sediment Transport And Geomorphological Evolution In The Northern Gulf Of Mexico, Kelli Moran

LSU Doctoral Dissertations

This dissertation explores the mechanisms driving sediment transport and deposition on the continental shelf and within the bays of the northern Gulf of Mexico via a suite of geophysical methods and sediment cores on a variety of timescales. This dissertation is comprised of three main chapters, each focusing on a different location, environment, and process but tied together using geophysical survey, a thematic focus on geomorphic change and sediment transport within the deltaic cycle and deltaic plain environments, and the implications this change poses for both past and future sediment transport and environmental change in response to sea level change. …

January 27, 2023 Minutes, Swosu Faculty Senate

Faculty Senate Minutes

SWOSU Faculty Senate Official Minutes from the January 27, 2023 meeting

Dosimetric Impact Of Lesion Number, Size, And Volume On Mean Brain Dose With Stereotactic Radiosurgery For Multiple Brain Metastases, Alonso La Rosa De Los Rios, D Jay Wieczorek, Ranjini Tolakanahalli, Cecilia Lee, Tugce Kutuk, Matthew Hall, Michael Mcdermott, Minesh Mehta, Alonso Gutierrez, Rupesh Kotecha

All Publications

We evaluated the effect of lesion number and volume for brain metastasis treated with SRS using GammaKnife® ICON™ (GK) and CyberKnife® M6™ (CK). Four sets of lesion sizes (<5 mm, 5-10 mm, >10-15 mm, and >15 mm) were contoured and prescribed a dose of 20 Gy/1 fraction. The number of lesions was increased until a threshold mean brain dose of 8 Gy was reached; then individually optimized to achieve maximum conformity. Across GK plans, mean brain dose was linearly proportional to the number of lesions and total GTV for all sizes. The numbers of lesions needed to reach this threshold for GK were …

Harmful Speech And The Covid-19 Penumbra, Kenneth Grad, Amanda Turnbull

Canadian Journal of Law and Technology

We make two central claims in this essay. First, the themes of malinformation have remained remarkably consistent across pandemics. What has changed is only the manner of their spread through evolving technologies and globalization. Thus, as with pandemic preparedness more generally, our failure to take proactive measures reflects a failure to heed the lessons of the past. Second, we argue that the COVID-19 pandemic presents a unique opportunity to tackle online falsehoods and mitigate their impact in the future.

We proceed in three parts. Part one addresses the harmful speech that inevitably follows in pandemic’s wake. We illustrate this through …

The Adverse Human Rights Impacts Of Canadian Technology Companies: Reforming Export Control With The Introduction Of Mandatory Human Rights Due Diligence, Siena Anstis, Rj Reid

Canadian Journal of Law and Technology

Netsweeper, a Canadian company, has produced and sold Internet-filtering technology to authoritarian regimes abroad. According to public research from the Citizen Lab, this technology has been used to censor religious content in Bahrain, information on Rohingya refugees in Myanmar and India, political campaign content in United Arab Emirates, and information on HIV/AIDS in Kuwait. This article considers how Canadian export control law deals with technologies that negatively impact human rights abroad and identifies a gap in the existing export control scheme. We suggest this gap could be closed by adopting a proactive human rights due diligence requirement on companies seeking …

Digital Surveillance Of Covid-19: Privacy And Equity Considerations, Elaine Gibson, Cal Dewolfe, Ilana Luther

Canadian Journal of Law and Technology

In this paper, we examine the potentially deleterious effects of surveillance on vulnerable Canadians. A wide range of digital surveillance technologies have either been deployed or considered for deployment both in Canada and around the world in response to the international emergency created by the COVID-19 pandemic. Some of these technologies are highly effective in predicting or identifying individual cases and/or outbreaks; others assist in tracing contacts or enforcing compliance with quarantine and isolation measures. However, there are necessarily risks associated with their deployment. First are the infringements on privacy rights of citizens and groups. Second, these technologies run the …

Drug Specificity And Affinity Are Encoded In The Probability Of Cryptic Pocket Opening In Myosin Motor Domains, Artur Meller, Jeffrey M Lotthammer, Louis G Smith, Borna Novak, Lindsey A Lee, Catherine C Kuhn, Lina Greenberg, Leslie A Leinwand, Michael J Greenberg, Gregory R Bowman

2020-Current year OA Pubs

The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at least six of its members cause numerous diseases. Allosteric modulators, like the myosin-II inhibitor blebbistatin, are a promising means to achieve specificity. However, it remains unclear why blebbistatin inhibits myosin-II motors with different potencies given that it binds at a highly conserved pocket that is always closed in blebbistatin-free experimental structures. We hypothesized that the probability of pocket opening is an important determinant of the …

Development Of De Novo Nonalcoholic Fatty Liver Disease Following Pancreatectomy, Vanisha Patel, Parth Shah, Daniel R. Ludwig, Chet W. Hammill, Motaz Ashkar

2020-Current year OA Pubs

De novo non-alcoholic fatty liver disease (NAFLD) after pancreatectomy is a recognized phenomenon; however, its pathophysiology is poorly understood. This study aimed to determine the incidence and identify peri-operative risk factors for the development of de novo NAFLD within various pancreatectomy groups. This single-center retrospective cohort study included patients who underwent pancreatectomy between 2000 and 2020. The incidence rate of de novo NAFLD and time to diagnosis were recorded across patients with malignant versus benign indications for pancreatectomy. The overall incidence of de novo NAFLD after pancreatectomy was 17.5% (24/136). Twenty-one percent (20/94) of patients with malignant indications for surgery …

Accomplishments And Challenges Of The Research On Antillean Manatee: A Bibliometric Analysis, Delma Nataly Castelblanco-Martínez, Daniel Gonzalez-Socoloske, Leslie Cabrias, Natalia Garcés-Cuartas, Gloria Katerin Arévalo-González, João Carlos Gomes Borges, Miriam Marmontel

Faculty Publications

The Antillean manatee (Trichechus manatus manatus) is an endangered subspecies of the West Indian manatee inhabiting countries of South America, Meso America and the Caribbean. Basic and applied research is necessary to inform management plans for the effective recovery of this subspecies. The purpose of this study was to systematically review literature regarding Antillean manatees, without restriction of the research topic. Article selection and screening process are described. Our final database consisted of 456 publications, of which peer-reviewed literature (articles, reviews, and notes in research journals) represent the most important type (63.4%), followed by BSc, MSc, and PhD theses (28.1%). …

Seeing In The Dark: A Review Of The Use Of Side-Scan Sonar To Detect And Study Manatees, With An Emphasis On Latin America, Daniel Gonzalez-Socoloske, León David Olivera-Gómez

Faculty Publications

Manatees are aquatic mammals that live in a variety of environments. Many of those shallow water environments have murky water, making detection using traditional visual surveys very challenging. Side-scan sonar was first proposed as a tool to detect and study manatees in these complicated habitats in 2005. Here, we summarize the use of this tool from 2005 to 2022 by searching the available literature. Our literature search revealed that this tool is being widely used in more than 20 locations and over 15 countries. All three manatee species are being studied with side-scan sonar. It is most useful in murky …

Session 4 - Ethnic Studies In The Library: Supporting New Curriculum, Nicole Hunter

High School Libraries Workshop

Starting in 2025, California public high schools will be required to offer Ethnic Studies courses. While this mandate may not affect your school, the waves of this movement are likely to impact course content at all grade levels and in all schools in coming years. How can we as library workers support the needs that will come with these exciting changes? In this session, I will talk about my role in piloting an Ethnic Studies course at San Francisco University High School, walk you through a short lesson, and then we will have time to talk about ways that libraries …

The Acute Effects Of Ischemic Preconditioning On Short-Duration Cycling: A Randomized Crossover Study, Cassidy R. Nelson, Colten R. Brand, Matthew R. Chitty, Chad B. Birger, Shane D. Scholten

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 148-158, 2023. There is recent interest from coaches and athletes regarding IPC as an effective way to generate better competitive outcomes. Regarding cycling specifically, the impact of IPC remains unclear. This study aimed to assess the effectiveness of IPC treatment for improving athletic performance during short-duration cycling. After the exclusion and inclusion criteria, there were 11 volunteers for the 3-minute cycling TT and 13 volunteers for the 6-minute cycling TT. All volunteers were competitive athletes of aerobic sports. The IPC treatment consisted of three alternating cycles of 5 minutes of 100% occlusion followed by …

Do Female University Varsity Athletes Have A Greater Risk Of Injury Within A Competitive Varsity Season?, Aidan K. Comeau, Eric C. Parent, Michael D. Kennedy

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 129-147, 2023. Previous varsity sport injury research has analyzed how acute and chronic injury severity, type, and location differs between sport and sexes, with limited research in time to injury. Canadian university varsity sport injury research is especially sparse and mostly retrospective. Thus, we aimed to understand injury differences in male and female competitive university athletes competing in the same sport. Athletes who competed on the basketball, volleyball, soccer, ice hockey, football (male), rugby (female), and wrestling teams were eligible for the study. There were 182 male and 113 female athletes who provided informed …

Acute Blood Flow Responses To Varying Blood Flow Restriction Pressures In The Lower Limbs, Bjoern Hornikel, Keith S. Saffold, Jacob A. Mota, Michael R. Esco, Michael V. Fedewa, Stefanie A. Wind, Lee J. Winchester

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 118-128, 2023. The purpose of this study was to investigate lower limb blood flow responses under varying blood flow restriction (BFR) pressures based on individualized limb occlusion pressures (LOP) using a commonly used occlusion device. Twenty-nine participants (65.5% female, 23.8 ± 4.7 years) volunteered for this study. An 11.5cm tourniquet was placed around participants’ right proximal thigh, followed by an automated LOP measurement (207.1 ± 29.4mmHg). Doppler ultrasound was used to assess posterior tibial artery blood flow at rest, followed by 10% increments of LOP (10-90% LOP) in a randomized order. All data were …

A Pilot Study On Cannabidiol (Cbd) And Eccentric Exercise: Impact On Inflammation, Performance, And Pain, Whitley J. Stone, Danilo Tolusso, Guillermo Pacheco, Shea M. Brgoch, Van T. Nguyen

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 109-117, 2023. Cannabidiol (CBD) is a non-psychoactive cannabinoid purported to reduce symptoms of discomfort. Individuals are now using CBD to treat symptoms of multiple sclerosis, seizures, and chronic pain. Animal models indicate that CBD may be effective at reducing inflammation post fatiguing exercise. However, little evidence is available to evaluate these findings in humans. Therefore, the purpose of this investigation was to evaluate the impact of two doses of CBD oil on inflammation (IL-6), performance, and pain after an eccentric loading protocol. Participants (n = 4) participated in three conditions (placebo, low dose, …

A Unique Path To Nationwide Paid Family And Medical Leave: Through The U.S. States, Yan Goodwin

DePaul Law Review

No abstract provided.

The Absurd Pandemonium Surrounding Spacs: An Argument In Favor Of Legislative And Judicial Restraint, Eric D. Guenther

DePaul Law Review

No abstract provided.

Against Personal Jurisdiction Law, John Leubsdorf

DePaul Law Review

No abstract provided.

Segregation On-Demand: Limiting Discriminatory Municipal Incorporations, Shai Stern

DePaul Law Review

No abstract provided.

Reflections On Establishing The Depaul Law Review, Allen Moye

DePaul Law Review

No abstract provided.